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Enzymes: A Practical Introduction to Structure, Mechanism, and Data Analysis
By Robert A. Copeland. 2023
ENZYMES A complete and approachable introduction to the study of enzymes, from theory to practice Enzymes catalyze the bulk of…
important biological processes, both metabolic and biochemical. They are specialized proteins whose function is determined by their structure, understanding which is therefore a key focus of biological, pharmacological, and agrarian research, among many others. A thorough knowledge of enzyme structure, pathways, and mechanisms is a fundamental building block of the life sciences and all others connected to them. Enzymes offers a detailed introduction to this critical subject. It analyzes enzyme proteins at the structural level and details the mechanisms by which they perform their catalyzing functions. The book’s in-depth engagement with primary literature and up-to-date research allows it to continuously deploy illustrative examples and connect readers with further research on key subjects. Fully updated after decades as the standard text, this book unlocks a thriving field of biological and biochemical research. Readers of the third edition of Enzymes will also find: Expanded chapters on steady-state and transient-state enzyme kinetics, structural components of enzymes, and more New chapters on enzyme regulation, enzyme-macromolecule interactions, enzyme evolution, and enzymes in human health Key Learning Points at the beginning of each chapter to assist students and instructors Enzymes promises to continue as the standard reference on this subject for practitioners of the life sciences and related fields in both academia and industry.The Disabled Body in Contemporary Art
By Ann Millett-Gallant. 2024
The second edition offers an essential update to the foundational first edition, The Disabled Body in Contemporary Art. Featuring updated chapters…
and case studies, this second edition will not only expand on the first edition but will bring a new focus to contemporary disabled artists and their embodied, multimedia work.Essential Clinical Global Health (Essentials)
By Brett D. Nelson. 2015
Essential Clinical Global Health is a brand-new, pioneering, and evidence-based textbook that provides a clinical overview of the increasingly prominent…
specialty of global health. Originally developed from a course at Harvard Medical School, and now with contributions from nearly 100 world-renowned global health experts from across the globe, this textbook presents vital information required of students, trainees, and clinicians during their international experiences and training. Essential Clinical Global Health introduces readers to the up-to-date knowledge, skills, and approaches needed for productive and rewarding global health experiences. It provides essential clinical information on the diagnosis, management, and prevention of the leading causes of morbidity and mortality in low- and middle-income countries. The textbook also includes practical guidance on topics such as health systems, population-based approaches, cultural awareness and sensitivity, travel preparedness and safety, and career development in global health. With key learning objectives in each chapter, practical clinical advice, setting-appropriate guidelines, personal field experiences from student and clinician contributors, Essential Clinical Global Health is the first global health textbook with a clinical focus for healthcare students, trainees, and providers.A companion website at www.wileyessential.com/globalhealth features self-assessment questions and videos.Herz-Kreislauf (Springer-Lehrbuch)
By Thomas F. Lüscher, Ulf Landmesser. 2024
Der Blick aufs GanzeEs ist immer wieder dasselbe: Wenn im klinischen Abschnitt endlich die spannenden Krankheitsbilder kommen, sind Anatomie und…
Physiologie längst vergessen. Mühsam muss man alles wiederholen, um zu verstehen, worum es bei der Erkrankung geht.Lernen Sie ein Organsystem doch einfach „am Stück“: von der Anatomie über die Physiologie bis zur Diagnostik und Therapie von Erkrankungen. Dieses Buch ist ideal für das Lernen im Modul, hier verstehen Sie das Organsystem im Zusammenhang. Die Erkrankungen des Herz-Kreislauf-Systems werden systematisch abgehandelt - endlich genügt ein einziges Buch, um den ganzen Themenblock durchzuarbeiten. Und dabei helfen Ihnen: Praktische Anleitungen für Diagnostik und TherapieZahlreiche diagnostische BilderNeueste Erkenntnisse und TherapieverfahrenMerksätze, Tabellen und Übersichten mit den wichtigsten FaktenWegen seiner Praxisnähe ist dieser Band sowohl für Medizinstudenten als auch für Ärzte in der kardiologischen Aus- und Weiterbildung bestens geeignet.Für die dritte Auflage wurde das Buch sorgfältig aktualisiert und um zwei neue Kapitel zur pulmonalen Hypertonie sowie Erkrankungen des venösen Systems ergänzt. So bleiben Sie auch mit der dritten Auflage am Puls der Zeit in der Kardiologie!Understanding Mental Health Apps: An Applied Psychosocial Perspective (Palgrave Studies in Cyberpsychology)
