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Autoimmune Disorders: Adjuvants and Other Risk Factors in Pathogenesis
By Abdulla Watad, Nicola Luigi Bragazzi, Yehuda Shoenfeld. 2024
Autoimmune Disorders Comprehensive resource on the science of autoimmune disorders, covering causes, treatment, prevention, and the latest research in the…
field Autoimmune Disorders is an authoritative reference on the science of autoimmune disorders, covering their causes, including infections, vaccine adjuvants, environmental stimuli, and silicone implants, the latest research on the genetics, epigenetics, and immunology of autoimmunity, predictive markers, therapeutic approaches for treatment and prevention, and suggestions for future research directions. This book explores the intricate connections between adjuvants and autoimmune responses, focusing on the emergence of the Autoimmune/Inflammatory Syndrome Induced by Adjuvants (ASIA syndrome), as well as autoimmune connections in areas such as chronic fatigue syndrome, autoantibodies targeting the autonomic system, and small fiber neuropathy. The authors emphasize the profound impact of vaccines on public health, underscoring that their benefits far outweigh potential side effects and exploring the historical context of adjuvants in vaccine development. From tattoos to environmental factors, each chapter adds a unique thread to the tapestry of adjuvants, autoimmune responses, and their interactions. Sample topics covered in Autoimmune Disorders include: Food additives and dental implants as a trigger of autoimmunity and increased risk of ASIA syndrome as a result of the chemical and social factors Sustained immune activation in ASIA syndrome as a bridge to lymphomagenesis and how immune checkpoints, metals, and bisphenol connect to autoimmunity Postural Orthostatic Tachycardia syndrome (POTS), Sick Building syndrome, and Gulf War syndrome (GWS) as parts of ASIA syndrome Sarcoidosis and Sjögren’s syndrome as a proof of concept of hyperstimulation syndrome Autoimmune Disorders is an essential reference on the subject for academics, specialized postgraduate students, and practicing professionals seeking to improve integrated research strategies and foster a deeper understanding of the complex relationship between immunology, public health, and individual well-being.Advanced Practice Psychiatric Nursing: From Bedside To Boardroom
By Rebecca M. Patton, Margarete L. Zalon, Ruth Ludwick. 2023
In 1949, Newfoundland and Labrador had a widely celebrated oral culture but little visual art. After entering the Canadian federation,…
recreational painters worked to create a venue for the display of art. The Cause of Art tells the story of the advocates, curators, and professional artists who laid the foundation for an artistic community in the province. The Memorial University Art Gallery was the site of a struggle between recreational painters who aspired to express their creative impulse and develop a Newfoundland art, and curators who wanted artists to participate in the Canadian art market and international artistic movements. The book recounts the history of passionate and strong-willed curators and cultural administrators who fought for control of the gallery. It reveals how they appealed to competing conceptions of professionalization, as well as diverse political and aesthetic preferences. Based on extensive archival research in previously unexamined collections, and oral interviews with key informants, this book examines a cultural institution that is widely remembered as the centre of the cultural renaissance in late twentieth-century Newfoundland and Labrador. As a result, The Cause of Art illuminates the relationship between the state and the university during a key period in the modernization of the province.The Beaches: Creation of a Toronto Neighbourhood
By Richard White. 2024
The Beaches is one of Toronto’s best known and most admired neighbourhoods. It has no striking works of architecture or…
splendid public spaces, no must-see galleries or public institutions, and no associations with historic events or great celebrities – the sort of things that create neighbourhood reputations and draw visitors. It does, however, have an attractive character, and it is this character that Richard White seeks to understand, offering insights into how it came to be and why it has endured. With an eye to the broader historical context, The Beaches recounts the neighbourhood’s initial colonial settlement, its development as a lakeside recreational community in the late nineteenth century, its emergence as a streetcar suburb after 1900, its maturation in the 1920s and 1930s, its relative decline in the 1950s and 1960s, and its revival in the 1970s and beyond. Utilizing a wide range of archival records, including council minutes, plans of subdivision, newspapers, public land records, city directories, assessment rolls, and historical photographs – as well as the present-day landscape – The Beaches reveals the various forces, public and private, local and international, that shaped this cherished urban neighbourhood.Gender-Based Violence in Canadian Politics in the #MeToo Era
