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Showing 61 - 80 of 2946 items
By Monica Muratori, Elisabetta Baldi. 2014
There are several types of damage that can be found in the male gamete. Genetic damage in spermatozoa can originate…
during spermatogenesis, or it can originate during transit in both male and female genital tracts. Damage can also be due to ageing, environmental or iatrogenic conditions, as well as to the protocols to cryopreserve and to select spermatozoa in assisted reproduction techniques. The purpose of this book is to provide a comprehensive resource for all possible DNA damages in sperm, the relation to fertility and infertility, and possible transgenerational heritable effects.By Thomas Boehm, Yousuke Takahama. 2014
The thymus is an evolutionarily ancient primary lymphoid organ common to all vertebrates in which T cell development takes place.…
Failing thymus function is associated with immunodeficiency and/or autoimmunity. In this volume, leading experts provide a comprehensive overview of recent advances in thymopoiesis research. The chapters cover the development of the thymic epithelial microenvironment, address the formation of a diverse and self-tolerant repertoire of T cell receptors as the basis for cellular immunity, discuss the mechanisms by which progenitor cells colonize the thymus and detail the molecular basis for T lineage decisions. The reviews illustrate the important role of the multifaceted process of thymopoiesis for adaptive immunity.By Rabbi Shmuley Boteach. 2010
Our culture is showing the cracks of a growing fracture. Soaring divorce rates; a crippled economy that rewards the few…
and punishes the many; religious-fueled hatred; record rates of depression--the headlines paint a grim picture. We inhabit a society that desperately needs fixing. But as Rabbi Shmuley Boteach reveals in his new book, Renewal, our society can made whole again when we as individuals make the choice to live a life based on values. For too long, conversations about values have been derailed by political movements trying to score points over hot-button issues like gay marriage or abortion. Boteach, one of our wisest and most respected counselors and spiritual experts, reaches deep into our history and into our shared religious legacy to revive the key universal values of Judaism for our struggling world. He presents these age-old ideas as guideposts for the challenges of modern times. These values, whose roots are in the Bible and thousands of years of Jewish spiritual living, can be applied to anyone in the modern world--from Christians and Muslims to atheists and agnostics--who want to renew their existence and recommit themselves to the most precious things in life. Renewal shows everyone how to use the timeless values of the Hebrew Bible and Judaism to live a more fulfilling, modern life. Destiny Unlike the Greeks, who believed that life was scripted from birth, the Jews believe in destiny. In short, they reject the idea of tragic fates and instead champion the individuals' capacity to create their own destiny through individual choice. Redemption Christians and Muslims emphasize salvation, or the need for man to become spiritual--to refine his character and earn a place in heaven. But Jews believe in world redemption, the capacity for the individuals to make heaven here on earth for,the betterment of the community. Action What you do is more important than what you believe. Good deeds always supersede good dogma. Enlightenment Jews are an infinitely curious people and believe that the great bane of existence--boredom--can only be cured by knowledge. Marriage Marriage refers not just to the institution, but rather the softening of the masculine by exposure to the feminine. A culture that does not know how to respect women is bound to collapse. Struggle It is wrestling with our nature, rather than attaining perfection, that constitutes true righteousness. Everyone is somehow flawed, but righteousness is found in the struggle to do right amid a predilection to act selfishly. Sacred Time Whereas other religions sanctify space, Jewish values privilege special moments. The Sabbath day, the holiest day of the week, provides a time for connecting with family and friends.By Kristy A. Brown, Evan R. Simpson. 2014
Obesity is a risk factor for breast cancer in older women. A number of adipose-derived and obesity-related factors have been…
shown to affect tumour cell growth. These include adipokines, insulin, IGF-1 and oestrogens. The majority of obesity-related postmenopausal breast cancers are oestrogen-dependent. Since the ovaries no longer produce oestrogens after menopause, and that circulating levels are negligible, it is evident that it is the oestrogens produced locally within the breast adipose that are responsible for the increased growth of breast cancer cells. Aromatase is the enzyme that converts androgens into oestrogens and its regulation is dependent on the activity of a number of tissue-specific promoters. Targeting oestrogen biosynthesis in obesity may be useful for the prevention of breast cancer. Aromatase inhibitors are efficacious at treating postmenopausal breast cancer and recent studies suggest that they may also be useful in the prevention setting. However, these compounds inhibit the catalytic activity of aromatase and as a consequence lead to a number of undesirable side-effects, including arthralgia and possible cognitive defects due to inhibition of aromatase in the bone and brain, respectively. Novel therapies, such as those employed to treat obesity-associated disease, including anti-diabetics, may prove successful at inhibiting aromatase specifically within the breast. This SpringerBrief will explore all of these issues in depth and the authors are in a unique position to write about this topic, having extensive experience in the field of aromatase research.By Terence Lovat, Robert Crotty. 2015
