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Showing 2141 - 2160 of 3496 items
By George S Eisenbarth. 2011
Immunoendocrinology is a rapidly developing field of research that seeks to understand the intersection of the immune and endocrine systems.…
Immunoendocrinology: Scientific and Clinical Aspects explores in detail the current knowledge of immunoendocrinology, namely endocrine disorders produced by disorders of immune function. Chapters cover both basic pathophysiology informed by studies of animal models as well as current understanding of multiple related clinical diseases--their pathophysiology, diagnosis, and therapy. Immunoendocrinology: Scientific and Clinical Aspects captures the central role of immunoendocrinologic processes in the pathogenesis of not only type 1 diabetes but in a range of other autoimmune and endocrine disorders.By V. Srinivasan, Amnon Brzezinski, Sukru Oter, Samuel D. Shillcutt. 2014
The book aims to cover basic physiologic functions of melatonin, and its therapeutic applications in humans for a variety…
of clinically relevant disorders. This book contains chapters on the recent aspects of melatonin physiology, its receptors and their role in mitochondrial function, its immunomodulatory role and importance in seasonal dependent diseases, role in human reproduction, role in sleep, circadian rhythm and sleep disorders, role in neurologic disorders such as Parkinson's disease, Alzheimer's disease. Additionally, melatonin's therapeutic use in neurobehavioral disorders in children, migraine and tension headache is also covered in this book. Melatonin's antioxidant role in Duchenne's muscular dystrophy and in glaucoma have also been discussed in short chapters. Two major melatonin agonists, ramelteon and agomelatine are discussed extensively on their current clinical application and ongoing research. Two chapters on agomelatonin and its role in mood disorders, particularly depressive disorders, are an important feature of this book. The chapters are written by experts from the global academia recognized for their original research and published work in the field of melatonin science.By John Greenya. 2018
Learn all about Neil Gorsuch, the youngest judge to be nominated to the Supreme Court in twenty-five years, with this…
comprehensive and fascinating biography.When forty-nine-year-old Neil Gorsuch was nominated to the Supreme Court by President Donald Trump, he was told by a senator, “We need to know what’s in your heart.” Now, acclaimed author John Greenya seeks to answer that question with this captivating book. Born in Colorado, Gorsuch remains somewhat of a mystery to Democrats and Republicans alike. Based on intense research and interviews with people who have known Gorsuch in all periods of his life, both his opponents and his friends—from his early work as a lawyer and his year as a Justice Department official, to his ten-and-a-half years on the Federal bench, this is the best way to learn more about the conservative replacement to Justice Antonin Scalia.By Naranjan S. Dhalla, Belma Turan. 2014
Diabetes has long been recognized as a disease of high blood sugar, and there has been a continuous search of…
the exact reason for its development and effective treatment. In 2005, the World Health Organization had estimated that more than 180 million people worldwide suffer from diabetes mellitus and indicated that this figure is likely to double within the next 20 years. Among the 3. 8 million deaths each year associated with diabetes, about two thirds are attributable to cardiovascular complications, and diabetes is now considered to be a major metabolic risk factor for the occurrence of heart disease. Diabetic Cardiomyopathy: Biochemical and Molecular Mechanisms is a compilation of review articles devoted to the study on the topic with respect to biochemical and molecular mechanisms of hyperglycaemia. The wide range of areas covered here is of interest to basic research scientists, clinicians and graduate students, who are devoted to study the pathogenesis of diabetes-induced cardiovascular dysfunction. Furthermore, some chapters are directed towards increasing our understanding of novel ways for the prevention/treatment of cardiomyopathy. Twenty five articles in this book are organized in three sections. The first section discusses general aspects of the metabolic derangements in diabetic cardiomyopathy including metabolic alterations and substrate utilization as well as cardiac remodelling in the heart; role of diet in the development of metabolic syndrome in the heart; effect of hyperglycaemia in terms of biochemical and structural alterations in heart. In the second section, several cellular and molecular mechanisms are discussed indicating that diabetic cardiomyopathy is a multifactorial and complex problem. The third section discusses the prevention and treatment of diabetes using appropriate diet, proper supplements including antioxidants, angiotensin inhibitors and some other drugs. All in all, this book discusses the diverse mechanisms of diabetic cardiomyopathy with some information on new therapeutic approaches for finding solutions to prevent or reverse the development of cardiac dysfunction.By J Patrick Boyer. 2008
