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Adhesion G Protein-coupled Receptors: Molecular, Physiological and Pharmacological Principles in Health and Disease (Handbook of Experimental Pharmacology #234)
By Tobias Langenhan, Torsten Sch neberg. 2016
Latest research on Adhesion GPCRs has unearthed surprising revelations about the events that govern the signal transduction of these receptor…
molecules and the cellular and organ requirements for these signals Unexpected and unprecedented findings suggest that Adhesion GPCRs constitute a group of receptors that sense mechanical stimuli and transcode them into metabotropic signals through the action of a novel activation paradigm Interdisciplinary efforts transcending many areas of biomedical research including pharmacology physiology genetics cell biology structural biology biochemistry and bioinformatics were necessary to unveil these fundamental properties The scientific leaders in the field that carried this research effort have teamed up here to provide a comprehensive overview of our current understanding how Adhesion GPCRs signal and how these receptors shape organ structure and functionCardiac Biomarkers: Case Studies and Clinical Correlations
By Alan Maisel, Allan Jaffe. 2017
This book covers ACS and Heart Failure the chapters represent the most current up to date and knowledgeable…
content on the topic available It is written by the worlds most respected leaders in biomarkers with a majority emphasis on what clinicians need to know The Editors and their contributors have provided algorithms annotated case discussions and caveats They cover biomarkers to predict risk of heart disease biomarkers of cardiorenal disease and conclude with a section on new and emerging biomarkers It be genuinely helpful and practical to those in the field including not just people working in the field but nurses doctors etc who practice medicine in the clinic the emergency department and the hospitalAtlas of Diffuse Lung Diseases: A Multidisciplinary Approach
By Giorgia Dalpiaz, Alessandra Cancellieri. 2017
This atlas is designed as an easy-to-use reference guide that identifies and illustrates the key patterns of diffuse lung diseases…
observed on high-resolution computed tomography HRCT and then documents in more detail the characteristics and appearances of the individual diseases grouped on the basis of their prevalent pattern A further feature of the book is its interdisciplinary nature contributions from experts in various specialties are tightly interwoven throughout and many pathologic correlations are included Less experienced readers will find that this atlas with its wealth of figures and helpful color coding steers them towards correct interpretation when confronted by the multiplicity and complexity of these diseases those who are already experts on the other hand will benefit from the detailed coverage of individual diseases which will deepen their understanding At the end of the book a graphically appealing and practice-oriented illustrated glossary with tips and tricks offers a further highly effective educational tool Given the clinical spectrum of diseases covered this atlas will prove invaluable for a wide range of healthcare workers especially radiologists pulmonologists and pathologistsAnticipation and Medicine
By Mihai Nadin. 2017
In this book practicing physicians and experts in anticipation present arguments for a new understanding of medicine …
Their contributions make it clear that medicine is the decisive test for anticipation The reader is presented with a provocative hypothesis If medicine will align itself with the anticipatory condition of life it can prompt the most important revolution in our time To this end all stakeholders--medical practitioners patients scientists and technology developers--will have to engage in the conversation The book makes the case for the transition from expensive and only marginally effective reactive treatment through spare parts joint replacements organ transplants and reliance on pharmaceuticals antibiotics opiates to anticipation-informed healthcare Readers will understand why the current premise of treating various behavioral conditions attention deficit disorder hyperactivity schizophrenia through drugs has to be re-evaluated from the perspective of anticipation In the manner practiced today medicine generates dependence and long-lasting damage to those it is paid to help As we better understand the nature of the living the proactive view of healthcare within which the science and art of healing fuse becomes a social and political mandateThe Atlas of Robotic Urologic Surgery provides a detailed step-by-step guide to common robotic urologic procedures for the purpose…
