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Storytelling with Data in Healthcare
By Kevin Masick, Eric Bouillon. 2021
With the constant evolution of change in healthcare from both a technology and governmental perspective, it is imperative to take…
a step back and view the big picture. Relying on hunches or beliefs is no longer sustainable, so avoid jumping to conclusions and making decisions without thoroughly understanding the statistics being analyzed. The triple aim of statistics is a conceptual model laying the foundation for improving healthcare outcomes through statistics. This foundation is: know your numbers; develop behavioral interventions; and set goals to drive change.With the availability of electronic data sources, the quantity and quality of data have grown exponentially to the point of information overload. Translating all this data into words that tell a meaningful story is overwhelming. This book takes the reader on a journey that navigates through this data to tell a story that everyone can understand and use to drive improvement. Readers will learn to tell a narrative story based on data, to develop creative, innovative and effective solutions to improve processes and outcomes utilizing the authors’ tools. Topics include mortality and readmission, patient experience, patient safety survey, governmental initiatives, CMS Star Rating and Hospital Compare.Storytelling with Data in Healthcare combines methodology and statistics in the same course material, making it coherent and easier to put into practice. It uses storytelling as a tool for knowledge acquisition and retention and will be valuable for courses in nursing schools, medical schools, pharmacy schools or any healthcare profession that has a research design or statistics course offered to students. The book will be of interest to researchers, academics, healthcare professionals, and students in the fields of healthcare management and operations as well as statistics and data visualization.Intelligent Healthcare Systems
By Vania V. Estrela. 2024
The book sheds light on medical cyber-physical systems while addressing image processing, microscopy, security, biomedical imaging, automation, robotics, network layers’…
issues, software design, and biometrics, among other areas. Hence, solving the dimensionality conundrum caused by the necessity to balance data acquisition, image modalities, different resolutions, dissimilar picture representations, subspace decompositions, compressed sensing, and communications constraints. Lighter computational implementations can circumvent the heavy computational burden of healthcare processing applications. Soft computing, metaheuristic, and deep learning ascend as potential solutions to efficient super-resolution deployment. The amount of multi-resolution and multi-modal images has been augmenting the need for more efficient and intelligent analyses, e.g., computer-aided diagnosis via computational intelligence techniques. This book consolidates the work on artificial intelligence methods and clever design paradigms for healthcare to foster research and implementations in many domains. It will serve researchers, technology professionals, academia, and students working in the area of the latest advances and upcoming technologies employing smart systems’ design practices and computational intelligence tactics for medical usage. The book explores deep learning practices within particularly difficult computational types of health problems. It aspires to provide an assortment of novel research works that focuses on the broad challenges of designing better healthcare services.The Nobel Prize is the highest award in science, as is the case with nonscience fields too, and it is,…
therefore, arguably the most internationally recognized award in the world. This unique set of volumes focuses on summarizing the Nobel Prize within organic chemistry, as well as the specializations within this specialty. Any reader researching the history of the field of organic chemistry will be interested in this work. Furthermore, it serves as an outstanding resource for providing a better understanding of the circumstances that led to these amazing discoveries and what has happened as a result, in the years since.This book summarizes the development and statistical validation of a guinea pig model as an alternative for potency testing of…
the viral antigens included in combined vaccines applied in cattle to control the respiratory, reproductive, and neonatal calf diarrhea syndromes. The model allows, in one serum sample, to test the vaccine quality for all the viral antigens included in aqueous as well as in oil-adjuvanted formulations of bovine vaccines. The methodology proposed for the control of bovine herpes virus, parainfluenza, and rotavirus were recommended by CAMEVET as guidelines for the 30 countries in the forum, including the US.Key Features Reviews combined vaccines used for cattle Summarizes animal models used for vaccine testing Focuses on bovine herpesviruses, rotaviruses, parainfluenza, and bovine viral diarrhea virus Provides guidance on the effectiveness of the Guinea Pig model for testing vaccine immunogenicityEnvironmental Policy and Public Health: Principal Health Hazards and Mitigation, Volume 1
