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Visual Dysfunction in Diabetes
By Colin J. Barnstable, Joyce Tombran-Tink, Thomas W. Gardner. 2012
An exciting contribution to the field, Visual Dysfunction in Diabetes: The Science of Patient Impairment and Improvement is designed with…
two overriding objectives: to help readers understand the impact of vision impairment in people living daily with diabetes rather than considering diabetic retinopathy solely as a medical problem, and to explore what we know and don't know about the ways diabetes affect the eye. With the plethora of new information being generated, there are still a series of fundamental questions that must be addressed if effective treatments for diabetic retinopathy are to be found and applied. Developed by a renowned group of authorities, Visual Dysfunction in Diabetes: The Science of Patient Impairment and Improvement offers responses and context for a range of questions, such as: do metabolic factors beyond glucose contribute to vision-threatening diabetic retinopathy? If so, how do these lead to vision impairment? Is diabetic retinopathy a response to systemic metabolic abnormalities or are there unique ocular problems related to insulin resistance? What is the relationship between the neural, vascular, and inflammatory abnormalities in diabetic retinopathy? Do they represent a pathological cascade induced sequentially or simultaneous responses to one or more metabolic perturbations? The authors note that if we do not address these types of questions, it is possible that the long process of developing new therapeutics will target only one arm of the pathology and leave the retina open to damaging consequences of the others. State-of-the-art, comprehensive, and an invaluable addition the research and clinical literature, Visual Dysfunction in Diabetes: The Science of Patient Impairment and Improvement offers guidance and a significant step toward new scientific approaches that can lessen the devastating vision impairment associated with diabetes.Molecular Dermatology
By Cristina Has, Cassian Sitaru. 2013
The sustained skin research efforts over the past decades has led to the accumulation of a significant collection of information…
on skin structure and physiology as well as on the pathogenesis of cutaneous diseases. In Molecular Dermatology: Methods and Protocols, leading experts in the field provide a collection of state-of-the-art reliable protocols covering a wide spectrum of techniques and experimental models, specific molecular assays and disease models, as well as overviews of diagnostic and research areas relevant to molecular dermatology. As a volume in the highly successful Methods in Molecular BiologyTM series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and authoritative, Molecular Dermatology: Methods and Protocols emphasizes the vital importance of skin research and collects the methodologies necessary to aid scientists in moving forward in this valuable field.The Diabetic Foot
By Aristidis Veves, Frank W. Logerfo, John M. Giurini. 2012
In The Diabetic Foot: Medical and Surgical Management, 3rd Edition, a distinguished panel of clinicians provides a thorough update of…
the significant improvements in knowledge surrounding the pathogenesis of diabetic foot problems, as well as the optimal healthcare treatment for this debilitating condition. The authors, many practicing at the famous Joslin-Beth Israel Deaconess Foot Center, again illuminate the successful new multidisciplinary approach now clearly required for the successful treatment of diabetic foot. Drawing on the experiences of diabetologists, podiatrists, vascular surgeons, infectious disease specialists, orthotists, plastic and orthopedic surgeons, this invaluable third edition, so timely given the continued rise of diabetes and its complications, clearly describes established techniques known to be effective. This updated edition blends new knowledge with the time-tested principles of diabetic foot management and will be of significant value to all physicians and researchers with an interest in a state-of-the-art understanding of diabetic foot.Ghrelin in Health and Disease
By Michael O. Thorner, Roy G. Smith. 2012
Ghrelin, the endogenous ligand for the growth hormone secretagogue (GHS) receptor, is critical in the control of food intake and…
