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The medical sector has been growing exponentially over the last decade and healthcare services are becoming more complex and costly. In…
order to continue efficiently and effectively managing patient safety, quality, and the effectiveness of the healthcare systems, new methodologies are needed. This book provides a platform to address this growing need and to improve practice. With the introduction of a new computer platform package for the management of medical organizations and healthcare systems, Modeling a New Computer Framework for Managing Healthcare Organizations aims to improve management techniques and increase overall satisfaction scores of patients, owners, and medical resources. The platform outlined will improve the daily operation of a healthcare system, focusing on the emergency department, and can be used to study the operation flow of a unit for performance optimization. It offers a user-friendly interface and proposed programming language, along with a visual and simple practice to collect and understand statistical outputs. Essential reading for decision makers on different levels in the healthcare organization hierarchy, this book can also be used by management to improve the performance of the organization and decision makers to hire resources, enhance workflows or both. It guides designers and system implementers in a step-by-step approach to make optimal decisions for resource allocation and helps designers and management to detect deficiencies in ongoing processes and fix or enhance them. Soraia Oueida is an instructor in the Department of Computer Engineering at the American University of the Middle East. She is an IEEE member and her research interests include Simulation Modeling, Discrete Mathematics, Petri Net, Workflows, Blockchain, IoT, Industrial Management Systems.Handbook of Biochemistry: Section B Nucleic Acids, Volume II (Routledge Revivals Ser.)
By Gerald D Fasman. 1976
The section of this handbook has been dividing into two volumes, the first volume contains information relating to purines, pyrimidine…
and nucleoside, oligonucleotide, polynucleotides, and their derivatives. Both ribo and deoxyribo compounds are listed also. The second volume will contain the remaining material similar to Volume 1 and material more relative to genetic and biological aspects such as enzymes involved in nucleic acid function, protein synthesis, linkage maps.Immunoassays For Drugs Subject To Abuse (Routledge Revivals)
By Irving Sunshine, S. Joseph Mulé, Monique C. Braude, R. E. Willette. 2019
First Published in 1974, this book offers a full, comprehensive guide into Drugs analysis and testing for drugs subject to…
abuse in samples from human subjects. Filled with a vast repertoire of factual data and statistics, this book serves as a useful reference for Students studying addiction and practitioners in their respective fields.Male Osteoporosis: Gender Differences in Pathophysiology, Clinical Aspects, Diagnosis and Treatment (Trends in Andrology and Sexual Medicine)
By Silvia Migliaccio, Alberto Ferlin. 2020
This book represents a comprehensive, clinically oriented text covering all aspects of male osteoporosis, from the basic concepts of bone…
physiology and regulation of bone remodeling in men, the causes and pathophysiological mechanisms responsible for the most frequent causes of osteoporosis, to diagnostic and screening protocols, as well as prevention and treatment approaches. It offers a broad overview of male osteoporosis by specialists involved in research and clinical practice and discusses the practical issues encountered. Filling a gap in the literature, this volume is a valuable resource for general practitioners, clinical endocrinologists, geriatricians and experts in osteoporosis.Salmonella: Methods and Protocols (Methods in Molecular Biology #2182)
By Heide Schatten. 2021
This third edition expands upon the previous edition with current, detailed methods on different aspects, and landmarks advancing knowledge on Salmonella…
research. With new chapters on molecular assays for detection, identification and serotyping of Salmonella, quantitative proteomic identification of host factors involved in salmonella infection, determination of antimicrobial resistance in salmonella, site-directed mutagenesis, chromosomal gene analysis, various microscopy methods to analyze salmonella interaction with host cells, in vitro modeling of gallbladder-associated salmonella colonization, and analysis of salmonella phages and prophages. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Salmonella: Methods and Protocols, Third Edition aims to provide methods that will have an impacted Salmonella researchPhysical Microbiology (Advances in Experimental Medicine and Biology #1267)
By Guillaume Duménil, Sven Van Teeffelen. 2020
This book emerges from the idea that specific physics-inspired approaches are necessary to understand different stage of bacterial physiology and…