By Lewis Goodings, Darren Ellis, Ian Tucker. 2024
This is the first book to look exclusively from at the use of MHapps from an applied psychosocial perspective. Much of…
the academic literature on MHapps in psychology focuses on the clinical efficacy of using apps (e.g., depression reduction as result of using a certain app) and will typically report on the use of randomised controlled trials (or a similar method) to illustrate the use of apps as a tool for improving a psychological condition. Therefore, the main benefit of this book is that it recognises the impact of apps from a social perspective and will aim to show how everyday forms of distress are embedded in the use of these apps and the broader set of relations that constitute people’s everyday lives. The content of this book will identify how an applied social perspective can offer insight into the power of apps to shape our sense of ourselves and of others. This book will be of use to educators and students in psychology, sociology, health studies, media studies andcultural studies.Surgery of Craniosynostosis and Related Midface Deformities: An Atlas and Step-by-Step Guide
By Michael Rasse. 2024
This atlas offers a comprehensive overview of osteotomies performed on the calvaria and midface for both syndromic and non-syndromic craniosynostosis.It…
presents a systematic approach, beginning with calvarial osteotomies. The author introduces a general type of osteotomy that can be applied for total vault remodeling in cases of total synostosis. These osteotomies can also be modified and used in single or combined synostoses. To shape the calvaria, the book describes the use of metal plates as a scaphold. These plates can be prebent on 3-D models and used to fix the segments after osteotomies. Following that, resorbable osteosynthesis is performed, and the metal plates are subsequently removed. This unique approach, combined with standardized osteotomies, ensures highly predictable results that are not currently described in textbooks. The book includes clinical examples for each type of synostosis and various combinations, including two-stage procedures and combinations with distraction techniques. These examples provide surgeons with a solid foundation for addressing different cases. In the chapter on midface osteotomies, the book explains the access and technique for performing the LeFort-III osteotomy using cadaver and clinical figures. It covers all types of LeFort-I to III osteotomies and their combinations through clinical cases. The book illustrates the osteotomies, osteosynthesis, distraction techniques, and combinations using clinical examples. Additionally, the book demonstrates the method of computer planning, the fabrication of osteotomy guides, and the use of preformed plates to define the position of the segments.The book's primary objective is to serve as a surgical guide that transcends the boundaries of medical specialties. Given that this type of surgery is often performed by different specialists across institutions and countries, the book aims to facilitate cooperation and provide a practical application tool for surgeons beyond offering a clinical overview.The Balance Within: The Science Connecting Health and Emotions
By Esther M. Sternberg. 2001
A thrilling scientific detective story, The Balance Within tells how researchers finally uncovered the elusive mind-body connection and what it…
means for our health. Since ancient times humans have felt intuitively that emotions and health are linked, and recently there has been much popular speculation about this notion. But until now, without compelling evidence, it has been impossible to say for sure that such a connection really exists and especially how it works. Now, that evidence has been discovered.In this beautifully written book, Dr. Esther Sternberg, whose discoveries were pivotal in helping to solve this mystery, provides first hand accounts of the breakthrough experiments that revealed the physical mechanisms - the nerves, cells, and hormones - used by the brain and immune system to communicate with each other. She describes just how stress can make us more susceptible to all types of illnesses, and how the immune system can alter our moods. Finally, she explains how our understanding of these connections in scientific terms is helping to answer such crucial questions as "Does stress make you sick?" "Is a positive outlook the key to better health?" and "How do our personal relationships, work, and other aspects of our lives affect our health?"A fascinating, elegantly written portrait of this rapidly emerging field with enormous potential for finding new ways to treat disease and cope with stress, The Balance Within is essential reading for anyone interested in making their body and mind whole again.Masters of Mystery: The Strange Friendship of Arthur Conan Doyle & Harry Houdini
By Christopher Sandford. 1997
