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Gamma Knife Neurosurgery in the Management of Intracranial Disorders II (Acta Neurochirurgica Supplement #128)
By Motohiro Hayashi, Mikhail F. Chernov, Clark C. Chen, Ian E. McCutcheon. 2021
The articles in this volume cover the various radiosurgical techniques used to treat benign and malignant intracranial tumors, cavernous malformations,…and functional disorders, as well as a wide array of specific details on medical physics, neuroimaging, and anesthetic support. Particular emphasis is put on the optimal combination of microneurosurgery and radiosurgery for attaining the best functional results in patients with vestibular schwannomas, craniopharyngiomas, and pituitary adenomas, and on the most effective methods of treatment planning and radiation dosimetry in cases of metastatic brain tumors. The highlighted clinical aspects include indications for radiosurgery and the prediction of patients’ prognosis, along with analysis of outcomes in comparison with results achieved by other modalities in the context of multifaceted therapeutic strategies. In addition, possible options for applying advanced treatment using such modern devices as Leksell Gamma Knife PerfexionTM and IconTM are presented in depth. This information will interest both radiosurgical practitioners and neurosurgeons, and help them to provide optimal care and to achieve the greatest benefit of their patients. This book will serve as an excellent companion for the previous publication “Gamma Knife Neurosurgery in the Management of Intracranial Disorders” (Acta Neurochirurgica Supplement, Volume 116, Springer, 2013).
By Ozren Bogdanovic, Michiel Vermeulen. 2021
This volume explores the latest methods used to study various aspects of TET proteins and their biology. Chapters in this…book are divided into five parts. Part One describes technologies aimed at detecting and quantifying DNA methylation turnover using massively parallel sequencing, ELISA, and mass spectrometry approaches. Part Two looks at data analyses protocols for distinguishing acting versus passive DNA demethylation and estimation of 5mC and 5hmC levels. Part Three deals with a new topic that takes advantage of modified CRISPR/Cas9 genome editing systems to target DNA demethylation activity to genomic loci of interest. Part Four discusses protocols that detail how to purify TET proteins and unravel their protein interactions, and Part Five looks at the assessment of TET protein function and activity in vivo and in vitro. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, TET Proteins and DNA Demethylation: Methods and Protocols is a valuable resource that aims to help research scientists at all levels working in the fields of DNA demethylation dynamics.Chapters 3, 7 and 17 are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
By Gordon McGranahan, Frank Murray. 2003
In developing countries the price of rapid growth is all too often noxious airborne pollution, which annually contributes to a…disturbing number of avoidable deaths. In recent decades, however, there has been considerable progress in the epidemiology of air pollution, significant changes in international air pollution guidelines, and the emergence of more systematic approaches to air pollution control. While many of these advances have originated in affluent countries, there have been major developments in other parts of the world. In this book, a distinguished cast of leading researchers in both the scientific and policy dimensions of air pollution and health have synthesized the recent developments in the field and their relevance for public health in developing countries. The authors review studies from a wide range of Asian, African and Latin American countries and contrast the findings with those from Europe and North America. They also describe various tools and systems for air pollution management and emphasize approaches that can be used when data is scarce. With a clear focus on the scientific and technical aspects of air pollution and health, this book is essential reading for pollution and health policy-makers, researchers and others concerned with air pollution and health in developing countries.
Metal Ions in Biological Systems is devoted to increasing our understanding of the relationship between the chemistry of metals and…life processes. The volumes reflect the interdisciplinary nature of bioinorganic chemistry and coordinate the efforts of researchers in the fields of biochemistry, inorganic chemistry, coordination chemis
By Alan Perkins. 2020
This unique book provides an accessible introduction to both the scientific background and the key people involved in the discovery…and use of radiation and radioactivity. It begins by providing a short history of radiation exposures and radiation poisoning; from the early inappropriate use of X-rays and radium cures through the misadventures of the Manhattan Project and the Chernobyl disaster, to the high-profile and deliberate poisoning of Alexander Litvinenko in London with polonium-210, which gave rise to worldwide media attention. The chapters provide a catalogue of deliberate criminal acts, unfortunate accidents, and inadvertent radiation exposures, exploring well-known events in detail, as well as some not so well-known occurrences. It works through the topics by focusing on human stories and events and their biological impact. In addition, it covers descriptions of the beneficial uses of radiation and radioactivity. This book can be enjoyed by any reader with a general interest in science, as well as by students and professionals within the scientific and medical communities. Key features Authored by a subject area specialist who has worked in both clinical practice and academia and was involved with the national media following incidents of national and international importance Provides a unique human perspective into well-known and some lesser known events and a concise history of the discovery of radiation and the events that followed Adds scientific and medical background to a subject of high media interest
By Alan White, Roger Kirby, Mike Kirby, Culley C Carson. 2021
Since its first edition, Men's Health has established itself as the essential reference for practitioners across the spectrum of medicine…- including those working in urology, andrology, cardiology, endocrinology, family practice and mental health. For this fully updated fourth edition the editors have again assembled an international team of expert authors to write on an encyclopedic range of topics, making this an invaluable resource for any health professional interested in maintaining and improving the health of their male patients. Comprehensive coverage of every aspect of men's health and the gender gap. Includes the latest research on cardiovascular risks. Assesses the specific issues concerning men and cancer. Examines the often overlooked aspects of mental health as it affects men. Incorporates new developments in metabolic medicine and men.
