Service Alert
Website maintenance April 24 10pm ET
On Wednesday April 24 at 10pm ET the CELA website will be unavailable for about 15 minutes for planned maintenance.
On Wednesday April 24 at 10pm ET the CELA website will be unavailable for about 15 minutes for planned maintenance.
Showing 161 - 180 of 46880 items
By Roger J. Narayan. 2024
"3D bioprinting" refers to processes in which an additive manufacturing approach is used to create devices for medical applications. This…
volume considers exciting applications for 3D bioprinting, including its use in manufacturing artificial tissues, surgical models, and orthopedic implants.The book includes chapters from leaders in the field on 3D bioprinting of tissues and organs, biomedical applications of digital light processing, biomedical applications of nozzle-free pyro-electrohydrodynamic jet printing of buffer-free bioinks, additive manufacturing of surgical models, dental crowns, and orthopedic implants, 3D bioprinting of dry electrodes, and 3D bioprinting for regenerative medicine and disease modeling of the ocular surface.This is an accessible reference for students and researchers on current 3D bioprinting technology, providing helpful information on the important applications of this technology. It will be a useful resource to students, researchers, and practitioners in the rapidly growing global 3D bioprinting community.By Mohamed Elgendi. 2021
This book serves as a current resource for Photoplethysmogram (PPG) signal analysis using MATLAB®. This technology is critical in the…
evaluation of medical and diagnostic data utilized in mobile devices. Information and methodologies outlined in the text can be used to learn the empirical and experimental process (including data collection, data analysis, feature extractions, and more) from inception to conclusion. This book also discusses how introduced methodologies can be used and applied as tools that will teach the user how to validate, test, and simulate developed algorithms before implementing and deploying the algorithms on wearable, battery-driven, or point-of-care devices.By Ying Yuan, Hoang Q. Nguyen, Peter F. Thall. 2016
Reliably optimizing a new treatment in humans is a critical first step in clinical evaluation since choosing a suboptimal dose…
or schedule may lead to failure in later trials. At the same time, if promising preclinical results do not translate into a real treatment advance, it is important to determine this quickly and terminate the clinical evaluation process to avoid wasting resources. Bayesian Designs for Phase I–II Clinical Trials describes how phase I–II designs can serve as a bridge or protective barrier between preclinical studies and large confirmatory clinical trials. It illustrates many of the severe drawbacks with conventional methods used for early-phase clinical trials and presents numerous Bayesian designs for human clinical trials of new experimental treatment regimes.Written by research leaders from the University of Texas MD Anderson Cancer Center, this book shows how Bayesian designs for early-phase clinical trials can explore, refine, and optimize new experimental treatments. It emphasizes the importance of basing decisions on both efficacy and toxicity.By Kwan Hoong Ng, Ngie Min Ung, Robin Hill. 2018
The third in a three-volume set exploring Problems and Solutions in Medical Physics, this volume explores common questions and their…
solutions in Radiotherapy. This invaluable study guide should be used in conjunction with other key textbooks in the field to provide additional learning opportunities.One hundred and forty-four solved problems are provided in ten chapters on basic physics topics, including: External Beam Therapy Equipment, Photon Beam Physics, Radiation dosimetry, Treatment Planning for External Beam Radiotherapy, and External Beam Commissioning and Quality Assurance.Each chapter provides examples, notes, and references for further reading to enhance understanding.Key features: Consolidates concepts and assists in the understanding and applications of theoretical concepts in medical physics Assists lecturers and instructors in setting assignments and tests Suitable as a revision tool for postgraduate students sitting medical physics, oncology, and radiology science examinationsBy Yingwei Peng, Binbing Yu. 2021
Cure Models: Methods, Applications and Implementation is the first book in the last 25 years that provides a comprehensive and…
systematic introduction to the basics of modern cure models, including estimation, inference, and software. This book is useful for statistical researchers and graduate students, and practitioners in other disciplines to have a thorough review of modern cure model methodology and to seek appropriate cure models in applications. The prerequisites of this book include some basic knowledge of statistical modeling, survival models, and R and SAS for data analysis.The book features real-world examples from clinical trials and population-based studies and a detailed introduction to R packages, SAS macros, and WinBUGS programs to fit some cure models. The main topics covered include the foundation of statistical estimation and inference of cure models for independent and right-censored survival data, cure modeling for multivariate, recurrent-event, and competing-risks survival data, and joint modeling with longitudinal data, statistical testing for the existence and difference of cure rates and sufficient follow-up, new developments in Bayesian cure models, applications of cure models in public health research and clinical trials.By Archana Bachheti, Rakesh Kumar Bachheti, Azamal Husen. 2023
