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Showing 101 - 120 of 1491 items
By David Clemmons, Iain C.A.F. Robinson. 2010
Insulin-like growth factors (IGFs), their binding proteins and their receptors play important roles in regulating growth, metabolism, proliferation and survival…
for many cells and tissues throughout lifespan in humans and other species. Circulating IGF1 is known to be an endocrine regulator, with metabolic effects related to, and partly convergent with, insulin signalling. IGF1 also mediates many of the growth promoting effects of GH, and there is an ongoing debate as to the relative contributions of endocrine-, vs locally-derived IGF1 for systemic growth. More recently however, it has become clear that IGFs may be key local growth and cellular survival factors for many different tissues, active from early in embryonic development, essential for normal maturation and growth during foetal life. IGFs continue to play important roles throughout adult life in many diverse processes such as tissue repair, cellular proliferation, tissue remodelling and metabolic regulation. IGF systems are tightly regulated; orderly control of cellular repair and metabolism is central to healthy ageing, whilst uncontrolled proliferation can lead to cancer.By Thomas E. Curry, Ok-Kyong Park-Sarge. 2009
Over the course of the last hundred years, the field of endocrinology has received ever-increasing attention. Research and developing technologies…
have resulted in a significant leap in our understanding of the causes and treatment of endocrine dysfunction. In Molecular Endocrinology: Methods and Protocols, leaders in the field share a diversity of cutting-edge techniques that are becoming routinely employed in the quest to further understand hormone action. In order to reach the widest number of labs, this volume includes protocols that allow investigators at all stages of their scientific career to successfully perform these techniques. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include brief introductions to their respective subjects, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and expert notes on troubleshooting and avoiding known pitfalls. Comprehensive and easy to use, Molecular Endocrinology: Methods and Protocols is an ideal guide for researchers in labs across the world who seek a deeper understanding of the complex processes and biology of hormones.By Vivian Cody, Samantha J. Richardson. 2009
There is a strong interest in transthyretin (TTR) in connection with protein evolution, medical and clinical research. Thus, this is…
an exciting time for experts in TTR research to come together to write a monograph covering both the basic and the clinical research into TTR. Transthyretin is a protein found in human blood and cerebrospinal fluid. It is directly involved in the transport of thyroid hormones, and indirectly in that of retinol. These hormones are essential for normal growth and development, particularly that of the brain. Spontaneous and inherited diseases affecting transthyretin result in amyloidosis. More than 80 point mutations in transthyretin lead to a variety of illnesses. Liver transplants are the most common treatment, although much research is also being carried out in drug therapies. The evolution of transthyretin has been extensively investigated - from humans to bacteria, invertebrate animals and plants. The structure of the protein has not changed, but its function has changed significantly. This is a most exciting example for the study of the evolution of protein structure-function relationships. This monograph will bring the reader up to date on the latest developments and discoveries.By James F. Mckinsey, Gautam V. Shrikhande. 2012
In Diabetes and Peripheral Vascular Disease, a panel of distinguished leaders in the field of medicine, podiatry, and vascular and…
endovascular therapy assimilate the latest literature on these issues and others for an in-depth review of the management of peripheral vascular disease. Providing an overview of the management of diabetes and diabetic foot changes as well as providing a view of cutting-edge and emerging topics in optimization of arterial status, this important title addresses pathophysiology, anatomy, diagnosis and management of diabetic peripheral vascular disease, emphasizing a multi-disciplinary approach. The first chapter of the book provides an overview of this complex disease process and discusses the teamwork required for optimal management. The chapters continue with the basic pathophysiology of diabetic atherosclerosis and a contemporary review of the management of diabetes. The genesis of diabetic foot ulceration and prevention and management strategies is covered, as is the effects of neuropathy and microvascular changes in the diabetic foot. In addition, Diabetes and Peripheral Vascular Disease covers the microbiology of diabetic foot infections, the role of endovascular interventions and vascular surgery as well as the management of the complications of these procedures, the process of amputation for those patients who have progressed beyond a limb salvage situation, and the effects of diabetes on the cerebrovascular system as well as its implications in patients with aortoiliac disease. An invaluable addition to the literature on diabetes and peripheral vascular disease, the book will be of great interest internists, family practitioners, surgeons, podiatrists, wound care specialists, and vascular specialists. Students, residents, and fellows in surgical and medical specialties should also find this book of significant value and interest.By Evanthia Diamanti-Kandarakis, Andrea C. Gore. 2012