This richly detailed biography illustrates how a determined Canadian seeking justice created an enduring legacy. Through vigorous battles, Jim McRuer’s…
passion for justice was translated into laws that daily touch and protect the lives of millions today. James Chalmers McRuer was not easy to get along with or even much liked by many lawyers who dubbed him ’Vinegar Jim.’ Yet countless others saw him as heroic, inspirational, a man above and apart from his times. His resolute focus on justice changed the lives of married women with no property rights, children without legal protection, aboriginals caught in the whipsaw of traditional hunting practices and imposed game laws, and prisoners locked away and forgotten. Environmental degradation and those causing it, murderers, stock fraud artists and Cold War spies all came within the ambit of J. C. McRuer’s sharp legal mind and passion for justice. Upon turning 75, McRuer embarked on his most important work of all, becoming Canada’s greatest law reformer and remaining active into his 90s.By Mia Flores, Olivia Flores. 2017
An astonishing, revelatory, and redemptive memoir from two women who escaped the international drug trade, with never-before-revealed details about El…
Chapo, the Sinaloa Cartel, and the dangerous world of illicit drugs.Olivia and Mia Flores are married to the highest level drug traffickers ever to become US informants. Their husbands worked with--and then brought down--El Chapo, as well as dozens of high-level members of the Mexican cartels. They had everything money could buy: luxury cars, huge houses, and expensive jewelry--but they chose to give it all up when they cooperated with the US government. They knew that life was about more than wealth; it was about love, family, and doing what's right. CARTEL WIVES is a love story, a "Married to the Mob" story, an insider's look into the terrifying but high-flying empire of the new world of drugs, and, finally, the story of a major DEA and FBI operation.By Julia Macconville, Julie Edge. 2014
Meet Debbie - a young girl with diabetes type 1. Debbie invites readers to learn about this type of diabetes…
from her perspective, describing how it feels to have high and low blood sugar levels. She explains how she can monitor her blood sugar and controls it with medication. Debbie also talks about the challenges of having diabetes and lets readers know how she can be helped and supported. This illustrated book is ideal for young people aged 7 upwards, as well as parents, friends, teachers and nurses. It is also an excellent starting point for family and classroom discussions.The #1 bestseller that offers "a ground breaking, science-based, easy-to-follow prescription. Start your journey to healing now!" - Mehmet Oz,…
MDDr. Mark Hyman reveals that the secret to losing weight and preventing not just diabetes but also heart disease, stroke, dementia, and cancer is balanced insulin levels. Dr. Hyman describes the seven keys to achieving wellness-nutrition, hormones, inflammation, digestion, detoxification, energy metabolism, and a calm mind-and explains his revolutionary six-week healthy-living program. With advice on diet, green living, supplements and medication, exercise, and personalizing the plan for optimal results, this book also teaches readers how to maintain lifelong health. Groundbreaking and timely, THE BLOOD SUGAR SOLUTION is the fastest way to lose weight, prevent disease, and feel better than ever.By Maria Diakonova. 2015
Recent Advances in Prolactin Research summarizes the current knowledge of prolactin (PRL), PRL receptor, PRL-dependent signaling pathways, the role of…
PRL in oncogenesis and PRL crosstalk with other oncogenic factors. The chapters are written by experts in these fields and focus on identifying and reviewing timely experimental findings that provide new insights into the expanding role of PRL in the pathophysiology associated with a variety of human conditions. Prolactin is a peptide hormone that is best known for its role in lactation. Prolactin also has an influence on hematopoiesis and angiogenesis, and is involved in the regulation of blood clotting through several pathways. Although PRL was discovered more than 80 years ago, the understanding of PRL signaling and its relationship to various pathologies is still very incomplete. PRL is not only a pituitary hormone with an important role in reproduction, but PRL also acts as a cytokine, modulating a wide variety of physiological processes. For example, data gathered during the last decade have demonstrated that locally produced PRL acts as the autocrine/paracrine factor and plays a contributory role during breast oncogenesis. In fact, the scientific and clinical communities have suggested that the manipulation of the PRL axis may lead to the successful treatment of breast cancer. However, recent work has demonstrated that the role of the PRL axis is much more complex than first envisaged.By Jack Sanders. 2016
Ridgefield is no stranger to life's shadier characters. The history of this idyllic community includes cunning crooks, suburban embezzlers, bungling…
