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Masterful, ambitious, and groundbreaking, this is a major new history of our country by one of our most respected thinkers…
and historians -- a book every Canadian should own. From the acclaimed biographer and historian Conrad Black comes the definitive history of Canada -- a revealing, groundbreaking account of the people and events that shaped a nation. Spanning 874 to 2014, and beginning from Canada's first inhabitants and the early explorers, this masterful history challenges our perception of our history and Canada's role in the world. From Champlain to Carleton, Baldwin and Lafontaine, to MacDonald, Laurier, and King, Canada's role in peace and war, to Quebec's quest for autonomy, Black takes on sweeping themes and vividly recounts the story of Canada's development from colony to dominion to country. Black persuasively reveals that while many would argue that Canada was perhaps never predestined for greatness, the opposite is in fact true: the emergence of a magnificent country, against all odds, was a remarkable achievement. Brilliantly conceived, this major new reexamination of our country's history is a riveting tour de force by one of the best writers writing today.Living with Lupus: Women and Chronic Illness in Ecuador
By Ann Miles. 2013
Once associated only with the wealthy and privileged in Latin America, lifelong illnesses are now emerging among a wider cross…
section of the population as an unfortunate consequence of growing urbanization and increased life expectancy. One of these diseases is the chronic autoimmune disorder lupus erythematosus. Difficult to diagnose and harder still to effectively manage, lupus challenges the very foundations of women's lives, their real and imagined futures, and their carefully constructed gendered identities. While the illness is validated by medical science, it is poorly understood by women, their families, and their communities, which creates multiple tensions as women attempt to make sense of an unpredictable, expensive, and culturally suspect medically managed illness. Living with Lupus vividly chronicles the struggles of Ecuadorian women as they come to terms with the experience of debilitating chronic illness. Drawing on years of ethnographic research, Ann Miles sensitively portrays the experiences and stories of Ecuadorian women who suffer with the intractable and stigmatizing disease. She uses in-depth case histories, rich in ethnographic detail, to explore not only how chronic illness can tear at the seams of women's precarious lives, but also how meanings are reconfigured when a biomedical illness category moves across a cultural landscape. One of the few books that deals with the meanings and experiences of chronic illness in the developing world, Living with Lupus contributes to our understanding of a significant global health transition. Once associated only with the wealthy and privileged in Latin America, lifelong illnesses are now emerging among a wider cross section of the population as an unfortunate consequence of growing urbanization and increased life expectancy. One of these diseases is the chronic autoimmune disorder lupus erythematosus. Difficult to diagnose and harder still to effectively manage, lupus challenges the very foundations of women's lives, their real and imagined futures, and their carefully constructed gendered identities. While the illness is validated by medical science, it is poorly understood by women, their families, and their communities, which creates multiple tensions as women attempt to make sense of an unpredictable, expensive, and culturally suspect medically managed illness. Living with Lupus vividly chronicles the struggles of Ecuadorian women as they come to terms with the experience of debilitating chronic illness. Drawing on years of ethnographic research, Ann Miles sensitively portrays the experiences and stories of Ecuadorian women who suffer with the intractable and stigmatizing disease. She uses in-depth case histories, rich in ethnographic detail, to explore not only how chronic illness can tear at the seams of women's precarious lives, but also how meanings are reconfigured when a biomedical illness category moves across a cultural landscape. One of the few books that deals with the meanings and experiences of chronic illness in the developing world, Living with Lupus contributes to our understanding of a significant global health transition.Managing Cardiovascular Complications in Diabetes
By Stephen Nicholls, D. John Betteridge. 2014
Of all the complications which arise from diabetes, cardiovascular complications are by far the most prevalent and the most deadly.…
Authored by some of the world's leading names in this area, this outstanding book provides all those managing diabetic patients with clinical, practical and succinct guidance to the diagnosis and management of cardiovascular complications in diabetes.With a joint endocrinology and cardiology focus, and with the very latest in clinical guidelines from the ADA, EASD, AHA, ASC and ESC, selected highlights include:- The role of new biomarkers of cardiovascular disease in diabetes- The latest on diagnosis of cardiovascular problems via vascular imaging- Hypertension and cardiovascular disease in the diabetic patient- Dyslipidaemia and its management in type 2 diabetes - Management of thrombosis, acute coronary syndrome and peripheral arterial disease in diabetes Key points, case studies and self-assessment questions allow for rapid-reference, quick understanding of all topics, thus ensuring that this is perfect reading for endocrinologists, diabetes specialists and cardiologists of all levels managing patients with diabetes and associated cardiovascular problems.The Last Gang in Town
