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The Genetics of Obesity
By Struan F.A. Grant. 2014
In the past four years, many genetic loci have been implicated for BMI from the outcomes of genome-wide association studies…
(GWAS), primarily in adults. Insulin-induced gene 2 (INSIG2) was the first locus to be reported by this method to have a role in obesity but replication attempts have yielded inconsistent outcomes. The identification of the second locus, the fat mass- and obesity-associated gene (FTO), h has been more robustly observed by others. Studies from both FTO knock out and FTO overexpression mouse model support the fact that FTO is directly involved in the regulation of energy intake and metabolism in mice, where the lack of FTO expression leads to leanness while enhanced expression of FTO leads to obesity. Along with numerous other studies, a number of genetic variants have been established robustly in the context of obesity, giving us fresh insights into the pathogenesis of the disease. This book will give a comprehensive overview of efforts aimed at uncovering genetic variants associated with obesity, which have been particularly successful in the past 5 years with the advent of genome-wide association studies (GWAS). This book will cover this state of the art technology and its application to obesity in great detail. Topics covered will include genetics of childhood obesity, genetics of syndromic obesity, copy number variants and extreme obesity, co-morbidities of obesity genetics, and functional follow-up of genetic variants. Bacardi and the Long Fight for Cuba: The Biography of a Cause
By Tom Gjelten. 2008
In this widely hailed book, NPR correspondent Tom Gjelten fuses the story of the Bacardi family and their famous rum…
business with Cuba's tumultuous experience over the last 150 years to produce a deeply entertaining historical narrative. The company Facundo Bacardi launched in Cuba in 1862 brought worldwide fame to the island, and in the decades that followed his Bacardi descendants participated in every aspect of Cuban life. With his intimate account of their struggles and adventures across five generations, Gjelten brings to life the larger story of Cuba's fight for freedom, its tortured relationship with America, the rise of Fidel Castro, and the violent division of the Cuban nation.Neoliberalism from Below: Popular Pragmatics and Baroque Economies
By Liz Mason-Deese, Ver nica Gago. 2017
In Neoliberalism from Below—first published in Argentina in 2014—Verónica Gago examines how Latin American neoliberalism is propelled not just from…
above by international finance, corporations, and government, but also by the activities of migrant workers, vendors, sweatshop workers, and other marginalized groups. Using the massive illegal market La Salada in Buenos Aires as a point of departure, Gago shows how alternative economic practices, such as the sale of counterfeit goods produced in illegal textile factories, resist neoliberalism while simultaneously succumbing to its models of exploitative labor and production. Gago demonstrates how La Salada's economic dynamics mirror those found throughout urban Latin America. In so doing, she provides a new theory of neoliberalism and a nuanced view of the tense mix of calculation and freedom, obedience and resistance, individualism and community, and legality and illegality that fuels the increasingly powerful popular economies of the global South's large cities.Francisco Pizarro: Destroyer of the Inca Empire
By John Diconsiglio. 2009
Only Yesterday, Since Yesterday, and The Lords of Creation: Three Popular Histories of 20th-Century America
By Frederick Lewis Allen. 1935
Three acclaimed chronicles of American life from a New York Times–bestselling author with a “style that is verve itself” (The…
New York Times). In these three popular histories of America—collectively ranging from the turn of the century through the 1930s—Frederick Lewis Allen confirms his reputation as one of the most influential journalists of the twentieth century and a “diligent and perceptive reporter” (Forbes). Only Yesterday: Allen’s bestselling account of the Roaring Twenties begins at the end of World War I and continues through Prohibition, the Big Red Scare, and the stock market crash of 1929. Originally published in 1931, the definitive account of twentieth-century America combines the immediacy of firsthand experience with clear-cut analysis. This iconic history sold over half a million copies in its first year of publication, reaching commercial and critical success unheard of during the Depression. Since Yesterday: Allen’s bestselling follow-up to Only Yesterday begins with America’s plunge into the Great Depression. With wit and empathy, Allen chronicles the 1930s from the Lindbergh kidnapping to the New Deal, from bank closures and devastating dust storms to the rise of Benny Goodman and our mass escape to the movies. The Lords of Creation: Allen’s history of American finance from the Reconstruction Era to the start of the Great Depression is a fascinating story of bankers, railroad tycoons, steel magnates, and robber barons. From the unprecedented corporate expansion that followed the Civil War, Allen traces a path of innovation and exploitation that put America’s fortunes in the hands of the Rockefellers, Fords, Vanderbilts, and other wealthy industrialists who set the stage for the most devastating financial collapse in history.Focus on Gynecologic Malignancies