the infections they cause. Many aspects of bacterial life depend on processes typically described by physical laws: The rheology of biofilms is determined by complex cohesive forces. Physical laws of diffusion are essential to all processes of bacterial metabolism. The formation of the numerous bacterial biomacromolecules require complex self-organization processes and their function are powered by potent molecular motors. Host-pathogen interactions during infection frequently occur in environments determined by fluid mechanics. In this book, different chapters represent research at the interface between microbiology and physics. Topics range from intracellular organization to cell-cell interactions. A good part of the book is devoted to mechanical forces, which are involved in the function of elaborate bacterial nanomachines, chromosome segregation, and cell division. The effect of bacterial toxins provides an example of the alteration of cellular membrane properties by bacteria. Symmetrically, histones from mammalian cells alter bacterial membranes as a defense mechanism during infection.The editors of this book, Guillaume Duménil and Sven van Teeffelen, have selected researchers at the forefront of research in physical microbiology to provide the most recent view in this fast-moving field. The contents of this book are designed to be accessible for scientists with training in biology and for scientists with training in physics. The objective is to provide a fresh perspective on microbiology and infection by highlighting recent multidisciplinary research and favor rapid advances at this fruitful interface.Metagenomics: Techniques, Applications, Challenges and Opportunities
By Neeta Raj Sharma, Reena Singh Chopra, Chirag Chopra. 2020
This book summarizes the various areas of research in metagenomics and their potential applications in medicine, the environment and biotechnology.…
The book presents the recent advances in theoretical, methodological and applied aspects of metagenomics and highlights their applications in the fields of environmental microbial forensics, bioremediation, drug-discovery and agriculture. In addition, the book discusses various metagenomics approaches used for understanding the microbial physiology and biochemistry. Lastly the book describes a range of bioinformatics tools and computational methods for metagenomics analysis as well as the functional diversity and dynamics of microbial communities colonizing the human skin.Senior Citizens of India: Emerging Challenges and Concerns
By Udaya S. Mishra, S. Irudaya Rajan. 2020
This book provides an overview of multiple facets of ageing and its evolving dynamics in various Indian states. It elaborates…
on key dimensions like health, dependence and disability, as well as living arrangements for the elderly. Drawing on information from National Sample Surveys to offer readers a broader and richer understanding of the evolving demographic reality in India, the book addresses a range of detailed policies and programmes for the elderly in India. Given its scope, the book is essential reading for students and researchers in the fields of sociology, demography, economics and development studies. It also offers a valuable reference guide for anyone engaged in planning and policy formulation for social security, welfare of the aged or mainstreaming ageing concerns.Clinical Cardiogenetics
By Hubert F. Baars, Pieter A. F. M. Doevendans, Arjan C. Houweling, J. Peter van Tintelen. 2020
This thoroughly revised third edition provides a comprehensive grounding on hereditary heart diseases with special emphasis on the genetic aspects…
of these conditions. It continues to provide the expertise that all cardiologists, clinical and molecular geneticists, and related medical professionals require to provide optimal care for patients with cardiac disease of genetic origin and for their relatives. Topics covered include the different cardiomyopathies, the primary arrhythmia syndromes and the hereditary thoracic aortic disorders. In addition other topics such as cardiac involvement in hereditary neuromuscular diseases, the clinical policy for sudden cardiac death and the possibilities of pre-implantation genetic diagnosis are included to extend the discussion. Clinical Cardiogenetics compiles current knowledge on the topic in an easy to understand reference. It provides a practical clinical primer for cardiologists, clinical geneticists, trainees and other physicians involved in the management of these patients.Druggable Lipid Signaling Pathways (Advances in Experimental Medicine and Biology #1274)
By Yasuyuki Kihara. 2020
Lipids are responsible not just for constituting cellular membrane but also for storing energy, transducing signaling, and modifying proteins. Bioactive…
lipids, or lipid mediators, transduce signaling as intracellular messenger like phosphoinoitides, and also regulate cell-cell communication through G protein-coupled receptors (GPCRs) that are potentially valuable drug targets in many diseases. Until now, about 40 GPCRs within ~300 rhodopsin-like (class A) GPCRs, are identified as lipid GPCRs. Advances of lipid research have enabled to develop novel small molecules targeting lipid GPCRs for several diseases. Most notably, fingolimod (FTY720), a sphingosine 1-phosphate (S1P) receptor modulator, became the first FDA-approved medicine as an orally bioavailable drug for treating relapsing forms of multiple sclerosis (MS). In addition to fingolimod, other drugs targeting lipid GPCRs had been developed such as latanoprost (prostaglandin F2a analogue, used for ocular hypertension and glaucoma), epoprostenol and