energy balance. The ghrelin receptors are now known to have important physiological properties as modulators of growth hormone release, appetite, glucose homeostasis, metabolism, immune function, neurotransmitter activity, cognitive function and neurodegeneration. Bringing all of this information together in the first comprehensive text on the topic, Ghrelin in Health and Disease provides a state-of-the-art synthesis of the latest work in this area for physicians and physician-scientists. This volume addresses the unique property of ghrelin as a modulator of function. Such a property provides potential utility for safe intervention in a wide variety of disease states. Indeed as we learn more about the basic physiology of ghrelin, the potential for treating new disease targets emerge requiring validation in the clinic. Each chapter in this volume is authored by a leading investigator in the field. The introductory chapter sets the background for the book and provides a superb overview of the relevance of ghrelin to physiology, describing how the discovery of ghrelin has prompted us to completely rethink traditional physiology. The authors conclude their chapters by critically addressing the future translational aspects of ghrelin biology and outlining what key basic research and clinical questions remain to be addressed. An invaluable resource, Ghrelin in Health and Disease distinguishes itself as the first comprehensive title covering all of the molecular and clinical issues relating to ghrelin and advancing our clinical understanding of obesity, growth, and reproductive pathogenesis.Obesity and Lung Disease
By Emmanuelle M. Clerisme-Beaty, Anne E. Dixon. 2013
As a result of the rapidly growing rate of obesity worldwide, clinicians are struggling to provide the best strategies for…
treating obese patients with concomitant pulmonary conditions. Obesity does not simply change the epidemiology of pulmonary disease; obesity has a profound impact on the pathophysiology of common pulmonary diseases. Obesity affects the severity of asthma, response to treatment, and is likely a major modifier of the phenotype of asthma. Obesity also appears to affect response to pathogens, and as such has a major influence on response to pneumonia, and has a significant impact on outcomes pertaining to acute lung injury in the intensive care unit. Obesity and Lung Disease: A Guide to Management is the first text in the field to cover the full range of issues related to managing obese patients with pulmonary problems. All the relevant conditions, in the context of obesity, are covered, including airway inflammation, sleep apnea, asthma, pulmonary hypertension, obesity hypoventilation, as well as others. Written by an international group of experts, this important new volume is an invaluable resource for all clinicians and scientists concerned with the challenging problems surrounding obesity and lung diseases.Re-Constructing the Man of Steel
By Martin Lund. 2017
In this book, Martin Lund challenges contemporary claims about the original Superman's supposed Jewishness and offers a critical re-reading of…
the earliest Superman comics. Engaging in critical dialogue with extant writing on the subject, Lund argues that much of recent popular and scholarly writing on Superman as a Jewish character is a product of the ethnic revival, rather than critical investigations of the past, and as such does not stand up to historical scrutiny. In place of these readings, this book offers a new understanding of the Superman created by Jerry Siegel and Joe Shuster in the mid-1930s, presenting him as an authentically Jewish American character in his own time, for good and ill. On the way to this conclusion, this book questions many popular claims about Superman, including that he is a golem, a Moses-figure, or has a Hebrew name. In place of such notions, Lund offers contextual readings of Superman as he first appeared, touching on, among other ideas, Jewish American affinities with the Roosevelt White House, the whitening effects of popular culture, Jewish gender stereotypes, and the struggles faced by Jewish Americans during the historical peak of American anti-Semitism. In this book, Lund makes a call to stem the diffusion of myth into accepted truth, stressing the importance of contextualizing the Jewish heritage of the creators of Superman. By critically taking into account historical understandings of Jewishness and the comics' creative contexts, this book challenges reigning assumptions about Superman and other superheroes' cultural roles, not only for the benefit of Jewish studies, but for American, Cultural, and Comics studies as a whole.Management of Pediatric Obesity and Diabetes
By Robert J. Ferry. 2010
The twin epidemics of obesity and type 2 diabetes mellitus (T2DM) continue to affect an ever increasing number of children,…
