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Showing 38481 - 38500 of 46887 items
By Julia Hornung. 2012
In dem Buch wird ein ganzheitliches und flexibel einsetzbares Personalmanagementkonzept vorgestellt. Ausgezeichnet mit dem HR-Nachwuchspreis 2011, kann das Konzept an…
jede Art von Einrichtung angepasst werden. Ausgangspunkt ist eine Analyse des Ist-Zustands einer Einrichtung für die Bereiche Gesundheitsmanagement, Lebenslanges Lernen, Organisation und Arbeitsgestaltung, Personal- und Rekrutierung sowie Führung. Jede der fünf "Säulen" wird mit Maßnahmen, Handlungsvorschlägen und Checklisten vorgestellt und anhand von Fallbeispielen erläutert.By Fazlul H. Sarkar. 2014
Since the discovery of microRNAs (miRNAs) some twenty years ago by Victor Ambros, David Baulcombe and Gary Ruvkun, these three…
scientists worked to uncover the mystery of miRNA, the small segments of nucleotides that silence genes. While studying the development of the nematode worm, Ambros and Ruvkun discovered miRNA in animals, while Baulcombe discovered it in plants. Since their discovery, it took more than two decade to fully appreciate the value of miRNA in human health and diseases. Emerging evidence suggest that the activation of oncogenes and/or the inactivation of tumor suppressor genes contribute to the development and progression of tumors. The regulation of genes is by far controlled by many transcription factors which are often deregulated during the development and progression of cancer. In addition, emerging evidence clearly suggests that the deregulation of miRNAs or small non-coding RNAs could also regulate the expression of genes and likewise, miRNA genes are also regulated by transcription factors. The most attractive feature of miRNAs is that one miRNA can regulate many target genes (mRNAs) and thus miRNA targeted therapy is highly promising because multiple genes could be regulated by targeting a single miRNA, which becomes very important for the killing of highly heterogeneous populations of cancer cells within a tumor mass. Therefore, miRNA targeted therapy is an attractive attribute of miRNA research, which is covered through eighteen chapters complied in this book "MicroRNA targeted Cancer therapy" and it is hoped that the field of miRNA research will be appreciated through critical reading of these chapters on the cutting-edge research on miRNAs.By Paul B.S. Lai, George G. Chen. 2011
Our recent understanding of the cellular and molecular defects and the regulation of the apoptotic signalling pathways has resulted in…
rationally designed anticancer strategies and the development of novel agents that regulates apoptosis. A comprehensive review of all apoptotic-related anticancer therapies is not the purpose of this book. However, in the volume of this book with 11 chapters, we have described a number of novel apoptotic regulators that have shown promising value and also great feasibility for cancer treatment. These novel agents either occur naturally or are chemically synthesized. While we are excited about the discovery and development of these novel apoptotic regulators as potential anticancer agents, a degree of caution should be always borne in mind when interpreting the success of preclinical pro-apoptotic candidates since potential problems inevitably lie ahead. These problems usually include target specificity, unanticipated toxicity, compound stability, formulation issues, pharmacokinetic and pharmacodynamic profiles. Nevertheless, we believe that this collection of 11 chapters by established leaders in the area of apoptosis will be of great interest to not only academics working in the field of cancer research and apoptosis but also pharmaceutical and pharmacological industries that . We are looking forward to the further development to push these potential agents toward clinical stage.By Rajarshi Gupta, Madhuchhanda Mitra, Jitendranath Bera. 2014
The book is focused on the area of remote processing of ECG in the context of telecardiology, an emerging area…
in the field of Biomedical Engineering Application. Considering the poor infrastructure and inadequate numbers of physicians in rural healthcare clinics in India and other developing nations, telemedicine services assume special importance. Telecardiology, a specialized area of telemedicine, is taken up in this book considering the importance of cardiac diseases, which is prevalent in the population under discussion. The main focus of this book is to discuss different aspects of ECG acquisition, its remote transmission and computerized ECG signal analysis for feature extraction. It also discusses ECG compression and application of standalone embedded systems, to develop a cost effective solution of a telecardiology system.By Hami Alpas, Simon Berkowicz, Irina Ermakova. 2010