of helping novice surgeons in their transition to robotic surgery and seasoned robotic surgeons to refine their surgical technique and expand their repertoire of robotic procedures In addition less commonly performed robotic procedures such as those for male infertility pelvic organ prolapse urinary tract reconstruction and pediatrics are included Each chapter is written by the thought leaders in robotic urologic surgery with descriptive step-by-step text complimented by figures and intraoperative photographs detailing the nuances of each procedure Emphasis is placed on operative setup instrument and equipment needs and surgical techniques for both the primary surgeon as well as the operative assistant The use of ancillary equipment and robotic instrument and endoscope exchanges are highlighted throughout the procedural text by tables designed to aid surgeons and their teams in improving efficiency This volume will provide unique insights into robotic urologic surgery and reduce the learning curve of accomplishing these increasingly popular proceduresAtlas of Craniocervical Junction and Cervical Spine Surgery
By Livio Presutti, Francesco Mattioli, Stefano Boriani, Alessandro Gasbarrini. 2017
This atlas documents current surgical approaches to the craniocervical junction and the cervical spine providing step-by-step guidance on procedures…
and cervical spine stabilization techniques Opening chapters present essential information on anatomy depict pathologies with the aid of illustrative cases describe the role of imaging techniques in patient evaluation and discuss surgical instrumentation and patient positioning The different techniques employed in this delicate anatomic region including transnasal and transoral endoscopic approaches to the craniocervical junction and posterior and anterior approaches to the cervical spine are then explained and illustrated with a view to providing the surgeon with a clear reference that can be used in the operating room In addition practical advice is offered on the treatment of potential complications postoperative management and rehabilitation This book will be of value not only to neurosurgeons but also to orthopedists ENT surgeons neurologists and physiatristsCurrent Concepts of Intestinal Failure
By Risto Rintala, Mikko Pakarinen, Tomas Wester. 2016
This book provides readers with a succinct but comprehensive overview of current concepts relating to intestinal failure including its…
treatment with a particular focus on recent advancements The opening chapters address basic aspects of intestinal failure including etiology clinical pathophysiology physiology of intestinal adaptation and intestinal microbiota The complications of intestinal failure such as bacterial overgrowth and intestinal failure-associated liver disease are then discussed A series of chapters specifically address important strategies in the nutritional pharmacological and surgical treatment of intestinal failure as well as the concept of intestinal rehabilitation Finally two significant emerging developments are considered regenerative medicine and distraction enterogenesis The authors are internationally recognized experts from Europe and North America who are ideally placed to describe current knowledge and progress in the fieldAtlas of Acquired Cardiovascular Disease Imaging in Children
By Randy Richardson. 2017
This atlas is a concise visual guide to the imaging of acquired heart disease in infants children and…
adolescents Imaging plays an ever-increasing vital role in diagnosis preoperative planning and postoperative management for children with these disorders The book reviews techniques for lowering radiation discusses protocols for imaging in children and provides recommendations for the most appropriate studies that decrease the time and cost of imaging these patients Focusing on functional and anatomic imaging with an emphasis on three-dimensional color-coded models derived from CT and MR scans this book promotes understanding of cardiovascular disorders in children including infectious neoplastic and metabolic diseases Atlas of Acquired Cardiovascular Disease Imaging in Children is a valuable resource through which cardiologists radiologists pediatric cardiothoracic surgeons and residents can improve the quality and treatment of pediatric and adolescent patients with acquired heart diseaseApplied Genomics of Foodborne Pathogens (Food Microbiology and Food Safety)
By Xiangyu Deng, Henk Bakker, Rene Hendriksen. 2017
This book provides a timely and thorough snapshot into the emerging and fast evolving area of applied genomics of foodborne…
