Title search results
Showing 1 - 20 of 75 items
Clinical Metabolomics Applications in Genetic Diseases
By Anas M. Abdel Rahman. 2023
This book helps readers discover the forefront of personalized medicine on clinical metabolomics and its applications in genetic diseases. This…
comprehensive guide offers a functional relationship map between cell components and genetic variations in various diseases, providing insights that can be applied to personalized medicine. The book covers the latest developments in metabolomics for health, with practical guidance for clinical experts looking to advance their laboratory techniques and career. The metabolomics profile is a powerful tool that has revolutionized our understanding of the relationship between genetics, clinical readouts, and disease outcomes. By integrating metabolomics with genomics and clinical phenotypes, the authors have developed diagnostic and prediction models that have vastly improved patient outcomes and deepened the understanding of disease mechanisms. This model has been successfully applied in various conditions, including inborn errors of metabolism, primary immunodeficiency, and endocrine disorders. However, integrating metabolomics with other omics datasets and clinical phenotypes requires careful study design, analytical tools, and data analysis and interpretation. This groundbreaking new book provides essential guidance for researchers, students, and professionals looking to leverage metabolomics in their own work, including biochemical and clinical geneticists, pharmacogenomics and pharmacometabolomics experts, pharmaceutics and diagnostic researchers, medical scientists, clinical dietitians, metabolic engineers, clinical chemists, and personalized medicine specialists.The Type 2 Diabetes Revolution: A Cookbook and Complete Guide to Managing Type 2 Diabetes
By Diana Licalzi, Jose Tejero. 2023
Discover how you can reverse the root cause of type 2 diabetes with this innovative, easy-to-follow guide, which includes a…
4-week meal plan and over 100 delicious, high-fiber, plant-based recipes.If you have prediabetes or type 2 diabetes, this approach can help you achieve non-diabetic blood sugar within weeks. The simple lifestyle changes outlined in this book focus on the reversal of insulin resistance—the root cause of high blood sugar.Developed by a registered dietitian and exercise physiologist, The Type 2 Diabetes Revolution uses a revolutionary, science-based program to provide:Daily meal plans for 4 weeks, designed to minimize your time in the kitchen Simple grocery shopping lists for every week of the meal plan and tips for meal prep100+ high-fiber, plant-based recipes that keep your blood sugar balanced Advice on how to create a balanced diet that includes whole, plant-based foods and meat, if desiredTips for grocery shopping and how to read nutritional labels Guidance on stocking your pantry and knowing which foods to always have on hand Useful lessons and tips on how nutrition, exercise, sleep, and stress impact your diabetes healthStart reversing the root cause of type 2 diabetes, eliminate or reduce your need for medication, and lower your blood sugar with The Type 2 Diabetes Revolution.Spanish translation of this book will be available in Spring 2024. ISBN: 9781958803622A practical, empowering guide to managing and reversing prediabetes through diet and exercise, from a registered dietitian. Affecting 96 million…
Americans, prediabetes often develops into full-blown type 2 diabetes, one of the leading causes of death in the United States. Increasingly diagnosed by doctors, prediabetes is a condition in which blood sugar levels are elevated, but not yet high enough to be labeled diabetes. While diabetes cannot be cured, prediabetes can be reversed, so it is critical to take action at an early stage. In straightforward, jargon-free language, The Prediabetes Diet Plan explains insulin resistance (the underlying cause of prediabetes and type 2 diabetes) and offers a comprehensive strategy of diet and lifestyle change, which has been proven more effective than medication. With sections on meal planning, grocery shopping, dining out, supplements, and exercise, this book empowers you to make healthier everyday choices that can effect real change on your insulin levels and overall well-being.Familial Endocrine Cancer Syndromes: Navigating the Transition of Care for Pediatric and Adolescent Patients
By Fady Hannah-Shmouni. 2023
This book is composed of 13 informative chapters written by world-renowned healthcare providers and researchers in the fields of endocrinology,…