Endocrine disruption represents one of the most controversial environmental issues of our time. Mounting evidence stemming from more than 10…
years of experimental, epidemiological and clinical studies has transformed the once generally discounted subject of endocrine disruptors into an issue of tremendous concern not only within the scientific community but among society as a whole. Following initial evidence from basic research, endocrine disruption in humans has now emerged as a major medical challenge. In this respect, puberty, a crucial developmental stage, has been definitively identified as a key window of vulnerability with regard to endocrine disruptors. Written by leading authorities in the field, Endocrine Disruptors and Puberty offers an engaging and comprehensive overview of this fascinating and rapidly growing problem. An indispensable resource for all clinicians and scientists interested in this challenging endocrinologic topic, Endocrine Disruptors and Puberty is a timely contribution that will help navigate a path toward understanding the problem and developing solutions.By Meidjie Ang. 2016
This SpringerBrief focuses on clinical nutrition research particularly on the effects of slowly absorbed carbohydrates on postprandial glucose…
metabolism in type 2 diabetes Slowlyabsorbed carbohydrates will cause gradual increases in blood glucose and insulin levels and may therefore be effective as part of a treatment strategy for glycemic control and reduction of cardiovascular complications in type 2 diabetesBy Michael Pugia. 2015
This book discusses recent advances in new anti- and pro-inflammatory pathways in diabetic disease and identifies new diagnostic immunological…
methods that offer potential companion diagnostics for diabetic diseases New methods in proteomics mass spectroscopy immunological assay design measurement of cellular signal transduction and protease inhibition are used to clarify new biochemical pathways Biomarker validation in animal models and correlations in humans for diagnostic clinical trials shed new light on the impact of diabetic diseases The book reviews current understanding of inflammatory pathways in the pathophysiology of insulin resistance metabolic syndrome nephritis and other diabetic inflammatory conditions and is the first to describe the impact of novel adipokines protease inhibitors and complement markers By presenting new methodologies for biomarker discovery it provides a valuable resource for researchers studying clinical diagnosis drug development bio-analytical chemistry proteomics and biochemistry It is also useful for those conducting clinical and biological studies for targeted drug development The methodologies and approaches can be applied to other markers and the information will be helpful in the preparation of research grant applicationsBy David Simmons, Helmut Wenzel, Janice C. Zgibor. 2017
Integrating care across disciplines and organisations around the needs of the person with diabetes has been proposed as an approach…
that could improve care while reducing cost- but has it and can it? Integrated Diabetes Care- A Multidisciplinary Approach collates evidence of worldwide approaches to both horizontal integration (across disciplines) and vertical integration (across organizations) in diabetes care and describe what was done, what worked and what appeared to be the barriers to achieving the goals of the programmes. Evidence is sought from groups who have developed different approaches to integrating diabetes care in different health systems (eg insurance vs tax payer funded, single vs multiple organization, published vs unpublished). A final chapter brings the evidence together for a final discussion about what seems to work and what does not.By Peter Hien. 2012
Der Band behandelt Grundlagen, Diagnostik und Therapie von Lungenerkrankungen. Was ist medizinisch und ökonomisch sinnvoll? Wie lässt sich die Kooperation…
zwischen ambulanter und stationärer Betreuung im Sinne des Patienten optimieren? Welche Werte müssen wie oft kontrolliert werden? Diese und andere Fragen beantwortet das Praxishandbuch knapp, klar und auf dem neuesten Stand von Diagnostik und Therapie. Vorgestellt wird eine individuell abgestimmte Stufentherapie, die Begleiterkrankungen, Alter und Geschlecht des Patienten berücksichtigt.By Aled Rees, Andrew Lansdown, Miles Levy. 2017
Recognising a need to promote and enhance teaching of clinical endocrinology and diabetes in UK medical schools, the Society for…
Endocrinology, in collaboration with Diabetes UK and the Association of British Clinical Diabetologists, created a national curriculum that sets out the minimum recommended standards for undergraduate medical education. Clinical Endocrinology and Diabetes at a Glance corresponds to the curriculum and covers all important areas of diabetes and endocrinology in a clinically relevant and concise manner, with complementary figures to ensure principles are explained clearly. It highlights key practical skills for undergraduates in line with the GMC recommendations that medical graduates should be well prepared for their Foundation posts. There is also emphasis on the importance of multidisciplinary teams in the management of endocrine diseases and diabetes. These include sections on structured education programmes, psychosocial aspects, and patient self-management and monitoring. Clinical Endocrinology and Diabetes at a Glance will serve as a valuable resource for medical students and junior doctors treating patients with these conditions.By Zvi Laron, J. Kopchick. 2011