By Tracey Raney, Cheryl N. Collier. 2024
Gender-based violence in politics is a significant and growing problem that threatens the democratic process in Canada. Despite its prevalence,…
little academic research has been conducted on this topic to date. Gender-Based Violence in Canadian Politics in the #MeToo Era raises awareness of and presents new innovative research on this timely and pressing public issue. Here, leading experts from across Canada uncover critical new insights and identify potential solutions that would help address gender-based violence in politics, improve gender equality, and strengthen Canadian democracy. Using an intersectional lens, chapters range in their approaches; offer new concepts and measures of gender-based violence in online political spaces, political media coverage and cartoons, campaigns, municipal politics, and legislatures; and explore Indigenous ways of knowing about gender-based violence in Canadian politics. Additionally, the volume presents recommendations for decision-makers, policymakers, anti-violence advocates, and the academic community on how to best address the problem of gender-based violence in the political sphere.Wheeling through Toronto: A History of the Bicycle and Its Riders
By Albert Koehl. 2024
Highlighting an important yet often ignored part of Toronto’s transportation story, Wheeling through Toronto chronicles the history of the bicycle…
and reveals a way forward for a world in climate crisis. Throughout its history in Toronto, the bicycle’s place on the roads and in public esteem has fluctuated wildly: flaunted as fashionable, disparaged and derided, rescued from looming obscurity, and promoted as a way to respond to the challenges of the day. What is it about the simple bicycle that it can be so loved by some yet despised and detested by others? Wheeling through Toronto offers a 130-year ride from the 1890s to the present to help answer this question. Albert Koehl, a Toronto lawyer and leading cycling advocate, chronicles the tumultuous history of this mode of transportation from the bicycle craze at the turn of the century, to the rise of the car and the motorway in the 1950s, to the intensifying cry for active transportation in the 1990s and into pandemic times. In an era of catastrophic climate events, Wheeling through Toronto highlights how the bicycle should be celebrated not only as hope for the future, but also for its affordability, for its contribution to clean and healthy mobility, and because it brings happiness and joy to so many. Drawing on archival materials, newspapers, and personal interviews, and full of fascinating vignettes, this book presents the story of how we got here and what Torontonians need to know as we pedal forward.Modern Medicine: Biomedical Devices, Medical Gases, Radiopharmaceuticals, New Drug Discovery, Volume 2
By Pronobesh Chattopadhyay, Danswrang Goyary. 2024
Modern Medicine: Biomedical Devices, Medical Gases, Radiopharmaceuticals, New Drug Discovery, Volume 2 discusses the procedures of drug approval and regulatory…
requirements that must be met according to the United States Food and Drug Administration (FDA), the European Medical Agency (EMA), and the Central Drug Standard Control Organization (CDSCO). In the rapidly evolving landscape of modern medicine, groundbreaking innovations have emerged that are reshaping the way we approach healthcare. Modern Medicine delves into the cutting-edge realms of medical devices, medical gases, radiopharmaceuticals, and new drug discovery, offering a comprehensive exploration of these transformative fields that are revolutionizing patient care and medical practices. Discover the future of healthcare technology, and uncover the intricate world of biomedical engineering, where state-of-the-art devices seamlessly merge with the human body to monitor, diagnose, and treat ailments Dive deep into the utilization of medical gases for respiratory conditions, pain management, and even novel applications in regenerative medicine Unravel the mysteries of radiopharmaceuticals, a fusion of molecular imaging and therapy that offers unprecedented insights into the inner workings of the human body Embark on a journey through the intricate processes of drug discovery, where groundbreaking research and cutting-edge technologies are yielding therapies that were once deemed impossible Modern Medicine is a must-read for medical professionals, researchers, students, and anyone intrigued by the remarkable intersection of science, technology, and patient well-being. Join us on a journey to the forefront of medical innovation, where the unimaginable becomes reality, and the future of healthcare takes shape before our eyes. The chapter on regulatory implications for the approval process in this book will be the most useful resource for researchers and students, particularly those with backgrounds in pharma, forensic medicine, regulatory affairs, or those who aspire to succeed in drug research. Additionally, the information contained in this volume of the book could be of great interest to researchers working in the pharmaceutical and health industries.Routledge Handbook of Medicine and Poetry