By Nathan A. Berger, Ann H. Klopp, Karen H. Lu. 2018
Gynecologic malignancies especially endometrial and ovarian cancers are among the most important and most severely affected by obesity …
This volume of Energy Balance and Cancer written by the world s leading experts in this field is arranged to provide a transdisciplinary assessment of the pertinent issues results of relevant research on mechanisms and control strategies for dealing with affected patients and improving outcomes and future research needs The volume comprehensively covers the epidemiology linking obesity to endometrial and ovarian cancer as well as the public awareness of this critical problem Subsequent chapters explain biologic aspects of linkages between energy balance and gynecologic malignancies The volume further outlines strategies to disrupt the linkage between obesity and gynecologic malignancies and concludes with a series of chapters focused on management strategies for obese patients with gynecologic malignancies This volume provides a valuable resource for all physicians scientists and other transdisciplinary investigators and practitioners interested and involved in energy balance and cancer It should be a particularly useful guide to optimize outcomes for all practitioners dealing with patients with gynecologic malignancies challenged by energy balance issues Moreover it should serve as a useful guide to students and investigators interested in conducting further research on defining and disrupting the important linkage between energy balance and gynecologic malignanciesBárbaros: las luchas contra el Imperio Romano.
By Canal Historia. 2016
De los púnicos a los godos, un apasionante recorrido por los siglos de decadencia del Imperio Romano a través de…
los pueblos que desafiaron su hegemonía. Con el sello de rigor y amenidad característico de Canal Historia. ¿Cómo fue realmente el viaje de Aníbal y su ejército cruzando los Alpes para conquistar Roma? ¿Cuáles fueron las causas de que el pequeño pueblo celtíbero de Numancia contuviera durante meses al poderosísimo ejército imperial? ¿Cuántas revueltas de esclavos y gladiadores hubo en el seno de la capital romana? ¿Qué problemas surgieron entre el Imperio y los germánicos y británicos para que se precipitara el fin de la famosa Pax Romana? Basado en la serie de televisión de Canal Historia, Bárbaros plantea la historia de Roma desde la perspectiva de los pueblos que hicieron frente a su imperialismo: los cartagineses, los persas, los galos, los hunos o los vándalos, entre otros muchos. Con el estilo ameno y riguroso que caracteriza a los libros de Historia, se acerca a las figuras más conocidas del período, como Espartaco, Boudica, Viriato o Atila, relata las batallas más decisivas y da las claves de la caída del gran imperio de Occidente. Un relato épico y trepidante sobre el período histórico que construyó la historia moderna del mundo occidental.For anyone who plays sports and is looking to facilitate recovery or prevent injuriesEveryone who plays sports experiences injuries. Many…
people never fully recover because they're not aware of what they can do to facilitate recovery. But there's no need to simply resign yourself to "living with" a sports injury. In The Anatomy of Sports Injuries, author Brad Walker brings years of expertise--he works with elite-level and world-champion athletes, and lectures on injury prevention--to this how-to guide. The book takes a fundamental approach, bringing you inside the body to show exactly what is happening when a sports injury occurs. At the heart of The Anatomy of Sports Injuries are 350 images. This second edition includes updated illustrations and more anatomical information and is for every sports player or fitness enthusiast who has been injured and would like to know what the injury involves, how to rehabilitate the area, and how to prevent complications or injury in the future.Vintage Tomorrows
By James H. Carrott, Brian David Johnson. 2012
With Early Release ebooks, you get books in their earliest form — the author's raw and unedited content as he…
or she writes — so you can take advantage of these technologies long before the official release of these titles. You'll also receive updates when significant changes are made, new chapters as they're written, and the final ebook bundle.nnIn this fascinating book, futurist Brian David Johnson and cultural historian James Carrott offer insights into what Steampunk’s alternative history says about our own world and its technological future. Interviews with experts such as William Gibson, Cory Doctorow, Bruce Sterling, James Gleick, and Margaret Atwood explore how this vision of stylish craftsmen making fantastic and beautiful hand-tooled gadgets has become a cultural movement—and perhaps an important countercultural moment.The New Zealand Wars 1820-72
By Raffaele Ruggeri, Ian Knight. 2013
Between 1845 and 1872, various groups of Maori - the Polynesian people who had inhabited New Zealand since medieval times…