By Nattaya Lourith, Karl W.K. Tsim. 2021
This concise guide to cosmetic active ingredients derived from plant sources will bring scientists, researchers in cosmetic science, and dermatology…practitioners up to speed with the basic science and its applications in manufacturing and dermatological practice. It acts as a concise and quick reference from key researchers and an up-to-date guide to translation into practice, providing an easy-to-consult resource on a topic of great current interest.
Drawing on anthropology, historical sociology and social-epidemiology, this multidisciplinary book investigates how pharmaceuticals are produced, distributed, prescribed, (and) consumed, and…regulated in order to construct a comprehensive understanding of the issues that drive (medicine) pharmaceutical markets in the Global South today. Based on primary research conducted in Benin and Ghana, and additional data collected in Cambodia and the Ivory Coast, this volume uses artemisinin-based combination therapies (ACTs) against malaria as a central case study. It highlights the influence of the countries colonial and post-colonial history on their models for state regulation, production, and distribution, explores the determining role transnational actors as well as industries from the North but also and increasingly from the South play in influencing local pharmaceutical markets and looks at the behaviour of health care professionals and individuals. Stepping back, the authors then unpick the pharmaceuticalization process and the multiple regulations at stake by looking at the workings of, and linkages between, (biomedical health) pharmaceutical systems, (representatives of companies) industries, actors in private distribution, and consumer practices. Providing a thorough comparative analysis of the advantages and disadvantages of different pharmaceutical systems, it is an important contribution to the literature on pharmaceutalization and the governance of medication. It is of interest to students, researchers and policy-makers interested in medical anthropology, the sociology of health and illness, global health, healthcare management and pharmacy.
By Marjolein De Vugt. 2022
Understanding Young Onset Dementia provides a state-of-the-art overview of approaches to care and evaluation for people with young onset dementia.…It reviews the challenges in providing care and services, outlines new innovations in treatment and explores the impact of the condition to offer guidance about best practice in care. Written by world-leading researchers and experts in the field, this book gives key evidence for best practice and focuses on lived experience of those with young onset dementia. It has a broad focus looking at aspects of care beyond diagnosis and gives a comprehensive summary of the current qualitative and quantitative research in the field of young onset dementia. This international collaboration fills a much-needed gap in the academic market and is vital to guide learning and deliver future innovations. This book will be of great interest for academics, scholars and post graduate students in the field of mental health and dementia research. It will also appeal to neurologists, psychiatrist, geriatricians and psychologists looking to update their knowledge or already working in the field.
Marketization in the healthcare sector affects the quality and delivery of care, as well as healthcare workers’ working conditions. Based…on a comparison of England and Germany, along with an in-depth case study looking at New York, USA, this volume examines how trade unions respond to marketization processes and the determinants of successful strategies. The author draws on a rich empirical study to develop a theoretical framework that accounts for sector-specific opportunity structures stemming from marketization processes and on the relevant unions’ local-level leeway that opens if they build up and mobilise the available resources and capacities. The book identifies determinants of successful trade union strategies, explains the puzzling observation of similar strategic choices across different systems, and draws conclusions for prospects of trade unionism in the marketized healthcare sector. This book emphasizes the transformative effect of marketization on healthcare and the opportunities this change creates for unions, while giving special attention to the local-level conditions of trade unionism in the analysis of conflicts evolving around marketization in the hospital sector. It is of interest to academics and practitioners working in healthcare management, human resource management, and employment relations.