adolescents, and young adults. Management of Pediatric Obesity and Diabetes provides healthcare trainees and professionals with practical, comprehensive, and contemporary approaches to the pediatric patient at risk for obesity, T2DM, and related conditions. A unique guide on the subject, this volume provides clinical paradigms for diagnosis and management of pediatric T2DM and related conditions, while succinctly describing state-of-the-art basic and clinical sciences underlying these problems. The chapters in this volume are independent and concise. Each chapter focuses on a key clinical issue or mechanism of disease. Providing practical, data-driven resources based upon the totality of the evidence, this important text helps the reader understand the basics of pediatric obesity and T2DM and implement strategies to prevent and treat obesity and diabetes in children and adolescents. Management of Pediatric Obesity and Diabetes provides health professionals across many areas of research and practice with up-to-date, well-referenced, and comprehensive evidence on identification, treatment, and prevention of these chronic, serious, metabolic diseases in children. This volume will serve the reader as the most authoritative resource in the field to date.Growth Hormone Related Diseases and Therapy
By Ken Ho. 2011
The molecular era ushered in the cloning of the growth hormone (GH) gene and the production of unlimited amounts of…
GH through recombinant technology. The continuing momentum of research from basic science to clinical evaluation has brought unprecedented advances to the understanding of GH biology for the clinical endocrinologist. Growth Hormone Related Diseases and Therapy: A Molecular and Physiological Perspective for the Clinician distills all the new information of relevance to the endocrinologist over the last 20 years by offering five sections: physiology, molecular genetics, GH deficiency, acromegaly and pharmacotherapy. The first section on physiology focuses on GH action. A review on the structure and function of the GH receptor is followed by a perspective on the regulatory role of ghrelin on GH secretion. The second section on genetics covers pituitary function and adenomas, including new and fascinating information on familial pituitary adenomas, their genotype and phenotype. The adult GH deficiency section spans the epidemiology and diagnosis of GH deficiency with a strong reminder for the clinician that the transition period represents a critical time of somatic maturation, which continues for years after cessation of liner growth. The section on acromegaly focuses on management, giving practical guides to the value of GH and IGF-1 measurements, the place of somatostatin analogues and of radiotherapy while reminding the reader as to why evaluating quality of life is an important part of management. Finally, the section on GH pharmacology takes the reader through innovative developments of long-acting GH formulations with some products on the threshold of clinical use. This section provides a balanced evidence based review of the effects of GH supplementation in aging and in sports where recent data indicates an enhancing effect on a selective aspect of performance. Growth Hormone Related Diseases and Therapy: A Molecular and Physiological Perspective for the Clinician integrates a wealth of information and will prove an invaluable reference for pediatric endocrinologists, adult endocrinologists, endocrine scientists and internists interested in the human biology of GH.Neuroendocrine Tumors
By Paulo M. Hoff, James C. Yao, Ana O. Hoff. 2012
New research has shown that neuroendocrine tumors are more common than previously thought. Progress in our understanding of the molecular…
pathogenesis of these not-so-rare cancers has resulted in renewed interest in developing innovative therapeutic options. In particular, novel molecular targeted agents have been shown to have significant anti-tumor activity, and integration of these therapies has led to critical advances in management. In this volume, an outstanding group of the world's leaders in the field have assembled to convey their knowledge of the epidemiology, biology, and management of all the major types of neuroendocrine tumors. The book takes a multi-modality approach to understanding disease processes and therapeutics, including chapters on medical and surgical treatment as well as a chapter devoted to imaging. Throughout, the authors emphasize recent advances in our understanding of molecular biology and the subsequent emerging therapeutic options.IGFs:Local Repair and Survival Factors Throughout Life Span
By David Clemmons, Iain C.A.F. Robinson. 2010
Insulin-like growth factors (IGFs), their binding proteins and their receptors play important roles in regulating growth, metabolism, proliferation and survival…
for many cells and tissues throughout lifespan in humans and other species. Circulating IGF1 is known to be an endocrine regulator, with metabolic effects related to, and partly convergent with, insulin signalling. IGF1 also mediates many of the growth promoting effects of GH, and there is an ongoing debate as to the relative contributions of endocrine-, vs locally-derived IGF1 for systemic growth. More recently however, it has become clear that IGFs may be key local growth and cellular survival factors for many different tissues, active from early in embryonic development, essential for normal maturation and growth during foetal life. IGFs continue to play important roles throughout adult life in many diverse processes such as tissue repair, cellular proliferation, tissue remodelling and metabolic regulation. IGF systems are tightly regulated; orderly control of cellular repair and metabolism is central to healthy ageing, whilst uncontrolled proliferation can lead to cancer.Molecular Endocrinology