By Barry L. Johnson, Maureen Y. Lichtveld. 2022
Written by environmental health experts with long teaching and professional careers in policy and public health, the third edition of…
Environmental Policy and Public Health comprises two volumes addressing key physical hazards in the environment that impact public health. The first volume on Principal Health Hazards and Mitigation is complemented by the second volume, Emerging Health Hazards and Mitigation. The health of the environment is inextricably linked to that of people. Thoroughly updated, Volume 1 describes how the quality of air, water, and food is threatened by the presence of toxic substances and explains why climate change is a global health priority already impacting human health and the environment. The mitigations discussed in this volume are twofold: policies that are intended for control of specific hazards and suggested hazard interventions. The role of policy in addressing each of these key environmental health areas is extensively discussed in this volume as well. Each chapter explains step by step how new environmental health issues are translated into public health policies and concludes with practice questions to facilitate interactive learning for upper-level undergraduate and graduate students taking courses in public health and environmental sciences. The step-by step approach, as well as the case studies and practice questions, allow for a diverse portfolio of in-person and hybrid pedagogical strategies and tools at the fingertips of faculty who not only teach policy courses, but whose course topics, such as climate and health, have policy relevance.Molecular Mechanisms of Action of Functional Foods and Nutraceuticals for Chronic Diseases: Volume II (Nutraceuticals)
By Shima Abdollahi, Syam Mohan, Yashwant V. Pathak. 2023
There has been a global rise in the incidence of chronic illnesses, which may be partially attributed to the lengthening…
of the average human lifespan. Functional foods and nutraceuticals have a potential role to play in the development and maintenance of health. They can assist the body in its battle against inflammation and chronic illnesses.Molecular Mechanisms of Action of Functional Foods and Nutraceuticals for Chronic Diseases addresses the effects and mechanism of functional foods in relation to chronic diseases such as obesity, cardiovascular diseases, diabetes, cancer, etc. This volume, like the first volume Applications of Functional Foods and Nutraceuticals for Chronic Diseases, inspires new thought processes and a paradigm shift in research and development.Key Features: Discusses the molecular mechanism of action, the range of toxicities exerted by these food components for functional foods for addressing chronic conditions Enhances scientists and industrial personnel knowledge of functional foods and in the management of chronic diseases Presents research on the role of functional foods/nutraceuticals in preventing and treating chronic diseases through epigenetic modulation Explores various subjects such as epigenetics, immunological, metabolic, technological and neurodenerative aspects affected by functional foods in chronic diseases The world’s leading wellness centers for chronic diseases are using functional foods and nutraceuticals in their practice and discovering their useful applications, and this second of two volume set is another great reference for practitioners, scientists, and clinicians in the management of chronic diseases. Contributors hail from different geographical locations around the world and have many years of research and scholarly experience in functional foods, nutraceuticals, and biology.Bioelectromagnetism: History, Foundations and Applications
By Shoogo Ueno. 2022
Bioelectromagnetism has been gradually developing and expanding into a variety of fields in engineering, biomedical engineering, life science, medicine and…
biology. Bioelectromagnetism: History, Foundations and Applications provides an overview of the field and its developments; from its inception and growth through the twenty-first century, to the latest advances in electro- and magnetobiology and hazard evaluations of electromagnetic fields.It is organized into three sections, each focusing on specific regions of bioelectromagnetism. It begins with the foundations of the field and its history, with a chronological treatment of the major subjects in bioelectromagnetism. The relationship between atmospheric electromagnetic phenomena, geomagnetism and biological systems are presented. It then discusses the many benefits of bioelectromagnetism: electroreception, magnetic navigation, magnetic sense and magnetic responses of plants, birds, animals and humans. It then moves on to human health issues and the impact of bioelectromagnetism. It also provides practical guidance on how to set safety guidelines. Finally, it looks forward to the future prospects of the field based on the latest research in the field.In exploring