pharmacy, radiology, infertility, pediatrics, internal medicine, psychology and genetics. From topics covering psychosocial impacts to pharmacokinetic and homecare resources, the intent of this book is to provide guiding principles for a safe and informative transition of care for pediatric and adolescent patients with various familial endocrine cancer syndromes that are transitioning from pediatric to adult health care. It provides an in-depth exploration of the diagnostic and therapeutic strategies, survivorship navigation intervention, patient, caregiver and primary care provider challenges, and multidisciplinary care plans for conditions such as MEN1, MEN2 and other familial and genetic endocrine neoplasias.Familial Endocrine Cancer Syndromes: Navigating the Transition of Care for Pediatric and Adolescent Patients is a much-needed resource, as the literature currently lacks a comprehensive publication to facilitate pediatric patients’ transition to adult clinics and resources following endocrine cancer diagnosis and treatment.Environment Impact on Reproductive Health: A Translational Approach
By Roberto Marci. 2023
This open access book focuses on of the impact of endocrine disrupting chemicals (EDCs) on human reproduction. It comprehensively discusses…
the three most important topics in the field: the basic biology of EDCs; the effects of EDCs on human reproduction and human reproductive systems; and potential interventions and practical advice for dealing with the problems caused by EDCs.Presenting a translational approach to endocrine disrupting chemicals research, spanning both basic biology and clinical applications, the book provides a critical link between laboratory investigations and clinical practice. Written by international experts in the field, it is a valuable reference resource for gynaecologists, obstetricians, endocrinologists and experts in reproductive medicine, and a useful tool for anyone interested in the impact of the environment on human reproduction.Sex and Gender Effects in Pharmacology (Handbook of Experimental Pharmacology #282)
By Stella E. Tsirka, Maricedes Acosta-Martinez. 2023
Biological sex and gender have a tremendous impact on the efficacy and safety of pharmacological interventions in virtually every disease…
state. This book presents a comprehensive and up-to-date overview on how sex-specific information is guiding the diagnosis and treatment of diseases affecting men and women, as well as of disease states that disproportionally affects women. Experts in various fields discuss both preclinical and clinical research that is contributing to a better understanding of the impact of sex in the presentation, etiology, treatment, and disease outcomes. Also discussed are the challenges encountered in implementing this growing body of knowledge into practice, as well as possible avenues to recognize and reduce health disparities between men and women so that therapeutic interventions are tailored and improved.Hydro Saline Metabolism: Epidemiology, Genetics, Pathophysiology, Diagnosis and Treatment (Endocrinology)
By Massimiliano Caprio, Fabio Luiz Fernandes-Rosa. 2023
This book provides an overview of endocrine diseases associated with alterations of salt metabolism, with a focus on clinical and…
pathophysiological aspects. It covers various topics in the endocrine control of salt and water homeostasis, such as neuroendocrine determinants of water balance, adrenal hormone biosynthesis, hormonal function in target renal cells, and dysfunction of hormonal target effectors in the kidney. It also features an update on the clinical management of these diseases, including new diagnostic and therapeutic tools. Written by a combination of recognized and emerging experts in the field, this book is intended as a major reference work, not only for endocrinologists and nephrologists, but also for pediatricians, neonatologists, cardiologists, and emergency medicine and intensive care specialists, who can be faced with the management of endocrine diseases responsible of salt and water imbalance. The book is part of the SpringerReference program, which provides access to ‘living editions’ that are constantly updated using a dynamic, peer-review publishing process.Diabetes and Me: Living a Healthy and Empowered Life in the Face of Diabetes
By David Novak, Wendy Louise Novak. 2023
"Children with diabetes can live full, happy, productive lives. I hope my story can stand as proof of that fact."Diagnosed…