Laron syndrome (LS), or primary growth hormone (GH) insensitivity, was first described in 1966. Since then, many patients worldwide have…
been diagnosed with LS, which involves defects in the GH receptor that cause combined congenital deficiency of GH and IGF-I activities. In this comprehensive book the authors draw upon 50 years of multidisciplinary clinical and investigative follow-up of the large Israeli cohort of LS patients. The genetic basis of the syndrome is fully considered, and all aspects of the pathophysiology of IGF-I deficiency are described. Data derived from the recently generated mouse model of LS are reviewed and compared with the human LS experience. Valuable advice is provided on treatment, and treatment effects, such as metabolic effects, adipose tissue alterations, and impact on aging, are fully explored. Together, this book condenses, consolidates, compares, and contrasts data derived from the human and mouse LS experiences and provides a unique resource for clinical and basic scientists to evaluate and compare IGF-I and GH actions.By Richard E. Brown, Michael Wilkinson, Wilkinson, Michael and Brown, Richard E.. 2015
How does the brain regulate sexual behavior, or control our body weight? How do we cope with stress? Addressing these…
questions and many more besides, this thoroughly revised new edition reflects the significant advances that have been made in the study of neuroendocrinology over the last twenty years. The text examines the importance of the hypothalamus in regulating hormone secretion from the endocrine glands, describing novel sites of hormone release including bone, heart, skeletal muscle and liver. The role of steroid hormone, neurotransmitter and peptide receptors, and the molecular responses of target tissues, is integrated into the discussion of the neuroendocrine brain, especially through changes in gene expression. Particular attention is attached to neuropeptides, including their profound influence on behavior. Complete with new full-color figures throughout, along with review and essay questions for each chapter, this is an ideal resource for undergraduate and graduate students of neuroscience, psychology, biology and physiology.By Adolf F. Holstein, Ralf Middendorff, Michail S. Davidoff, D. Müller. 2009
The discovery of the neuroendocrine features of Leydig cells gave rise to the hypothesis of a potential neuroectodermal and/or neural…
crest origin of testicular Leydig cells. In an experimental animal model the authors revealed that adult Leydig cells originate by transdifferentiation from stem/progenitor cells (pericytes and smooth muscle cells), underlying the close relationship of Leydig cells with testis microvasculature. This and the supporting data from the literature provided the basis for revealing the pericytes as a common adult stem cell type of mammalian species. Distributed by the microvasculature through the entire body, the pericyte, acting as a resting early pluripotent adult stem cell, provides an ingenious system to assure the maintenance, physiological repair and regeneration of organs, each under the influence of specific local environmental factors.By Jr., Brendan C. Stack, Donald L. Bodenner. 2016
Medical and Surgical Treatment of Parathyroid Diseases is an accessible and user-friendly guide, addressing the key points of parathyroid diseases…
using case studies, as well as hundreds of high quality images and illustrations. Written and edited by respected leaders in the field of parathyroid surgery, this book aids in the comprehension of innovative concepts and focuses on the latest in clinical research. Written for otolaryngologists and oncologists at various stages of experience, Medical and Surgical Treatment of Parathyroid Diseases includes chapters dedicated to parathyroid anatomy, physiology, and embryology, medical therapy for parathyroid disease (indications and pharmacotherapy), diagnostic imaging, surgical treatments, and special topics such as health services and healthcare economics related to parathyroid surgery. By Celia Roberts. 2015
Puberty has long been recognised as a difficult and upsetting process for individuals and families, but it is now also…
being widely described as in crisis. Reportedly occurring earlier and earlier as each decade of the twenty-first century passes, sexual development now heralds new forms of temporal trouble in which sexuality, sex/gender and reproduction are all at stake. Many believe that children are growing up too fast and becoming sexual too early. Clinicians, parents and teachers all demand something must be done. Does this out-of-time development indicate that children's futures are at risk or that we are entering a new era of environmental and social perturbation? Engaging with a diverse range of contemporary feminist and social theories on the body, biology and sex, Celia Roberts urges us to refuse a discourse of crisis and to rethink puberty as a combination of biological, psychological and social forces.By Leo Plouffe. 2015
A practical approach to the field of androgen excess or deprivation in women's health. The content includes multiple viewpoints on…
