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Showing 4861 - 4880 of 5208 items
By Saikat Sen, Raja Chakraborty, Biplab De. 2016
In the context of the continual increase in the global incidence of diabetes, this book focuses on particular aspects of…
the disease such as the socio-economic burden and the effects on individuals and their families. It addresses a wide range of topics regarding its physiological relevance, metabolic angles, biochemistry, and discusses current and upcoming treatment approaches. It is unique in offering a chapter dedicated to herbal remedies for diabetes. Appealing to a broad readership, it is a valuable resource for students, researchers and practitioners working in the area of glucose metabolism, diabetes and human health.By Stephan Herzig. 2016
The HEP issue on Metabolic Control provides a state-of the art overview over both classical concepts and emerging areas in…
metabolism and associated disorders. In this context, metabolic control is highlighted at various levels of complexity ranging from transcriptional mechanisms in metabolic pathway control over metabolic communication routes in physiology and pathophysiology to current treatment modalities and options in metabolic disorders, including type 2 diabetes and obesity. Dedicated chapters by leading experts in their fields provide a concise overview over important areas in metabolic research at a molecular level, including the role of the central nervous system in metabolism, inflammation and metabolism, pancreatic hormone signaling, brown adipose tissue, and therapeutic concepts.By Deborah L. Hay, Ian M. Dickerson. 2009
This book contains a comprehensive series of reviews on the calcitonin gene-related peptide (CGRP) family of peptides. This family of…
peptide hormones has a diverse and constantly expanding range of important physiologic functions, including regulation of blood calcium, vascular tension, feeding behavior and pain recognition. This volume includes chapters on: The adrenomedullin peptides and signalling Ligand binding and activation of the CGRP receptor Understanding amylin receptors The CGRP-receptor component protein The calcitonin peptide family Genetic regulation of CGRP Vascular actions of CGRP and adrenomedullin Intermedin/adrenomedullin 2 function CGRP and adrenomedullin as pain-related peptides Amylinergic control of ingestive behaviour Calcitonin receptors This book discusses their receptors, physiological and pathophysiological functions and potential as clinical targets. It will appeal to researchers who study any of these peptides and those with an interest in migraine therapy due to the involvement of CGRP in this disorder. The book is unique because it brings together research on the whole peptide family for the first time in several years. It will be a useful reference volume for researchers in this area. This book will also appeal to researchers in the broader field of bioactive peptides.By Richard C. Boucher, Maryse Picher. 2010
We proudly present the first book to integrate all aspects of purinergic signaling in the respiratory system. The first chapters…
introduce basic notions of purinergic pharmacology and metabolism, which allows readers from all scientific backgrounds to fully grasp the importance of these signaling networks for airway defenses, including mucociliary clearance and inflammatory responses. Then, chapters are devoted to the groundbreaking discovery that chronic respiratory diseases, including asthma, cystic fibrosis and chronic obstructive pulmonary disease (COPD), present specific aberrances in purinergic signaling which essentially drive lung complications. The last chapters describe the animal models used to investigate purinergic signaling in respiratory diseases, and the therapeutic applications developed by the pharmaceutical industry based on receptor agonists/antagonists and metabolic correctors. This highly comprehensive manuscript constitutes an invaluable tool for beginners and experts to follow the rapidly evolving research field of purinergic signaling. Furthermore, the critical analysis of past clinical protocols should facilitate the identification of potent therapeutic targets, and provide a better understanding of the data acquired in current clinical trials.By Geert Jan Biessels, Jose A. Luchsinger. 2010
Diabetes, particularly type 2, has become increasingly more common around the world. Consequently, the effect of diabetes on the brain…
has achieved enormous public health importance. A surge in pre-clinical and clinical research on topics ranging from management of hyperglycemia in acute stroke to disturbances in insulin signaling in Alzheimer's disease has led to substantial progress in the field. Written by a panel of international experts, Diabetes and the Brain provides in depth reviews on the cerebral complications of diabetes, and offers introductory chapters on current insights on the pathophysiology and clinical management of diabetes, as well as neuropsychological assessment and dementia. This relevant and easily accessible book explains the cerebral complications of diabetes, with an update on diabetes for neurologists, psychiatrists, and mental health providers and researchers in general,and on stroke and dementia for those involved in research and clinical practice in diabetes.By Irina Obrosova, Martin J. Stevens, Mark A. Yorek. 2014