both the history of the field and the latest developments in today’s research advances, this book provides a comprehensive and self-contained treatment on the subject, which will be a valuable reference for researchers in biophysics, medicine, electrical engineering and biomedical engineering.It can be used as a companion to the editor’s previously published books: Biomagnetics: Principles and Applications of Biomagnetic Stimulation and Imaging (9781482239201, 2016, CRC Press); and Bioimaging: Imaging by Light and Electromagnetics in Medicine and Biology (9780367203047, 2020, CRC Press).Key Features: Provides both a historical view of the field, along with the latest developments in the field Contains practical guidance for researchers on how to set safety guidelines for those working in the area Edited by authorities in the field, with chapter contributions from specialistsCooking for Health and Disease Prevention: From the Kitchen to the Clinic
By Nicole M. Farmer. 2022
Poor diet and substandard nutrition are underlying causes of many diseases including cardiovascular disease, diabetes, and cancer. Collectively, these ailments…
are the leading causes of premature death, most of which are preventable. Cooking for Health and Disease Prevention: From the Kitchen to the Clinic helps demonstrate cooking as a fundamental bridge between ideal nutrition and long-term health. Clinicians, patients, and the public often lack adequate knowledge to help select and prepare foods for optimal disease management. This book provides information to clinicians and their patients about foods and cooking principles to help prevent common health conditions.Features: Focuses on disease endpoints, reviewing the disease biology and epidemiology and presenting dietary interventions for disease prevention. Provides recommendations for translating dietary and culinary principles of health prevention into clinical practice and includes a recipe appendix with practical examples. Features information on healthy cooking techniques as well as food selection, storage, and preparation to help maximize nutritional value. Introduces the reader to fundamental concepts in nutrition and culinary principles explaining the relationship between food processing and food preparation and nutritional quality of foods. This book is accessible to patients and offers evidence-based practical interventions for healthcare professionals. It is authored by Nicole Farmer, physician scientist at the NIH Clinical Center, and nutrition researcher Andres Ardisson Korat, awarded a doctorate degree in nutrition and epidemiology from the Harvard T.H. Chan School of Public Health.Short Bowel Syndrome: Practical Approach to Management
By John K. DiBaise. 2016
Short Bowel Syndrome: Practical Approach to Management is the first reference exclusively about the issues experienced by patients with a…
short bowel. It covers all aspects of normal and abnormal physiology, the presenting features, and outcomes, including metabolic problems, gallstones, and renal stones. It discusses both medical and surgical treatments, including intestinal transplantation.The use of growth factors, which is likely in the future to become increasingly important in promoting intestinal structural adaptation, is extensively discussed. Special emphasis is given to the psychosocial aspects of the quality of life of patients, including support groups. Emphasis is also given to the importance of an experienced multidisciplinary team in caring for these patients.This book is particularly timely given the recent advances in the management of Short Bowel Syndrome, including the availability of pharmacologic agents to enhance intestinal absorption, refinements in parenteral nutrition, and surgical procedures designed to eliminate the need for parenteral nutrition support.The goal of this international, interdisciplinary book is to bring the subject of Short Bowel Syndrome to a wide audience. A wide range of specialists have contributed to this book to provide various viewpoints on the state-of-the-art care of those with this condition.Flavonoids and Anti-Aging: The Role of Transcription Factor Nuclear Erythroid 2-Related Factor2 (Nutraceuticals)
By Karam F.A. Soliman. 2023
The nuclear factor erythroid 2-related factor 2 (Nrf2) was described as a master regulator of the cellular antioxidant response. Moreover,…