burglars and wandering scallywags. In 1894, a group of bank robbers literally blew it in a heist at the Saving Bank--the explosion attracted witnesses to see the gang miss out on a grand haul of fifty dollars. Half a decade later, in 1940, a skeleton whose origins still befuddle experts was unearthed in a tree nursery. This look at the darker side of Ridgefield's past includes sad and tragic moments as well, such as newlyweds imprisoned in the Tombs, the Satanists of the '70s and a hermit murdered for love. Local editor Jack Sanders tells fascinating tales of two centuries of Ridgefield criminals, n'er-do-wells and even wayward do-gooders in this entertaining--and occasionally humorous--glimpse into some of the town's wickedest moments.By Jiri Neuzil, Shazib Pervaiz, Simone Fulda. 2014
This book will be focused on mitochondria as very promising targets for anti-cancer drugs, yet to be fully exploited. It…
will contain chapters focused on aspects of basic research as well as on clinical relevance, which will be written by specialists in the field. That the role of mitochondria in human pathologies goes beyond the neoplastic diseases will be documented by a chapter of the role of mitochondria in Friedreich's ataxia.By Sharon Stewart. 2007
Louis Riel devoted his life to the Metis cause. A fiery activist, he struggled against injustice as he saw it.…
He was a pioneer in the field of Aboriginal rights and land claims but was branded an outlaw in his own time. In 1885, he was executed for treason. In 1992, the House of Commons declared Riel a founder of Manitoba. November 16 is now designated Louis Riel Day in Canada.By Edward Butts. 2006
Short-listed for the 2007 Arthur Ellis Award for Best Non-Fiction They were among Canada’s most desperate criminals, yet their names…
have been all but forgotten in the annals of history - until now! In their day these lawless men made headline news. Author Ed Butts has rescued their stories from dusty newspaper pages and polished them up for today’s readers in this fascinating volume. The Markham Gang introduced Canada West to organized crime long before anyone had heard of the Mafia. Lew Bevis took on the whole Halifax Police Department in a blazing gun battle. The wild Macdonald cousins went to Michigan, where they ended their violent careers as victims of a savage lynching. Reid and Davis, the notorious Border Bandits of the Roaring Twenties, were the nightmare of every banker from Manitoba to the state of Washington. This rogues’ gallery of killers, robbers, and men of mystery shocked the nation, challenged the forces of law and order, and sometimes even got away with it.By Beverley Boissery, F Murray Greenwood. 2000
In 1754 Eleanor Powers was hung for a murder committed during a botched robbery. She was the first woman condemned…
to die in Canada, but would not be the last.In Uncertain Justice, Beverley Boissery and Murray Greenwood portray a cast of women characters almost as often wronged by the law as they have wronged society. Starting with the Powers trial and continuing to the not-too-distant past, the authors expose the patriarchal values that lie at the core of criminal law, and the class and gender biases that permeate its procedures and applications.The writing style is similar to that of a popular mystery: "Harriet Henry lay dead. Horribly and indubitably. Her body sprawled against the bed, the head twisted at a grotesque angle. Foam engulfed the grinning mouth." Scholarly analysis combines with the narrative to make Uncertain Justice a fascinating and engaging read.There is a wealth of information about the emerging and evolving legal system and profession, the state of forensic science, the roles of juries, and the political turmoil and growing resistance to a purely class-based aristocratic form of government.By Capt. R. G. Carter. 2017
When it was first published in 1935, On the Border with Mackenzie, or Winning West Texas from the Comanches quickly…
became known as the most complete account of the Indian Wars on the Texas frontier during the 1870s, and remains one of the most exhaustive histories ever written by an actual participant in the Texas Indian Wars.The author, Capt. Robert G. Carter, a Union Army veteran and West Point graduate, was appointed in 1870 to serve as second lieutenant in the Fourth United States Cavalry stationed at Fort Concho, Texas. He was awarded the Medal of Honor in 1900 for his gallantry in action against the Indians occurring on October 10, 1871, during the battle of Blanco Canyon. Led by Col. Ranald Slidell Mackenzie, the Fourth Cavalry moved its headquarters to Fort Richardson, Texas, in 1871 where they soon became one of the most effective units on the western frontier. Among the battles and skirmishes they participated in were the Warren wagon train raid of 1871; the Kicking Bird pursuit of 1871; the Remolino fight of 1873; the Red River War of 1874-75; and the Black Hills War of 1876.“…a splendid contribution to the early frontier history of West Texas…a story filled with humor and pathos, tragedies and triumphs, hunger and thirst, war and adventure.”—L. F. Sheffy“…[Carter] pulls no punches in this outspoken narrative, and the reader always knows where he stands.”—John H. Jenkins, Texas Basic Books“…essential to any study of the Indian Wars of the Southern Plains.”—Charles Robinson, ForewordBy M D Byron Hoogwerf, Mark Victor Hansen, Jack Canfield. 2012