- were involved in a series of wars of resistance against British settlers, which in many ways mirrored the American Indian Wars. Like some Native Americans, the Maori had a fierce and long-established warrior tradition (epitomized today by the intimidating haka war-challenge performed by the All Blacks rugby team), and lived in tribal communities dispersed throughout rough and thickly wooded terrain. Subduing them took a lengthy British Army commitment, only surpassed in the Victorian period by that on the North-West Frontier of India.Warfare had been endemic in pre-colonial New Zealand - in contests over territory and group prestige, and in generations-long feuds - and Maori groups maintained fortified villages or pas. The small early British coastal settlements, also widely dispersed, were tolerated, and in the 1820s a chief named Hongi Hika travelled to Britain with a missionary and returned laden with gifts. He promptly exchanged these for muskets, and began an aggressive 15-year expansion at the expense of neighbouring tribes. When new waves of major British settlement arrived between the 1840s and 1860s, competition over the available productive land caused increased friction and clashes. British troops were shipped in, and fought a series of essentially local wars in both North and South Islands over more than 25 years. However, some Maori groups always allied themselves with the Europeans, in pursuit of ancient enmities with their neighbours.By the 1860s many Maori had acquired firearms and had perfected their bush-warfare tactics. Their defences also evolved, with conspicuous log fortifications giving way to deep entrenchments less visible and vulnerable to artillery. The British, too, were adapting their uniforms, equipment and tactics to broken-country fighting in the bush, and employing more portable artillery and mortars. In the last phase of the wars a religious movement, Pai Maarire ('Hau Hau'), inspired remarkable guerrilla leaders such as Te Kooti Arikirangi to renewed resistance. This final phase saw a reduction in British Army forces as operations were increasingly taken over by locally recruited constabulary and militia units. European victory was not total, but led to a negotiated peace that preserved some of the Maori people's territories and freedoms; in modern times this has allowed a real (if sometimes strained) progress towards a genuinely unified national identity.Seeking Good Debate
By Michael S. Evans. 2016
Why do religion and science often appear in conflict in America's public sphere? In Seeking Good Debate, Michael S. Evans…
examines the results from the first-ever study to combine large-scale empirical analysis of some of our foremost religion and science debates with in-depth research into what Americans actually want in the public sphere. The surprising finding is that apparent conflicts involving religion and science reflect a more fundamental conflict between media elites and ordinary Americans over what is good debate. For elite representatives, good debate advances an agenda, but, as Evans shows, for many Americans it is defined by engagement and deliberation. This hidden conflict over what constitutes debate's proper role diminishes the possibility for science and religion to be discussed meaningfully in public life. Challenging our understanding of science, religion, and conflict, Seeking Good Debate raises profound questions about the future of the public sphere and American democracy.Psycho-Oncology
By Ute Goerling, Anja Mehnert. 2014
Psycho-oncology is a thriving discipline in cancer care, and numerous research activities have been undertaken in the endeavour to improve…
treatment outcomes and to gain a better understanding of the psychosocial consequences of cancer. This book presents and discusses the latest findings from science and practice for a broad range of psychological and social issues related to cancer and its treatments. Not only are general psychosocial impacts of cancer described, but the very common fear of progression is elucidated. The relevance of psycho-oncology at different stages of disease (during oncological treatment, in rehabilitation, and during palliative care) is explained, and various psycho-oncological interventions are illustrated. Other important topics are the experience of being a cancer survivor, who may be cured but not be healthy, the psychological burden on relatives, and gender differences in coping with cancer. Quality of life and patient-reported outcomes are also commented on since they are among the key benchmarks for successful coping with the diagnosis of cancer, its treatment, and its late effects. The chapters are almost all written by distinguished scientists, but as we often learn most from those affected by cancer, one author speaks for herself as a patient.A penetrating critique tracing how under-regulated trading between European and U.S. banks led to the 2008 financial crisis—with a prescription…
for preventing another meltdown There have been numerous books examining the 2008 financial crisis from either a U.S. or European perspective. Tamim Bayoumi is the first to explain how the Euro crisis and U.S. housing crash were, in fact, parasitically intertwined. Starting in the 1980s, Bayoumi outlines the cumulative policy errors that undermined the stability of both the European and U.S. financial sectors, highlighting the catalytic role played by European mega banks that exploited lax regulation to expand into the U.S. market and financed unsustainable bubbles on both continents. U.S. banks increasingly sold sub-par loans to under-regulated European and U.S. shadow banks and, when the bubbles burst, the losses whipsawed back to the core of the European banking system. A much-needed, fresh look at the origins of the crisis, Bayoumi’s analysis concludes that policy makers are ignorant of what still needs to be done both to complete the cleanup and to prevent future crises.Don Mills: From Forests and Farms to Forces of Change