By Alan Bleakley, Shane Neilson. 2024
The Routledge Handbook of Medicine and Poetry draws on an international selection of authors to ask what the cultures of…
poetry and medicine may gain from reciprocal critical engagement. The volume celebrates interdisciplinary inquiry, critique, and creative expansion with an emphasis upon amplifying provocative and marginalized voices.This carefully curated collection offers both historical context and future thinking from clinicians, poets, artists, humanities scholars, social scientists, and bio-scientists who collectively inquire into the nature of relationships between medicine and poetry. Importantly, these can be both productive and unproductive. How, for example, do poet-doctors reconcile the outwardly antithetical approaches of bio-scientific medicine and poetry in their daily work, where typically the former draws on technical language and associated thinking and the latter on metaphors? How does non-narrative lyrical poetry engage with narrative-based medicine? How do poets writing about medicine identify as patients? Central to the volume is the critical investigation of the consequences of varieties of medical pedagogy for clinical practice.Presenting a vision of how poetic thinking might form a medical ontology this thought-provoking book affords an essential resource for scholars and practitioners from across medicine, health and social care, medical education, the medical and health humanities, and literary studies.Hemodynamic Monitoring and Fluid Therapy during Surgery
By Alexandre Joosten, Maxime Cannesson, Robert G. Hahn. 2024
Combining two successful texts, Clinical Fluid Therapy in the Perioperative Setting, 2nd edition and Perioperative Hemodynamic Monitoring and Goal Directed…
Therapy, this revised volume provides a guide to fluid management and hemodynamic therapy for the perioperative practitioner. The book begins with an up-to-date overview of the basics before then exploring most of the current and controversial topics within hemodynamic monitoring and fluid therapy. This is followed by a section on practical use which explores hemodynamic and fluid therapy in various types of surgery and patient conditions. The book closes with a discussion of the future concepts in fluid and hemodynamic therapy ranging from microcirculation, to closed-loop and mobiles technologies. With contributions from the world's leading experts, chapters guide the reader in the application of fluid and hemodynamic therapy in all aspects of perioperative patient care. A valuable resource for those involved in perioperative patient management, including anaesthesiologists, intensivists, and surgeons.Diffusive Spreading in Nature, Technology and Society
By Armin Bunde, Jürgen Caro, Christian Chmelik, Jörg Kärger, Gero Vogl. 2023
What do the movements of molecules and the migration of humans have in common? How does the functionality of our…
brain tissue resemble the flow of traffic in New York City? How can understanding the spread of ideas, rumors, and languages help us tackle the spread a pandemic? This book provides an illuminating look into these seemingly disparate topics by exploring and expertly communicating the fundamental laws that govern the spreading and diffusion of objects. A collection of leading scientists in disciplines as diverse as epidemiology, linguistics, mathematics, and physics discuss various spreading phenomena relevant to their own fields, revealing astonishing similarities and correlations between the objects of study—be they people, particles, or pandemics.This updated and expanded second edition of an award-winning book introduces timely coverage of a subject with the greatest societal impact in recent memory—the global fight against COVID-19. Winner of the 2019 Literature Prize of the German Chemical Industry Fund, this book targets an interdisciplinary readership, featuring an introductory chapter that sets the stage for the topics discussed throughout. Each chapter provides ample opportunity to whet the appetite of those readers seeking a more in-depth treatment, making the book also useful as supplementary reading in appropriate courses dealing with complex systems, mass transfer, and network theory.James Taylor: Cut Short (Authentic Guitar-tab Editions Ser.)