By Aaron Chapman. 2016
Decades before organized crime syndicates brought sensational drug wars to Vancouver, street gangs held sway over its unruly east side.…
None was considered tougher or more feared than the Clark Park gang, a wild, two-fisted crew of characters from Vancouver's post-1960s counterculture. In 1972, after a number of headline-making riots and clashes with police―including an infamous altercation outside a Rolling Stones concert―the Clark Parkers became the target of a secret undercover police squad. Their hostile interactions culminated in a notorious police shooting, resulting in the death of a Clark Park gang member. Combining meticulous research with a keen flair for storytelling, The Last Gang in Town features previously unpublished photos and police documents, as well as testimonials by surviving gang members and police officers who speak for the first time on the subject. The book is a compelling portrait of early-1970s Vancouver and an intriguing and sensational history that puts the spotlight on the after-dark underbelly of the city's not-so-distant criminal past.Passages: Welcome Home to Canada
By Shyam Selvadurai, Anna Porter, Alberto Manguel, M. G. Vassanji, Nino Ricci, Michelle Berry, Ying Chen, Brian D. Johnson, Dany Laferriere, Ken Wiwa, Moses Znaimer. 2002
Foreword by Michael Ignatieff, Preface by Rudyard Griffiths, The Dominion Institute. Without departure, there is no arrival -- this is…
the experience of some of Canada's best-known émigré authors and public figures, shared in Passages: Welcome Home to Canada. In first-hand accounts, these celebrated writers explore the excitement and anguish of uprooting to a new country. Childhood memories, familiar streets, the aromas of local cooking, long-cherished plans -- to leave all this behind can only be traumatic. And yet, to find a haven from oppression and danger, a place to carve out a new identity and put down new roots -- this is a thrill only an emigrant can know. In Passages we see this terrible pain and once-in-a-lifetime opportunity for growth in delicate balance. Alberto Manguel discovers the quiet pleasure of citizenship after years of cosmopolitan wandering. Ken Wiwa looks for a fresh start, far from the shadow of his martyred father in Africa. Nino Ricci, having grown up in an old-world Italian community transplanted to rural Ontario, describes his passage into the larger world, where other families don't bake their own bread or slaughter their own pigs. Shyam Selvadurai tells of his flight from the intolerance of his native Sri Lanka, where, as a Tamil and a homosexual, he found himself unwelcome. Moses Znaimer describes his parents' hair-raising escape first from Hitler and then Stalin, a series of adventures through Eastern Europe and Central Asia and finally across the Atlantic. Introduced by Michael Ignatieff, Passages explores what it means to be a foreigner, what it means to be a writer and what it means to be a Canadian -- and what it means to be all three at once. Contributors: Michelle Berry * Ying Chen * Brian D. Johnson * Dany Laferriere * Alberto Manguel * Anna Porter * Nino Ricci * Shyam Selvadurai * M. G. Vassanji * Ken Wiwa * Moses Znaimer.The Budget-Friendly Fresh and Local Diabetes Cookbook
By Charles Mattocks, The Poor Chef. 2014
Local food traditions can blossom into regional cuisines and offer tastes and memories that last a lifetime. With some smart…
selections, these cuisines, made with fresh, local ingredients, can also improve your health and the health of your family. What most people don't know? Foods from your local market are an incredible bargain. Chef Charles Mattocks combines his flair for using fresh, locally grown foods with his engaging presentation to offer a budget-friendly taste of what your local farmer's market can bring to your table. Diagnosed recently with type 2 diabetes, Chef Mattocks offers tips on creating and maintaining the perfect pantry, finding fresh foods, and, most important of all, preparing and serving meals that won't break the bank. The Budget-Friendly Fresh and Local Diabetes Cookbook is the perfect collection for those who want to improve their health, take advantage of local and sustainable foods, and save money at the same time.Inside the Law: Canadian Law Firms in Historical Perspective
By Carol Wilton. 1991
Law firms are important economic institutions in this country: they collect hundreds of millions of dollars annually in fees, they…
order the affairs of businesses and of many government agencies, and their members include some of the most influential Canadians. Some firms have a history stretching back nearly two hundred years, and many are over a century old. Yet the history of law firms in Canada has remained largely unknown. This collection of essays, Volume VII in the Osgoode Society's series of Essays in the History of Canadian Law, is the first focused study of a variety of law firms and how they have evolved over a century and a half, from the golden age of the sole practitioner in the pre-industrial era to the recent rise of the mega-firm. The volume as a whole is an exploration of the impact of economic and social change on law-firm culture and organization. The introduction by Carol Wilton provides a chronological overview of Canadian law-firm evolution and emphasizes the distinctiveness of Canadian law-firm history.Tissue-Specific Estrogen Action