By Scott Kennedy. 2013
How Toronto’s own city farms were crowded out First settled in the early nineteenth century, the area now known as…
Don Mills retained its rural character until the end of the Second World War. After the war, population growth resulted in pressure to develop the area around Toronto and, in a relatively short time, the landscape of Don Mills was irreparably altered. Today, the farms are all gone, as are almost all of the barns and farmhouses. Fields and forests have been replaced by the industries, homes, and shops of Canada’s “first subdivision.” In Don Mills: From Forests and Farms to Forces of Change, author Scott Kennedy remembers Don Mills as it was and takes great care to make sure that the farms and farmers are not forgotten.Careless at Work: Selected Canadian historical studies
By J M S Careless. 1996
This sampling of the work of J.M.S. Careless in the area of Canadian historical studies was selected by the eminent…
scholar himself, and represents much of his finest work. The collection spans the years from 1940 to 1990 in the long and distinguished career of one of Canada’s best-known historians. In Careless’s own words, History is dated. Its very claim is that the past does not fade into nothing but continues to matter, whether or not the purely present-minded are able to recognize that basic fact. These essays cover the main lines of Careless’s career in Canadian scholarship. The collection is divided into four general subject areas each covering a main preoccupation in a distinguished career of over forty years. The first section concentrates on the earliest theme in his writing, George Brown and his times. The second centres on exploring various aspects of frontierism and metropolitanism in Canadian history. The third part deals with cities and regions focusing particularly on the West and nineteenth century Ontario. The final section picks up the threads of other themes including limited identities Canada and multiculturalism.The Sensory Processing Disorder Answer Book provides advice and answers to your most pressing questions about SPD. Written in a…
question and answer format, The Sensory Processing Disorder Answer Book helps you understand SPD, conquer your fears, and seek help for your child when necessary.Overcoming Arthritis
By Dr Sarah Brewer. 2012
Practical Handbook of School Psychology
By Gretchen Gimpel Peacock, Ruth Ervin. 2010
Bringing together leading authorities, this state-of-the-science handbook delves into all aspects of problem-solving-based school psychology practice. Thirty-four focused chapters present…
data-based methods for assessment, analysis, intervention, and evaluation, with special attention given to working in a response-to-intervention framework. Tools and guidelines are provided for promoting success in key academic domains reading, writing, and math. Social-emotional and behavioral skills are thoroughly addressed in chapters on self-management interventions, peer and family support, cognitive-behavioral interventions, medication use, and more. This accessible work is an invaluable reference for practitioners and an ideal resource for school psychology training programs.Lose It for Life for Teens
By Stephen Arterburn. 2004
Weight is such a critical issue with teenagers. They are overwhelmed with messages that present unrealistic and unhealthy body images.…
This book will prevent a lifetime of struggles and negative self-perceptions.Citizen and Subject: Contemporary Africa And The Legacy Of Late Colonialism
By Meike De Goede. 2017
Mahmood Mamdani’s 1996 Citizen and Subject is a powerful work of analysis that lays bare the sources of the problems…
that plagued, and often still plague, African governments. Analysis is one of the broadest and most fundamental critical thinking skills, and involves understanding the structure and features of arguments. Mamdani’s strong analytical skills form the basis of an original investigation of the problems faced by the independent African governments in the wake of the collapse of the colonial regimes imposed by European powers such has Great Britain and France. It had long been clear that these newly-independent governments faced many problems – corruption, the imposition of anti-democratic rule, and many basic failures of day-to-day governance. They also tended to replicate many of the racially and ethnically prejudiced structures that were part of colonial rule. Mamdani analyses the many arguments about the sources of these problems, drawing out their hidden implications and assumptions in order to clear the way for his own creative new vision of the way to overcome the obstacles to democratization in Africa. A dense and brilliant analysis of the true nature of colonialism’s legacy in Africa, Mamdani’s book remains influential to this day.