treprostinil (prostaglandin I2 analogue, used for pulmonary arterial hypertension), montelukast and pranlukast (cysteinyl leukotriene receptor antagonist, used for asthma and allergies), etc. Novel drugs are also expected like lysophosphatidic acid (LPA) receptor antagonist for treatment of pulmonary fibrosis. Drug development targeting lipid signalling pathways are backdated to more than a century, when aspirin was synthesized and selling by Bayer, while the basic mechanism of aspirin's effects (block prostanoid synthesis by inhibiting cyclooxygenases) had not been discovered until 1970s. Nowadays, non-steroidal anti-inflammatory drugs (NSAIDs) like aspirin and ibuprophen are commonly used as antipyretic analgesics and available readily over-the-counter oral drugs. Both upstream and downstream enzymes, such as phospholipase A2s and prostaglandin E synthases, respectively, are also potential therapeutic targets for inflammatory diseases. Recent studies of lipid metabolism expand the lipid biology field from pro-inflammatory lipid mediators to anti-inflammatory epoxy fatty acids (epoxyeicosatrienoic acids), and also omega-3 fatty acid-derived pro-resolving lipid mediators (lipoxin, resolvin, and neuroprotectin). These bioactive lipids, their metabolic pathways and receptors are of great interest in developing next-generation anti-inflammatory and pro-resolving drugs for a wide variety of diseases including. This book summarizes not only historical overview of lipid signaling pathways but also provides summary of cutting-edge studies that may provide some hints of novel “druggable” lipid signaling targets.Facharztwissen Endokrinologie und Diabetologie: Klinik, Diagnostik, Therapie
By Birgit Harbeck, Iris van de Loo. 2020
Dieses Buch bietet kompakt das gesamte praxisrelevante Wissen zu Hormonen und Stoffwechsel. Oft handelt es sich um angeborene bzw. chronische…
Erkrankungen. Hier ist es wichtig, frühzeitig die richtigen Weichen zu stellen und die potentiell lebenslange Therapie optimal auf den Patienten anzupassen. Diagnostik, Differentialdiagnostik Leitsymptome, FrüherkennungWelche Verdachtsdiagnose ist plausibel?Erkrankungen zuverlässig nachweisen bzw. ausschließenWelche Begleit- und Folgeerkrankungen müssen bedacht werden?Stufendiagnostik: Was ist medizinisch und wirtschaftlich sinnvoll und effizientTestdurchführung und –auswertungVerlaufskontrolle: Was, wann, wie häufig Therapiestrategien Individuell auf den Patienten abgestimmt(Alter, Schwangerschaft, Begleiterkrankungen, Lebensumstände …)Konservativ/operativ – interdisziplinär abgestimmtKomplikationenVerlauf, Prognose, Nachsorge, Beratung für Patienten und Familienangehörige Konkret und zuverlässig Zahlen, Fakten, Dosierungen in zahlreichen Algorithmen und TabellenTipps für die Praxis (z.B. Verhalten bei Sport, Reisen), FAQs, typische FehlerFallbeispiele Für die FacharztprüfungLern- und Strategiebuch, um sicher die Facharztprüfung Innere Medizin und Endokrinologie und Diabetologie zu bestehen.Für den erfahrenen AnwenderNachschlagewerk für den klinisch-praktischen Alltag für Endokrinologen, Internisten, Allgemeinmediziner, Gynäkologen, pädiatrische Endokrinologen, Nuklearmediziner.Functional Brain Mapping: Methods and Aims (Brain Informatics and Health)
By Ning Zhong, Vicky Yamamoto, Vassiliy Tsytsarev. 2020
This book provides an essential overview of the broad range of functional brain imaging techniques, as well as neuroscientific methods…
suitable for various scientific tasks in fundamental and clinical neuroscience. It also shares information on novel methods in computational neuroscience, mathematical algorithms, image processing, and applications to neuroscience.The mammalian brain is a huge and complex network that consists of billions of neural and glial cells. Decoding how information is represented and processed by this neural network requires the ability to monitor the dynamics of large numbers of neurons at high temporal and spatial resolution over a large part of the brain. Functional brain optical imaging has seen more than thirty years of intensive development. Current light-using methods provide good sensitivity to functional changes through intrinsic contrast and are rapidly exploiting the growing availability of exogenous fluorescence probes. In addition, various types of functional brain optical imaging are now being used to reveal the brain’s microanatomy and physiology.Sudden Death: Advances in Diagnosis and Treatment
By Haiyan Zhu. 2021
This book provides up-to-date guidance on the diagnosis and treatment of sudden death, including sudden cardiac and non-cardiac death. Sudden death (SD) has become a major…
challenge confronting not only cardiologists, but also specialists in respiratory medicine, endocrine medicine, infectious diseases, etc. Chronic diseases are also among the causes of SD. This book summarizes the occurrence of SD, especially in specific groups (such as women, young and middle-aged groups), its causes, predisposing factors, lifestyle, morbidity, point of care testing, and advanced treatment methods including extra-corporeal membrane oxygenation, cardiopulmonary resuscitation and hypothermia treatment. In order to improve the early diagnosis, prevention and treatment of SD in clinical practice, the book also provides extensive data on its pathophysiological mechanism, epidemiology and etiology, together with detailed analyses.Composite Materials: Applications in Engineering, Biomedicine and Food Science