with type 1 diabetes at age seven, Wendy Louise Novak had to create her own path in a world defined by stigma, struggle, and hope.With little public awareness of her condition, Wendy's only role model was her fiercely independent father, who grew up in an era when diabetes meant a difficult, and often short, life. He taught her to "follow the rules" and stay self-reliant. That sense of independence carried Wendy through college to a successful career, globetrotting excitement, and a whirlwind romance with her husband, David.Wendy built a loving family as she navigated the highs and lows of a condition that was still widely misunderstood. Despite tough times, she learned to balance following the rules with following her passions, saying, "I never wanted to be the kind of person who stayed home and worried about whether or not I could take it, and so I didn't."Today, Wendy is the face of the Wendy Novak Diabetes Institute, which supports groundbreaking clinical services, education, and research to ensure young people with diabetes can thrive. In this honest but uplifting account of a life well lived, Wendy shares what she has learned, including practical tips for managing diabetes.With a foreword by the author's husband, businessman and philanthropist David Novak, Diabetes and Me shows patients and families that a diagnosis doesn't define your life."There are always ways to experience the joys in life, no matter what it throws at you."Thyroid Hormone Disruption and Neurodevelopment (Contemporary Clinical Neuroscience)
By Noriyuki Koibuchi, Paul Yen. 2016
Thyroid hormone plays an important role in development and functional maintenance in the central nervous system. Deficiency of thyroid hormone…
during fetal and early postnatal life induces abnormal development known as cretinism in humans. However, the molecular mechanism of thyroid hormone action has not yet been fully understood. Thyroid hormone action in the brain may be disrupted under various pathological conditions. In addition, environmental factors including endocrine-disrupting chemicals and bacterial endotoxins may disrupt thyroid hormone action in brain, causing abnormal brain development and functional disruption. This is a first book to comprehensively describe the effect of thyroid hormone disruption in the central nervous system. The first section deals with the disruption of thyroid hormone action at the molecular level. First the authors provide a summary of the possible molecular mechanisms of thyroid hormone action in the brain, then they discuss several factors that may disrupt thyroid hormone action. In the second section, animal models to study thyroid hormone action will be introduced. An interesting character of thyroid hormone deficiency is that, without thyroid hormone, the thyroid hormone receptor may act as a “repressor” of gene expression, causing more severe consequence than those of thyroid hormone receptor knockout animals. Thus, several different kind of animal models may be used to clarify the role of thyroid hormone and its receptor in the brain. In the third section, human studies on thyroid disease and neurodevelopment will be introduced. Although endemic cretinism induced by iodine deficiency and sporadic cretinism by various thyroid mutation are well known, the pathophysiological mechanisms that create each abnormal phenotype are not fully understood. Testosterone: From Basic to Clinical Aspects
By Alexandre Hohl. 2017
Research on testosterone is increasing in many senses; however there is still much controversy regarding its physiology and clinical use.…
This book addresses these topics, providing a broad overview about testosterone, from its basic features to the most recent evidence of clinical applicability. Also, specific conditions in which testosterone play a pivotal role are discussed in detail, such as hypogonadism, misuse and abuse, puberty, cardiovascular effects and testosterone therapy. Although not essential for survival, testosterone represents the essence of male biological function, being the important testicular androgen in men. Low serum testosterone levels are associated with cardiovascular morbidity, metabolic syndrome, type 2 diabetes mellitus, atherosclerosis, osteoporosis, sarcopenia, and mortality. Conversely, increased serum levels of testosterone may lead to deleterious events. In general, there is increasing evidence that serum testosterone is a major biomarker status of men’s health in general. Testosterone: From Basic to Clinical Aspects is an indispensable reference for all those who seek state-of-the-art knowledge regarding this hormone, from basic issues (including pharmacology and physiology) through clinical aspects (related diseases and supplementation therapy).Post-transcriptional Mechanisms in Endocrine Regulation
By Aaron Goldstrohm, K. Menon. 2016
This book examines how post-transcriptional mechanisms control endocrine function. This includes newly identified regulatory mechanisms involved in hormone biosynthesis, control of…