At the present time, when so-called Islamic radicalism, terrorism and Jihadism occupy major media space, with Islam often depicted as…
the main culprit, the book attempts a tour de force. It proposes that Islam is as much victim as culprit in the history that has led to the current hostility. This is because the common claims of both mainstream and radical Islam that Islam represents the high point of the Abrahamic tradition, and therefore a purification of Judaism and Christianity, have been largely ignored, misunderstood or blatantly rejected by these faiths and therefore by 'the West' in general. This rejection has effectively rendered Islam as the poor cousin, if not the illegitimate sibling, of the tradition. In turn, this has created long-term resentment and hostility within Islam as well as robbed the 'Judaeo-Christian West' of a rich, inter-faith understanding of the wider Abrahamic tradition. The book explores these claims through textual, historical and theological analyses, proposing that many of them stand up better to critical scrutiny than has been commonly acknowledged. It further proposes that seeing Islam in this way has potential to re-awaken its self-understanding as a leader of accord among the Abrahamic faiths, of the kind that characterized the era of Convivencia when, in medieval Spain, Islam constructed and contributed to advanced civilizations characterized by relatively harmonious co-existence between Muslims, Christians and Jews. The book focuses on the role that a more respected and self-confident Islam could play in forging enhanced inter-faith relations in a world that desperately needs them as it struggles to understand and deal with modern and particularly vicious forms of radical Islamism.By Ahmet Bahadir Ergin, A. Laurence Kennedy, Manjula K. Gupta, Amir H. Hamrahian. 2015
Developed via a peer review process that included 25 experienced endocrinologists and utilizing the best current evidence, The Cleveland Clinic…
has created a practical set of protocols for over 25 commonly used dynamic endocrine tests. The cornerstone of clinical endocrinology, these evidence-based protocols play an important role in clinical decision-making and are important element of billing and compliance with high quality standards. Included here are various tests for pituitary and adrenal disorders, thyroid disorders, and glucose metabolism and pancreatic disorders, presented systematically with indications, preparation, materials needed, precautions, procedure, interpretation, and caveats. Filling the gap left by a lack of national guidelines, The Cleveland Clinic Manual of Dynamic Endocrine Testing is an up-to-date practical guide for endocrinologists, nurses, and their staff, inside or outside of the US, who need to perform and interpret dynamic endocrine testing in their everyday practice, as well as medical students, residents and fellows who have interest in endocrinology.By Jaap Jan Boelens, Robert Wynn. 2013
Stem Cell therapy for lysosomal diseases (LSDs) is developing rapidly. This volume discusses the history, current practice and future perspectives…
of stem cells in inborn errors of metabolism (IEM) and provides an international perspective on progress, limitations, and future directions (e. g. gene therapy, iPS, ES) in the field. Beginning with an overview of these diseases, the book covers the breadth of this topic from treatment options, bone marrow transplantation, and alternative treatment options, through long-term outcomes and future perspectives.By Prachi Singh, Ganesh R Kokil, Karnaker R Tupally, Kingshuk Poddar, Aaron Tan, Venky Venkatesan, Harendra S. Parekh, Giorgia Pastorin. 2016
This book provides critical insights into and appraisals ofrecent breakthroughs in type 1 diabetes modulation, with a particular emphasison the…
potential impact of current prevention and treatment strategies. It alsodiscusses recent successes and failures in clinical trials. Presenting ancomprehensive overview of the disease, it is especially useful for newcomers inthe field. It also includes illustrations, which make it easy for the reader tograsp the basic concepts involved. Furthermore, the tables include concise andeasy-to-understand information on current clinical trials.By Tahseen A. Chowdhury. 2014
At a time when clinicians are bombarded with masses of clinical information from numerous sources, and the wide variety of…