The use of medicinal plants in herbal and modern medicine has gained popularity over the last few decades due to…
consumers taking more natural approaches to medicine. Aquatic medicinal plants are rich in bioactive compounds and demonstrate various commercial, nutraceutical, and biological applications. Aquatic Medicinal Plants offers the reader a wealth of information on uses of bioactive components of these plants, along with crucial references, and explains their traditional uses, phytochemistry, and pharmacological properties.Features Provides information on aquatic and semiaquatic medicinal plants and their uses globally. Discusses phytochemical components with the known active constituents and their pharmaceutical applications. This volume in the Exploring Medicinal Plants series is appropriate for scientists, experts, and consultants associated with the exploration of aquatic medicinal plant usage. This book is an essential tool for identifying important aquatic medicinal plants and possibilities for the synthesis or preparation of modern drugs.Mathematical modelling is an important part of nuclear medicine. Therefore, several chapters of this book have been dedicated towards describing…
this topic. In these chapters, an emphasis has been put on describing the mathematical modelling of the radiation transport of photons and electrons, as well as on the transportation of radiopharmaceuticals between different organs and compartments. It also includes computer models of patient dosimetry. Two chapters of this book are devoted towards introducing the concept of biostatistics and radiobiology. These chapters are followed by chapters detailing dosimetry procedures commonly used in the context of diagnostic imaging, as well as patient-specific dosimetry for radiotherapy treatments. For safety reasons, many of the methods used in nuclear medicine and molecular imaging are tightly regulated. Therefore, this volume also highlights the basic principles for radiation protection. It discusses the process of how guidelines and regulations aimed at minimizing radiation exposure are determined and implemented by international organisations. Finally, this book describes how different dosimetry methods may be utilized depending on the intended target, including whole-body or organ-specific imaging, as well as small-scale to cellular dosimetry.This text will be an invaluable resource for libraries, institutions, and clinical and academic medical physicists searching for a complete account of what defines nuclear medicine. The most comprehensive reference available providing a state-of-the-art overview of the field of nuclear medicine Edited by a leader in the field, with contributions from a team of experienced medical physicists, chemists, engineers, scientists, and clinical medical personnel Includes the latest practical research in the field, in addition to explaining fundamental theory and the field's historyBy Gustavo Molina, Zeba Usmani, Minaxi Sharma, Abdelaziz Yasri, Vijai Kumar Gupta. 2023
This book explores recent advances on the use of microbes for agri-forestry biotechnological applications. It provides technical concepts and discussions…
on the use of microorganisms for processes such as bioprocessing, bioremediation, soil enhancement, aquaponics advances, and plant-host symbiosis. The book provides an overview of the microbial approach to the tools and processes used in agriculture and forestry that make or modify products, improve plants for specific uses, and make use of livestock in agricultural systems. The authors discuss the main process conditions that enhance agri-forestry applications with the use of microbes and introduce the use of genetically modified (GM) microbes in agrobiotechnology. Finally, the authors explore the main technological advances in the production of secondary metabolites with potential applications in agri-forestry. This book is intended for biotechnologists, biologists, bioengineers, biochemists, microbiologists, food technologists, enzymologists, and related researchers.By A. K. Ganguly, Sesha Sridevi Alluri. 2022
Medicinal Chemistry: A Look at How Drugs Are Discovered is written for those who are interested in learning how drugs…
are discovered. Compared to other books on the market, this text takes a different approach by presenting the subject on chemical reaction mechanism terms, which ideally makes the subject matter more interesting and easier to comprehend. The authors describe the drug discovery process, from advancing an initial lead to the approval process, and include drug discovery sources. Additional features: Explains medicinal chemistry on chemical mechanism terms, allowing for a more interesting and easier to comprehend text Includes valuable insights toward the various pathways taken at pharmaceutical industries in drug discoveries Improved by including questions raised and suggestions made from students in the authors’ medicinal chemistry classes This book will benefit both upper level undergraduates and graduates studying in the fields of medicinal chemistry and drug discovery, as well as scientists working in the pharmaceutical industry.By Cyrus R. Safinya, Joachim O. Rädler. 2021
This handbook provides a unique overview of lipid membrane fundamentals and applications. The fascinating world of lipids that harbor and…
