Title search results
Showing 31621 - 31640 of 46878 items
Cutaneous Neural Neoplasms: A Practical Guide (Current Clinical Pathology)
By Zsolt Argenyi, Chris Jokinen. 2011
As a result to the recent significant developments both in the field of cutaneous pathology and clinical dermatology …
many cutaneous neural tumors are now being diagnosed by specialists like dermatopathologists and treated by dermatologists or dermatologic surgeons Cutaneous Neural Neoplasms A Practical Guide provides an essential aid in diagnosis by discussing the cardinal clinico-pathologic features of cutaneous tumors relevant to these specialists It covers detailed pathologic features and their differential diagnosis Applicable special diagnostic techniques are extensively illustrated Whenever relevant key therapeutic recommendations are provided The authors approach each entity by presenting clinical and or gross photographs when relevant with discussion of the clinical features followed by the tabulated list of key pathologic features with corresponding histopathologic illustrations Therapeutic recommendations are summarized Cutaneous Neural Neoplasms A Practical Guide is an important new volume that fills a major gap in the currently available resources for practicing physicians and provides them with an appropriate knowledge base to handle these challenging tumors in the most up-to-date fashionBreast Cancer in the Post-Genomic Era (Current Clinical Oncology)
By Antonio Giordano, Nicola Normanno. 2009
Breast Cancer is the most common tumor in women and the second leading cause of cancer deaths worldwide Due…
to breakthroughs in gene profiling the knowledge of the pathophysiology of the mammary gland had greatly increased over the last decade In Breast Cancer in the Post Genomic Era Antonio Giordano Nicola Normanno and a panel of international authorities in their field provide a comprehensive approach to the biology diagnosis prevention and treatment of human breast carcinoma The book provides a comprehensive approach to breast cancer describing the use of gene profiling techniques to distinguish specific features of individual carcinomas as well as emerging novel therapeutic approaches to treatment Additional chapters cover the use of transgenic mice to model human breast cancer and the role of the EGF-CFC family in mammary gland development and neoplasia Breast Cancer in the Post Genomic-Era succeeds in looking at breast cancer pathogenesis diagnosis and treatment under a more comprehensive light and is a valuable resource for any Radiation or Surgical Oncologist Cancer Biologist or PathologistBiosensors combine biological recognition elements and signal conversion elements into a biodetection system They have been developed for a…
wide variety of biodetection applications offering the advantages of increased speed and ease of use compared to traditional detection methods In Biosensors and Biodetection Methods and Protocols leading experts describe the major technologies in the field in extensive technical detail allowing readers both to understand the technology and to construct similar devices Volume 2 Electrochemical and Mechanical Detectors Lateral Flow and Ligands for Biosensors focuses on direct measurement sensors indirect methods ligands and related technologies including methods involving electrochemical detectors recognition ligands antibodies aptamers and peptides amongst many other subjects Written in the highly successful Methods in Molecular Biology series format chapters include brief introductions to the topics lists of the necessary materials step-by-step readily reproducible protocols and Notes sections which highlight tips on troubleshooting and avoiding known pitfalls P P Comprehensive and up-to-date Biosensors and Biodetection Methods and Protocols is an ideal user-friendly guide to this vital versatile technology and a perfect tool for those who wish to further the fieldBacteriophages, Volume 2: Methods and Protocols, Volume 2: Molecular and Applied Aspects (Methods in Molecular Biology #502)
By Andrew Kropinski, Martha Clokie. 2009
Ranging from the evolution of pathogenicity to oceanic carbon cycling the many and varied roles that bacteriophages play in…
microbial ecology and evolution have inspired increased interest within the scientific community Bacteriophages Methods and Protocols pulls together the vast body of knowledge and expertise from top international bacteriophage researchers to provide both classical and state-of-the-art molecular techniques With its well-organized modular design Volume 2 Molecular and Applied Aspects examines a multitude of topics including the bacteriophage genomics metagenomics transcriptomics and proteomics along with applied bacteriophage biology Written in the highly successful Methods in Molecular Biology series format chapters consist of brief introductions to the subject lists of the necessary materials and reagents readily reproducible laboratory protocols and a Notes section which details tips on troubleshooting and avoiding known pitfalls P P Thorough and cutting-edge Bacteriophages Methods and Protocols is a valuable reference for experienced bacteriophage researchers as well as an easily accessible introduction for newcomers to the subjectErectile dysfunction can affect all age groups Numerous physical and emotional risk factors may contribute to the problem …