By Tim Wintermantel, Kenneth S. Korach. 2007
Current molecular understanding of estrogen action has greatly profited from advances in molecular cell biology. These advances, and their implications…
for clinical use, were discussed by leading researchers from industry and academia during an international symposium held in Berlin, 1-3 March 2006 and are featured in this volume.Pediatric Metabolic Syndrome
By Tracie Miller. 2012
In just under three decades, the world has witnessed an enormous rise in obesity with a parallel growth in cardiometabolic…
disease risk factors characterized by insulin resistance, dyslipidemia, and hypertension, together known as the metabolic syndrome - conditions previously unheard of in children and adolescents. During this time, we have little knowledge of the global and cumulative detrimental health effects of childhood obesity. As obese children age, not only will their health be negatively affected, but infertility and pregnancy complications associated with the metabolic syndrome will affect generations to come. The work force will undoubtedly be affected because of increased sick days and decreased work productivity. Identifying children and adolescents at the earliest stages of chronic disease onset should be the goal of clinical practice, yet there is no clear guidance for defining the risk of metabolic syndrome or appropriate risk-factor thresholds in these groups. If children are identified early in the disease process, lifestyle and clinical interventions can be instituted when they are potentially more effective. Pediatric Metabolic Syndrome: Comprehensive Clinical Review and Related Health Issues approaches the pediatric metabolic syndrome by elucidating its effects on specific organ systems and by considering the problem through understanding the social, psychological and economic consequences of it. The Editors have recruited an invited group of esteemed experts in the field to provide the most timely and informative approaches on how to deal with this health crisis. Through educating our practitioners, our future researchers, our health and community organizations, our legislators and our families and children, we have the best chance at improving the health trajectory of the next generation.Pancreatic Cancer, Volume 1
By John P. Neoptolemos, Markus W. Büchler, Raul A. Urrutia, James Abbruzzese. 2010
Worldwide, there are an estimated 232, 000 new cases of pancreatic cancer annually. In the United States, it is the…
fourth leading cause of cancer death, and approximately 30,000 people die of pancreatic cancer each year. The disease is difficult to diagnose in its early stages, and most patients have incurable disease by the time they present with symptoms. The overall 5-year survival rate for this disease is less than 5%. In organizing this handbook, Dr. Neoptolemos and his co-editors will produce a distinguished Major Reference Work devoted to pancreatic cancer. This handbook will have widespread appeal among clinicians, pathologists and basic scientists who are now struggling to understand this complex and rapidly expanding field. Because of the recent and vast growth in both the clinical and scientific research being done in pancreatic cancer (there is currently an unprecedented investment by academia and industry in this field), each researcher’s knowledge of other specialty areas outside his or her own is now often quite limited. The aim of this book is to place these the tangible advances—those that are indispensable to all working on pancreatic cancer—readily at hand. The book will focus on advances that will not become dated, and the editors will choose authors who are the very best in each area.Diabetes und Schwangerschaft
By Gabriele Buck, Helmut Kleinwechter, Simone Claudi-Böhm, Wolfgang E. Paulus, Gudrun Jütting, Bernhard Böhm. 2012
Schwangerschaft bei Diabetes? Dank neuer Therapien können sich Diabetikerinnen heutzutage ihren Kinderwunsch erfüllen. Voraussetzung ist allerdings die kompetente, lückenlose Begleitung…
der Schwangerschaft. Experten bieten hierfür alle notwendigen Informationen (inkl. Gestationsdiabetes) - praxisbezogen, übersichtlich und verständlich. Exakt erläutern sie welche Maßnahmen, wann und wie einzusetzen sind. Alles rund um die Prävention sowie Begleit- und Folgeerkrankungen: wichtige Parameter und deren Überwachung, Diagnose, Therapie, medikamentöse Intervention. Ein hilfreicher Ratgeber für werdende Mütter sowie alle Fachleute, die sie betreuen.A Dutch Homesteader On The Prairies: The Letters of Wilhelm de Gelder 1910-13
By Herman Ganzevoort, Willem De Gelder. 1973
The letters in this volume, found in the original Dutch in the archives of the Netherlands Emigration Service in Holland,…