govern so many biological functionalities are discussed within the context of membrane structures, interactions, and shape evolution. Beyond the fundamentals in lipid science, this handbook focuses on how scientists are building bioinspired biomimetic systems for applications in medicine, cosmetics, and nanotechnology. Key Features: Includes experimental and theoretical overviews on the role of lipids, with or without associated biomolecules, as structural components imparting distinct membrane shapes and intermembrane interactions Covers the mechanisms of lipid-membrane curvature, by peptide and protein binding, and the roles of signalling lipids and the cytoskeleton in plasma membrane shape evolution Covers advanced X-ray and force measurement techniques Discusses applications in biomedicine, cosmetics, and nanotechnology, including lipid vectors in nucleic acid, drug delivery in dermal applications, and lipid-based sensors and artificial biointerfaces Covers artificial membranes from block copolymers, synthetic copolypeptides, and recombinant proteins Includes an exciting section that explores the role of lipids in the origin of life in hydrothermal conditions This book is a highly informative companion for professionals in biophysics, biochemistry, physical chemistry, and material and pharmaceutical sciences and bioengineering.By Anthony T. Tu. 1991
In 24 contributed chapters, 37 international specialists describe the latest developments in research on snake venom including different types of…
venoms and toxins, actions, antidotes, and applications and summarize what is known to date on Gila monster and frog toxins. Some 70 tables provide essentBy Gavin Poludniowski, Artur Omar, Pedro Andreo. 2022
Calculating x-ray tube spectra provides a comprehensive review of the modelling of x-ray tube emissions, with a focus on medical…
imaging and radiotherapy applications. It begins by covering the relevant background, before discussing modelling approaches, including both analytical formulations and Monte Carlo simulation. Historical context is provided, based on the past century of literature, as well as a summary of recent developments and insights. The book finishes with example applications for spectrum models, including beam quality prediction and the calculation of dosimetric and image-quality metrics.This book will be a valuable resource for postgraduate and advanced undergraduate students studying medical radiation physics, in addition to those in teaching, research, industry and healthcare settings whose work involves x-ray tubes.Key Features: Covers simple modelling approaches as well as full Monte Carlo simulation of x-ray tubes. Bremsstrahlung and characteristic contributions to the spectrum are discussed in detail. Learning is supported by free open-source software and an online repository of code. An online repository of the code that accompanies this book can be found here: https://bitbucket.org/caxtusBy Scott D Mendelson. 2020
This unique volume presents new understandings of the neurochemical nature of major depression, and how herbs and their constituent flavonoids…
and terpenes appear to address some of the mechanisms now thought to be involved. It explores how recent studies of the rapid antidepressant effects of ketamine inform neuroscientists about deep intracellular mechanisms of antidepressant action that have little to do with simple enhancement of monoaminergic activity. These mechanisms include actions on PI3K, Akt, mTOR, GSK3, BDNF, and other intracellular pathways. New theories of the pathophysiology underlying major depression, such as oxidative damage, inflammation, stress and insulin resistance are then explored.Key Features: Focuses on oxidative damage, inflammation, and metabolic syndrome. Explains that a significant percentage of people treated for major depression obtain little if any relief from standard antidepressant medications. These facts lead to discussion of herbs that can be used to treat major depression, as well as consideration of the scientific basis for how these herbs act. The antidepressant properties of 66 herbs are discussed, along with dosing and safety information.By Yashwant V. Pathak, Sarvadaman Pathak, and Con Stough. 2024
Healthy gut function is associated with normal central nervous system (CNS) function. Hormones, neurotransmitters, and immunological factors released from the…
gut are known to send signals to the brain either directly or via autonomic neurons. Recently, studies have emerged focusing on variations in the microbiome and the effect on various CNS disorders, including, but not limited to anxiety, depressive disorders, schizophrenia, and autism. Anxiety, Gut Microbiome, and Nutraceuticals: Recent Trends and Clinical Evidence is focused on understanding the role of gut microbiomes on anxiety and how it can be treated using various nutraceuticals. It covers recent trends and clinical evidence in application of nutraceuticals in treating anxiety and related disorders.Key Features Explains various factors related to anxiety and anxiety-related disorders including pathophysiological and pharmacological factors Discusses the pharmacology behind anxiety and related disorders Explores the role of gut microbiota and its relationship with anxiety and related disorders Describes different nutraceuticals and classes of nutraceuticals which can be useful to treat anxiety and related disorders In recent years, there has been an increased interest in nutraceuticals and their applications in treating many diseases and disorders. The market has grown tremendously, and this book focuses on the many clinical studies reporting on the usefulness of nutraceuticals in treating such health conditions.By Dong-Hwa Shin, Kalidas Shetty. 2023