In recent years, the concept of environmental security has been adapted to include preparedness for acts of ecoterrorism. This latter…
term has now become synonymous with environmental terrorism where the perpetrator uses the environment as a weapon to harm an opponent. The intended outcome is usually large-scale deaths, severe damage to the environment, and instilling fear in the general population. This book explores various facets of ecoterrorism including the role of the state in pursuing and maintaining environmental security, a review of the concept of ecoterrorism, food security challenges and weaknesses, technological countermeasures to enable rapid detection or response, and existing pollution sources and hazards that may serve as targets for terrorist acts. In sum, this volume provides a useful overview for both the layperson and experienced researchers.By Mia Levite. 2011
"Nerve-Driven Immunity: Neurotransmitters and Neuropeptides in the Immune System" summarizes, analyzes and sheds new light on an unrecognized, yet very…
important role of key neurotransmitters and neuropeptides in the immune system. Each chapter of the book deals with a different neurotransmitter/neuropeptide from the following list: Dopamine, Adrenaline, Noradrenaline, Acetylcholine, Glutamate, GABA, Somatostatin, Neuropeptide Y (NPY), Vasoactive intestinal polypeptide (VIP), Calcitonin gene related peptide (CGRP), Opioids and Cannabinoids. For each of these neurotransmitters/neuropeptides, the following four topics are discussed: The specific receptors for the neurotransmitter/neuropeptide expressed in various types of immune cellsThe direct effects induced by the neurotransmitter/neuropeptide in various types of immune cells (either resting or activated), and the specific immune functions and features it activates/elevates or rather inhibits in specific concentrationsThe production of the neurotransmitter/neuropeptide in, and its release by, various types of immune cellsThe involvement of the neurotransmitter/neuropeptide in various diseases of the immune system (among them autoimmune diseases, immunodeficiency diseases and hematological cancers)The book includes many original figures, overview tables, and proposed models of events which are instrumental, enriching and stimulating for the reader. In light of the above-mentioned aspects, "Nerve-Driven Immunity: Neurotransmitters and Neuropeptides in the Immune System" is ideally suited as a textbook for new courses in Immunology, Neurology, Neuro-immunology or Pharmacology. The book chapters were written by highly skilled authors from 10 countries: the USA, the United Kingdom, Italy, Israel, Sweden, France, Germany, Spain, Serbia and Romania."Nerve-Driven Immunity" is a term first coined by Dr. Mia Levite (the editor of the book).By Alexey Melkikh, Maria Sutormina. 2012
Understanding the general laws of an effective system for the transport of substances in cells is an important goal of…
systems and synthetic biology and will help us to answer why the transport subsystem of a cell is arranged as it is. In addition, the construction of models for optimizing transport systems is of considerable importance in the early stages in the development of a functioning protocell. The aim of this book is to describe the latest techniques for the calculation of the optimal parameters of the transport subsystem of a cell at its maximum efficiency. The book will describe linear and nonlinear programming, dynamic programming, game theory for models of ion transport in different types of cells (e.g. mammalian cells, bacteria, plants and fungi).By Yu-Kang Tu, Darren C. Greenwood. 2011
Routine applications of advanced statistical methods on real data have become possible in the last ten years because desktop computers…
have become much more powerful and cheaper. However, proper understanding of the challenging statistical theory behind those methods remains essential for correct application and interpretation, and rarely seen in the medical literature. Modern Methods for Epidemiology provides a concise introduction to recent development in statistical methodologies for epidemiological and biomedical researchers. Many of these methods have become indispensible tools for researchers working in epidemiology and medicine but are rarely discussed in details by standard textbooks of biostatistics or epidemiology. Contributors of this book are experienced researchers and experts in their respective fields. This textbook provides a solid starting point for those who are new to epidemiology, and for those looking for guidance in more modern statistical approaches to observational epidemiology. Epidemiological and biomedical researchers who wish to overcome the mathematical barrier of applying those methods to their research will find this book an accessible and helpful reference for self-learning and research. This book is also a good source for teaching postgraduate students in medical statistics or epidemiology.By George Chen. 2011