hormone receptors and the outputs of hormone mediated signal transduction. Chapters address endocrine hormones including protein peptide/peptide, steroid, and non-steroidal hormones. The impacts of these mechanisms on disease and health are covered, providing a novel update to the scientific literature. Post-transcriptional regulatory mechanisms play an essential role in controlling dynamic gene expression. The outcome of this regulation includes control of the amount, timing, and location of protein expression. Regulation is mediated by cis-acting RNA sequences and structures and transacting RNA binding proteins and non-coding RNAs, including microRNAs. Recent advances in characterization of these regulatory factors have revealed enormous regulatory potential.Andrology: Male Reproductive Health and Dysfunction
By Eberhard Nieschlag, Hermann Behre, Susan Nieschlag, Sabine Kliesch. 2023
The successful book of andrology now in a new edition! This book gives a complete, interdisciplinary overview of the central…
topics of andrology, infertility, hypogonadism, contraception and erectile dysfunction. It contains detailed information on the clinical practice of couple treatment, andrology-relevant gynecology and modern methods of assisted fertilization, psychological factors of infertility, endocrinology and reproductive functions of the aging man as well as on an important sub-area of andrology, the male contribution to contraception. In addition, the relevant scientific foundations (including molecular biology and genetics) are also covered. Completely revised and updated according to the latest scientific research, the new edition represents a reference for andrology, which no doctor who deals with the topic can miss. For andrologists, practitioners and residents, urologists, dermatologists and internists who deal with the area of andrology and male reproductive medicine.Chronic Hope: Raising a Child with Chronic Illness with Grace, Courage, and Love
By Bonnie O’Neil. 2021
Chronic Hope helps parents of children living with chronic disease gain practical wisdom for managing the emotional stress of raising…
a chronically ill child, so they can navigate these challenges with grace, courage, and love.Ultrastructural Investigations on the Pituitary-Gonadal Axis
By D. Bhiwgade, Sasikumar Menon. 2023
This book provides the ultrastructural study of the pituitary–gonadal axis through the electron microscope. It is a compilation of extensive…
work carried out by Dr. D.A. Bhiwgade and his researchers over the last four decades. It explains the ultrastructural characteristics of pituitary cells in different morphological states and provides a comprehensive approach to identifying the structural and functional distinctions between various pituitary cell types. The book includes ultrastructural evaluations of the testis and epididymis after different experimental interventions to study the physiological correlations of the organs with spermatogenesis and the consequent structural deformities in sperm. An extensive section of different types of placentae is added for understanding the varied interactions of fetal and maternal tissues in the placental barrier. Placental types seen in bats, shrews, rodents, and monkeys are explained at the ultrastructural level to distinguish the tissue interrelationships within different placental layers. Detailed sketches have been provided to illustrate the correlations between the maternal and fetal tissues in different placental types for better understanding. This book is a ready reckoner and offers guidance to researchers and clinicians in understanding the cellular architecture and intracellular changes associated with various physiological states and clinical conditions of the pituitary, testis, epididymis, and placenta. This book offers assistance to all those using electron microscopy to evaluate cellular and tissue systems.Fast Carbs, Slow Carbs: The Simple Truth About Food, Weight, and Disease
By David Kessler. 2020
The American body is in trouble. Unprecedented numbers of us suffer from obesity, heart disease, diabetes, and other debilitating illnesses.…
The root cause is a once-revolutionary idea that seemed to offer so much promise, but instead has become the cause of a global health crisis: processed foods. Over the past seventy-five years, a number of factors aligned to create a reality in which processed carbohydrates became our main food source. In Fast Carbs, Slow Carbs, bestselling author and former FDA Commissioner David A. Kessler explains how the quest to feed a nation resulted in a population that is increasingly suffering from obesity and chronic disease and offers a solution for changing course.For decades, no one questioned the effects of these processed carbohydrates. The focus was on fertile grassland, ideal for growing vast amounts of wheat and corn; an industrial