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Management of Neuroendocrine Tumors of the Pancreas and Digestive Tract
By Eric Raymond, Philippe Ruszniewski. 2014
This book pursues a multidisciplinary approach, presenting chapters with updated information on various aspects of treatment for patients with neuroendocrine…
tumors. Authors have been selected from expert centers in Europe and the United States. The goal of this book is to comprehensively summarize recent data and provide inspiring ideas to optimize the care of patients with neuroendocrine tumors. Neuroendocrine tumors are fascinating multifaceted diseases that can primarily localize in many organs with various presentations. These tumors are rare but their increasing incidence renders likely that physicians caring for cancers may have either already faced or may be certainly exposed to diagnose and/or treat a patient with neuroendocrine tumors. Over the last years, novel therapeutic options have emerged for neuroendocrine tumors, profoundly challenging practices that had previously been the standards for decades. These include - but are not limited to - somatostatin analogues, targeted therapies such as tyrosine kinase and mTOR inhibitors, antiangiogenic compounds, but also peptide-receptor targeted therapy or radioembolization. This changing field has generated novel treatment algorithms to guide medical decisions. To better understand and handle the multidisciplinary approaches that are required for optimizing the care of neuroendocrine tumor patients, physicians are now looking for references from experts and comprehensive reviews summarizing current knowledge on treatments for patients with neuroendocrine tumors.JIMD Reports - Case and Research Reports, 2011/2
By Ssiem. 2011
JIMD Reports publishes case and short research reports in the area of inherited metabolic disorders. Case reports highlight some unusual…
or previously unrecorded feature relevant to the disorder, or serve as an important reminder of clinical or biochemical features of a Mendelian disorder.Nuclear Receptors
By Moray J. Campbell, Chris M. Bunce. 2009
In 1890 a case of myxedema was treated in Lisbon by the implantation of a sheep thyroid gland with the…
immediate improvement in the patient's condition. A few years later, medications for the then ill-explained condition of the menopause included tablets made from cow ovaries. In the first quarter of the 20th century the identification of vitamin D, and its sunlight driven production in skin, paved the way to the elimination of rickets as a major medical problem. Twenty years or so later, Sir Vincent Wigglesworth established the endocrine basis of developmental moulting in insects, arguably the most commonly performed animal behaviour on Planet Earth. A paradigm that would unify these disparate observations arose between 1985 and 1987 beginning with the identification of the glucocorticoid receptor and the nuclear receptor super-family. What follows is a timely and positive manifestation of the capacity, productivity and value of international human scientific endeavour. Based on intrigue, lively competition and cooperation a global effort has rapidly fostered a school of biology with widespread ramifications for the understanding of metazoan animals, the human condition and the state of the planet. This book is the first this century to try and capture the spirit of this endeavour, to depict where the field is now and to identify some of the challenges and opportunities for the future.Prediabetes For Dummies
By Alan L. Rubin. 2010
Accessible information on the causes, health risks, and treatment of prediabetes If you or someone you love has been diagnosed…
with prediabetes - a heightened level of glucose, and/or impaired glucose tolerance - the time to act is now. Prediabetes For Dummies examines the signs and symptoms of this potential precursor to diabetes and offers up-to-date information about treatment. It provides clear, practical advice on steps you can take to minimize the risk of serious health consequences. This plain-English guide shows you how to stop prediabetes in its tracks and prevent it from progressing to diabetes. You'll learn how to recognize the symptoms of this often-undiagnosed condition, and what to do if you think you may be prediabetic. You'll also discover how simple lifestyle changes, such as changes in your diet and moderate exercise, can put the brakes on prediabetes and even reverse the condition. Offers clear explanations of prediabetes causes, health risks, and treatment Includes the latest advances in the use of diabetes medications to treat prediabetes Provides diet suggestions, meal plans, and exercise tips Contains helpful suggestions for friends and family members who want to support a loved one with prediabetes While there is no cure for diabetes, it can be prevented if prediabetes is diagnosed and treated early. Packed with valuable information for patients of all ages, Prediabetes For Dummies is an important resource for taking control of this dangerous condition.Musculoskeletal Disease Associated with Diabetes Mellitus
By Masaaki Inaba. 2016
The aim of this book is to review the latest findings on musculoskeletal disease associated with diabetes. It has been…