Renowned mystery author Arthur Conan Doyle and famous illusionist Harry Houdini first met in 1920, during the magician's tour of…
England. At the time, Conan Doyle had given up his lucrative writing career, killing off Sherlock Holmes in the process, in order to concentrate on his increasingly manic interest in Spiritualism. Houdini, who regularly conducted séances in an attempt to reach his late mother, was also infatuated with the idea of what he called a "living afterlife," though his enthusiasm came to be tempered by his ability to expose fraudulent mediums, many of whom employed crude variations of his own well-known illusions. Using previously unpublished material on the murky relationship between Houdini and Conan Doyle, this sometimes macabre, sometimes comic tale tells the fascinating story of the relationship between two of the most loved figures of the 20th century and their pursuit of magic and lost loved ones.Some Enchanted Evenings: The Glittering Life and Times of Mary Martin
By David Kaufman. 2016
Mary Martin was one of the greatest stars of her day. Growing up in Texas, she was married early to…
Benjamin Hagman and gave birth to her first child, Larry Hagman. She was divorced even more quickly. Martin left little Larry with her parents and took off for Hollywood. She didn't make a dent in the movie industry and was lured to New York where she found herself auditioning for Cole Porter and his new show "Leave It to Me!". After she sang the bawdy "My Heart Belongs to Daddy", she ended up on the cover of Life magazine. Six years later, she became the Toast of Broadway when she starred in "South Pacific". After that, she flew as "Peter Pan", yodeled in "The Sound of Music", took "Hello, Dolly!" on the road and shared a four-poster with Robert Preston in "I Do! I Do!". Her personal life was just as interesting: In NYC, she met and married Richard Halliday, a closeted upper-class homosexual who adored her, Broadway and interior decorating (though probably not in that order). They were a powerful twosome. There were rumors about Martin, too, being in a lesbian relationship with both Janet Gaynor and Jean Arthur. Peopled with legends like Ethel Merman, Ezio Pinza, Noel Coward and a starry cast of thousands, David Kaufman's "Some Enchanted Evenings" is the delectable story of the one and only Mary Martin, a woman who described herself as a chicken farmer from Texas only to become Peter Pan and capture America's heart.Knee Surgery: The Essential Step-by-Step Guide to Total Knee Recovery
By Daniel Fulham O'Neill. 2009
In this age of same-day surgery and do-it-yourself health, Knee Surgery presents an easy-to-do, well-illustrated program of movement for knee…
rehabilitation - with a special focus on the mind/body connection - and describes the physical and mental rehabilitation process in complete detail, providing all the guidance you need to decrease pain and increase fitness after knee surgery. Millions of people have knee surgery each year, and in the years to come millions more will head to the O.R. Chances are, you or someone you know has had or will undergo knee surgery. Busy doctors, therapists, and athletic trainers have limited time to spend on quality physical and mental rehabilitation education, yet this is the key to full recovery.Written by renowned knee surgeon and Sport Psychologist Daniel F. O'Neill, M.D., Ed.D., this comprehensive and accessible guide presents what you'll want and need the most after knee surgery: a scientifically-based recovery program you can understand that will get you back to work and sports as quickly as possible.But What I Really Want to Do Is Direct: Lessons from a Life Behind the Camera
By Ken Kwapis. 2020
For over three decades, director Ken Kwapis has charted a career full of exceptional movies and television, from seminal shows…
like The Office to beloved films like He’s Just Not That Into You.He is among the most respected directors in show business, but getting there wasn’t easy. He struggled just like everyone else. With each triumph came the occasional faceplant. Using his background and inside knowledge, But What I Really Want To Do is Direct tackles Hollywood myths through Ken’s highly entertaining experiences. It’s a rollercoaster ride fueled by brawls with the top brass, clashes over budgets, and the passion that makes it all worthwhile.This humorous and refreshingly personal memoir is filled with inspiring instruction, behind-the-scenes hilarity, and unabashed joy. It’s a celebration of the director’s craft, and what it takes to succeed in show business on your own terms. "Ken Kwapis always brought out the best in the actors on The Office. Whenever Ken was directing, I always felt safe to go out on a limb and take chances, knowing he had my back. Every aspiring director should read this book. (I can think of several 'professional' directors that should read it too!)" -Jenna Fischer"A vital, magnificent manifesto on the art and craft of directing, written with emotional, instinctual and intellectual depth by one of America's most