form a unique chronicle of one European homesteader in Saskatchewan from 1910 to 1913. They were written by Willem dr Gelder whose experience as a homesteader was typical of that of hundreds of thousands of newcomers to the prairies in the greatest years of western expansion just before the First World War. As a European immigrant he was able to write from a special perspective often ignored in Anglo-Saxon accounts of western development. Minute and perceptive observations of daily life are contained in his letters; together with the recollections of friends and neighbours who spoke well of him, this volume forms the portrait of a singular man who personified the toughness and persistence of the western pioneer. De Gelder was born in the 1880s in Doorn, the son of a well-to-do banker, and received all the benefits of birth in an upper-class home, including a university education. He came to Canada in 1910 and by the 1920s he had become a successful homesteader owning a half-section of land, meeting his bills, and joining in the community life. But in 1922 he rented out his land, went to the Netherlands to see his family, and returning to Canada he disposed of his homestead – and vanished. This book traces the compass of his life in Canada, revealing the doubts and fears which culminated in his disappearance; it highlights the anguish that all immigrants, new and old, suffered when they took the crucial step of beginning a new life.Canadian Whisky: The Portable Expert
By Davin De Kergommeaux. 2012
Davin de Kergommeaux takes readers on a journey through the first systematic presentation of Canadian whisky: how it's made, who…
makes it, why it tastes the way it does, its history, and the rich, centuries-old folklore surrounding it. Join whisky authority Davin de Kergommeaux on a pan-Canadian journey from British Columbia to Nova Scotia, celebrating the diversity of Canada's unique spirit. With his conversational and accessible tutelage, de Kergommeaux offers readers a carefully researched, reliable, and authoritative guide to Canadian whisky that is, quite simply, not available anywhere else. Not only a book describing the history and culture of the spirit, Canadian Whisky: The Portable Expert is also an informed exploration of taste. For the first time, whisky consumers -- experts and novices alike -- can approach Canadian whisky with a connoisseur's appreciation of its rich subtleties.Sex Hormones and Immunity to Infection
By Craig Roberts, Sabra L. Klein. 2010
Why sex matters Among human and nonhuman animals, the prevalence and intensity of infection typically is higher in males than…
females and may reflect differences in exposure as well as susceptibility to pathogens. Elevated immunity among females is a double-edged sword in which it is beneficial against infectious diseases but is detrimental in terms of increased development of autoimmune diseases. The present book critically reviews the evolutionary origin and the functional mechanisms responsible for sexual dimorphism in response to infection. It emphasizes the value of examining responses in both males and females to improve our understanding about host-pathogen interactions in both sexes. The contributors are experts in their specific disciplines which range from microbiology and immunology to genetics, pathology, and evolutionary biology. The book aims at bringing insight to the treatment and management of infectious diseases; it delineates areas where knowledge is lacking and highlights future avenues of research.Sperm Chromatin
By Ashok Agarwal, Armand Zini. 2011
Sperm DNA damage is common and has been associated with reduced rates of conception, impaired embryonic development and increased risk…
of miscarriage. Although the exact causes of sperm DNA damage are unknown, it is clear that infertile men possess substantially higher levels of sperm DNA damage than do fertile men. Written by leading, internationally renowned clinicians and basic scientists with expertise in sperm DNA, Sperm Chromatin: Biological and Clinical Applications in Male Infertility and Assisted Reproduction provides readers with a thoughtful and comprehensive review of the biological and clinical significance of sperm DNA damage. The work covers the fundamental principles of sperm chromatin architecture and function, the proposed modes of DNA damage and repair, the tests of sperm DNA damage, the clinical aspects of DNA damage and the impact of DNA damage on reproductive outcome. Unlike any other title on the topic, Sperm Chromatin: Biological and Clinical Applications in Male Infertility and Assisted Reproduction is an invaluable addition to the literature and will serve as an indispensable resource for basic scientists with an interest in sperm biology and for urologists, gynecologists, reproductive endocrinologists, and embryologists working in the field of infertility.Startle and Illuminate: Carol Shields on Writing
By Carol Shields, Anne Giardini. 2016
In the course of her extraordinary career, which included the novels The Stone Diaries, Larry's Party, The Republic of Love…