increasingly recognized that maintaining skeletal health is an important factor in achieving longevity in healthy subjects. Diabetes has been established as a disease independently associated with sarcopenia and increased risk of bone fracture resulting from osteoporosis; therefore, it is reasonable to maintain that musculoskeletal health is important in preserving good health. As either bone or muscle is intimately involved in the regulation of metabolic status, keeping the musculoskeletal system healthy is important for improving abnormal glucose metabolism toward normal levels and is vital, as well, for maintaining normal activities of daily living. Muscle is a target of insulin for enhancing the entry of glucose; thus it is conceivable that sarcopenia and muscle containing fat streaks causes insulin resistance in diabetic patients. Furthermore, bone is an organ that regulates Ca and Pi levels in serum by releasing or resorbing Ca and Pi to and from bone tissue. It is now known that bone is a definitive endocrine organ for regulating glucose metabolism and Pi metabolism by secreting osteocalcin and FGF-23 from osteocytes/osteoblasts. Readers will learn of the recent findings in this area, and this book will benefit physicians who deal with diabetes, particularly orthopedists and bone specialists, as well as all physical therapists.Nutrition and Diet in Maternal Diabetes
By Victor R. Preedy, Vinood B. Patel, Rajkumar Rajendram. 2018
This comprehensive volume covers all aspects of nutrition in different scenarios of maternal diabetes, including the Type 1 or Type…
2 diabetic mother, gestational diabetes, and postpartum diabetes. The volumes offer a comprehensive, yet thorough, overview of the subject, from the prevalence, risk factors, and insulin requirements of the mother; to possible outcomes and effects on the infant; to dietary advice in general and specific scenarios; and information on macro and micronutrient supplements. There is also a special section on international perspectives on maternal diabetes, with ten chapters that each focus on a different country. Nutrition and Diet in Maternal Diabetes: An Evidence-Based Approach offers an overview of the Type 1 and type 2 diabetic mother, maternal and offspring aspects of gestation diabetes, and breastfeeding and maternal gestational diabetes. Histiocytic Disorders
By Oussama Abla, Gritta Janka. 2018
This volume provides a comprehensive and world-class review of the field of histiocytic neoplasms and hemophagocytic lymphohistiocytosis (HLH). It reviews…
all the advances in the field of histiocytoses during the last ten years, particularly with regards to the genomic findings in LCH and other histiocytic neoplasms and the new suggested classification of the histiocytic disorders. Additionally, it features a state-of-the art update on the most recent treatment strategies for LCH, including the results of the last LCH-III international trial, salvage therapies such as reduced-intensity conditioning (RIC) stem cell transplant (SCT), and targeted therapies with BRAF and MEK inhibitors, as well as the challenging cases of CNS-neurodegenerative LCH and its therapeutic perspectives. For primary and secondary HLH the book updates the most recent genetic and pathophysiological findings, including macrophage-activation syndrome (MAS), and includes a special chapter on HLH in adults. Treatment chapters encompass therapy for newly diagnosed HLH and refractory disease as well as stem-cell transplantation and novel therapies. The text also highlights the most recent advances in the treatment of the uncommon histiocytic disorders, such as Erdheim-Chester disease (ECD), Juvenile xanthogranuloma (JXG) and JXG-like conditions, Rosai-Dorfman disease (RDD), and the very rare malignant histiocytoses. Written by international experts in the field, Histiocytic Disorders is a valuable resource for clinicians, researchers, fellows and residents who are interested in or manage histiocytic disorders in children and adults.Application of Systematic Review Methods in an Overall Strategy for Evaluating Low-Dose Toxicity from Endocrine Active Chemicals
By Engineering, Medicine, National Academies of Sciences. 2017
To safeguard public health, the US Environmental Protection Agency (EPA) must keep abreast of new scientific information and emerging technologies…
so that it can apply them to regulatory decision-making. For decades the agency has dealt with questions about what animal-testing data to use to make predictions about human health hazards, how to perform dose-response extrapolations, how to identify and protect susceptible subpopulations, and how to address uncertainties. As alternatives to traditional toxicity testing have emerged, the agency has been faced with additional questions about how to incorporate data from such tests into its chemical assessments and whether such tests can replace some traditional testing methods. Endocrine active chemicals (EACs) have raised concerns that traditional toxicity-testing protocols might be inadequate to identify all potential hazards to human health because they have the ability to modulate normal hormone function, and small alterations in hormone concentrations, particularly during sensitive life stages, can have lasting and significant effects. To address concerns about potential human health effects from EACs at low doses, this report develops a strategy to evaluate the evidence for such low-dose effects.A Practical Manual of Diabetes in Pregnancy
By Michael Maresh, David Mccance, David A. Sacks. 2018
The revised and updated second edition of a multidisciplinary, evidence-based clinical guide for the care of pregnant women with diabetes…