beloved film and television directors" -Amber Tamblyn"In the years that I was fortunate to work with Ken on Malcolm in the Middle, he had an uncanny ability to guide actors right to the heart of a scene and reveal its truths. He admits that he doesn’t have all the answers, he’ll make mistakes, and at times he’ll struggle, but as he says in the book, 'It’s the struggle to get it right that makes us human.'" -Bryan Cranston"Good luck finding a more kind, passionate, and talented director alive than Ken. Seriously, good luck." -Tig Notaro“'Action!' is what most directors bark out to begin a scene. But Ken Kwapis starts by gently intoning the words 'Go ahead…' That simple suggestion assures everyone they’re in smart, capable, humble hands. That’s how you’ll feel reading this book. And so, if you’re anxious to discover how a top director always brings humor, honesty, and humanity to his work, all I can tell you is…Go ahead." -Larry WilmoreThe Excruciating History of Dentistry: Toothsome Tales & Oral Oddities from Babylon to Braces
By James Wynbrandt. 1998
For those on both sides of the dreaded dentist's chair, James Wynbrandt has written a witty, colorful, and richly informative…
history of the art and science of dentistry. To all of those dental patients whose whine rises in tandem with that of the drill, take note: You would do well to stifle your terror and instead offer thanks to Apollonia, the patron saint of toothache sufferers, that you face only fleeting discomfort rather than the disfiguring distress, or slow agonizing death oft meted out by dental-care providers of the past. The transition from yesterday's ignorance, misapprehension, and superstition to the enlightened and nerve-deadened protocols of today has been a long, slow, and very painful process.For example, did you know that: *Among the toothache remedies favored by Pierre Fauchard, the father of dentistry, was rinsing the mouth liberally with one's own urine.*George Washington never had wooden teeth. However, his chronic dental problems may have impacted the outcome of the American Revolution. *Soldiers in the Civil War needed at least two opposing front teeth to rip open powder envelopes. Some men called up for induction had their front teeth extracted to avoid service. *Teeth were harvested from as many as fifty thousand corpses after the Battle of Waterloo, a huge crop later used for dentures and transplants that became known as "Waterloo Teeth."The Matter of the Heart: A History of the Heart in Eleven Operations
By Thomas Morris. 2017
An eye-opening and heroic story of pioneering heart surgeons, structured around eleven operations.For thousands of years the human heart remained…
the deepest of mysteries; both home to the soul and an organ too complex to touch, let alone operate on. Then, in the late nineteenth century, medics began going where no one had dared go before. The following decades saw the mysteries of the heart exposed, thanks to pioneering surgeons, brave patients and even sacrificial dogs. In eleven landmark operations, Thomas Morris tells us stories of triumph, reckless bravery, swaggering arrogance, jealousy and rivalry, and incredible ingenuity: the trail-blazing ‘blue baby’ procedure that transformed wheezing infants into pink, healthy children; the first human heart transplant, which made headline news around the globe. And yet the heart still feels sacred: just before the operation to fit one of the first artificial hearts, the patient’s wife asked the surgeon if he would still be able to love her.The Matter of the Heart gives us a view over the surgeon’s shoulder, showing us the heart’s inner workings and failings. It describes both a human story and a history of risk-taking that has ultimately saved millions of lives.So As I Was Saying . . .: My Somewhat Eventful Life
By Frank Mankiewicz, Joel Swerdlow. 2016
“I first met Robert Kennedy because I spoke Spanish. I spoke Spanish because the U.S. Army taught me that before…
sending me to France, Belgium, and Germany to fight Hitler’s Army. This makes complete sense if you are familiar with military bureaucracy.”Such is the trademark wit of Frank Mankiewicz. With his dry sense of humor and self-deprecating humility—despite his many accomplishments—Frank’s voice speaks from the pages of So as I was Saying... in a way that is both conversational and profound. Before he died in 2014 Frank’s fascinating life took him from Beverly Hills to the battlefields of Europe; from the halls of power in Washington D.C. to the far corners of the world. A lifelong student of humanity and mentor to many, including presidents, Frank was a loving father, husband, and friend, and his legacy is will endure for generations.Born into Hollywood royalty but determined to make his own way, Frank served in World War Two, wrote speeches for Robert Kennedy, ran a presidential campaign, carried messages to Fidel Castro, served as president of National Public Radio (helping create Morning Edition), and as regional director for the Peace Corps. Naturally such a long and interesting life gave rise to a myriad of opinions, and Frank was not afraid to share them. In this intriguing, insightful, and often humorous memoir, Frank recalls his favorite memories while sharing his opinions on everything from Zionism to smartphones. Imbued with the personality of one of the twentieth century’s most gifted raconteurs, So As I Was Saying... invokes nostalgia for the past even as it gives hope for the future.Mad Women: The Other Side of Life on Madison Avenue in the '60s and Beyond