These risk factors can range from chronic diseases and medications to psychological factors In the U S alone it has been estimated that 18 to 30 million men suffer from erectile dysfunction This number has increased significantly as awareness of the disorder has heightened Researchers and health care professionals now have a better understanding of what causes erectile dysfunction and the effective medications and non-medication treatments used to treat the condition Comprehensive and state-of-the-art Contemporary Treatment of Erectile Dysfunction A Clinical Guide synthesizes the literature and covers all aspects of treating erectile dysfunction and other related male sexual dysfunctions This invaluable title offers all physicians residents and fellows -- and even medical students and other health professionals such as nurse practitioners and physician assistants - an essential reference for enhancing diagnosis and treatment of this debilitating disorderPopulation studies and epidemiology facilitate the discovery of genetic and environmental determinants of cancer and the development of new approaches…
to cancer control and prevention therefore they play a central role in the creation of health policies Cancer Epidemiology compiles areas of research which cover etiological factors or determinants that contribute to the development of cancer and describe the the latest technologies in cancer epidemiology In Volume 2 Modifiable Factors leading experts provide chapters on modifiable factors in cancer epidemiology epidemiology of organ specific cancer and environmental and life style factors Although a non-standard volume of the highly successful Methods in Molecular Biology series this comprehensive text retains the commitment of the series to collecting the kind of detailed up-to-date information and implementation advice that is crucial for getting optimal results P P Cutting-edge and essential Cancer Epidemiology allows readers to get the maximum advantage of the methods involved in this exciting and important field Cutting-edge and essential Cancer Epidemiology allows readers to get the maximum advantage of the methods involved in this exciting and important fieldBone densitometry BD is an extraordinary clinical tool It provides a safe non-invasive window to the…
skeleton Through that window a physician can obtain vital clinical information that enhances diagnosis and improves patient management Further much has changed in the last decade to make bone densitometry the especially fascinating field of medicine it is today incorporating imaging physics quantitative analysis statistics and computer technology -- all applied in the diagnosis and management of osteoporosis No text details the state-of-the-art and value of densitometry better than Bone Densitometry in Clinical Practice Applications and Interpretation Third Edition Written by renowned expert Sydney Lou Bonnick MD this edition improves remarkably on her highly regarded previous volumes with a significant update and expansion of material New chapters reflect densitometry s growing applications as well as the evolving needs of the densitometrist New material on radiation safety and assessment for secondary causes of bone fragility is included and the text also incorporates material from the recent ISCD Position Development Conferences PDC s both the 4th adult and the 1st pediatric Moreover an entire appendix devoted to the PDCs has been added providing solutions to many unanswered questions concerning bone densitometry applications Comprehensive and invaluable Bone Densitometry in Clinical Practice Application and Interpretation Third Edition offers all primary care physicians and specialists the ideal reference for practicing state-of-the-art bone densitometry and caring for patients with or at risk for osteoporosisBiosensors combine biological recognition elements and signal conversion elements into a biodetection system They have been developed for a…
wide variety of biodetection applications offering the advantages of increased speed and ease of use compared to traditional detection methods In Biosensors and Biodetection Methods and Protocols leading experts describe the major technologies in the field in extensive technical detail allowing readers both to understand the technology and to construct similar devices Volume 1 Optical-Based Detectors delves into direct and indirect optical detectors including methods involving surface plasmon resonance interferometric sensors CCD based detectors and spectrometers among many other cutting-edge technologies Written in the highly successful Methods in Molecular BiologyTM series format chapters include brief introductions to the subjects lists of the necessary materials step-by-step readily reproducible protocols and Notes sections which highlight tips on troubleshooting and avoiding known pitfalls P P Comprehensive and up-to-date Biosensors and Biodetection Methods and Protocols is an ideal user-friendly guide to this vital versatile technology and a perfect tool for those who wish to further the fieldAnalgesia: Methods and Protocols (Methods in Molecular Biology #617)
By Arpad Szallasi. 2010
Chronic pain is a complex phenomenon which continues to remain undertreated in the majority of affected patients thus representing…