Studies on Diabetes examines how increased oxidative and nitrosative stress - one of the leading causes of diabetes complications -…
pathologically affects multiple tissues in the body. The volume editors and chapter authors are leading investigators in the field of basic and clinical research in diabetes and vascular disease. Their contributions represent a wealth of knowledge on and research into how diabetes triggers metabolic abnormalities that lead to hyperactivation of cellular and mitochondrial pathways that ultimately result in oxidative and nitrosative stress that left un-neutralized, results in tissue damage. Each chapter provides the reader with invaluable insight to the complicated mechanisms responsible for diabetes complications and vascular disease. Potential treatments for diabetes complications from animal models to the patient will also be discussed. This is essential reading for researchers and clinicians in endocrinology, diabetes, vascular disease and oxidative stress.By Kathleen M. Gillespie. 2016
The aim of this volume is to presentcurrent methodologies to predict and understand the pathogenesis of Type-1Diabetes for clinical and…
non-clinical researchers. Writtenin the highly successful Methods in Molecular Biology series format,chapters include introductions to their respective topics, lists of thenecessary materials and reagents, step-by-step, readily reproducible laboratoryprotocols, and key tips on troubleshooting and avoiding known pitfalls. Practicaland reliable, Type-1 Diabetes: Methods and Protocols will aidresearchers in using these methods to advance their own studies.By Andrea R. Genazzani, Mark Brincat. 2014
This volume represents an up-to-date overview on the major areas of gynecological endocrinology, providing the reader with a complete explanation…
of female endocrine regulation and metabolism and relevant disorders and treatment. It is published within the International Society of Gynecological Endocrinology (ISGE) Series and is based on the 2013 International School of Gynecological and Reproductive Endocrinology Summer Course. The book covers a very wide range of topics - from primary amenorrhea to menopause, from the impact of ovarian surgery on fertility to fertility cryopreservation, from metabolic syndrome and polycystic ovary to premature ovarian failure and from the clinical impact of selective progesterone receptor modulators to the use of progesterone in prevention of premature labor. It will be an important tool for obstetricians and gynecologists, endocrinologists and experts in women's health as well as interested GPs.By Beata Lecka-Czernik, John L. Fowlkes. 2016
Providing the most up-to-date research and current clinical knowledge of diabetic bone disease and the challenges still facing the research…
and clinical care communities, this book unites insights from endocrinology and orthopedics to create a truly unique text. The first part covers clinical and pre-clinical applications and research. The first two chapters present the clinical and epidemiological data about diabetic bone disease, evaluated and reviewed for type 1 and type 2, respectively. This is followed by discussions of how the propensity to fracture in diabetic bone disease can impact fracture risk assessments and how it can be adjusted for using current clinically relevant fracture risk models. A comprehensive overview of orthopedic complications observed in diabetes is next, as well as a focus on the consequences of diabetes on periodontal disease. Other topics include the utility of skeletal biomarkers in assessing diabetic bone disease, how drugs used to treat diabetes may also have skeletal consequences, and the possibility that diabetes may fundamentally impact early progenitor cells of various bone lineages and thus globally impact bone. The second part covers biomechanics and bone quality in diabetes: how diabetes ultimately may impact the architecture, integrity, and quality of bone. Utilizing the expertise of top researcher and clinicians in diabetic bone disease in one comprehensive text, this volume will be a useful and thought-provoking resource for endocrinologists and orthopedic surgeons alike.By Clifford P. Shearman. 2015
Public and political concern about the increasing prevalence of diabetes has prompted major concern about treatment of patients withthe condition.…
Foot complications are some of the commonest causes ofhospitalisation of people with diabetes and if not treated well often lead toamputation. There is evidence that 85% of these amputations can be prevented by better understanding of the problem and by multi-disciplinary teams working more effectively together. This has been recognised and NICE have recently published guidelines on diabetic footcomplications as have Diabetes UK and NHS Diabetes. These have been successful in raising awareness of the problem but the local multi-disciplinary teams need clear practical advice on how to manage the foot in diabetes and deliver high quality care. With the current interest in improving outcomes for patients with foot complications this is an ideal time to make a practical evidence-basedhandbook available. This book will provide clear practical guidelineson how to manage all aspects of the foot in diabetes as well as an in-depthanalysis of the most recent evidence. The book will be based on care pathways with algorithms for each section so it would be of practical value in any clinic in primary or secondary care. It will appeal to a wide range of health care professionals treating people with diabetes: vascular surgeons and trainees, orthopaedic surgeons, diabetes specialist nurses, podiatrists and tissue viability nurses.By Atilla Engin, Ayse Basak Engin. 2015