pathogens Driven by the drastic advance of whole genome shot gun sequencing WGS technologies genomics applications are becoming increasingly valuable and even essential in studying surveying and controlling foodborne microbial pathogens The vast opportunities brought by this trend are often at odds with the lack of bioinformatics know-how among food safety and public health professionals since such expertise is not part of a typical food microbiology curriculum and skill set Further complicating the challenge is the large and ever evolving body of bioinformatics tools that can obfuscate newcomers to this area Although reviews tutorials and books are not in short supply in the fields of bioinformatics and genomics until now there has not been a comprehensive and customized source of information designed for and accessible to microbiologists interested in applying cutting-edge genomics in food safety and public health research This book fills this void with a well-selected collection of topics case studies and bioinformatics tools contributed by experts at the forefront of foodborne pathogen genomics researchIncluding comprehensive coverage of health disparities commonly encountered in pediatric and adult pulmonary critical care and sleep…
medicine Achieving Respiratory Health Equality in the United States provides a definitive reference on this prominent issue Expert authors explore questions such as What is the evidence that respiratory health disparities exist What do we know about the causes of the disparities What are the clinical implications What can be done to address the particular disparities and thus achieve health equality Recognizing the magnitude of this problem the American Thoracic Society ATS Executive Committee created a Health Equality Sub-Committee with an initial mandate of defining respiratory health disparities and respiratory health equality in the United States This book will follow the format of a workshop on respiratory health equality held before the 2015 ATS International Meeting and led by editor Juan Carlos Celed 65533 n Written by the workshop presenters this book focuses closely on major risk factors for health specific respiratory diseases for which health disparities are known to occur and potential approaches to eliminate such disparities Achieving Respiratory Health Equality in the United States is a timely resource for researchers clinicians and public health practitioners in respiratory medicineBowel Dysfunction: A Comprehensive Guide for Healthcare Professionals
By Brigitte Collins, Elissa Bradshaw. 2017
The editors aim to provide the definitive guide for healthcare professionals on functional disorders of the gastrointestinal tract and pelvic…
floor and the treatments used within the current healthcare context This book will help the reader to access and understand relevant information within a variety of clinical settings and scenarios It will be relevant and useful to a variety of disciplines e g Physicians Nurses Physiotherapists who work within the field of gastrointestinal care This book will be written by a team from the worlds most well established colorectal specialist hospital presenting a definitive guide to care of the patient groupAdipocytokines, Energy Balance, and Cancer (Energy Balance and Cancer #12)
By Nathan Berger, Ofer Reizes. 2017
Adipocytokines provide the circuitry by which adipose tissue communicates among its component cells which include adipocytes stromal cells …
immune cells and vascular elements with adipose tissue depots in other locations throughout the body and with other tissues in order to regulate physiologic processes of energy intake utilization and distribution Since disturbances both qualitative and quantitative in adipocytokine function contribute significantly to many of the comorbidities associated with obesity including diabetes cardiovascular disease and cancer this volume which discusses most of the major adipocytokines independently and collectively and their roles in normal and pathologic processes should be useful to all individuals seeking a deeper understanding of these processes Moreover it provides a valuable complement to the series on Energy Balance and Cancer in which each volume is focused on a specific aspect of this process which now constitutes an expanding problem as the obesity pandemic continues and more of the population reaches the age where cancer is most prevalent This volume should provide a valuable resource to all clinicians and scientists engaged in caring for susceptible patients and in exploring the relation between energy balance and cancer as well as an important platform to providing the background for research developmentChikungunya Virus: Advances in Biology, Pathogenesis, and Treatment
By Chioma Okeoma. 2016
This book describes the molecular biology pathogenesis epidemiology and potential strategies for control of chikungunya virus …