a significant unmet medical need but the development of cellular subcellular and molecular methods of approaching this epidemic of pain shows great promise In Analgesia Methods and Protocols experts in the field present thorough coverage of molecular analgesia research methods from target discovery through target validation and clinical testing to tolerance and dependence with extensive chapters on emerging receptor classes as targets for analgesic drugs and innovative analgesic strategies As a volume in the highly successful Methods in Molecular BiologyTM series the chapters include introductions to their respective topics lists of the necessary materials and reagents step-by-step readily reproducible protocols and notes sections with tips on troubleshooting and avoiding known pitfalls Comprehensive and essential Analgesia Methods and Protocols promises to aid and enrich the research of all those scientists and clinicians who are interested in what the increasingly molecular future has in store for analgesia research from the molecular research bench through the animal laboratory to the bedsideChallenging Cases in Allergy and Immunology
By Massoud Mahmoudi. 2009
In medical practice there are often complex cases that make extraordinary demands on a clinician s knowledge and ingenuity …
In Challenging Cases in Allergy and Immunology the authors provide these types of fascinating and informative cases to complement a basic knowledge of diagnosis and management in these fields As such this novel title will be of interest to a wide array of allergists and clinical immunologists as well as all students of medicine and allied health Written by a multidisciplinary group of national and international experts the book covers in detail two or more challenging real-life cases in each disorder discussed Each case is followed by a work-up treatment plan and discussion that includes a differential diagnosis up-to-date references and up to ten thought-provoking multiple-choice questions that enhance the book s value as a comprehensive reference and teaching text The cases include not only the common allergic diseases such as allergic rhinitis asthma and food allergy but also disorders in immune regulation autoimmunity and immunodeficiencies There are chapters on subjects as wide-ranging as anaphylaxis occupational asthma and immune-mediated rheumatic diseases State-of-the-art and evidence-based Challenging Cases in Allergy and Immunology is an important resource for all clinicians searching for ways to improve their ability to diagnose and manage patients with allergic and immunologic problemsBiennial Review of Infertility: Volume 1
By Peter Schlegel, Catherine Racowsky, Bradley Voorhis. 2009
Infertility is a widespread medical condition As new technologies emerge the rate at which our understanding of reproductive…
medicine grows can be overwhelming The Biennial Review of Infertility provides the most up to date advances ideas and controversies together in one volume Due to the distinctive nature of infertility a panel of well-respected experts strives to present each chapter in a clear manner specifically focused on evidence-based medicine The Biennial Review of Infertility presents a balanced view of clinically relevant existing information for the evolving areas Created to provide an ongoing appraisal of current knowledge the Biennial Review of Infertility motivates communication amongst all those working to help couples resolve their infertilityA Clinician's Guide to Sperm DNA and Chromatin Damage
By Ashok Agarwal, Armand Zini. 2018
This comprehensive up-to-date text which brings together the key practical elements of the rapidly evolving field of sperm…
DNA and chromatin abnormalities is divided thematically into five main sections Part I discusses human sperm chromatin structure and nuclear architecture while part II presents laboratory evaluation of sperm DNA damage including SCSA SCD TUNEL and Comet assays and cytochemical tests Biological and clinical factors in the etiology of sperm DNA damage are discussed in part III including oxidative stress abortive apoptosis cancer and environmental and lifestyle factors Part IV presents clinical studies on the utility of sperm DNA damage tests both with natural and ART-assisted pregnancies and debates the clinical utility of such tests Finally part V discusses current treatment options such as antioxidant therapy varicocelectomy advanced sperm processing techniques and the use of testicular sperm We are now beginning to better understand the unique organization of the sperm chromatin as well as the nature and etiology of sperm DNA damage Written and edited by worldwide experts in andrology A Clinician s Guide to Sperm DNA and Chromatin Damage is an excellent resource for reproductive medicine and REI specialists urologists reproductive biologists and any professional working with the infertile maleCell-Free Protein Production: Methods and Protocols (Methods in Molecular Biology #607)
By Yaeta Endo, Kazuyuki Takai. 2010
During the past decade as the data on gene sequences and expression patterns rapidly accumulated cell-free protein synthesis technology…