By Jane Maas. 2012
"Breezy and salty." -The New York Times"Hilarious! Honest, intimate, this book tells it as it was." -Mary Wells Lawrence, author…
of A Big Life (In Advertising) and founding president of Wells Rich Greene "Breezy and engaging [though] ...The chief value of Mad Women is the witness it bears for younger women about the snobbery and sexism their mothers and grandmothers endured as the price of entry into mid-century American professional life." -The Boston Globe"A real-life Peggy Olson, right out of Mad Men." -Shelly Lazarus, Chairman, Ogilvy & MatherWhat was it like to be an advertising woman on Madison Avenue in the 60s and 70s - that Mad Men era of casual sex and professional serfdom? A real-life Peggy Olson reveals it all in this immensely entertaining and bittersweet memoir.Mad Women is a tell-all account of life in the New York advertising world by Jane Maas, a copywriter who succeeded in the primarily male jungle depicted in the hit show Mad Men. Fans of the show are dying to know how accurate it is: was there really that much sex at the office? Were there really three-martini lunches? Were women really second-class citizens? Jane Maas says the answer to all three questions is unequivocally "yes." Her book, based on her own experiences and countless interviews with her peers, gives the full stories, from the junior account man whose wife almost left him when she found the copy of Screw magazine he'd used to find "a date" for a client, to the Ogilvy & Mather's annual Boat Ride, a sex-and-booze filled orgy, from which it was said no virgin ever returned intact. Wickedly funny and full of juicy inside information, Mad Women also tackles some of the tougher issues of the era, such as unequal pay, rampant, jaw-dropping sexism, and the difficult choice many women faced between motherhood and their careers.Movie Stars Do the Dumbest Things
By Margaret Moser, Michael Bertin, Bill Crawford. 1999
Johnny Depp. Marilyn Monroe. Marlon Brando. Leonardo DiCaprio. Woody Allen. Shanron Stone. What do all of these actors have in…
common? They're outrageous, receive huge salaries, have enormous egos, and have way too much spare time. Their out-of-control lifestyles prove that, as one Hollywood observer noted, "Hollywood is a trip through a sewer in a glass-bottomed boat." You'll learn which director was furious when he was misquoted as saying, "Actors are cattle." He claimed he had really said, "Actors should be treated as cattle." You'll discover that Bruce Wilis ordered the final scenes in Striking Distance to be re-shot at a cost of over $750,000 because the original shots exposed his toupee.You'll find that Melanie Griffith explained her ignorance of the Nazi holocaust by saying, "I don't know why I didn't know. Maybe I missed school that day...I'm not stupid." Whether you're a fan of Hugh Grant, Dennis Hopper, or Whoopi Goldberg, you'll learn about all of the embarrassing moments in your favorite star's life. From actors like Ben Affleck and Cameron Diaz to screen legends like Frank Sinatra and Judy Garland, Movie Stars Do the Dumbest Things is proof that actors are more childish and impulsive than you've ever imagined.To millions of fans, All About Eve represents all that's witty and wonderful in classic Hollywood movies. Its old-fashioned, larger-than-life…
stars--including Bette Davis, Marilyn Monroe, Anne Baxter, George Sanders, and Celeste Holm--found their best roles in Eve and its sophisticated dialogue has entered the lexicon.But there's much more to know about All About Eve. Sam Staggs has written the definitive account of the making of this fascinating movie and its enormous influence on both film and popular culture. Staggs reveals everything about the movie--from who the famous European actress Margo Channing was based on to the hot-blooded romance on-set between Bette Davis and costar Gary Merrill, from the jump-start the movie gave Marilyn Monroe's career and the capstone it put on director Joseph L. Mankeiwicz's.All About "All About Eve" is not only full of rich detail about the movie, the director, and the stars, but also about the audience who loved it when it came out and adore it to this day.When Blanche Met Brando: The Scandalous Story of A Streetcar Named Desire
By Sam Staggs. 2005
Exhaustively researched and almost flirtatiously opinionated, When Blanche Met Brando is everything a fan needs to know about the ground-breaking…