many critical biological functions linked to cell viability, metabolism, autophagy, inflammation, immunity, and differentiation have been attributed to Nrf2, which regulates over 600 genes. It is well known that oxidative stress, which Nrf2 can ameliorate, plays a key role in many pathologic processes such as aging, obesity, diabetes, cancer, and neurodegenerative diseases. Flavonoids, on the other hand, through their ability to activate and upregulate Nrf2, can have anti-oxidative, anti-inflammatory, anti-mutagenic, and anti-carcinogenic properties. Flavonoids are an essential ingredient in nutraceuticals, functional foods, and pharmaceuticals. The present book Flavonoids and Anti-Aging: The Role of Transcription Factor Nuclear Erythroid 2-Related Factor2 focuses on the interaction between Nrf2 and flavonoids and their applications in various conditions such as aging, osteoporosis, cardiovascular diseases, and neurodegenerative disease and many other areas. Key Features: Focuses on the mechanisms and use of flavonoids in activating Nrf2 as an anti-aging and "WELLNESS" molecule Provides a specific approach to flavonoid activation of Nrf2 and its implications in aging and various disease conditions and its applications as nutraceuticals Presents flavonoid-based functional foods Discusses the flavonoid nutraceuticals market and future trends Written by experts in the field, this book provides a unique approach to understanding the flavonoid activation of the transcription factor Nrf2, which is responsible for many different disease conditions due to increased reactive oxidative species in the body caused by some physiological triggers.Modern medicine is undergoing a paradigm shift from a "one-size-fits-all" strategy to a more precise patient-customized therapy and medication plan.…
While the success of precision medicine relies on the level of pharmacogenomic knowledge, dissecting the genetic mechanisms of drug response in a sufficient detail requires powerful computational tools. Quantitative Methods for Precision Medicine: Pharmacogenomics in Action presents the advanced statistical methods for mapping pharmacogenetic control by integrating pharmacokinetic and pharmacodynamic principles of drug-body interactions. Beyond traditional reductionist-based statistical genetic approaches, statistical formulization in this book synthesizes elements of multiple disciplines to infer, visualize, and track how pharmacogenes interact together as an intricate but well-coordinated system to mediate patient-specific drug response.Features: Functional and systems mapping models to characterize the genetic architecture of multiple medication processes Statistical methods for analyzing informative missing data in pharmacogenetic association studies Functional graph theory of inferring genetic interaction networks from association data Leveraging the concept of epistasis to capture its bidirectional, signed and weighted properties Modeling gene-induced cell-cell crosstalk and its impact on drug response A graph model of drug-drug interactions in combination therapies Critical methodological issues to improve pharmacogenomic research as the cornerstone of precision medicine This book is suitable for graduate students and researchers in the fields of biology, medicine, bioinformatics and drug design and delivery who are interested in statistical and computational modelling of biological processes and systems. It may also serve as a major reference for applied mathematicians, computer scientists, and statisticians who attempt to develop algorithmic tools for genetic mapping, systems pharmacogenomics and systems biology. It can be used as both a textbook and research reference. Professionals in pharmaceutical sectors who design drugs and clinical doctors who deliver drugs will also find it useful.Microbial Bioprocessing of Agri-food Wastes: Food Ingredients (Advances and Applications in Biotechnology)
By Gustavo Molina, Minaxi Sharma, Vipin Chandra Kalia, Franciele Maria Pelissari, Vijai Kumar Gupta. 2023
Food ingredients are important molecules of the most diverse chemical classes responsible for conferring nutrition, stability, color, flavor, rheological and…
sensorial characteristics, in addition to several other important uses in the food industry. In this way, the production routes of these ingredients have gained more and more attention from consumers and producing industries, who expect that, in addition to their technological properties, these ingredients are still obtained without synthetic means, with savings of natural resources and mainly with less environmental impact. This book is intended for bioengineers, biologists, biochemists, biotechnologists, microbiologists, food technologists, enzymologists, and related professionals/ researchers. • Explores recent advances in the valorization of agri-food waste into food ingredients • Provides technical concepts on the production of various food ingredients of commercial interest• Explores novel technologically advanced strategies for the extraction of bioactive compounds from food wastes• Presents important classes of food ingredients obtained from alternative raw materials• Presents sustainable food waste resources and management strategies• Presents different pretreatment technologies and green extraction methodologies to support a green environment in the circular economy concept.• Challenges in applications of re-derived bioactive compounds from food wastes in food formulationsNutrition and Diabetes: Pathophysiology and Management
By Emmanuel C. Opara and Sam Dagogo-Jack. 2019
Diabetes occurs at such an alarming rate that it can be described as a global epidemic. Following its predecessor, Nutrition…