Quality healthcare is a cornerstone of any healthy society. In the U.S., we have access to sophisticated medical technology, world…renowned physicians, highly trained nurses and hospital personnel, advanced pharmaceuticals, and innovations in diagnosis and treatment. But for all of our sophistication, serious problems afflict healthcare systems across the U.S. today – problems that cause severe hardship for families in communities large and small. Considering its impact on society, healthcare is arguably our most important industry. Good health is a key aspect of a productive and fulfilling life no matter what a person’s age, cultural background, social status or career. To live well and provide for ourselves and others, we all depend on a strong healthcare system that can help us prevent illness and access effective treatment when we need it. Needless to say, building and maintaining that robust healthcare system is no easy task. According to a report by the Institute of Medicine, up to 98,000 deaths per year occur in U.S. hospitals as a result of adverse events. In other words, errors in hospitals cause more annual deaths than acceptable and are totally preventable. With the healthcare system in such critical condition, Lean is the best possible treatment as it moves to eliminate waste and improve processes. The revised edition of Taking Improvement from the Assembly Line to Healthcare supplies step-by-step guidance on how to implement Lean methods to achieve world-class improvement with the healthcare industry. The updated edition of this Shingo award winner book provides specific examples of Lean implementation in emergency medicine, diagnostic imaging, orthopedic clinics, general internal medicine, administration, and community care. Highlighting quality, safety, and financial evidence as to why immediate change is both possible and essential, the book provides a firm foundation in Lean improvement and the tools used to deliver sustainable solutions. This revised edition presents new and updated client interviews and how the process has changed or been enhanced, what worked and what didn’t work. New case studies from U.S. and Canada provide readers with the real-world understanding needed to embark and sustain a successful improvement journey.
By Dr Jen Gunter. 2021
#1 NATIONAL BESTSELLER In her follow-up to the #1 bestseller The Vagina Bible, Dr. Jen Gunter, Canadian OB/GYN and the…internet's most fearless advocate for women's health, brings us empowerment through knowledge by countering stubborn myths and misunderstandings about menopause with hard facts, real science, fascinating historical perspective, and expert advice.The only thing predictable about menopause is its unpredictability. Factor in widespread misinformation, a lack of research, and the culture of shame around women's bodies, and it's no wonder women are unsure what to expect during the menopause transition and beyond. Menopause is not a disease--it's a planned change, like puberty. And just like puberty, we should be educated on what's to come years in advance, rather than the current practice of leaving people on their own with bothersome symptoms and too much conflicting information. Knowing what is happening, why, and what to do about it is both empowering and reassuring. Frank and funny, Dr. Jen debunks misogynistic attitudes and challenges the over-mystification of menopause to reveal everything you really need to know about:* Perimenopause * Hot flashes * Sleep disruption * Sex and libido * Depression and mood changes * Skin and hair issues * Outdated therapies * Breast health * Weight and muscle mass * Health maintenance screening * And much more! Filled with practical tips, useful information and startling insights, this essential guide will revolutionize how women experience menopause--and show them how their lives can be even better for it.
By Will King. 2010
HOW TO BUILD A GREAT BUSINESS IN TOUGH TIMES is the inspiring entrepreneurial from-the-kitchen-table-to-supermarket-shelf story.Entrepreneur Will King hand-filled the first…10,000 bottles of his original King of Shaves (KoS) shaving oil at his kitchen sink, even getting his ironing lady to pitch in! From such humble beginnings, King of Shaves has grown to become a multi-million pound business. In 2008 a KoS product was sold every 3 seconds. Will explains how to keep the faith and follow your business dream even when the odds are heavily stacked against you.
By Nicola Tyrer. 2008
The remarkable true story of the Queen Alexandra frontline nurses in the Second World War.The amazing experiences of the Queen…Alexandra nurses in the Second World War form one of the greatest adventure stories of modern times, and - incredibly - remain largely untold. Thousands of middle-class girls, barely out of school, were plucked from sheltered backgrounds, subjected to training regimes unimaginably tough by today's standards, and sent forth to share the harsh conditions of the fighting services. They had to deal with the most appalling suffering, yet most found reserves of inner strength that carried them through episodes of unrelieved horror.Over 200 nurses died, torpedoed in hospital ships, bombed in field hospitals or murdered in Japanese prison camps. Dozens won medals for gallantry. From the beaches of Dunkirk, to Singapore and D-Day, they saw it all. Whether tending burned pilots from the Battle of Britain or improvising medical treatment in Japanese death camps, their dedication was second to none. This is their story.
Overcoming app now available via iTunes and the Google Play Store.A Books on Prescription TitleBreak free from the hell of…depressionIf you suffer from depression you are far from alone. Depression is very common, affecting over 300 million people around the world. Written by Professor Paul Gilbert, internationally recognised for his work on depression, this highly acclaimed self-help book has been of benefit to thousands of people including sufferers, their friends and families, and those working in the medical profession.This fully revised third edition has been extensively updated and rewritten to reflect over ten years of new research on understanding and treating depression, particularly the importance of developing compassionate ways of thinking, behaving and feeling. It contains helpful case studies and new, easy-to-follow, step-by-step suggestions and exercises to help you understand your depression and lift your mood.