CHIKV infection It offers insight into the structure and functions of CHIKV proteins as they relate to host response interaction with the arthropod vector and vaccination A detailed account of both the epidemiological outlook and the clinical syndrome of CHIKV infection is provided The complex host-virus interaction and the signaling pathways that mediate such interactions are also covered Throughout the book graphics and charts are used to provide stimulating discussion on important findings in the field of chikungunyalogy The chapters are written with a global perspective by experts of CHIKV from around the world This project is especially significant given that CHIKV is a pathogen of worldwide public health concern Although the presence of CHIKV infection is not global yet worldwide dissemination is predicted in the future due largely to the lack of effective treatment therapy efficient control of transmission and knowledge about mechanisms of pathogenesis Additionally globalization of CHIKV is predicated on its mode of dissemination mosquito vector and cross border travel and migrationBreast Oncology: Techniques, Indications, and Interpretation
By Linda Moy, Samantha L Heller. 2016
This book presents up to date debates and issues in the world of breast MRI with a very practical focus…
on how to incorporate current understanding of breast MRI into clinical practice. The book is divided into three key sections, all of which have critical impact for the breast imager: Techniques introduces the reader to the parameters of breast MRI from standard sequences to up-to-date cutting edge techniques. Indications provides a careful review of the accepted indications for breast MRI from High Risk Screening to use of breast MRI, in the context of neoadjuvant chemotherapy with a detailed analysis of the evidence-based support for these indications and a careful look at controversies and debates within the field. MRI Findings, Interpretation, and Management takes on the topics of how to interpret and manage specific MRI findings from benign to malignant disease with a focus on radiologic-pathologic correlation. The section also incorporates a focus on key management dilemmas, including appropriate follow-up intervals for benign findings on MRI and management of probably benign lesions assessed as a Breast Imaging Reporting and Dictating System (BI-RADS)-3 category on MRI.Critical Issues in Head and Neck Oncology: Key concepts from the Fifth THNO Meeting
By Brian O Sullivan, Jan Vermorken, Volker Budach, C Leemans, Jean, Piero Nicolai. 2017
This book offers a selection of the critical current issues and challenges in head and neck cancer …
It covers most key concepts of the subject from diagnostic challenges to multidisciplinary decision-making aspects in head and neck oncology Starting with the Make Sense Campaign and examining its impact on clinical practice readers also gain insight into current and novel therapeutic approaches including radiotherapy cytotoxic chemotherapy targeted therapy and immunotherapy as well as the importance of adequate supportive care Surgical interventions such as endoscopic surgery salvage surgery dentistry and implants are also discussed Moreover the changing respective roles of the involved caregivers are highlighted and extensively discussed The chapters are based on the latest data presented at the 5th Trends in Head and Neck Oncology Conference and reflect the most up-to-date information in the field Taking into account the ample current treatment options for patients with head and neck cancer and discussing side effects survivorship issues and treatment in the elderly this book provides and up-to-date coverage of all the critical topics in the field Highlighting the increasing importance of decision-making in recurrent and metastatic head and neck cancer as well as quality of life and end of life issues this reference book also emphasizes a multidisciplinary approach that plays such an important role in the outcome for this disease Edited by a team of world leaders in Head and Neck Cancer this volume serves as an easy reference to the head and neck oncology practitioner and provides an up-to-date overview for specialists the fieldCancer, Intimacy and Sexuality: A Practical Approach
By Yacov Reisman, Woet Gianotten. 2017
This book provides a wide-ranging overview of the sexual consequences of cancer and its treatment with the aim of equipping…
physicians and other health care providers with the awareness and knowledge required in order to offer patients effective treatment While sexuality may not be the primary focus for cancer patients at some point whether because of sexual changes or relationship issues many patients come to acknowledge the effects that cancer and its treatment have had on their sexuality Although the impacts are frequently similar significant variation is observed Some patients experience changes in all phases of sexual response while others experience no moreover the consequences of the effects may be felt differently by patients and partners Unfortunately many physicians and health care providers remain insufficiently aware of the impact of cancer on sexuality and or lack knowledge about the concerns of patients and the available treatments and coping strategies A further issue is the reticence of physicians to discuss sexuality and the fear of sexologists to talk to patients about cancer Readers will find this book to be a rich source of help in overcoming these constraints and delivering suitable care to patientsClinical Image-Based Procedures. Translational Research in Medical Imaging: 5th International Workshop, CLIP 2016, Held in Conjunction with MICCAI 2016, Athens, Greece, October 17, 2016, Proceedings (Lecture Notes in Computer Science #9958)