infrastructure perfect for refining those grains into starch; a food production behemoth that turns refined grains into affordable, appealing, and ever-present food items, from pizza to burritos to bagels; and an efficient distribution network that ensures consumption by Americans nationwide.But during those same decades, our bodies quietly contended with the metabolic chaos caused by consuming rapidly absorbable starch. Slowly but surely, these effects accumulated and became disastrous, leading to the public health crisis in which we find ourselves today.In Fast Carbs, Slow Carbs, Kessler explains how eating refined grains such as wheat, corn, and rice leads to a cascade of hormonal and metabolic issues that make it very easy to gain weight and nearly impossible to lose it. Worse still is how excess weight creates a very real link to diabetes, heart disease, cognitive decline, and a host of cancers.We can no longer afford to dismiss the consequences of eating food that is designed to be rapidly absorbed as sugar in our bodies. Informed by cutting-edge research as well as Dr. Kessler’s own personal quest to manage his weight, Fast Carbs, Slow Carbs reveals in illuminating detail how we got to this critical turning point in our health as a nation—and outlines a plan for eliminating heart disease, allowing us to, finally, regain control of our health.Plan D: How to Lose Weight and Beat Diabetes (Even If You Don't Have It)
By Sherri Shepherd. 2013
Popular host of The View set to debut new daytime talk show on FOX TV, SHERRI*In Plan D, Sherri Shepherd,…
Emmy Award winner and cohost of The View, presents her easy-to-follow program for losing weight, managing sugar sensitivity, and getting moving—all to help you feel and look your best.For years, Sherri Shepherd was told that she was pre-diabetic. And for years, she ignored her doctor’s advice to lose weight and get healthy before she developed full blown diabetes. When she finally got the big-D diagnosis of Type 2 diabetes, the same disease that took her mother’s life, Sherri vowed that she’d change her ways so that her son wouldn’t be left alone, without a mother, as she had been.With the help of her doctor, she created this program, lost more than 40 pounds, and she looks great and has more energy than she did in her twenties. Sherri’s diabetes is under control, and she was happy to show her stuff, wowing the world on Dancing with the Stars.With tools to help you live a long and healthy life, Plan D is a smart and supportive plan designed to help you lose weight safely, make exercise a real, and fun, part of your life, and control your sugar sensitivity. And through it all, Sherri Shepherd is there, like a trusted friend, offering advice, encouragement, and of course a healthy dose of humor.Atkins Diabetes Revolution: The Groundbreaking Approach to Preventing and Controlling Type 2 Diabetes
By Robert Atkins, Mary Vernon, Jacqueline Eberstein. 2004
More than a program for living with diabetes, here is a groundbreaking approach to preventing, treating, and even reversing an…
American epidemic, based on the science of the doctor who invented the low-carb lifestyle and wrote the #1 New York Times bestseller Dr. Atkins’ New Diet Revolution featuring the Atkins Nutritional Approach™— a celebrity-favorite diet perfect for losing weight before your wedding or to bounce back into shape post-baby, or if you just want to look and feel your best.The statistics are staggering. Thirteen million Americans have been diagnosed with Type 2 diabetes; another 5.2 million don't know that they have it. During the past thirty years the diabetes rate has tripled, and each year about 200,000 people die from complications of the disease. The Centers for Disease Control project that one out of every three children born in the year 2000 will develop the disease. But Type 2 diabetes is largely preventable. Find out how you can avoid becoming a statistic.As a respected physician and pioneer in the field of complementary medicine, Dr. Robert C. Atkins recognized early on that diabetes and obesity are twin epidemics, and that the way to reverse both is to permanently change the way people eat. Yet much of the mainstream medical establishment continues to advocate the treatment of diabetes with insulin and other drugs, while recommending a diet high in carbohydrates including sugar, which raises your blood sugar. What you'll learn from reading Atkins Diabetes Revolution is that rather than correcting your metabolism, such a diet can actually increase your risk of developing diabetes—and heart disease.The Atkins Blood Sugar Control Program (ABSCP) helps you identify the metabolic signposts that indicate trouble long before the onset of Type 2 diabetes so you can stop it in its tracks. If you already have the disease, the ABSCP offers you and your physician a strategy for weight management and blood-sugar control, while minimizing your exposure to drugs.Atkins Diabetes Revolution presents a comprehensive lifestyle program, including diet, exercise, and nutrient supplementation. The book also contains meal plans, recipes, a fitness routine, and case studies. This revolutionary book, a fitting tribute to Dr. Atkins, tackles one of the greatest health challenges you and your family may ever face.General and Comparative Endocrinology: An Integrative Approach