This new book in the successful Healthy Living formula--inspirational stories followed by positive, practical medical advice for caregivers and patients--addresses…
one of America's most frustrating and dangerous recurring conditions Diabetes isn't just an illness anymore: It is an epidemic in American society that has increasingly been explained as an outgrowth of our lifestyle choices. This book explains what causes diabetes, how to prevent it--especially how to prevent it in loved ones like husbands and children--and most importantly how to live well once you've developed the condition. Most of us know what we should do; this book gives you the inspiration you need to actually follow through. In the Healthy Living series, Chicken Soup for the Soul partners with the nation's top medical experts and organizations to give emotional support and important information to people with specific medical needs. The books feature approximately twelve positive, heartwarming stories from real people, followed by relevant expert medical advice that will positively impact the reader's life. Subjects such as diet, psychological issues, family relations, and alternative therapies exist side-by-side with traditional subjects such as understanding common medical terms, the effects of treatment options, and the doctor-patient relationship. Each book contains source notes and a resources section for more information and support.By Kerry Karram. 2013
A harrowing tale of human intelligence pitted against the forces of nature. With prospectors, trappers, and whalers pouring into northwestern…
Canada, the North West Mounted Police were dispatched to the newest frontier to maintain patrols, protect indigenous peoples, and enforce laws in the North. In carrying out their duties, these intrepid men endured rigorous and dangerous conditions.On December 21, 1910, a four-man patrol left Fort McPherson, Northwest Territories, heading for Dawson City, Yukon, a distance of 670 kilometres. They never arrived. The harrowing drama of their 52-day struggle to survive is an account of courageous failure, one that will resonate strongly in its depiction of human intelligence pitted against the implacable forces of nature. Based on Fitzgerald’s daily journal records, Death Wins in the Arctic tells of their tremendous courage, their willingness to face unthinkable conditions, and their dedication to fulfill the oath they took. Throughout their ordeal, issues of conservation, law enforcement, Aboriginal peoples, and sovereignty emerge, all of which are global concerns today.By Susan Goldenberg. 2004
In 1934, fifty-three-year-old beer tycoon John Sackville Labatt was kidnapped from his Lake Huron summer home and held ransom for…
three days. His captors, a group of ex-rumrunners, desperate in the days following prohibition and the Great Depression, were hoping for a big payday. This bizarre true crime story traces the abduction through to the trials of the abductors. From a heavily populated hideout to a case of mistaken identity, follow the story of Labatt, the first person in Canada to be kidnapped for high ransom.By George D Finlayson. 2003
John J. Robinette, Canada’s greatest trial lawyer, was admired and respected by the bench and his fellow lawyers alike. A…
quiet, unassuming man outside the courtroom, he was a consummate performer when appearing before a judge and jury. Robinette became a household name as the defender of Evelyn Dick, who was charged with killing her husband and infant son in Hamilton in 1946, and of Steven Suchan, a member of the infamous Boyd Gang. He was Canada’s pre-eminent lawyer from the 1930s to the 1980s, showing unparalleled versatility and virtuosity whether acting as counsel in criminal, civil, or constitutional cases, at both the trial and appeal levels. This is the story of a great man, of the maturing of the legal profession in Canada, and of Canada in the twentieth century.By William A. Noguera. 2018
An ABA Indies Introduce Top Ten Title for Winter 2018William A. Noguera has spent thirty-four years at the notorious San…
Quentin Prison, home to the nation’s largest and deadliest death row. Each day, men plot against you and your life rests on a razor’s edge. In Escape Artist, he describes his personal growth as a man and artist and shares his insights into daily life and the fight to survive in the underworld of prison culture. After being sentenced to death, he arrived at San Quentin Prison and was thrown into a rat-infested cell—it was there that he discovered the key to his escape: art. Over the next three decades, Noguera rebelled against conventional prison behavior, and instead forged the code he lives by today—accepting responsibility for his actions, and a self-imposed discipline of rehabilitation. In the process, he has explored his capacity to bring focus and clarity to his artistic vision. Escape Artist exposes the violence, politics and everyday existence within the underbelly of society that is prison life. In an unprecedented narrative, Noguera reveals the emotional and heart-wrenching loss that landed him on death row and the journey he has taken to become an award-winning artist, speaker, and author—a tale of one man’s transformation through tragedy.