By Cristina Laura, Raj Shekhar, Stefan Wesarg, Miguel ngel Gonz lez Ballester, Klaus Drechsler, Yoshinobu Sato, Marius Erdt, Marius Linguraru. 2016
This book constitutes the revised selected papers from the 5th International Workshop on Clinical Image-Based Procedures CLIP 2016 …
held in conjunction with MICCAI 2016 in Athens Greece in October 2016 The 10 papers presented in this volume were carefully reviewed and selected from 16 submissions Specific topics include various image segmentation and registration techniques applied to various parts of the body They range from interventional planning to navigation of devices and navigation to the anatomy of interest Clinical applications cover the skull the cochlea cranial nerves the aortic valve wrists and the abdomen among othersBone Metastases from Prostate Cancer: Biology, Diagnosis and Management
By Francesco Bertoldo, Francesco Boccardo, Emilio Bombardieri, Laura Evangelista, Riccardo Valdagni. 2017
This book presents up-to-date information on one of the hottest topics in prostate cancer namely bone metastases …
The most recent developments with respect to biology pathology diagnosis and treatment are described providing readers with an excellent understanding of the mechanisms of metastasis formation the characteristics of metastases their aggressiveness and prognostic factors for treatment response The coverage includes discussion of all of the best available options laboratory radiology and nuclear medicine for achieving early diagnosis and both established and novel therapeutic approaches Detailed information is provided on hormonal manipulations bone-targeted agents vaccines taxanes and other treatments that are enriching the therapeutic armamentarium The editors can be considered leaders in the field with great experience in diagnostic and clinical oncology and research and the authors are experts in diverse specialties This ensures a multidisciplinary approach mirroring the current situation in which treatment in patients with bone metastases is undertaken by a team of specialists and health professionals in a variety of fieldsClinical Urodynamics in Childhood and Adolescence (Urodynamics, Neurourology and Pelvic Floor Dysfunctions)
By Giulio Popolo, Giovanni Mosiello, Jian Wen, Mario Gennaro. 2018
This book aims to impart all the practical knowledge required in order to evaluate and treat children with anatomical …
neurological and functional incontinence It explains how appropriate choice of management in childhood depends first of all on a correct diagnosis then on thorough urodynamic evaluation and finally on sound assessment of the condition of the individual patient The full range of relevant pathologies are considered and all of the treatment options are extensively discussed including behavioral therapy rehabilitation physiotherapy pharmacotherapy neuromodulation endoscopic procedures and surgical reconstruction Careful attention is paid to the impacts that treatments performed during childhood may have on later adult life including on fertility and pregnancy with a view to ensuring that the reader will be in a position to time treatments correctly thereby avoiding adverse effects and possess all the information needed to address the concerns of patients and their families The book will be of value to pediatricians urologists nurses physiotherapist students and all others with an interest in the fieldAllergy and Respiration (Advances in Experimental Medicine and Biology #921)
By Mieczyslaw Pokorski. 2016
Allergy is an increasing health issue It often targets the respiratory tract and entwines with respiratory ailments …
which makes it difficult to discern the cause-effect linkage Nonetheless measures to counter the allergic background are a linchpin in preserving respiratory health This book is an update on current advances in clinical and basic science on allergy and related topics The diagnostics of allergy requires a multidisciplinary approach including molecular examinations aimed at unraveling the intracellular control cascades Chapters give insight into the innovations concerning modern pulmonary function tests discuss pharmacological paradigms and tackle the overlapping infectious aspects and clinical symptoms and markers Environmental and genetic factors elicit a spectrum of inflammatory phenotypes linked to differential body responses to allergic perturbations The book is intended for healthcare professionals notably pulmonologists primary care physicians and medical researchers