By A. M. Schreiber. 2024
General and Comparative Endocrinology: An Integrative Approach, takes a holistic approach to endocrinology, introducing students to the diverse facets of…
this interdisciplinary science ranging from the medical to comparative domains, while also exploring evolutionary, environmental, and conservation specializations within the field. The textbook is founded on the principle that students interested in the health sciences will benefit from understanding how proficiency in endocrine function among a diversity of organisms contributes to advances in modern medicine. Likewise, students intrigued by comparative physiology will benefit from the wealth of knowledge derived from medical/clinical endocrinology, the historical bedrock of the field. This textbook represents the modern field of endocrinology in its totality by addressing topics and recent advances not currently discussed in other introductory endocrinology textbooks. Key Features Introduces the broad and interdisciplinary scope of endocrinology. Provides clear chapter objectives and key concepts. Includes summary and synthesis questions for each chapter that are suitable for exams and quizzes. Includes a chapter devoted to endocrine-disrupting chemicals. Describes the roles played by the endocrine system in important health challenges related to appetite regulation, obesity, diabetes, and other diseases stemming from ‘mismatches to modernity’. Integrates evolutionary and comparative approaches to hormones and health.Cardiovascular Neuroendocrinology (Masterclass in Neuroendocrinology #14)
By Gina Yosten, J. Cunningham. 2023
The cardiovascular system and the neuroendocrine system are integrated at multiple levels. This integration is key to normal physiological function.…
Further, it adapts to accommodate changes related to aging, the organism’s reproductive state, or physiological challenges. This type of adaptability, or plasticity, also can contribute to pathophysiology when these systems are stressed. This volume discusses how neuroendocrine systems influence cardiovascular function in health and disease. The first section provides detailed background information on neuronal and neuroendocrine control of cardiovascular function. This is followed by chapters highlighting the cardiovascular role of neuroendocrine hormones in regulating physiological states, such as pregnancy, and the effects of biological sex on vascular function. The influence of exercise, stress, psychology, and aging on cardiovascular function and dysfunction, and the possibility of therapeutically targeting the neuroendocrine axis for the treatment of cardiovascular disease are discussed in the final section of the book.This book is of relevance for students, trainees and established researchers alike who are seeking for an overview on the neuroendocrine control of cardiovascular function and disease. This is the fourteenth volume in the International Neuroendocrine Federation (INF) Masterclass in Neuroendocrinology series, which aims to illustrate the highest standards and encourage the use of the latest technologies in basic and clinical research and hopes to provide inspiration for further exploration into the exciting field of neuroendocrinology.Obesity in the 21st Century
By Alfred Poulos. 2023
In recent years, the focus of obesity prevention has been on diet. However, diet is only one of many factors…
which play a role in the development of obesity. This book looks at these factors and the latest research on how they contribute to the development of obesity, and the many different methods that have been and are being used to treat and prevent obesity. Written in an accessible language, this book provides the latest and most up to date information on research into the causes, health consequences and treatment of obesity. It educates and advocates for healthier lifestyles, a better understanding of diets and weight loss programs, and associated chronic diseases. It is written for everyone interested in obesity and enables the reader to take informed action to reduce the likelihood of putting on weight and the risk of developing chronic illnesses.