By Thomas E. Curry, Ok-Kyong Park-Sarge. 2009
Over the course of the last hundred years, the field of endocrinology has received ever-increasing attention. Research and developing technologies…
have resulted in a significant leap in our understanding of the causes and treatment of endocrine dysfunction. In Molecular Endocrinology: Methods and Protocols, leaders in the field share a diversity of cutting-edge techniques that are becoming routinely employed in the quest to further understand hormone action. In order to reach the widest number of labs, this volume includes protocols that allow investigators at all stages of their scientific career to successfully perform these techniques. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include brief introductions to their respective subjects, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and expert notes on troubleshooting and avoiding known pitfalls. Comprehensive and easy to use, Molecular Endocrinology: Methods and Protocols is an ideal guide for researchers in labs across the world who seek a deeper understanding of the complex processes and biology of hormones.Recent Advances in Transthyretin Evolution, Structure and Biological Functions
By Vivian Cody, Samantha J. Richardson. 2009
There is a strong interest in transthyretin (TTR) in connection with protein evolution, medical and clinical research. Thus, this is…
an exciting time for experts in TTR research to come together to write a monograph covering both the basic and the clinical research into TTR. Transthyretin is a protein found in human blood and cerebrospinal fluid. It is directly involved in the transport of thyroid hormones, and indirectly in that of retinol. These hormones are essential for normal growth and development, particularly that of the brain. Spontaneous and inherited diseases affecting transthyretin result in amyloidosis. More than 80 point mutations in transthyretin lead to a variety of illnesses. Liver transplants are the most common treatment, although much research is also being carried out in drug therapies. The evolution of transthyretin has been extensively investigated - from humans to bacteria, invertebrate animals and plants. The structure of the protein has not changed, but its function has changed significantly. This is a most exciting example for the study of the evolution of protein structure-function relationships. This monograph will bring the reader up to date on the latest developments and discoveries.Diabetes and Peripheral Vascular Disease
By James F. Mckinsey, Gautam V. Shrikhande. 2012
In Diabetes and Peripheral Vascular Disease, a panel of distinguished leaders in the field of medicine, podiatry, and vascular and…
endovascular therapy assimilate the latest literature on these issues and others for an in-depth review of the management of peripheral vascular disease. Providing an overview of the management of diabetes and diabetic foot changes as well as providing a view of cutting-edge and emerging topics in optimization of arterial status, this important title addresses pathophysiology, anatomy, diagnosis and management of diabetic peripheral vascular disease, emphasizing a multi-disciplinary approach. The first chapter of the book provides an overview of this complex disease process and discusses the teamwork required for optimal management. The chapters continue with the basic pathophysiology of diabetic atherosclerosis and a contemporary review of the management of diabetes. The genesis of diabetic foot ulceration and prevention and management strategies is covered, as is the effects of neuropathy and microvascular changes in the diabetic foot. In addition, Diabetes and Peripheral Vascular Disease covers the microbiology of diabetic foot infections, the role of endovascular interventions and vascular surgery as well as the management of the complications of these procedures, the process of amputation for those patients who have progressed beyond a limb salvage situation, and the effects of diabetes on the cerebrovascular system as well as its implications in patients with aortoiliac disease. An invaluable addition to the literature on diabetes and peripheral vascular disease, the book will be of great interest internists, family practitioners, surgeons, podiatrists, wound care specialists, and vascular specialists. Students, residents, and fellows in surgical and medical specialties should also find this book of significant value and interest.Endocrine Disruptors and Puberty
By Evanthia Diamanti-Kandarakis, Andrea C. Gore. 2012
Endocrine disruption represents one of the most controversial environmental issues of our time. Mounting evidence stemming from more than 10…