By James Taylor. 1992
A superstar athlete&’s inspiring autobiography—from his cricket-loving youth to the diagnosis of a career-ending heart condition and its aftermath. James…
Taylor was born in Burrough on the Hill, Leicestershire, in 1990. A sporting phenomenon from an early age, he chose to forge a life in cricket, establishing himself as one of the country&’s leading batsmen and an England regular. And then tragedy struck. In April 2016, a serious heart condition left Taylor fighting for his life in the changing room. Told he faced possible death if he played cricket, or exercised, ever again, James&’s bright and brilliant career was over at the age of 26. In Cut Short, Taylor reveals his route to the top. On the way, he describes how he encountered prejudice against his size and takes us through the highs and lows of his international career, including a century against the Australians and a closeup view of the unsavory nature of David Warner. With the world at his feet, Taylor reveals just what it was like to have sporting ambition snatched away right at the point of international breakthrough. He relives in breathless detail the horrific events of the day he thought he was going to die and his desolation at watching a fine sporting career torn from his grasp. At the same time he faced a battle to rebuild his life and his future, he was getting used to a body which, on several occasions, left him fearing for his existence. That James has emerged from these dark days with courage, good humor, and renewed ambition is testament to a remarkable personality.No Call Too Small
By Oscar Martens. 2020
&“Martens&’ work would be impressive in any era, but it is particularly timely today. It is wonderful to come upon…
an author who faces into the horrific absurdities of modern life without flinching, a stylist who delivers his most powerful satiric points with laser sharp accuracy and lyrically beautiful language."—Vancouver Sun&“Haunting, darkly funny situations, captured in crisp, spare prose, will appeal to fans of George Saunders.&”—Publishers WeeklyBy the end of the day, a cop must choose between ethics and social death. A camp counsellor, stuck deep in the woods with a small group of boys, only has a few hours before the DTs kick in. Adult children scramble to get the best of what remains of their mother's estate, but funeral plans may be premature. Sandwiched between a depressed mother and a careless father, a young girl must help attract customers to the family business, no matter the cost.The stories in No Call Too Small represent micro-scale disaster tourism on a winding road that is long and dark. Driving too fast, weaving between flaming wrecks, and drifting through cliff-side curves, there's little choice but to hang on and meet whatever's over the rise head on.&“Marten&’s strong prose is a pleasure to read, with dark humour and lively storytelling that brings a quirky humanity to his characters.&”—Janie Chang, Globe and Mail bestselling author of Dragon Springs Road&“A beautifully crafted collection.&”—Marcia Butler, author of Pickle&’s ProgressThe Excruciating History of Dentistry: Toothsome Tales & Oral Oddities from Babylon to Braces
By James Wynbrandt. 1998
For those on both sides of the dreaded dentist's chair, James Wynbrandt has written a witty, colorful, and richly informative…
history of the art and science of dentistry. To all of those dental patients whose whine rises in tandem with that of the drill, take note: You would do well to stifle your terror and instead offer thanks to Apollonia, the patron saint of toothache sufferers, that you face only fleeting discomfort rather than the disfiguring distress, or slow agonizing death oft meted out by dental-care providers of the past. The transition from yesterday's ignorance, misapprehension, and superstition to the enlightened and nerve-deadened protocols of today has been a long, slow, and very painful process.For example, did you know that: *Among the toothache remedies favored by Pierre Fauchard, the father of dentistry, was rinsing the mouth liberally with one's own urine.*George Washington never had wooden teeth. However, his chronic dental problems may have impacted the outcome of the American Revolution. *Soldiers in the Civil War needed at least two opposing front teeth to rip open powder envelopes. Some men called up for induction had their front teeth extracted to avoid service. *Teeth were harvested from as many as fifty thousand corpses after the Battle of Waterloo, a huge crop later used for dentures and transplants that became known as "Waterloo Teeth."The Fever: How Malaria Has Ruled Humankind for 500,000 Years
By Sonia Shah. 2010
In recent years, malaria has emerged as a cause célèbre for voguish philanthropists. Bill Gates, Bono, and Laura Bush are…
