Physics of Nerves and Excitatory Membranes
Médecine, Sciences et technologies
Audio avec voix de synthèse, Braille automatisé
Résumé
Ground-breaking reference explaining the biological properties of nerve cell membranes from a unifying physical perspective Without neglecting the known theories of nerve impulse propagation, Physics of Nerves and Excitatory Membranes focuses on the less known features of nerve cell membranes,… such as their mechanical, caloric and optical properties. Based on these properties, the author then develops an electromechanical theory of pulse propagation, offering the most plausible explanation yet for some unresolved questions regarding the effects observed during general anesthesia. Physics of Nerves and Excitatory Membranes is didactically written and includes information on: The structure and electrical properties of nerves, dimensions and mechanical properties of the nerve pulse, and optical changes during the action potential Cable theory, voltage gating, the Hodgkin-Huxley model, and protein ion channels Membrane structure and melting, phase behavior, domains, and rafts, and the influence of pressure, voltage, drugs, proteins, pH, and ionic strength Heat capacity, sound propagation, relaxation timescales, and capacitance and capacitive susceptibility The emergence of solitary nerve pulses in a biological membrane under physiological conditions Voltage-gated and mechanosensitive lipid channels, temperature sensing, and selectivity of lipid channels Physics of Nerves and Excitatory Membranes is of prime interest for biophysicists studying biomembranes as well as for neurobiologists and clinical researchers studying anesthesia. Its accessible style makes it very well suited for teaching the subjects that it covers.