By Shafiquzzaman Siddiquee, Md. Mizanur Rahman, Melvin Gan Jet Hong. 2020
Composite materials are formed when the combination of separate materials acquire new properties distinct from its components. They have a…
range of applications in fields such as mechanical and electrical engineering, food science and biomedicine and represent a fast-growing area of research. Composite Materials: Applications in Engineering, Biomedicine and Food Science provides an overview of current technologies and applications related to composite materials in these fields. Organized by discipline, the text encompasses a wide variety of composite materials, including polymer, ceramic, biomaterial, hydroxyapatite, nanofiber and green composites. Early chapters detail the enhanced mechanical, magnetic, dielectric properties of electrical and thermal conductive composite materials, which are essential in daily science. Subsequent chapters focus on filler or reinforcement materials, including carbon materials, hybrid materials and nanomaterials. Particular emphasis is placed on nanocomposite materials, as these have increasingly diverse field applications. Various manufacturing methods, such as the synthesis method and top-down/bottom-up manufacturing, are also discussed. Coverage of the recent progress, challenges and opportunities surrounding composite materials make this text a one-stop reference for engineers, scientists and researchers working in this exciting field.Electron-Based Bioscience and Biotechnology
By Masaharu Ishii, Satoshi Wakai. 2020
This book offers a comprehensive introduction to electron-based bioscience, biotechnology, and biocorrosion. It both explains the importance of electron flow…
during metabolic processes in microorganisms and provides valuable insights into emerging applications in various fields. In the opening section, readers will find up-to-date information on topics such as electron transfer reactions, extracellular electron transfer mechanisms, direct interspecies electron transfer, and electron uptake by sulfate-reducing bacteria. The focus then shifts to state-of-the-art advances and applications in the field of biotechnology. Here, the coverage encompasses e.g. progress in understanding electrochemical interactions between microorganisms and conductive particles, enzymatic reactions and their application in the bioproduction of useful chemicals, and the importance of redox balance for fatty acid production. In closing, the book addresses various aspects of the complex phenomenon of microbiologically induced corrosion, highlighting novel insights from the fields of electromicrobiology and electrochemistry and their implications.Clinical Xenotransplantation: Pathways and Progress in the Transplantation of Organs and Tissues Between Species
By David K. C. Cooper, Guerard Byrne. 2020
This title provides an illuminating examination of the current state of xenotransplantation – grafting or transplanting organs or tissues between…
members of different species – and how it might move forward into the clinic. To be sure, this is a critical topic, as a major problem that remains worldwide is an inadequate supply of organs from deceased human donors, severely limiting the number of organ transplants that can be performed each year. Based on presentations given at a major conference on xenotransplantation, this title includes important views from many leading experts who were invited to present their data and opinions on how xenotransplantation can advance into the clinic. Attention was concentrated on pig kidney and heart transplantation as it is in regard to these organs that most progress has been made. Collectively, these chapters effectively highlight the many advantages of xenotransplantation to patients with end-stage organ failure, thereby encouraging the mapping of a concrete pathway to clinical xenotransplantation. The book is organized across 22 chapters, beginning with background information on clinical and experimental xenotransplantation. Following this are discussions addressing how pigs can be genetically engineered for their organs to be resistant to the human immune response through deletion of pig xenoantigens, and the insertion of ‘protective’ human transgenes. Subsequent chapters analyze complications that arise in practice, comparing allotransplant and xenotransplant rejection. The selection of the ideal patients for the first clinical trials is discussed. Finally, the book concludes with an analysis on the regulatory, economic, and social aspects of this research, including FDA perspectives and the sensitive, psychosocial factors regarding allotransplantation and xenotransplantation. A major and timely addition to the literature, Clinical Xenotransplantation will be of great interest to all researchers, physicians, and academics from other disciplines with an interest in xenotransplantation.Athletic Footwear and Orthoses in Sports Medicine
By E Knight, Matthew Werd, Paul Langer. 2017
Now in a revised and expanded second edition including an expanded section on running footwear and additional sports-specific recommendations…