only a few of the personalities who have lent their names—and opened their pocketbooks—in hopes of curing the disease. Still, in a time when every emergent disease inspires waves of panic, why aren't we doing more to eradicate one of our oldest foes? And how does a parasitic disease that we've known how to prevent for more than a century still infect 500 million people every year, killing nearly 1 million of them?In The Fever, the journalist Sonia Shah sets out to answer these questions, delivering a timely, inquisitive chronicle of the illness and its influence on human lives. Through the centuries, she finds, we've invested our hopes in a panoply of drugs and technologies, and invariably those hopes have been dashed. From the settling of the New World to the construction of the Panama Canal, through wars and the advances of the Industrial Revolution, Shah tracks malaria's jagged ascent and the tragedies in its wake, revealing a parasite every bit as persistent as the insects that carry it. With distinguished prose and original reporting from Panama, Malawi, Cameroon, India, and elsewhere, The Fever captures the curiously fascinating, devastating history of this long-standing thorn in the side of humanity.The Balance Within: The Science Connecting Health and Emotions
By Esther M. Sternberg. 2001
A thrilling scientific detective story, The Balance Within tells how researchers finally uncovered the elusive mind-body connection and what it…
means for our health. Since ancient times humans have felt intuitively that emotions and health are linked, and recently there has been much popular speculation about this notion. But until now, without compelling evidence, it has been impossible to say for sure that such a connection really exists and especially how it works. Now, that evidence has been discovered.In this beautifully written book, Dr. Esther Sternberg, whose discoveries were pivotal in helping to solve this mystery, provides first hand accounts of the breakthrough experiments that revealed the physical mechanisms - the nerves, cells, and hormones - used by the brain and immune system to communicate with each other. She describes just how stress can make us more susceptible to all types of illnesses, and how the immune system can alter our moods. Finally, she explains how our understanding of these connections in scientific terms is helping to answer such crucial questions as "Does stress make you sick?" "Is a positive outlook the key to better health?" and "How do our personal relationships, work, and other aspects of our lives affect our health?"A fascinating, elegantly written portrait of this rapidly emerging field with enormous potential for finding new ways to treat disease and cope with stress, The Balance Within is essential reading for anyone interested in making their body and mind whole again.The Afterworld: Long COVID and International Relations (Health and Society)
By Anthony Amicelle, Valérie Amiraux, Vincent Arel-Bundock, Ari Van Assche, Daniel Béland, Karim Benyekhlef, Mark R. Brawley, Dominique Caouette, Allison Christians, Ryoa Chung, François Crépeau, Pierre-Marie David, Magdalena Dembińska, Peter Dietsch, Thomas Druetz, Pearl Eliadis, Philippe Fournier, François Furstenberg, Pablo Gilabert, Timothy Hodges, Maya Jegen, Juliet Johnson, Nicholas King, Erick Lachapelle, Justin Leroux, Pierre Martin, Sarah-Myriam Martin-Brûlé, María Martín Iniesta, Erik Martinez Kuhonta, Theodore McLauchlin, Frédéric Mégret, Cynthia Milton, Laurence Monnais, Christian Novak, Mme Mireille Paquet, T. V. Paul, Krzysztof Pelc, Pierre-Olivier Pineau, Vincent Pouliot, René Provost, Lee Seymour, Thomas Soehl, Maïka Sondarjee, Samuel Tanner, Jean-Philippe Thérien, Hamish Van Ven, Luna Vives, Marie-Joëlle Zahar, Alain Gagnon. 2024
La COVID-19 a provoqué la crise mondiale la plus importante et la plus globale du 21e siècle. Pour certains, les…
répercussions ont été rapides et dramatiques, la pandémie poussant des dizaines de millions de personnes dans la pauvreté et générant une insécurité alimentaire extrême. Pour d’autres, les transformations bouillonnent encore sous la surface et des questions demeurent quant à savoir si les changements de société induits par la COVID-19 perdureront dans la période post-pandémique. Le retour de la géopolitique, avec la guerre en Ukraine et les tensions en Asie, complexifie le portrait mondial.Depuis mars 2020, on a vu une explosion d'analyses à propos de l'impact à court terme et des conséquences futures de la « longue COVID » sur les relations internationales. On a rapidement établi des parallèles établis avec l’effondrement de l'Europe des années 1930, raconté par Stefan Zweig dans ses célèbres mémoires, Le monde d’hier. Alors que la plupart des commentateurs font preuve de pessimisme, certains cherchent des lueurs de changement positif. Cette crise sans précédent exige de réfléchir à la manière dont, dans le « monde d’après », nous pouvons travailler à améliorer l'économie, la justice sociale, l'environnement, les relations entre les sexes, la santé et les institutions politiques - ou, à tout le moins, à faire en sorte qu'elles ne se détériorent pas davantage.Dans ce livre, 50 professeurs des quatre universités montréalaises, parmi les meilleurs experts de leur domaine, braquent le projecteur sur un défi spécifique : celui des relations internationales. À partir de leurs analyses, ils proposent des idées progressistes, pragmatiques et fondées sur les sciences sociales qui pourraient améliorer la coopération internationale, la sécurité et la prospérité durable après la fin de la pandémie.Note : Ce livre est publié en anglais aux Presses de l'Université d'Ottawa. La version originale de l'ouvrage est disponible aux Presses de l'Université de Montréal.Facing the Unseen: The Struggle to Center Mental Health in Medicine