The Republic of Korea (ROK) is projected by 2030 to have the longest living population compared to any nation on…
earth. A girl born in the ROK in 2030 will live up to 90.8 years on average. What are the reasons for this improvement in longevity?Among many insights for longevity among the people of the ROK is the diverse Korean ethnic diet with roots in a traditional diet that has been preserved for centuries. Korean Food Systems: Secrets of the K-Diet for Healthy Aging provides an integrated and holistic approach towards the understanding how food systems of the ROK and experiences of the last 60-plus years has been sustained by traditions and ecology integrated with contemporary advances in technology and the economy.Key Features: Discusses the rationale and basis of food systems, traditions of healthy eating, and healthy aging in the Korean population and why by 2030 they will be the longest living population on the planet Reflects on the role of historical, cultural, and traditional food and dietary concepts of Korea and how they have influenced healthy eating habits, contributing to health and longevity Discusses the relevance of the modern genetic concepts of nutrigenomics and epigenetics, metabolic concepts such as circulation, and food concepts such as fermented and functional foods in advancing healthy food concepts and longevity Provides insights how a large population can advance an integrated holistic food-based approach to longevity and wellness As a collaboration between various outstanding authors, the insights from this book can provide global examples to align similar approaches and policies in other countries in different ecologies of planet earth.By Emmanuel Olufemi Ekundayo, Arinze Stanley Okoli, Abubakar Gidado, Charles Oluwaseun Adetunji, Abdulrazak B. Ibrahim, Benjamin Ewa Ubi, Olawole O. Obembe. 2021
This book covers a range of important topics on crop and animal genetics, breeding and genomics, as well as biodiversity…
and genetic resources conservation and utilization reflecting three thematic sections of working groups of the Biotechnology Society of Nigeria. The topics range from agricultural biotechnology, including genetically modified organisms and gene-editing for agronomically important traits in tropical crops, to Nigeria’s mega biodiversity and genetic resources conservation. This book will engender a deeper understanding of underpinning mechanisms, technologies, processes and science–policy nexus that has placed Nigeria as a leader in biotechnology in Africa. The book will be useful reference material for scientists and researchers working in the fields of food and agricultural biotechnology, bioinformatics, plant and animal genetics, breeding and genomics, genetic resources conservation and enhancement. Emphasizes recent advances in biotechnologies that could ameliorate the high-level global food and nutrition insecurity through plant and animal genetics, breeding, as well as genomics Provides detailed information towards harnessing indigenous bioresources for food and nutrition security and climate change adaptation Introduces new frontiers in the area of genomics, most especially their relevant applications in crop and animal breeding Reviews biotechniques that could enhance plant genetic resources conservation and utilization Discusses current biotechnological approaches to exploit genetic resources including the development of synthetic hexaploid wheat (SHW) for crop adaptation to the increasingly changing global climateWithin the United Kingdom (UK), most mainstream healthcare practitioners receive little or no nutrition education during their years of training.…
As a consequence, the understanding of nutrition amongst primary care practitioners such as general practitioners, pharmacists, midwives, and practice nurses is limited and is largely focused on energy consumption and obesity. There is little knowledge of the wealth of micronutrients that underpin health, nor of the ticking timebomb of insufficient intakes of those micronutrients amongst a significant proportion of the population in the UK.The Building Blocks of Life: A Nutrition Foundation for Healthcare Professionals is a step towards redressing that balance. It sets out an informative and engaging narrative on how and why nutrition is the basis for good health. It discusses UK-specific issues with regards to diet and intakes of vitamins, minerals, essential fatty acids and other micronutrients. It also raises concerns about the potential negative health implications of the generally poor UK diet and suggests ways that healthcare practitioners can support patients in improving their long-term health outlook.Nutrition policy in the UK needs to be dragged into the 21st century and this book sets out evidence-based arguments which challenge current public health myths such as the idea that 10 micrograms of vitamin D is all anyone needs or the messaging around the consumption of saturated fat vs highly processed seed oils or that everyone can get all the nutrients they need from a varied and balanced diet.Although The Building Blocks of Life: A Nutrition Foundation for Healthcare Professionals focuses on concerns around poor diet and the consequent micronutrient inadequacies in the UK, the nutritional detail is relevant no matter where you are in the world. Everyone eats, all the time. It is time that mainstream medicine looked towards food as both a cause and a solution to many of the chronic degenerative conditions that plague modern life.By John Measey. 2022