has also experienced a revolution becoming a powerful tool for the preparation of proteins for their functional and structural analysis In Cell-Free Protein Production Methods and Protocols experts in the field contribute detailed techniques the uses of which expand deep into the studies of biochemistry molecular biology and biotechnology Beginning briefly with basic methods and historical aspects the book continues with thorough coverage of protein preparation methods the preparation of proteins that are generally difficult to prepare in their functional forms applications of the cell-free technologies to protein engineering as well as some methods that are expected to constitute a part of future technologies Written in the highly successful Methods in Molecular BiologyTM series format the chapters include introductions to their respective topics lists of the necessary materials and reagents step-by-step readily reproducible laboratory protocols and notes on troubleshooting and avoiding known pitfalls Authoritative and cutting-edge Cell-Free Protein Production Methods and Protocols aims to help researchers continue the growth of the vital exploration of cell-free sciences and technologies in order to better understand the dynamic lives of cellsAutism: Current Theories and Evidence (Current Clinical Neurology)
By Andrew Zimmerman. 2008
Creative thinking and collaborative scientific research have advanced our understanding of autism and we are now beginning to synthesize…
the data into evidence and theories Autism Current Theories and Evidence presents current theories about autism and the evidence that supports them The goal is to show how the scientific method is revealing the biological bases of this spectrum of disorders thereby leading the way to their treatment and prevention using evidence-based medicine This book has 20 chapters divided into 6 sections Molecular and Clinical Genetics Neurotransmitters and Cell Signaling Endocrinology Growth and Metabolism Immunology Maternal-Fetal Effects and Neuroinflammation Neuroanatomy Imaging and Neural networks and Environmental Mechanisms and Models The subjects cover a wide range of current scientific work in the field of autism with strong and growing evidence to support them and demonstrate both the breadth and depth of current autism research The reader is encouraged to consider how theories and the scientific method in the hands of these and other dedicated researchers are leading to greater knowledge and continued progress in autism researchChromatin Immunoprecipitation Assays: Methods and Protocols (Methods in Molecular Biology #567)
By Philippe Collas. 2009
Over the past twenty years the development of chromatin immunoprecipitation or ChIP assays has immensely enhanced the…
biological significance of the multifaceted DNA-binding proteins In Chromatin Immunoprecipitation Assays Methods and Protocols researchers deeply involved in the development and improvement of the field provide cutting-edge protocols devoted to the most recent progress in ChIP and related subjects The thorough chapters involve topics such as the characterization of ChIP antibodies ChIP methods for small cell numbers fast ChIP protocols assays adapted to various species and cell types as well as several strategies for the analysis of genome-wide datasets while also extending a bit beyond ChIP assays to cover immunoprecipitation-based DNA methylation analyses determination of spatial chromatin organization of large genomic regions and RNA immunoprecipitation Written in the highly successful Methods in Molecular BiologyTM series format chapters contain brief introductions to their respective subjects lists of the necessary materials and reagents step-by-step readily reproducible laboratory protocols and notes on troubleshooting and avoiding known pitfalls Authoritative and easy-to-use Chromatin Immunoprecipitation Assays Methods and Protocols is a timely guide for all those who wish to further the development of this powerful tool and continue delving into the incredible complexity of the cell s biologyEncyclopedia of Ophthalmology
By Ursula Schmidt, Thomas Kohnen. 2018
Rapid advances in pathogenetic insight diagnostic and therapeutic modalities and basic research continuously influence the state of the…
art in ophthalmology This comprehensive encyclopedia offers a systematic and complete source of information including basic principles and novel updates both clinical and scientific The encyclopaedic format offers comprehensive access to focused information on all relevant topics in a clear and user-friendly manner The spectrum ranges from short definitions cross references acronyms to disease chapters including epidemiology symptoms and differential diagnosis sections on diagnostic and therapeutic technologies and comprehensive scientific summaries describing recent findings as well as results from relevant studies The material is presented in a standardized uniform and concise way throughout all clinical and academic sections High-quality images highlight visual information and tables and graphs summarize important data The encyclopaedia is available in book and electronic format which is linked to relevant ophthalmologic journals and is continuously updated All chapters are authored by leading experts in the specific field The target audiences are clinicians in ophthalmology and related specialties researchers and studentsA Primer for the Exercise and Nutrition Sciences: Thermodynamics, Bioenergetics, Metabolism
By Christopher Scott. 2008
The subject of thermodynamics is rarely found in Nutrition and Exercise Physiology textbooks Yet this material is fundamental to…