This book discusses the relationship between cellular immunity and tryptophan metabolism, as well as its products, serotonin and melatonin, in…
the development of several diseases and reappraises the common signal transduction pathways of the neurodegenerative diseases, carcinogenesis, immune tolerance, inflammation, hypersensitivity reactions, neuropsychiatric disorders, in addition to bacterial tryptophan biosynthesis and novel antimicrobials. Tryptophan Metabolism: Implications for Biological Processes, Health and Disease presents fundamental information on tryptophan related metabolic pathways and metabolites, implications of these products for specific biological processes, diseases and conditions. This book focuses on effects of tryptophan metabolites on human health and will appeal to researchers, clinicians and students within this field.By Hieronim Jakubowski. 2013
Excess of homocysteine, a product of the metabolism of the essential amino acid methionine, is associated with poor health, is…
linked to heart and brain diseases in general human populations, and accelerates mortality in heart disease patients. Neurological and cardiovascular abnormalities occur in patients with severe genetic hyperhomocysteinemia and lead to premature death due to vascular complications. Although it is considered a non-protein amino acid, studies over the past dozen years have discovered mechanisms by which homocysteine becomes a component of proteins. Homocysteine-containing proteins lose their normal biological function and become auto-immunogenic and pro-thrombotic. In this book, the author, a pioneer and a leading contributor to the field, describes up-to date studies of the biological chemistry of homocysteine-containing proteins, as well as pathological consequences and clinical implications of their formation. This is a comprehensive account of the broad range of basic science and medical implications of homocysteine-containing proteins for health and disease.By Michael J. Wheeler. 2013
Hormone measurement is necessary for the diagnosis of a wide range of clinical conditions and is essential for monitoring the…
effectiveness of treatment. As the number of hormone requests in the clinical field rises exponentially, it has become imperative to create hormone assays accessible to researchers with a varied range of equipment. Hormone Assays in Biological Fluids, Second Edition reviews common techniques used to measure hormones as well as relatively new methods such as tandem mass spectrometry. Additionally, subsequent chapters detail methods for a broad range of hormones; Techniques and principles covered are transferable to a wide range of substances across species. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Hormone Assays in Biological Fluids, Second Edition will serve students, technologists, laboratory scientists, and researchers looking to apply, or attain a greater understanding of, methods for measuring hormones.By Dorte Møller Jensen, Per Glud Ovesen. 2011
A dramatic and worldwide increase is occurring in the prevalence of overweight and obesity in women of childbearing age. Obese…
women carry a significant excess risk of a variety of serious complications during pregnancy, and in addition, maternal obesity predisposes to obesity in the offspring. This book provides a timely update on the latest knowledge on maternal obesity and pregnancy. A very wide range of issues are covered, including macrosomia and associated shoulder dystocia; the risk of miscarriage, malformations, and complications of pregnancy; the impact of hyperglycemia; clinical management; consequences for anesthesia and ultrasound; impacts on breastfeeding, fertility, and childhood obesity; and pregnancy following gastric surgery. All of the authors are recognized experts in their fields, and the book has been designed to meet the practical needs of obstetricians, gynecologists, internists, and general practitioners.By Peter H. Lim. 2013
Men's Health is a concise, didactic compendium that covers three important aspects of male sexual health:- Testosterone Deficiency Syndrome; Premature…