Our recent understanding of the cellular and molecular defects and the regulation of the apoptotic signalling pathways has resulted in…
rationally designed anticancer strategies and the development of novel agents that regulates apoptosis. A comprehensive review of all apoptotic-related anticancer therapies is not the purpose of this book. However, in the volume of this book with 11 chapters, we have described a number of novel apoptotic regulators that have shown promising value and also great feasibility for cancer treatment. These novel agents either occur naturally or are chemically synthesized. While we are excited about the discovery and development of these novel apoptotic regulators as potential anticancer agents, a degree of caution should be always borne in mind when interpreting the success of preclinical pro-apoptotic candidates since potential problems inevitably lie ahead. These problems usually include target specificity, unanticipated toxicity, compound stability, formulation issues, pharmacokinetic and pharmacodynamic profiles. Nevertheless, we believe that this collection of 11 chapters by established leaders in the area of apoptosis will be of great interest to not only academics working in the field of cancer research and apoptosis but also pharmaceutical and pharmacological industries that . We are looking forward to the further development to push these potential agents toward clinical stage.By Mieczyslaw Pokorski. 2012
This book, written for pulmonary and family doctors, general practitioners, allergologists, and neuropsychologists, presents cutting-edge clinical research and therapy-oriented knowledge…
in the field of respiratory medicine. Clinical knowledge is undergoing dramatic improvement. Respiration is one such prominent field. A better understanding of the pathogenesis of respiratory ailments and the regulation of lung ventilation is essential for advances in pharmacotherapy and the patient's quality of life. The book discusses a wide scope of topics, notably, innovations in detection and management of chronic inflammatory conditions such as COPD or asthma, acute infections of the respiratory tract, airway allergies and hyper-responsiveness, lung cancer, interstitial lung diseases, pulmonary function in health, disease and aging, sleep disordered breathing, interaction between the respiratory system and other bodily functions, and psychosomatic aspects of disease. After all, respiration is generated and integrated by the brain; therefore brain function is influential in respiratory regulation. The book is a platform that fosters the exchange of new clinical data between clinicians and academic neuroscientists, bringing a unique blend of medical diagnosis and practice to the leadership in respiratory medicine.By Xiaoyang Zhao. 2014
Stem cells have the ability to differentiate into all types of cells within the body, thus have great therapeutic potential…
for regenerative medicine to treat complicated disorders, like Parkinson's disease and spinal cord injury. There will also be many applications in drug development. However, several roadblocks, such as safety issues and low efficiency of pluripotent stem cell (PSC) line derivation need to be resolved before their clinical application. This thesis focuses on these two areas, so as to find methods to overcome the limitation. It covers deriving embryonic stem cells (ESCs) from several different species and reports an efficient system to generate induced pluripotent stem cells (iPSCs), and the first iPSC mice in the world. The results in this thesis confirm that somatic cells can be fully reprogrammed with the four Yamanaka factors. In addition, we have found that the Dlk1-Dio3 region can be a potential molecular marker to distinguish the fully reprogrammed iPSCs from partially reprogrammed ones. All of these results will help improve the safety of PSCs in the clinical applications and increase the current low induction efficiency of their production.By Mikhail V Kiselevsky. 2012
Malignant effusions (pleurites, ascites and pericarditis) are some of the most frequent manifestations of dissemination process of malignant tumors. Accumulation…