and Diabetes: Pathophysiology and Management, Second Edition, is a comprehensive resource that describes various factors that drive the accumulation of excess body weight and fat resulting in obesity. The book discusses the metabolic aberrations found in obesity and how they lead to the association of obesity with diabetes. This new edition highlights the role played by diet and the interrelationships in the metabolism of key nutrients in the pathogenesis of obesity and diabetes which provides the scientific basis for treatment and management approaches.Features Highlights the role of nutrition in the pathogenesis of obesity and diabetes Organized logically into two easy-to-use sections - Pathophysiology and Management of Obesity and Pathophysiology and Treatment of Diabetes Features emerging therapeutic approaches for management of obesity and diabetes Discusses experience in the management of obesity and diabetes in developing countries Presents challenges in insulin therapy and provides guidelines to overcome them The first section of the book retains key topics from the previous edition and contains new chapters including genetic determinants of nutrient processing; fat distribution and diabetes mellitus; combined effect of diet and physical activity in the management of obesity; pharmacologic treatment of obesity; and the role of gut microbiota in the pathogenesis and treatment of obesity. The second section features updated versions of most of the other chapters in the first edition comprising a modified chapter on oxidative stress and the effects of dietary supplements on glycemic control in Type 2 diabetes. In addition, new chapters are added in this section and include the contribution of iron and transition metal micronutrients to diabetes; role of microbiota in the pathogenesis and treatment of diabetes; primary prevention of Type 2 diabetes; and the pathophysiology and management of Type 1 diabetes.Kierkegaard and Bioethics (Routledge Studies in Nineteenth-Century Philosophy)
By Johann-Christian Põder. 2023
This book explores Kierkegaard’s significance for bioethics and discusses how Kierkegaard’s existential thinking can enrich and advance current bioethical debates.A…
bioethics inspired by Kierkegaard is not focused primarily on ethical codes, principles, or cases, but on the existential 'how' of our medical situation. Such a perspective focuses on the formative ethical experiences that an individual can have in relation to oneself and others when dealing with medical decisions, interventions, and information. The chapters in this volume explore questions like: What happens when medicine and bioethics meet Kierkegaard? How might Kierkegaard’s writings and thoughts contribute to contemporary issues in medicine? Do we need an existential turn in bioethics? They offer theoretical reflections on how Kierkegaard’s existential thinking might contribute to bioethics and apply Kierkegaardian concepts to debates on health and disease, predictive medicine and enhancement, mental illness and trauma, COVID-19, and gender identity.Kierkegaard and Bioethics will be of interest to scholars and advanced students working on Kierkegaard, bioethics, moral philosophy, existential ethics, religious ethics, and the medical humanities.Microbial Bioprocessing of Agri-food Wastes: Industrial Enzymes (Advances and Applications in Biotechnology)
By Gustavo Molina, Minaxi Sharma, Vipin Chandra Kalia, Franciele Maria Pelissari, Vijai Kumar Gupta. 2023
Enzymes are biological molecules of great relevance. In addition to the fundamental role in metabolic reactions, they have diverse applications…
in industrial processes in generating products of great commercial utility for the most diverse areas. Thus, industries seek to expand research to select microorganisms capable of producing enzymes according to their commercial objectives. Considering the diversity of the microbiota kingdom, as well as the diversity of mode of action of different classes of enzymes, this is an area that deserves constant investments to elucidate new applications, considering that these biological catalysts have great selectivity and a diversity of mode of action, reusable, and operate under mild process conditions, becoming the bridge for the development of sustainable processes and for adding value to commercial products. This book is intended for bioengineers, biologists, biochemists, biotechnologists, microbiologists, food technologists, enzymologists, and related professionals/ researchers.• Explores recent advances in the valorization of agri-food waste into enzymes • Explores the main technological advances in the recovery of residues and their use for the production of enzymes• Provides technical concepts on the production of various enzymes of commercial interest • Presents the main classes of enzymes obtained from alternative raw materials.Testing the immunogenicity, protective efficacy and safety in animal models is a crucial step in vaccine development. Pigs raised in…