By Akash Kumar Bhoi, Pradeep Kumar Mallick, Victor Hugo C. de Albuquerque, Mihir Narayana Mohanty. 2021
This book covers applications for hybrid artificial intelligence (AI) and Internet of Things (IoT) for integrated approach and problem solving…in the areas of radiology, drug interactions, creation of new drugs, imaging, electronic health records, disease diagnosis, telehealth, and mobility-related problems in healthcare. The book discusses the convergence of AI and the hybrid approaches in healthcare which optimizes the possible solutions and better treatment. Internet of Things (IoT) in healthcare is the next-gen technologies which automate the healthcare facility by mobility solutions are discussed in detail. It also discusses hybrid AI with bio-inspired techniques, genetic algorithm, neuro-fuzzy algorithms, and soft computing approaches which significantly improves the prediction of critical cardiovascular abnormalities and other healthcare solutions to the ongoing challenging research.
This book introduces the UTCI (Universal Thermal Climate Index) and summarizes progress in this area. The UTCI was developed as…part of the European COST Action Program and first announced to the scientific community in 2009. Since then, a decade has followed of applicability tests and research results, as well as knowledge gained from applying the UTCI in human adaptation and thermal perception. These findings are of interest to researchers in the interdisciplinary areas of biometeorology, climatology and urban planning. The book summarizes this progress, discussing the limitations found and provides pointers to future developments. It also discusses UTCI applications in the areas of human biometeorology and urban planning including possibilities of using UTCI and similar indices in climate-responsive urban planning. The book’s message is illustrated with many case studies from the real world.Chapter 10 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
By Ankur Saxena, Shivani Chandra. 2021
This book reviews the application of artificial intelligence and machine learning in healthcare. It discusses integrating the principles of computer…science, life science, and statistics incorporated into statistical models using existing data, discovering patterns in data to extract the information, and predicting the changes and diseases based on this data and models. The initial chapters of the book cover the practical applications of artificial intelligence for disease prognosis & management. Further, the role of artificial intelligence and machine learning is discussed with reference to specific diseases like diabetes mellitus, cancer, mycobacterium tuberculosis, and Covid-19. The chapters provide working examples on how different types of healthcare data can be used to develop models and predict diseases using machine learning and artificial intelligence. The book also touches upon precision medicine, personalized medicine, and transfer learning, with the real examples. Further, it also discusses the use of machine learning and artificial intelligence for visualization, prediction, detection, and diagnosis of Covid -19. This book is a valuable source of information for programmers, healthcare professionals, and researchers interested in understanding the applications of artificial intelligence and machine learning in healthcare.
By Clemens Sedmak, Michael Breitenbach, Elisabeth Kapferer. 2021
The word stress is everywhere and highly overused. Everyone is stressed, it seems, all the time. Looking into the meaning of stress…in the natural science and the humanities, this book explores cellular stress as cause of and in correlation with what humans experience as stress. When do we psychologically feel stress and when do we show physiological evidence of stress in our brain? Stress is a deviation from what feels normal and healthy. It can be created by social or economic factors and become chronic, which has substantial impacts on the individual and society as a whole. Focusing on poverty as one chronic inducer of stress, this book explores how the lack of pressure-free time, the hardships and unpredictability of everyday life and a general lack of protection lead to destructive toxic stress. This pressure affects cognitive and social functioning, brain development during childhood and may also result in premature aging. How can the sciences inform our understanding of and our response to stress? What can be done about toxic stress both on a personal level and in terms of structures and policies? The book is written for anyone interested in stress, its causes and consequences, and its relationship to poverty.
By Sir Ronald Cohen. 2007
'One of the best books written on entrepreneurship in recent years' FINANCIAL TIMES In business, everyone can see the first…bounce of the ball. It is the second bounce that is uncertain. Ronald Cohen, one of the world's leading private-equity investors, argues that the entrepreneur's aim is to take advantage of that uncertainty: for it is only in situations of uncertainty that significant gains can be made. Putting it another way, successful entrepreneurs know how to turn risk into opportunity.The book is essential reading for entrepreneurs, wannabe entrepreneurs and all those who want to apply entrepreneurial approaches in all walks of life. It provides relevant background on the development of entrepreneurship and of the venture-capital and private-equity industry through the prism of Cohen's experience at Apax. It provides guidance about how to take advantage of business opportunity: the right people and the right money and the roles played by personality and luck and underlines the importance of ethics.