This book is a guide specifically for Early Career Researchers on how to publish in the Biological Sciences, whether that…
be your first manuscript or if you’re already experienced – there’s something for everyone.Following on from How to Write a PhD in Biological Sciences: A Guide for the Uninitiated, it will guide you through taking your manuscript to publication in peer-reviewed journals and disseminating your research more broadly. It talks you through the peer-review process, including how to respond to reviewers’ comments, the meaning and importance of Impact Factors and how to get citations. It also explores the challenges in the academic community around Open Access and other debates, including transparency, overlay journals, paywalls, publication bias, predatory journals and the dangers of bullying.Whether you are a student just completing your studies, or a supervisor struggling with rejections, this book will provide the insider information you need to get ahead.By AnnaMarie Bliss, Dak Kopec. 2023
This edited collection explores disease transmission and the ways that the designed environment has promoted or limited its spread. It…
discusses the many design factors that can be used for infection and disease control through lenses of history, public health, building technology, design, and education.This book calls on designers to consider the role of the built environment as the primary source of bacterial, viral, and fungal transfers through fomites, ventilation systems, and overcrowding and spatial organization. Through 19 original contributions, it provides an array of perspectives to understand how the designed environment may offer a reprieve from disease. The authors build a historical foundation of infection and disease, using examples ranging from lazarettos to leprosy centers to show how the ability to control infection and disease has long been a concern for humanity. The book goes on to discuss disease propagation, putting forth a variety of ideas to control the transmission of pathogens, including environmental design strategies, pedestrian dynamics, and open space. Its final chapters serve as a prospective way forward, focusing on COVID-19 and the built environment in a post-pandemic world.Written for students and academics of architecture, design, and urban planning, this book ignites creative action on the ways to design our built environment differently and more holistically.Please note that research on COVID-19 has exponentially grown since this volume was written in October 2020. References cited reflect the evolving nature of research studies at that time.By James F. Jordan. 2022
Innovation is a translation of a new method, idea, or product into reality and profit. It is a process of…
connected steps that accumulates into a brand reputation required for success. Unlike Fortune 500 companies, whose projects are self-funded, a start-up must simultaneously have a value proposition that attracts a customer (for revenue), investors (for capital), and acquirers (for a liquidity event or IPO). A high percentage of start-ups fail before attaining positive cashflow, due to a variety of reasons that are detailed in this book.Avoiding the pitfalls and wrong turns are the goals of this book. Innovation, Commercialization, and Start-Ups in Life Sciences details the methodologies necessary to create a successful life science start-up from initiation to exit. Written by an expert who has worked with more nearly 500 life science start-ups, this book discusses specific processes and investor milestones that must be navigated to align customer, funder, and acquirer needs. Successful commercialization requires attention to multiple constituents, such as investors, regulators, and customers. Investors require liquidity for their return, which is achieved through selling their stock in a public or private sale. The reader will gain an appreciation for the necessary data, partnerships, and skills needed to create a competitive and sustainable company. The author discusses such specific issues as customer problems, demonstrating sales access, and ensuring intellectual property is impervious to competitive advancement. This book is intended to be suitable for entrepreneurs, venture capitalists, and investors in both business and academic settings. These organizations have specific departments, such as R&D, operations, business development, legal, regulatory, and marketing, that would also benefit from this book.FEATURES Focuses specifically on life science start-ups Examines how to determine a company valuation and future "fundable milestones" Explores how to align regulatory and clinical strategies Discusses intellectual property derived from a university or individual through formation to exit. Reviews how start‐ups must simultaneously meet the needs of multiple constituencies at once: investors, regulators, customers and exit candidates James F. Jordan is an author, consultant, and speaker. He is a Distinguished Service Professor of Healthcare & Biotechnology Management, a former Fortune 100 executive, and a managing director of a venture fund.Access the Support Material: https://healthcaredata.center/ Cover design by Sarah Mailhott.