By Damon Tweedy. 2024
From the New York Times bestselling author of Black Man in a White Coat comes a powerful and urgent call…
to center psychiatry and mental health care into the mainstream of medicineAs much as we all might wish that mental health problems, with their elusive causes and unsettling behaviors, simply did not exist, millions of people suffer from them, sometimes to an extreme extent. Many others face addiction to alcohol and other drugs, as overdose and suicide deaths abound. Yet the vast majority of doctors receive minimal instruction in treating these conditions during their lengthy medical training. This mismatch ignores the clear overlap between physical and mental distress, and too-often puts psychiatrists on the outside looking in as the medical system continues to fail many patients. In Facing The Unseen, bestselling author, professor of psychiatry, and practicing physician Damon Tweedy guides us through his days working in outpatient clinics, emergency rooms, and hospitals as he meets people from all walks of life who are grappling with physical and psychological illnesses. In powerful, compassionate, and eloquent prose, Tweedy argues for a more comprehensive and integrated approach where people with mental illness have a health care system that places their full well-being front and center.Front of the Class: How Tourette Syndrome Made Me the Teacher I Never Had
By Brad Cohen, Lisa Wysocky. 2008
Now a Hallmark Hall of Fame Movie Event available on streaming platforms. Front of the Class is now in e-book…
format for the first time and includes a new epilogue. As a child with Tourette syndrome, Brad Cohen was ridiculed, beaten, mocked, and shunned. Children, teachers, and even family members found it difficult to be around him. As a teen, he was viewed by many as purposefully misbehaving, even though he had little power over the twitches and noises he produced, especially under stress. Even today, Brad is sometimes ejected from movie theaters and restaurants.But Brad Cohen's story is not one of self-pity. His unwavering determination and fiercely positive attitude conquered the difficulties he faced in school, in college, and while job hunting. Brad never stopped striving, and after twenty-four interviews, he landed his dream job: teaching grade school and nurturing all of his students as a positive, encouraging role model. Front of the Class tells his inspirational story.Knee Surgery: The Essential Step-by-Step Guide to Total Knee Recovery
By Daniel Fulham O'Neill. 2009
In this age of same-day surgery and do-it-yourself health, Knee Surgery presents an easy-to-do, well-illustrated program of movement for knee…
rehabilitation - with a special focus on the mind/body connection - and describes the physical and mental rehabilitation process in complete detail, providing all the guidance you need to decrease pain and increase fitness after knee surgery. Millions of people have knee surgery each year, and in the years to come millions more will head to the O.R. Chances are, you or someone you know has had or will undergo knee surgery. Busy doctors, therapists, and athletic trainers have limited time to spend on quality physical and mental rehabilitation education, yet this is the key to full recovery.Written by renowned knee surgeon and Sport Psychologist Daniel F. O'Neill, M.D., Ed.D., this comprehensive and accessible guide presents what you'll want and need the most after knee surgery: a scientifically-based recovery program you can understand that will get you back to work and sports as quickly as possible.Yukon Alone: The World's Toughest Adventure Race
By John Balzar. 1999
In the tradition of Into the Wild, John Balzar's Yukon Alone is a story of daring and determination in one…
of nature's harshest, loneliest, and most beautiful places.The Yukon Quest International Sled Dog Race is among the most challenging and dangerous of all the organized sporting events in the world. Every February, a handful of hardy souls sps over two weeks racing sleds pulled by fourteen dogs over 1,023 miles of frozen rivers, icy mountain passes, and spruce forests as big as entire states. It's not unusual for the temperature to drop to 40-below or for the night to be seventeen hours long.Why would anyone want to run this race? To find out, John Balzar moved to Alaska months before The Quest began and he spent time in the homes of many of the mushers. Balzar then spent many days and nights on the trail, and the result is a book that not only treats us to a vivid day-by-day account of the grueling race itself but also offers an insightful look at the men and women who have moved to this rugged and beautiful place, often leaving behind comfortable houses and jobs in the lower forty-eight states for the sense of exhilaration they find in their new lives. Readers will also be fascinated by Balzar's account of what goes into the training and care of the majestic dogs who pull the sleds and whose courage, strength, and devotion make them the true heroes of this story. For anyone captivated by the wild north country, this riveting tale of courage and adventure will inspire and entertain.