The second edition of A Practical Manual of Diabetes in Pregnancy offers a wealth of new evidence, new material, new technologies, and the most current approaches to care. With contributions from a team of international experts, the manual is highly accessible and comprehensive in scope. It covers topics ranging from preconception to postnatal care, details the risks associated with diabetic pregnancy, and the long-term implications for the mother and baby. The text also explores recent controversies and examines thorny political pressures. The manual’s treatment recommendations are based on the latest research to ensure pregnant women with diabetes receive the best possible care. The text takes a multi-disciplinary approach that reflects best practice in the treatment of diabetes in pregnancy. The revised second edition includes: New chapters on the very latest topics of interest Contributions from an international team of noted experts Practical, state-of-the-art text that has been fully revised with the latest in clinical guidance Easy-to-read, accessible format in two-color text design Illustrative case histories, practice points, and summary boxes, future directions, as well as pitfalls and what to avoid boxes Multiple choice questions with answers in each chapter Comprehensive and practical, the text is ideal for use in clinical settings for reference by all members of the multi-disciplinary team who care for pregnant women with diabetes. The manual is also designed for learning and review purposes by trainees in endocrinology, diabetes, and obstetrics.A pre-diabetes diagnosis is a wake-up call. And with this book, you can make the lifestyle changes you need to…
ensure your good health. This book guides you not only through what to eat and when, but how to prepare delicious, healthy meals such as:Honey-Oat Bran BreadLayered Veggie CasseroleCold Roasted Red Pepper SoupRoasted Garlic Mashed PotatoesStrawberry-Banana Sorbet Reversing a diagnosis can be daunting, but with this guide, you learn to take the process one step--and one meal--at a time.The Parathyroid Glands
By Alexey V. Pavlov, Arian P. Kalinin, Irina V. Kotova, Sergey N. Pamputis, Yury K. Alexandrov, Yury N. Patrunov. 2012
This book is based on the authors' extensive practical experience in the use of modern radiological methods to diagnose parathyroid…
diseases and the application of advanced surgical techniques. Detailed attention is devoted to the embryological background to emphasize the significance of diagnostic and surgical peculiarities. Pre- and intraoperative imaging is discussed in depth, with a special focus on localizing techniques. Ultrasound-guided minimally invasive techniques, including percutaneous laser ablation, are fully considered. This up-to-date and richly illustrated book will interest and assist specialists in ultrasound diagnostics, radiologists, endocrinologists, and surgeons.Minimally Invasive Thyroidectomy
By Dimitrios Linos, Woong Youn Chung. 2011
This book describes in detail the various techniques of minimally invasive thyroidectomy that have emerged in recent years and presents…
the new supportive equipment, including intraoperative monitoring and energy devices. In addition, the basic preoperative techniques that are a prerequisite to successful thyroidectomy are covered, and individual chapters are devoted to complications, outcomes, and post-thyroidectomy quality of life. Important related topics are also discussed, including guidelines for managing papillary and medullary thyroid cancer and the surgical management of metastatic lymph nodes. Both the editors and the authors are internationally renowned experts, and they include the founders of several of the techniques described. The up-to-date text is supplemented by many color pictures and medical illustrations, making the book very user-friendly and ideal for the busy surgeon or endocrinologist who is interested in the management of thyroid diseases.Metabolic Syndrome
By Rexford S. Ahima. 2015
This comprehensive reference work edited by one of the leading authorities on obesity presents an up-to-date survey of the current…
scientific understanding of the metabolic syndrome, as well as an overview of the most significant changes to the field over the past 30 years. This volume is a thorough reference for obesity and the metabolic syndrome and will prove an indispensable resource for clinicians and researchers at levels worldwide. The obesity epidemic has generated immense interest in recent years due to the wide-ranging and significant adverse health and economic consequences that surround the problem. Much attention has been focused on behaviors that lead to obesity, in particular to over consumption of energy-dense food and to sedentary lifestyle. However, obesity is an extremely complex condition with poorly defined pathogenesis. In addition, when combined with other comorbidities such as hypertension and dyslipidemia, obesity often leads to a patient diagnosis of metabolic syndrome, a very troubling condition that has grown, and is continuing to grow, rapidly each year in prevalence worldwide. Metabolic syndrome is a cluster of conditions -- increased blood pressure, a high blood sugar level, excess body fat around the waist and abnormal cholesterol levels -- that occur together, increasing one's risk of heart disease, stroke and diabetes. This resource covers the full range of scientific and clinical aspects: epidemiology, genetics, environmental factors, pathophysiology, diseases associated with obesity, and clinical management.Endocrinology and Diabetes
By Francisco Bandeira, Hossein Gharib, Airton Golbert, Luiz Griz, Manuel Faria. 2014
Endocrinology, and diabetes care in particular, is a dynamic field where clinicians must translate new evidence into clinical practice at…