the most common disorders in this class, such as polycystic ovary disease, hirsutism and menopausal issues. Each chapter provides a combination of long-lasting clinical principles in the diagnosis and management of these patients along with a state-of-the-art review. This text takes an innovative approach to uncommon conditions (such as congenital adrenal hyperplasia, transgender conditions). In addition to presenting clinical insights, and a review of the basic science underpinning these conditions, it focuses on key concepts that can be derived from these rare conditions to the entire field. This book is an essential addition to the library for any busy clinician who is looking for a practical reference guide but also for the sub-specialist who is looking for new and thought-provoking insights in this complex scientific area.By Leonard Wartofsky, Douglas Van Nostrand. 2016
Thoroughly revised and extensively expanded, this encyclopedic, highly acclaimed title addresses all aspects of the etiology, pathogenesis, diagnosis, initial treatment…
and long-term management of all varieties of thyroid cancer. Expertly edited by Drs. Leonard Wartofsky and Douglas Van Nostrand, this gold standard reference is divided into 11 Parts: General Considerations on Thyroid Cancer; General Considerations on Nuclear Medici≠ the Thyroid Nodu≤ Well-Differentiated Thyroid Cancer; Variants of Thyroid Cancer, Undifferentiated Tumors: Medullary Thyroid Carcinoma; Undifferentiated Tumors: Thyroid Lymphoma; Undifferentiated Tumors: Anaplastic Thyroid Cancer; New Frontiers and Future Directions; and Additional Resources. With exceptional breadth and depth, the book includes chapters dedicated to isotopes, isotope uptake and scanning procedures such as SPECT/CT, radioiodine ablation (with or without recombinant human TSH), stunning, dosimetry (with or without recombinant human TSH), Octreotide and FDG-PET scanning and other alternative imaging modalities. There is a valuable reference atlas of scan images and illustrations, and a scholarly summary of the side effects of radioiodine and how to avoid or minimize adverse effects of treatment. In addition to an updated section on ultrasonography of the thyroid gland, new sections have been added, including ones on ultrasonography of cervical lymph nodes and imaging for thyroid cancer employing computerized tomography (CT), positron emission tomography (PET) and magnetic resonance imaging (MRI). An indispensable reference source with chapters written by the field's leading authoritative experts, Thyroid Cancer: A Comprehensive Guide to Clinical Management, Third Edition, will be of great interest to not only pathologists, endocrine surgeons, endocrinologists, nuclear medicine physicians, and oncologists but all clinicians with an interest in thyroid cancer.This volume provides a detailed step-by-step description of protocols for the establishment of in vitro cultures of important medicinal plants,…
their mass multiplication in controlled environment, and step-wise secondary metabolite analysis. Many of these protocols also provide a basis for in vitro germplasm conservation or cryopreservation of medicinal plant species. Written for the Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Protocols for In Vitro Cultures and Secondary Metabolite Analysis of Aromatic and Medicinal Plants, Second Edition aims to ensure successful results in the further study of this vital field.By Michael Freemark. 2010
Childhood obesity and its co-morbidities -- including type 2 diabetes, hypertension, dyslipidemia, sleep apnea, and fatty liver disease -- have…
seen striking increases in recent years. Despite a wealth of investigation, there is considerable controversy regarding the etiology of childhood obesity and the optimal approaches for prevention and treatment. Pediatric Obesity: Etiology, Pathogenesis, and Treatment addresses the controversy with a range of features that make it a unique resource for those who care for obese children and their families. Written from a perspective that is international in scope, the distinguished authors re-assess the roles of genetic and environmental factors in the pathogenesis of childhood obesity and critically review new studies of the effects of lifestyle, pharmacologic, and surgical interventions. The evidence-based approach of Pediatric Obesity: Etiology, Pathogenesis, and Treatment provides a comprehensive and invaluable guide for all healthcare providers concerned with the evaluation and care of children with nutritional and metabolic disease and with the societal implications of the obesity epidemic.Diabetes is a complex disease--but learning about it shouldn't be!A Type 2 diabetes diagnosis can be daunting, but it is…
also manageable. With this all-in-one guide, you will get expert advice on establishing a healthier lifestyle and getting control of your diabetes. The Everything Guide to Managing Type 2 Diabetes provides easy-to-follow advice on all aspects of living with diabetes, and helps you:Recognize the symptoms of prediabetes and diabetesMonitor your blood glucose levelsLearn about the types of insulin and insulin-delivery systemsUnderstand the importance of nutrition and exerciseReduce the short- and long-term effects of diabetes Filled with reliable advice and the latest information on medication, therapies, blood sugar monitoring, and more, this invaluable guide shows you how to take control of your diabetes and enjoy your life!