of the malignant fluid in serous cavities results in impairment of respiratory and cardiac functions, however long-term evacuation of the fluid leads to severe disorders of homeostasis that may directly cause the patient's death. The aim of this comprehensive book is to provide detailed information of pathogenesis and management of malignant effusions. The current book focuses on three of these categories: pleuritis, acsites and pericarditis. This book, written by recognized experts in the field, provides a detailed overview of current knowledge on this subject. The presented book reports valuable information about malignant effusions to basic and clinical medical specialists in academia, practice, as well as industry. The main topics considered include contemporary diagnostic approaches and modern therapeutic strategies, including conventional drugs, methods of intracavitary adoptive immunotherapy, chemotherapy and hyperthermia, commercial and experimental drugs being still under study. The material is presented in an easy to read and understandable language and uses a plethora of tables and figures. This book is aimed at oncologists, as well as phthisiatrician, surgeons, therapists and physicians of various specializations, who have to make diagnosis and treat effusions during their professional activity, and it will be undoubtedly helpful for interns, post-graduates and Ph.D. fellows of medical centers.By Marié P. Wissing. 2013
This is the first book to bring together examples of research in positive psychology / psychofortology conducted in the multi-cultural…
South African context with its diverse populations and settings. The volume reflects basic as well as applied well-being research in the multicultural South African context, as conducted in various contexts and with a variety of methods and foci. Theoretical, review, and empirical research contributions are made, reflecting positivist to constructivist approaches, and include quantitative, qualitative, and mixed-method approaches. Some findings support universality assumptions, but others uncovered unique cultural patterns. Chapters report on well-being research conducted in the domains of education, work, health, and family, and in clinical, urban vs. rural, and unicultural vs. multicultural contexts. Studies span the well-being of adolescents, adults, and older people, and topics include resilience in individuals, families, and groups, measurement issues and coping processes, the role of personal and contextual variables, and facets such as hope, spirituality, self-regulation, and interventions.By Gary Stephens, Sumiko Mochida. 2012
This book will bring together leading international experts to discuss recent advances in basic scientific knowledge regarding the regulation of…
presynaptic Ca2+ channels. Importantly, Ca2+ channels represent one of the most widely modulated proteins in the body, being the target of a range of effector pathways and drugs; this range will be fully represented here. A number of therapeutic drugs target the Ca2+ channel complex, including the anti-epileptic gabapentinoid and analgesic ziconotide drugs and the pharmaceutical industry is searching for Ca2+ channel blocking drugs, particularly in the pain, epilepsy, ataxia and migraine areas. Such potential future therapies will be discussed here. Scientific disciplines will focus on electrophysiological studies, but will extend to neuroscience, genetics and biochemical areas. The work described will represent advances at the cutting edge of current neuroscience research and is timely and highly appropriate for the Springer book series.By Hami Alpas, Simon M. Berkowicz, Irina Ermakova. 2010
In recent years, the concept of environmental security has been adapted to include preparedness for acts of ecoterrorism. This latter…
term has now become synonymous with environmental terrorism where the perpetrator uses the environment as a weapon to harm an opponent. The intended outcome is usually large-scale deaths, severe damage to the environment, and instilling fear in the general population. This book explores various facets of ecoterrorism including the role of the state in pursuing and maintaining environmental security, a review of the concept of ecoterrorism, food security challenges and weaknesses, technological countermeasures to enable rapid detection or response, and existing pollution sources and hazards that may serve as targets for terrorist acts. In sum, this volume provides a useful overview for both the layperson and experienced researchers.By E. Carlos Rodrìguez-Merchán. 2012
This book reviews the most important traumatic injuries that occur around the knee joint, providing detailed information on mechanisms of…
injury, diagnosis, and treatment. A wide range of injuries are covered, including jumper's knee, meniscus tears, knee ligament injuries, knee extensor mechanism injuries, and the floating knee. Dislocations of the knee and patella are carefully considered. Osteochondral fractures and fractures of the distal femur and tibial plateau are discussed in individual chapters that provide clear guidance on treatment. The book closes by reviewing the management of malunion and non-union about the knee. The authors are acknowledged experts in the field and have taken care to ensure that all information is completely up to date. This well-illustrated and instructive book will be of value to orthopedic surgeons, sports medicine specialists, and others who work with patients with traumatic knee injuries.By Jean-Nicolas Vauthey, Antoine Brouquet. 2012