and Unless, as well as poetry, short stories, biography and plays, Carol Shields was unfailingly encouraging of other writers. She read and commented on her friends' manuscripts. She taught writing classes and she spoke and wrote on the craft of writing. Her own discipline rarely faltered. Her daily practice was to write a new page, then edit the page written the day before, then repeat, until, after a year or so, her book was finished. Now in her own words, as clear and straightforward as a glass of water, comes Startle and Illuminate, the best possible guide to the writing process, from conception to publication. This essential work, drawn by her daughter and grandson from her voluminous correspondence with other writers, essays, notes, comments, criticism and lectures, is a last gift from one of our finest novelists meant for both aspiring and established writers. It helps answer some of the most fundamental questions about writing: such as, why we write at all, whether writing can be taught, what keeps a reader turning the pages, and how a writer knows when a work is done. For Shields's devoted readers, Startle and Illuminate reveals her own thoughts on why we read--to be the other, to touch and taste the experience of the other; and why we write--for the joy of the making, to reimagine our world, to discover patterns and uncover forms that echo our realities as well as interrogate them, to imagine alternate worlds. It is a beautiful legacy.Diabetes Mellitus in Developing Countries and Underserved Communities
By Sam Dagogo-Jack. 2017
Adopting a truly global perspective and a practical approach to diabetes--including pathophysiology, genetics, regional peculiarities, management, prevention and best practices--this…
book is an excellent resource for clinicians and policy-makers working with patients in more austere settings. The global prevalence of diabetes is estimated to increase from 422 million in 2014 to 592 million in 2035. Sadly, low- and middle-economy countries are projected to experience the steepest increase, but even in developed economies, vulnerable demographic subgroups manifest disparities in diabetes prevalence, quality of care, and outcomes. This book extends coverage to those underserved and minority communities in the developed world. In a consistent chapter format, it discusses classification, pathophysiology, genomics, diagnosis, prevention and management of diabetes in economically challenged regions as well as underserved populations in affluent nations. Suggestions regarding future directions in the organization of diabetes care delivery, prevention and research priorities are also provided. The detailed identification of barriers to optimal care and the practical approach to the management and prevention of diabetes make Diabetes Mellitus in Developing Countries and Underserved Communities a valuable resource for clinicians, researchers and health policy leaders.Thyroid Hormone Receptors
By Aria Baniahmad. 2002
A panel of outstanding investigators surveys and explains the major cutting-edge methods used in thryroid receptor (TR) research and explains…
their practical experimental details. Described in step-by-step detail to ensure robust experimental results, the techniques presented cover a wide variety of key areas, including TR in development and knockout (mouse and Xenopus), transcriptional regulation by TRs in both cell-free systems and in living cells, and TR mutant analysis of patients. Additional methods provide powerful tools for the isolation of TR-regulated protein complexes, for studying the oncogene v-Erba in blood cell differentiation, and for target gene analysis in the brain. Microarray chip methods are also presented for analyzing the organs of transgenic mice to identify target genes in the liver.Pediatric Endocrinology
By Sally Radovick, Margaret H. Macgillivray. 2013
A state-of-the-art and concise guide to the clinical management of pediatric endocrine disorders, the second edition of the highly regarded…
Pediatric Endocrinology: A Practical Clinical Guide covers the most common and challenging conditions seen by practicing endocrinologists and primary care physicians, including growth, hypothalamic, pituitary, adrenal, thyroid, calcium and bone, and reproductive disorders, as well as metabolic syndromes. This expanded second edition includes new topics being seen more commonly in pediatric endocrinology practices related to obesity and type 2 diabetes mellitus and lipid disorders. Each chapter contains an introductory discussion of the problem, a review of the clinical features that characterize it, the criteria needed to establish a diagnosis, and a comprehensive therapy section delineating the risks and benefits of the best therapeutic options available. Invaluable tables summarize the critical factors in etiology, clinical presentation, diagnosis, and therapeutic dosages. Pediatric Endocrinology: A Practical Clinical Guide, Second Edition, is a comprehensive resource for all clinicians concerned with the myriad endocrinologic disorders seen in children and adolescents.Stem Cell Therapy for Diabetes
By Shimon Efrat. 2010
Stem Cell Therapy for Diabetes, one of the latest installments of the Stem Cell Biology and Regenerative Medicine series, reviews…
the three main approaches for generation of sufficient numbers of insulin-producing cells for restoration of an adequate beta-cell mass: beta-cell expansion, stem-cell differentiation, and nuclear reprogramming. Adeptly collecting the research of the leading scientists in the field, Stem Cell Therapy for Diabetes compares the merits of employing autologous versus banked allogeneic cell sources for generation of surrogate beta cells, and addresses tissue engineering and ways for cell protection from recurring autoimmunity and graft rejection. Stem Cell Therapy for Diabetes provides essential reading for those especially interested in tracking the progress in applying of one of the most exciting new developments in bio-medicine towards a cure for diabetes.