changes/advances in diabetes management, there is a need for a concise, easy-to-read book that provides an up-to-date review of the major advances in management of diabetes, with an evidence-based approach. This book is a collection of short chapters, each focused on a subject related to the management of diabetes and its complications. The chapters are written by acknowledged experts in the field, who are also clinicians dealing with diabetes on a day-to-day basis. The text is highly evidence based and well referenced with reviews of relevant trials. It includes the latest developments in diabetes management, prospects for future therapies and avenues of research, as well as therapies currently undergoing clinical trial. In order to facilitate ease of reading, it has a user-friendly appearance, with multiple headings, illustrations and summary boxes. The primary audience is clinical, including all healthcare professionals involved in the management of diabetes and its complications. This encompasses diabetologists and endocrinologists, family practitioners with an interest in diabetes, specialist nurses, dietitians and podiatrists.By Lillian F. Lien, Leonor Corsino, Mark N. Feinglos, Mary E. Cox. 2011
Glycemic Control in the Hospitalized Patient: A Comprehensive Clinical Guide is a unique, practical resource for health care providers dealing…
with hyperglycemia in the inpatient setting. Outlining a hands-on approach used by the Duke University Inpatient Diabetes Management team, the book discusses a wide range of scenarios that occur while treating patients with hyperglycemia, including challenging circumstances such as steroids and tube feeding regimens. Special emphasis is given to insulin therapy. The chapters are written by a group of health care providers with extensive, pioneering experience in hyperglycemia control in the inpatient setting at the Duke University Medical Center. The book includes the most up-to-date scientific evidence and information and is addressed to not only hospitalists and general internists but also endocrinology fellows, residents, nurse practitioners, nurses, and other primary care practitioners who treat patients in the inpatient setting. The focus is clearly on practical, patient-care topics. Glycemic Control in the Hospitalized Patient: A Comprehensive Clinical Guide is a first-of-its kind, comprehensive guide to state-of-the-art inpatient glycemic management.By Jonathan R Seckl, Yves Christen. 2014
The authors address in particular the role of hormones and their links with other maternal environmental mediators in developmental programming.…
The crucial nature of the placenta as an interface and target between maternal and foetal environments is addressed. Emphasis is made on the emerging science of epigenetics as a potential explanation for how environmental events that occur during brief windows of development may exert effects that impact upon somatic cells through many rounds of mitosis for much of the life span of the subsequent organism.By George L. L. Bakris, Allison Hahr, Romesh Khardori, Daisuke Koya, Mark Molitch, Friedrich C. C. Prischl, Guntram Schernthaner, Bijin Thajudeen. 2017
An overview of the diagnosis, treatment, and long-term management of diabetic-related kidney disease in clinical practice. Includes an evidence-based discussion…
of currently available and experimental drug therapies currently in development, guided by international consensus guidelines. Ideal for physicians, medical trainees, nurses and other medical professional that regularly screen and treat patients with all types of diabetes.By Patricia Keer Munro. 2016
The Jewish practice of bar mitzvah dates back to the twelfth century, but this ancient cultural ritual has changed radically…
since then, evolving with the times and adapting to local conditions. For many Jewish-American families, a child's bar mitzvah or bat mitzvah is both a major social event and a symbolic means of asserting the family's ongoing connection to the core values of Judaism. Coming of Age in Jewish America takes an inside look at bar and bat mitzvahs in the twenty-first century, examining how the practices have continued to morph and exploring how they serve as a sometimes shaky bridge between the values of contemporary American culture and Judaic tradition. Interviewing over 200 individuals involved in bar and bat mitzvah ceremonies, from family members to religious educators to rabbis, Patricia Keer Munro presents a candid portrait of the conflicts that often emerge and the negotiations that ensue. In the course of her study, she charts how this ritual is rife with contradictions; it is a private family event and a public community activity, and for the child, it is both an educational process and a high-stakes performance. Through detailed observations of Conservative, Orthodox, Reform, and independent congregations in the San Francisco Bay Area, Munro draws intriguing, broad-reaching conclusions about both the current state and likely future of American Judaism. In the process, she shows not only how American Jews have forged a unique set of bar and bat mitzvah practices, but also how these rituals continue to shape a distinctive Jewish-American identity.By Leslie Josel, Susan Weiner. 2013
Is your lack of organization impacting your ability to effectively manage your diabetes? Do you run out of supplies and…