It is now widely accepted that multidisciplinary collaboration and multimodality treatment approaches are important in improving the survival of patients…
with hepatocellular carcinoma. In this comprehensive textbook, internationally renowned experts in the field present and discuss the various strategies employed in the treatment of the disease. Up-to-date information is provided on the indications for and outcome of a range of treatment options, including surgical resection, liver transplantation, radiofrequency ablation, transarterial chemoembolization, yttrium-90 transarterial radioembolization, and systemic therapy. In addition, important background information is included on biology, pathology, staging, and imaging. This book will be particularly helpful to all professionals and trainees worldwide who have an interest in the diagnosis and treatment of hepatocellular carcinoma.By Maritza Padrón-Nieves, Emilia Diaz, Alicia Ponte-Sucre. 2012
One of the main problems concerning therapeutic tools for the treatment of parasitic diseases, including leishmaniasis, is that some field…
parasites are naturally resistant to the classical drugs; additionally, current therapies may select parasites prone to be resistant to the applied drugs. These features are (at least partially) responsible for the disappointing persistence of the disease and resultant deaths worldwide. This book provides a comprehensive view of the pathology of the disease itself, and of parasitic drug resistance, its molecular basis, consequences and possible treatments. Scientists both from academic fields and from the industry involved in biomedical research and drug design, will find in this book a valuable and fundamental guide that conveys the knowledge needed to understand and to improve the success in combating this disease worldwide.By Xueji Zhang, Haifeng Dong, Yaping Tian. 2015
This book summarizes microRNA (miRNA) biology in a variety of pathological processes, emphasizing the significant potential applications of miRNA in…
diagnostics and prognostics, as well as novel drug targets. The conventional techniques used for miRNA detection including standard PCR, Northern blotting, microarray and clone methods are addressed. Recent emerging strategies in miRNA detection and quantification with superior flexibility and adaptability, such as novel molecular biological techniques and locked nucleic acid (LNA) modified probes, as well as nanotechnology-based approaches, are also included. The book also highlights the latest advances in clinical-related miRNA detection methods in living cells, circulating blood and tissue, such as in situ hybridization (ISH) and molecular imaging techniques, which are useful to elucidate the biogenesis and biological function of miRNAs in vivo. Finally, the respective advantages and drawbacks of various detection techniques in this fast-moving field are discussed, along with the challenges and promising new directions. This book offers a valuable resource for analytical chemists, biologists and physicians involved in miRNA research. Dr. Xueji Zhang and Dr. Haifeng Dong are Professors at the School of Chemistry & Biological Engineering, University of Science & Technology Beijing (USTB), China. Dr. Yaping Tian is a Professor at the Department of Clinical Biochemistry, Chinese PLA General Hospital and Military Medical School, China.By Christos Sotiriou, Michail Ignatiadis, Klaus Pantel. 2011
This important book provides up-to-date information on a series of topical issues relating to the approach to minimal residual disease…
in breast cancer patients. It first explains how the study of minimal residual disease and circulating and disseminated tumor cells (CTCs/DTCs) can assist in the understanding of breast cancer metastasis. A series of chapters then discuss the various technologies available for the detection and characterization of CTCs and DTCs, pinpointing their merits and limitations. Detailed consideration is given to the relevance of CTCs and DTCs, and their detection, to clinical research and practice. The role of other blood-based biomarkers is also addressed, and the closing chapters debate the challenges facing drug and biomarker co-development and the use of CTCs for companion diagnostic development. This book will be of interest and assistance to all who are engaged in the modern management of breast cancer.