germ-free environments, called gnotobiotic (Gn) pigs, are one of the most useful animal models for testing vaccines. The Gn pig model is a widely accepted model for studying pathogenesis and immunity and an ideal model for pre-clinical testing for the safety and efficacy of enteric viral vaccines. Through these studies and others, the Gn pig model has been established as the most reliable animal model for pre-clinical evaluation of human rotavirus and norovirus vaccines. This book provides detailed information on establishing Gn pig models, determining a proper virus inoculum pool and challenge dose, measuring protection and calculating efficacy, and delineating intestinal and systemic immune responses associated with the protection.Key Features Provides a natural history of human rotavirus and norovirus infection in Gn pigs Establishes the optimal virus challenge doses in Gn pigs for vaccine evaluation Evaluates various candidate rotavirus and norovirus vaccines Discusses human gut microbiota transplanted Gn pig models Documents the role of probiotics and rice bran as prophylactics and vaccine adjuvantsHandbook of Drug Metabolism, Third Edition (ISSN #Vol. 186)
By Paul G. Pearson and Larry C. Wienkers. 2019
This book continues to be the definitive reference on drug metabolism with an emphasis on new scientific and regulatory developments.…
It has been updated based on developments that have occurred in the last 5 years, with new chapters on large molecules disposition, stereo-selectivity in drug metabolism, drug transporters and metabolic activation of drugs. Some chapters have been prepared by new authors who have emerged as subject area experts in the decade that has passed since publication of the first edition.Hybrid Frequentist/Bayesian Power and Bayesian Power in Planning Clinical Trials provides a practical introduction to unconditional approaches to planning randomised…
clinical trials, particularly aimed at drug development in the pharmaceutical industry. This book is aimed at providing guidance to practitioners in using average power, assurance and related concepts. This book brings together recent research and sets them in a consistent framework and provides a fresh insight into how such methods can be used.Features: A focus on normal theory linking average power, expected power, predictive power, assurance, conditional Bayesian power and Bayesian power. Extensions of the concepts to binomial, and time-to-event outcomes and non-inferiority trials An investigation into the upper bound on average power, assurance and Bayesian power based on the prior probability of a positive treatment effect Application of assurance to a series of trials in a development program and an introduction of the assurance of an individual trial conditional on the positive outcome of an earlier trial in the program, or to the successful outcome of an interim analysis Prior distribution of power and sample size Extension of the basic approach to proof-of-concept trials with dual success criteria Investigation of the connection between conditional and predictive power at an interim analysis and power and assurance Introduction of the idea of surety in sample sizing of clinical trials based on the width of the confidence intervals for the treatment effect, and an unconditional version.Dietary Supplements in Health Promotion
By Taylor C. Wallace. 2015
The supplement market continues to grow annually with more than half of the population using these products for reasons spanning…
from health maintenance to disease prevention and/or treatment. Dietary Supplements in Health Promotion presents clear and concise evidence on how dietary supplements may contribute to maintaining health status. The bookImagining Imaging
By Michael R. Jackson. 2022
From Roentgen to Rembrandt, Hounsfield to Hollywood and Vesalius to videogames, Imagining Imaging explores the deeply entwined relationship between art…
(and visual-based culture) and radiology / medical imaging. Including artworks from numerous historical eras representing varied geographic locations and visual traditions, alongside a diverse range of contemporary artists, Dr Jackson argues that the foundations of medical image construction and interpretation were laid down in artistic innovations dating back hundreds and thousands of years. Since the discovery of X-rays, artists and moviemakers have, in turn, drawn rich inspiration from radiographic imagery and concepts, but the process of cross-pollination between art and science has continued, with creative endeavour continuing to mould medical imaging examinations to this day.Blending a unique mix of art, science and medical history, together with aspects of visual neurophysiology and psychology, Imagining Imaging is essential reading for radiologists, radiographers and artists alike. Peppered with familiar TV and film references, personal insights into the business of image interpretation, and delivered in an accessible and humorous style, the book will also appeal to anyone who enjoys looking at pictures.Key features: Engaging synthesis of art and medical history, combined with anecdotes and experiences from a working clinical radiologist Diverse range of visual reference points including astronomy, botany and cartography, alongside comprehensive discussion of medical imaging modalities including plain radiography, ultrasound, CT and MRI 200 full colour illustrations