years of experimental, epidemiological and clinical studies has transformed the once generally discounted subject of endocrine disruptors into an issue of tremendous concern not only within the scientific community but among society as a whole. Following initial evidence from basic research, endocrine disruption in humans has now emerged as a major medical challenge. In this respect, puberty, a crucial developmental stage, has been definitively identified as a key window of vulnerability with regard to endocrine disruptors. Written by leading authorities in the field, Endocrine Disruptors and Puberty offers an engaging and comprehensive overview of this fascinating and rapidly growing problem. An indispensable resource for all clinicians and scientists interested in this challenging endocrinologic topic, Endocrine Disruptors and Puberty is a timely contribution that will help navigate a path toward understanding the problem and developing solutions.Dialogic Moments: From Soul Talks to Talk Radio in Israeli Culture
By Tamar Katriel. 2004
Metabolic Response of Slowly Absorbed Carbohydrates in Type 2 Diabetes Mellitus
By Meidjie Ang. 2016
This SpringerBrief focuses on clinical nutrition research particularly on the effects of slowly absorbed carbohydrates on postprandial glucose…
metabolism in type 2 diabetes Slowlyabsorbed carbohydrates will cause gradual increases in blood glucose and insulin levels and may therefore be effective as part of a treatment strategy for glycemic control and reduction of cardiovascular complications in type 2 diabetesInflammatory Pathways in Diabetes
By Michael Pugia. 2015
This book discusses recent advances in new anti- and pro-inflammatory pathways in diabetic disease and identifies new diagnostic immunological…
methods that offer potential companion diagnostics for diabetic diseases New methods in proteomics mass spectroscopy immunological assay design measurement of cellular signal transduction and protease inhibition are used to clarify new biochemical pathways Biomarker validation in animal models and correlations in humans for diagnostic clinical trials shed new light on the impact of diabetic diseases The book reviews current understanding of inflammatory pathways in the pathophysiology of insulin resistance metabolic syndrome nephritis and other diabetic inflammatory conditions and is the first to describe the impact of novel adipokines protease inhibitors and complement markers By presenting new methodologies for biomarker discovery it provides a valuable resource for researchers studying clinical diagnosis drug development bio-analytical chemistry proteomics and biochemistry It is also useful for those conducting clinical and biological studies for targeted drug development The methodologies and approaches can be applied to other markers and the information will be helpful in the preparation of research grant applicationsIntegrated Diabetes Care
By David Simmons, Helmut Wenzel, Janice C. Zgibor. 2017
Integrating care across disciplines and organisations around the needs of the person with diabetes has been proposed as an approach…
that could improve care while reducing cost- but has it and can it? Integrated Diabetes Care- A Multidisciplinary Approach collates evidence of worldwide approaches to both horizontal integration (across disciplines) and vertical integration (across organizations) in diabetes care and describe what was done, what worked and what appeared to be the barriers to achieving the goals of the programmes. Evidence is sought from groups who have developed different approaches to integrating diabetes care in different health systems (eg insurance vs tax payer funded, single vs multiple organization, published vs unpublished). A final chapter brings the evidence together for a final discussion about what seems to work and what does not.Interfaith Just Peacemaking: Jewish, Christian, and Muslim Perspectives on the New Paradigm of Peace and War
By Susan Brooks Thistlethwaite. 2011
Interfaith Just Peacemaking is a collected work by 27 Jewish, Muslim and Christian scholars and religious leaders on the ten…
'practice norms' of the peacemaking paradigm called 'Just Peace. 'Just Peace theory, like the paradigm it most resembles, Just War theory, is a list of specific practices that are applied to concrete contexts.Praktische Pneumologie
By Peter Hien. 2012
Der Band behandelt Grundlagen, Diagnostik und Therapie von Lungenerkrankungen. Was ist medizinisch und ökonomisch sinnvoll? Wie lässt sich die Kooperation…
zwischen ambulanter und stationärer Betreuung im Sinne des Patienten optimieren? Welche Werte müssen wie oft kontrolliert werden? Diese und andere Fragen beantwortet das Praxishandbuch knapp, klar und auf dem neuesten Stand von Diagnostik und Therapie. Vorgestellt wird eine individuell abgestimmte Stufentherapie, die Begleiterkrankungen, Alter und Geschlecht des Patienten berücksichtigt.