any serious inquisition concerning energy exchange This book provides a fresh approach to the study of energy expenditure by introducing the latest concepts in open system thermodynamics and cellular to whole-body energy exchange The text traces biological energy exchange from the molecules in the food we eat to the energy demands of rest physical exertion and its recovery The carefully researched text advances traditional exercise physiology concepts by incorporating contemporary thermodynamic and cellular physiology principles into the context of a working metabolism This book is written for upper level undergraduate and graduate students but will also appeal to exercise physiologists registered dieticians and nutritionists and applies to cardiac rehabilitation exercise science and health fitness programsPatients with chronic pain present a unique set of challenges to the primary care clinician In Chronic Pain …
A Primary Care Guide to Practical Management Second Edition leading pain specialist Dawn A Marcus MD again offers practical clear and succinct evidence-based approaches to the diagnosis and treatment of the myriad painful conditions clinicians see in their offices every day such as headache back pain arthritis fibromyalgia and abdominal pain Sections addressing pain management in children pregnant women and seniors are also included This new edition is designed to provide a pragmatic approach to assessing and treating the complex issues and characteristics of chronic pain patients New chapters expand upon the evidence-based recommendations and practical office tools previously provided with the addition of new chapters addressing risk management pain syndromes in the shoulder upper extremity and lower extremity and cancer and end-of-life pain Chronic Pain A Primary Care Guide to Practical Management Second Edition provides strategies and techniques that are designed to improve the confidence with which the primary care physician can approach patients with complex pain complaints reduce staff stress and improve patient successEssentials of Hypertension
By Fl vio Fuchs. 2018
The main purpose of this book is to select and present the most essential information about hypertension It aims…
to select all the more relevant data to guide the attitudes to prevent diagnose and treat hypertension Hypertension accounts for more than 50 of deaths from stroke and ischemic heart disease worldwide New blood pressure BP diagnostic thresholds for hypertension were released which were set at 130 80 mmHg As a consequence millions of individuals in the world will be diagnosed as hypertensive recognizing that they are at greater risk of presenting a CV event Prevention and control of high BP will become the main focus for reducing the burden of CV disease requiring a changing of cultural beliefs in some way similar to what happened in the last century with smoking Strategies for prevention of the rising of BP with age and the BP reduction in individuals already with high levels are more complex than those related to smoking control These strategies involve solid evidence to be implemented in populations The extensive scientific literature dealing with hypertension and BP regulation is among the top dedicated to a single disease The chapters and contents follow the clinical reasoning pathways The characterization of the risks of high blood pressure is presented in the first chapter discussing the evidence that led to changes in diagnostic thresholds and to the recommendations for maintaining BP within these limits in populations Reasons for BP rising with age will follow identifying the causes that must be fought to preventing the incidence of hypertension Diagnosis of hypertension deserves a special chapter The final chapter presents the fundamentals to select drug and non-drug therapies indicated in the prevention and controlling of high blood pressureChemokine Receptors in Cancer (Cancer Drug Discovery and Development)
By Amy Fulton. 2009
Chemokines are a superfamily of low molecular weight cytokines that were initially described based on their ability to induce the…
directed migration of leukocytes to sites of inflammation or injury In humans there are approximately 45 chemokines that bind to 19 G-protein-coupled receptors In addition to mediating cellular migration chemokines have now been shown to affect many cellular functions including survival adhesion invasion proliferation and to regulate circulating chemokine levels Although chemokine receptors were first described on leukocytes it is now appreciated that chemokine receptors are also expressed by many other cells including endothelial and epithelial cells Since the first description of chemokine receptors on malignant cells in 2001 an extensive literature has developed describing the expression and function of chemokine receptors in many malignancies These studies support the initial hypothesis that malignant cells use chemokine receptors to migrate to distant sites of ligand expression and that expression of certain receptors is associated with a poor prognosis It has also become apparent that malignancies of different tissues may use a diverse profile of chemokine receptors and that the same receptor may mediate metastasis to different sites in tumors of different histological origins Receptor function may also maintain survival and expansion of the primary tumor