this updated practical resource provides a concise and logical approach to prescribing footwear that will maximize performance and minimize injury in athletes From fundamentals -- including athletic foot types basic biomechanics and gait evaluation -- to step-by-step guidance through assessment and prescription of shoes socks lacing inserts and orthoses this book is both comprehensive and easily accessible A new section has been added to cover the array of different considerations for running footwear barefoot minimalist maximalist as well as new sport-specific recommendations As in the previous edition referral coding and billing are also addressed Photographs and drawings clearly illustrate key concepts and wherever relevant the authors have incorporated evidence-based medicine By presenting new and updated essential information in a user-friendly format Athletic Footwear and Orthoses in Sports Medicine Second Edition will prove to be invaluable for sports medicine physicians podiatrists orthopedists physical therapists and athletic trainersEvidence-Based Podiatry: A Clinical Guide to Diagnosis and Management
By Dyane E. Tower. 2020
This practical text reviews the most recent literature supporting clinical decisions regarding over a dozen common foot and ankle conditions,…
along with presentations of the techniques themselves, both surgical and non-surgical. The conditions are presented anatomically from forefoot to ankle, beginning with issues surrounding toenails, such as fungal infection and treatment of ingrown toenails, then proceeds to discuss the toes and toe joints, including hammertoe fixation, 2nd MPJ pathology, and Lapidus bunionectomy. Treatmentsfor arthritis of the midfoot and flatfoot follow, along with arthroscopy and arthroplasty of the ankle, surgical and non-surgical approaches for Achilles tendon ruptures, and treatments for Charcot neuroarthropathy, clubfoot and general considerations of wound care of the foot and ankle. Throughout, an emphasis is placed on the best available evidence for each treatment strategy.Evidence-Based Podiatry will be a valuable resource for podiatrists, orthopedic surgeons, and residents, fellows and trainees treating these common foot and ankle conditions.Chiropractic: Not All That It's Cracked Up to Be
By Edzard Ernst. 2020
Of all forms of alternative medicine, chiropractic is the one that is most generally accepted. In the UK, for instance,…
chiropractors are regulated by statute and even have their own ‘Royal College of Chiropractic’. In the US, chiropractic’s country of origin, most chiropractors carry the title ‘doctor’ and many consumers believe they are medically trained. Despite this high level of acceptance, chiropractic is wide open to criticism. The claims and assumptions made by chiropractors are far from evidence based. Chiropractic manipulations are of doubtful effectiveness and have regularly been associated with severe adverse effects, including multiple fatalities. The advice issued by chiropractors to patients and consumers is often less than responsible. The behaviour of chiropractors and their organisations is frequently less than professional. This book presents and discusses recent evidence in and around chiropractic in a factual and unemotional manner. It amounts to an evidence-based critique of this profession and discloses the often dangerously misleading information published for the lay audience. It thereby contributes to advancing public health and critical thinking.Veterinary Cytology
By Leslie C. Sharkey, M. Judith Radin, Davis Seelig. 2020
This book offers a state-of-the-art, evidence-based reference to all aspects of veterinary cytology. Truly multidisciplinary in its approach, chapters are…
written by experts in fields ranging from clinical pathology to internal medicine, surgery, ophthalmology, and dermatology, drawing the various specialties together to create a comprehensive picture of cytology's role in diagnosis and treatment of animal disease. Firmly grounded in the primary literature, the book focuses on companion animals, with special chapters for species with fewer publications. Chapters are logically organized by body system, with additional chapters on tumors of particular import and diagnostic decision making. The first two sections of Veterinary Cytology focus on cytology techniques, quality control, and special laboratory techniques. Subsequent sections are organ/tissue-based and reflect what is known about the canine, feline, and equine species. This is followed by chapters on non-traditional species, including exotic companion mammals, rabbits, cattle, camelids, non-human primates, reptiles and birds, amphibians, fish, invertebrates, and sheep and goats. The last section highlights some unique features of the applications of cytology in industry settings. Provides a gold-standard reference to data-driven information about cytologic analysis in companion animal species Brings together authors from a wide range of specialties to present a thorough survey of cytology's use in veterinary medicine Offers broader species coverage and greater depth than any cytology reference currently available Veterinary Cytology is an essential resource for clinical and anatomic pathologists and any specialist in areas using cytology, including veterinary oncologists, criticalists, surgeons, ophthalmologists, dermatologists, and internists.