a rapid pace. Designed in an engaging, case-based format, Endocrinology and Diabetes: A Problem Oriented Approach offers a wide range of thought-provoking case studies that reflect contemporary, challenging, hands-on clinical care. Further, by providing a list of specific clinical problems, this format offers the reader a more convenient and pointed way to solve precise clinical problems in a timely manner. Developed by a renowned, international group of experts, this comprehensive title covers the most common clinical problems in endocrinology and diabetes and should be of great interest to endocrinologists, diabetologists, internal medicine physicians, family physicians, fellows, and residents. Medullary Thyroid Carcinoma
By Friedhelm Raue. 2015
This book offers a comprehensive overview of medullary thyroid carcinoma, both in the more common sporadic form and in the…
familial form, multiple endocrine neoplasia (MEN) types 2A and 2B. The coverage includes, but is not limited to, molecular biology and genetics, pathology, clinical presentation, imaging techniques, surgical treatment, and follow-up. The role of calcitonin as a highly sensitive and specific tumor marker for the screening, diagnosis, and follow-up of MTC and metastatic disease is described, and the significance of other tumor markers is also considered. With regard to treatment, the use of thyroidectomy is fully discussed, including in children carrying the mutations in the RET proto-oncogene considered causative for MEN 2. Additionally, the value of tyrosine kinase inhibitors as the most effective treatment modality in patients with a large tumor burden or rapid tumor growth, or both, is explained. Medullary Thyroid Carcinoma and Multiple Endocrine Neoplasia Type 2 will be an ideal source of up-to-date information for a wide range of practitioners, including endocrinologists, oncologists, internal medicine specialists, geneticists, and nuclear medicine physicians.Pheromone Signaling: Methods and Protocols
By Kazushige Touhara. 2013
Providing experimental methods and protocols for performing pheromone research in a variety of organisms ranging from invertebrates to vertebrates, Pheromone…
Signaling: Methods and Protocols covers a wide spectrum of experimental approaches necessary for handling pheromone molecules, measuring receptor response and neural activation, and analyzing behavioral output. A great deal of progress has been made in understanding the molecular mechanisms underlying pheromone action, largely due to the discovery of receptor genes, the advancement of imaging techniques, and key multi-disciplinary approaches including aspects of organic chemistry, biochemistry, molecular biology, electrophysiology, and behavioral science. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips for troubleshooting and avoiding known pitfalls. Authoritative and practical, Pheromone Signaling: Methods and Protocols details the key methodologies utilized in laboratories all over the world, making them accessible to those who want to begin investigation in the area of pheromone research.Medullary Thyroid Cancer
By Tracy S. Wang, Douglas B. Evans. 2016
This text provides a comprehensive, contemporary review of this disease and serves as an important resource for clinicians and researchers…
with an interest in medullary thyroid cancer. The book reviews the initial management of the patient with thyroid nodules, including risk factors, appropriate genetic evaluation of suspected/known medullary thyroid cancer, and appropriate screening for diseases associated with inherited forms of medullary thyroid cancer, including primary hyperparathyroidism and pheochromocytomas. It includes an in-depth discussion of the optimal surgical management of patients with sporadic and inherited disease, those with locoregional metastases, distant metastases, and recurrent medullary thyroid cancer. The long-term follow-up and management of patients with medullary thyroid cancer is highlighted. Medullary Thyroid Cancer will serve as a useful resource for all providers and researchers interested in this relatively rare and challenging malignancy. It highlights recent guidelines for the management of patients with medullary thyroid cancer and discusses controversies within the literature. All chapters are written by experts in the field and incorporate multiple disciplines, including Surgery (Endocrine Surgery, General Surgery, and Otolaryngology), Endocrinology, Radiology, Medical Oncology and Genetic Counseling.American Diabetes Association Complete Guide to Diabetes (3rd Edition)
By American Diabetes Association. 2002
Funktionsdiagnostik in Endokrinologie, Diabetologie und Stoffwechsel
By Christiane Girlich, Charalampos Aslanidis, Roland Büttner, Margarita Bala, Andreas Schäffler, Sylvia Wurm, Viktoria Guralnik, Thomas Karrasch, Cornelius Bollheimer. 2012
Der Leitfaden zur endokrinologischen Funktionsdiagnostik unterstützt eine effiziente Diagnostik und hilft, zuverlässige Ergebnisse zu erstellen. Dargestellt werden die 75 wichtigsten…
Funktionstests, darunter neueste Verfahren: Prinzip, Vorbereitung, Durchführung und Interpretation. Indikationen, Kontraindikationen und Nebenwirkungen werden detailliert und praxisgerecht erläutert. Ausgerichtet an den Leitlinien der Fachgesellschaften, liefert der praxistaugliche Leitfaden verlässliche Werte sowie konkrete Handlungsanweisungen und Entscheidungshilfen.Computational Neuroendocrinology
By Gareth Leng, Duncan J. Macgregor. 2016
A key aim of this cutting edge volume is to encourage interaction between researchers in neuroendocrinology and mathematical and computer…
modellers of biological systems, by showing the usefulness of this approach in analysing neuroendocrine systems, and in better understanding of the important disorders that result from their dysfunction. Computational modelling works through simulations, and providing readers with supporting video clips so that they can see the simulations discussed within the text will be a particularly important feature of this book.