Ejaculation and Sexually Transmitted Infections (STIs). The chapters that deal with Testosterone Deficiency Syndrome cover the epidemiology of the condition in the local context, the science behind the condition, its clinical presentation and treatment choices. The section on Premature Ejaculation advises the health practitioner on how to investigate this condition and describes the various treatment options available to the patient. The chapters on Sexually Transmitted Infections cover special aspects of the diagnosis, prevention and treatment of STIs occurring in Men which are not normally highlighted in the usual texts on STI management. Written by experts in the field, Men's Health is a valuable and timely resource for urologists, andrologists, endocrinologists as well as other health professionals practicing in these areas.By Ichiro Wakabayashi, Klaus Groschner. 2013
This book provides an introduction to the principles of both cardiovascular epidemiology and molecular pathophysiology; as a unique aspect, it…
also outlines and discusses the molecular concepts underlying epidemiological observations. This first volume is focused on the genetic and molecular basis of pathogenesis and the role of environmental factors triggering cardiovascular dysfunctions. The book promotes the use of interdisciplinary approaches in the field of preventive medicine based on recent advances in molecular and cellular pathophysiology. The book offers a valuable resource work for researchers in basic biomedical fields and clinical scientists alike, as well as guidelines for novel avenues of research in both basic pathophysiology and cardiovascular therapy and prevention.By Lee B Smith, Rod T Mitchell, Iain J Mcewan. 2013
This volume provides a brief résumé of the history of testosterone research, from the early pioneers through to the most…
recent advances in the field. We discover how steroid hormones were first identified and how testosterone was shown to be essential for male development. Moving forward we explore how and where testosterone is produced, and how the body controls testosterone production. We then investigate the impact testosterone has on different body systems both during their development and function, and how perturbation of testosterone action is associated with disease. We complete our story with an exploration of the emerging roles of testosterone in clinical therapy, and the future potential for manipulation of the testosterone signaling system for human health benefit.By María Alejandra Alvarez. 2014
In this book emphasis will be put in the relevance of Plant Biotechnology for producing compounds of pharmaceutical and industrial…
relevance specifically the contribution of in vitro plant cell cultures for producing recombinant proteins (molecular farming) and compounds produced by plants useful for human and animal health (secondary metabolites) will be discussed. Also the description of some process held by whole plants will be included. The aim will be to provide relevant theoretical frameworks and the latest empirical research findings for professionals and researchers working in the field of Plant Biotechnology, molecular farming and biochemical engineering.By Catherine Kim, Assiamira Ferrara. 2010
Gestational Diabetes Mellitus is becoming an increasingly prevalent disease as obesity and other chronic diseases are on the rise. It…
requires careful and informed clinical management as the care received during pregnancy affects not only perinatal health but the risk of developing type 2 diabetes even decades into the future, in both the mother and the child.From epidemiology and pathophysiology to diagnosis and management, covering recent breakthroughs in research and up-to-date developments in clinical practice, Gestational Diabetes During and After Pregnancy offers the reader a comprehensive and current look at Gestational Diabetes. Anyone involved in the research, public health or clinical aspects of Gestational Diabetes will find this volume a valuable aid in consolidating all recent developments regarding this disease.By John Merendino. 2009
LET BOB GREENE HELP YOU TAKE CONTROL OF YOUR HEALTH AND CLAIM THE LIFE YOU DESERVE! BOB GREENE has helped…
millions of Americans become fit and healthy with his life-changing Best Life plan. Now, for the first time, Oprah's trusted expert on diet and fitness teams up with a leading endocrinologist and an expert dietitian to offer a Best Life program tailored to the needs of people with diabetes and pre-diabetes. Coping with the unique challenges of living with these conditions can feel like a full-time job, but The Best Life Guide to Managing Diabetes and Pre-Diabetes gives you a gradual, three-phase plan designed to improve your blood sugar and stave off heart disease, neuropathy, and other diabetes- and pre-diabetes-related conditions. Whether you are controlling your disease simply with diet and exercise, taking drugs orally, or need injected insulin, this comprehensive volume gives you all the information you need to stay healthy and motivated. Detailed but flexible meal plans take the guesswork out of eating, and recipes for budget- and family-friendly dishes come with complete nutritional analyses. Extensive reference sections, including a complete guide to diabetes drugs and a chart of the carbohydrate value of foods, give you quick answers you can trust, while a log for tracking your blood sugar readings, exercise, diet, and medication helps you stay organized without hassle or added expense. With The Best Life Guide to Managing Diabetes and Pre-Diabetes, you won't have to let your life be defined by your diagnosis.