forget endocrinologist appointments? Do you find snacks in your pantry that expired sometime before the insulin pump was invented? Do you struggle to keep track of health-care invoices and payments? Do you succeed at keeping an active health journal for a week or two and then neglect it for a year or two?It sounds like you could use The Complete Diabetes Organizer!Within the pages of this book, diabetes educator Susan Weiner and organizing guru Leslie Josel provide you with dependable strategies and ideas designed to help streamline your diabetes care and simplify your life. From her distinguished career and experience in the fields of diabetes and dietetics, Susan Weiner brings helpful tips and tricks that are guaranteed to ease daily mechanics, promote improved nutrition, and relieve stress caused by disorder and confusion. Certified professional organizer and ADHD Specialist Leslie Josel applies her expertise to the topic of diabetes, with simple, surefire techniques that will allow you to disentangle yourself from the clutches of chronic disorganization.The Complete Diabetes Organizer is your guidebook to maintaining your diabetes with less effort and more confidence, allowing you to focus on enjoying a healthier, stress-free life.By Blu Greenberg. 1983
Filled with practical advice as well as history, Blu Greenberg's book is a comprehensive guide to the joys and complexities…
of running a modern Jewish home. How to Run a Traditional Jewish Household is a modern, comprehensive guide covering virtually every aspect of Jewish home life. It provides practical advice on how to manage a Jewish home in the traditional way and offers fascinating accounts of the history behind the tradition. In a warm, personal style, Blu Greenberg shows that, contrary to popular belief, the home, and not the synagogue, is the most important institution in Jewish life. Divided into three large sectionsD'The Jewish Way,' 'Special Stages of Life,' and 'Celebration and Remembering'Dthis book educates the uninitiated and reminds the already observant Jew of how Judaism approaches daily life. Topics include prayer, dress, holidays, food preparation, marriage, birth, death, parenthood, and many others. This description of the modern-yet-traditional Jewish household will earn special regard among the many American Jews who are reexploring their ties to Jewish tradition. Such Jews will find this book a flexible guide that provides a knowledge of the requirements of traditional Judaism without advocating immediate and complete compliance. How to Run a Traditional Jewish Household will also appeal to observant Jews, providing them with helpful tips on how to manage their homes and special insights into the most minute details and procedures in a traditional household. Herself a traditional Jew, Blu Greenberg is nevertheless quite sympathetic to feminist views on the role of women in Jewish observance. How to Run a Traditional Jewish Household therefore speaks intimately to women who are struggling to reconcile their identities as modern women with their commitments to traditional Judaism.By Deborah E. Lipstadt. 2016
Immediately after World War II, there was little discussion of the Holocaust, but today the word has grown into a…
potent political and moral symbol, recognized by all. In Holocaust: An American Understanding, renowned historian Deborah E. Lipstadt explores this striking evolution in Holocaust consciousness, revealing how a broad array of Americans--from students in middle schools to presidents of the United States--tried to make sense of this inexplicable disaster, and how they came to use the Holocaust as a lens to interpret their own history. Lipstadt weaves a powerful narrative that touches on events as varied as the civil rights movement, Vietnam, Stonewall, and the women's movement, as well as controversies over Bitburg, the Rwandan genocide, and the bombing of Kosovo. Drawing upon extensive research on politics, popular culture, student protests, religious debates and various strains of Zionist ideologies, Lipstadt traces how the Holocaust became integral to the fabric of American life. Even popular culture, including such films as Dr. Strangelove and such books as John Hershey's The Wall, was influenced by and in turn influenced thinking about the Holocaust. Equally important, the book shows how Americans used the Holocaust to make sense of what was happening in the United States. Many Americans saw the civil rights movement in light of Nazi oppression, for example, while others feared that American soldiers in Vietnam were destroying a people identified by the government as the enemy. Lipstadt demonstrates that the Holocaust became not just a tragedy to be understood but also a tool for interpreting America and its place in the world. Ultimately Holocaust: An American Understanding tells us as much about America in the years since the end of World War II as it does about the Holocaust itself.By Barry Steffi Rubin. 1998
By Dr Jeffrey L. Seif. 2011
You do know that the first followers of Yeshua (Jesus) were Jews. And everyone knows by now that Jews spread…
his message through the ministry of Paul, Peter, and the other apostles.By Jamie Lash, Neil Lash. 2009
Most people know that Shabbot--the Sabbath Day--begins Friday evening at sundown with a special ceremoney. But most people don't know…
that the Sabbath ends with another shorter, yet equally sweet, ceremony called havdalah. Practiced by observant Jews die millennia, it is now returning, not just among Jews, but among Christians who are searching to understand the Jewish background of their faith. Dr. Neil and jamie Lash have written a short introduction to havdalah, which can be used by anyone--Jew or Gentile--who wants to experience the important biblical principle of separation.