New York and London stage productions of Williams' "Streetcar" as well as the classic Brando/Leigh film. Sam Staggs' interviews with all the living cast members of each production will enhance what's known about the play and movie, and help make this book satisfying as both a pop culture read and as a deeper piece of thinking about a well-known story. Readers will come away from this book delighted with the juicy behind-the-scenes stories about cast, director, playwright and the various productions and will also renew their curiosity about the connection between the role of Blanche and Viven Leigh's insatiable sexual appetite and later descent into breakdown. They may also-for the first time-question whether the character of Blanche was actually "mad" or whether her anxiousness was symptomatic of another disorder."A Streetcar Named Desire" is one of the most haunting and most-studied modern plays. Staggs' new book will fascinate fans and richen newcomers' understanding of its importance in American theater and movie history.The Fever: How Malaria Has Ruled Humankind for 500,000 Years
By Sonia Shah. 2010
In recent years, malaria has emerged as a cause célèbre for voguish philanthropists. Bill Gates, Bono, and Laura Bush are…
only a few of the personalities who have lent their names—and opened their pocketbooks—in hopes of curing the disease. Still, in a time when every emergent disease inspires waves of panic, why aren't we doing more to eradicate one of our oldest foes? And how does a parasitic disease that we've known how to prevent for more than a century still infect 500 million people every year, killing nearly 1 million of them?In The Fever, the journalist Sonia Shah sets out to answer these questions, delivering a timely, inquisitive chronicle of the illness and its influence on human lives. Through the centuries, she finds, we've invested our hopes in a panoply of drugs and technologies, and invariably those hopes have been dashed. From the settling of the New World to the construction of the Panama Canal, through wars and the advances of the Industrial Revolution, Shah tracks malaria's jagged ascent and the tragedies in its wake, revealing a parasite every bit as persistent as the insects that carry it. With distinguished prose and original reporting from Panama, Malawi, Cameroon, India, and elsewhere, The Fever captures the curiously fascinating, devastating history of this long-standing thorn in the side of humanity.Skylark: The Life and Times of Johnny Mercer
By Philip Furia. 2003
Skylark is the story of the tormented but glorious life and career of Johnny Mercer, and the first biography of…
this enormously popular and influential lyricist. Raised in Savannah, Mercer brought a quintessentially southern style to both his life in New York and to his lyrics, which often evoked the landscapes and mood of his youth ("Moon River", "In the Cool, Cool, Cool of the Evening"). Mercer also absorbed the music of southern blacks--the lullabies his nurse sang to him as a baby and the spirituals that poured out of Savannah's churches-and that cool smooth lyrical style informed some of his greatest songs, such as "That Old Black Magic".Part of a golden guild whose members included Cole Porter and Irving Berlin, Mercer took Hollywood by storm in the midst of the Great Depression. Putting words to some of the most famous tunes of the time, he wrote one hit after another, from "You Must Have Been a Beautiful Baby" to "Jeepers Creepers" and "Hooray for Hollywood." But it was also in Hollywood that Mercer's dark underside emerged. Sober, he was a kind, generous and at times even noble southern gentleman; when he drank, Mercer tore into friends and strangers alike with vicious abuse. Mercer's wife Ginger, whom he'd bested Bing Crosby to win, suffered the cruelest attacks; Mercer would even improvise cutting lyrics about her at parties.During World War II, Mercer served as Americas's troubadour, turning out such uplifting songs as "My Shining Hour" and "Ac-cent-tchu-ate the Positive." He also helped create Capitol Records, the first major West Coast recording company, where he discovered many talented singers, including Peggy Lee and Nat King Cole. During this period, he also began an intense affair with Judy Garland, which rekindled time and again for the rest of their lives. Although they never found happiness together, Garland became Mercer's muse and inspired some of his most sensuous and heartbreaking lyrics: "Blues in the Night," "One for My Baby," and "Come Rain or Come Shine."Mercer amassed a catalog of over a thousand songs and during some years had a song in the Top Ten every week of the year--the songwriting equivalent of Joe DiMaggio's hitting streak--but was plagued by a sense of failure and bitterness over the big Broadway hit that seemed forever out of reach.Based on scores of interviews with friends, family and colleagues, and drawing extensively on Johnny Mercer's letters, papers and his unpublished autobiography, Skylark is an important book about one of the great and dramatic characters in 20th century popular music.