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Showing 649861 - 649880 of 1369767 items
By Johanna-Gabriela Walter, Katharina Urmann. 2020
This book reviews the development, characterization and applications of aptamers in different areas of biotechnology ranging from therapeutics to diagnostics…
and protein purification. Hailed as chemical antibodies, these single-stranded nucleic acid receptors were predicted to supersede antibodies in traditional assays, such as ELISA, within a short time. While this has yet to happen, readers will find in this book a deep insight into the progress of aptamer technology and a critical discussion about the limitations that need to be overcome in order to find wider acceptance and use outside of the still relatively small aptamer-community. This book covers all aspects of aptamer generation and application for the aptamer-experienced reader and curious novice alike, with the addition of an industry perspective on the future of aptamer-use in biotechnology.By Christoph W. Michalski, Jonas Rosendahl, Patrick Michl, Jörg Kleeff. 2020
This book incorporates a multi-disciplinary approach to present how research results can be translated into clinical trials. The first part…
begins with a chapter on variants of pancreatic cancer, precursor lesions and groups of people at risk to developing the disease. There is a particular focus on intraductal papillary mucinous neoplasia as a large-scale clinical challenge in pancreatology. The next two parts focus on diagnosis, biomarkers and stratification that emphasize how various approaches to biomarker development are important as both prognostic and predictive tools. The final part consists of personalized treatment approaches that include preclinical models of pancreatic cancer and stromal, epigenetic and metabolism targeting as promising approaches to be translated into early phase clinical trials. Chapters within this part also deal with approaches that are close to being implemented in clinical practice or are already being tested in (early) clinical trials, such as those that targeting the immune systems and strategies to overcome immunotherapy resistance; phase 1 clinical trials and translational approaches in surgical treatment. Written by experts in their fields, Translational Pancreatic Cancer Research provides an outlook towards future directions by integrating information both from basic and clinical research and though demonstrating pathways to better understanding pancreatic cancer and current approaches to translating these into clinical practice.M&A-Transaktionen sind deutlich komplexere Vorgänge als der bloße Kauf und Verkauf von Gütern - da können KMU schnell in unbekanntes…
Terrain geraten – ganz besonders, wenn es sich um vielschichtige Aktivitäten mit Akteuren aus völlig anderen Kulturen handelt, insbesondere aus China, als Deutschlands größtem Außenhandelspartner. Entsprechend groß ist der Wissensbedarf in der Praxis. Dieser Herausgeberband bündelt daher auf theoretischer Basis das praktische Wissen für die erfolgreiche Planung, Durchführung und Integration deutsch-chinesischer Unternehmensübernahmen im Mittelstand. Nach einer kompakten Darstellung von volkswirtschaftlichem Hintergrund, kulturellen Aspekten der Verhandlungsführung und regulatorischen Rahmenbedingungen wird detailliert auf den Ablauf von Unternehmenstransaktionen und deren deutsch-chinesische Besonderheiten eingegangen. Den Abschluss bilden ein Leitfaden rund um die Kernaspekte solcher Transaktionen und die exemplarische Darstellung von Fallstudien. In allgemeinverständlicher Sprache und gut veranschaulicht zeigen sich so die Erfolgsfaktoren genauso wie mögliche Stolperfallen. Ein klar strukturiertes und klug formuliertes Handbuch, das jeder Akteur griffbereit haben sollte.By Manish Soneja, Puneet Khanna. 2020
Infections in intensive care is a very broad topic, and this book provides concise yet comprehensive coverage. It focuses on…
the appropriate and judicious use of microbiological, radiological and point-of-care tests in diagnostic work-ups and evidence-based management protocols. Moreover, it offers essential information on the diagnosis and management of commonly encountered infections in the intensive care unit, making it a handy ready-reference manual for intensivists.By Tim Lahaye, Jerry B. Jenkins. 2000
from Nicolae High, Vicki and Judd attempt escape. A friend's betrayal puts Vicki on trial. With Old Testament prophecies coming…
true before their eyes, the Young Trib Force struggles to spread the truth no matter what the cost. But the noose is tightening. Will the group stick together? Who is the insider at the school helping them? Follow Judd, Vicki, Lionel, and Ryan and the growing Young Trib Force as they continue their perilous journey through the earth's last days.By Barbara Schöning. 2015
Considered to be sub-ordinated and sub-prime to the city, sub-urban areas receive little attention by researchers and designers. However, it's…
the rapidly growing areas outside the central cities that pose the biggest questions of the urban millennium: How can the scattered patchwork of urban areas and social spaces linked by networks of highways and public transportation function as a sustainable and livable urban environment? Answering this question requires understanding suburban spaces as heterogeneous urban areas with distinct local characteristics, qualities, and problems. Following this path, Variations of Suburbanism explores formation, characteristics, and trends of suburban areas all over the world. It provides insights on common features and differences of suburban governance, design, and infrastructure and discusses strategies to understand and design suburban areas in an increasingly sub-urbanizing world.By Edited by Chongyang Institute for Financial Studies Renmin University of China. 2016
How can the G20 fulfill their role most efficiently in the post-crisis era, and what role do the emerging economies…
play in the new global economic order? This timely volume provides an overview of the most important challenges ahead for the G20, especially China.By Conrad Kunze, Sören Becker. 2015
This book offers a comprehensive and detailed overview of successful renewable energy projects in the European Union. After the decision…
of several European governments to change energy policies in favor of renewable energy sources, the number of nuclear power plants as well as overall coal production have decreased significantly already. Conrad Kunze and Sören Becker present recent energy projects that have successfully managed the change towards sustainable energy while functioning within local economies and adhering to the principles of participation, collective property, and ecologic awareness. Using a selection of 15 examples, the authors showcase the already existing parallel universe of 'small alternatives' and argue that, if used properly, renewable energy projects can not only lead the way in the fight against climate change but facilitate societal change on an even larger scale.By Timofey Agarin. 2014
Antiziganism is a widespread phenomenon in all European societies. Poor or rich, 'postcommunist' or 'traditional', North or South, with 'lean'…
or 'thick' welfare systems?all European societies demonstrate antiziganist prejudice. All across Europe Romanis are among the poorest, most destitute, and most excluded communities. Widespread prejudice and stereotypical representations of Romani individuals limit their chances for participation in democratic decision making processes and their access to services. Unable to counteract majority stereotypes systematically, more often than not they remain on the fringes of society. This edited volume asks where these stereotypes and prejudices come from, why they are ubiquitous to all societies, and how pertinent their impact on antiziganist attitudes found in European societies really is.By Yana Zausaeva, Artemy Pozanenko, Natalia Zhidkevich, Juri Plusnin. 2015
This timely book offers a fresh perspective on the issue of contemporary migratory labor, otkhodnichestvo, in Russia—the temporary departure of…
inhabitants from small towns and villages for short-term jobs in the major cities of Russia. Although otkhodnichestvo is a mass phenomenon, it is not reflected in official economic statistics. Based on numerous interviews with otkhodniks and local experts, this stunningly original work focuses on the central and northern regions of European Russia. The authors draw a social portrait of the contemporary otkhodnik and offer a sociological assessment of the economic and political status these "wandering workers" live with.This book deals with the Slovak National Uprising (SNP) that was launched on 29 August 1944 in Banská Bystrica, Slovakia.…
In the West, the uprising is an under-researched topic in the history of WWII. The Slovak state was an ally of Nazi Germany, but the uprising proved that the population did not share the regime’s ideology.This captivating volume brings together case studies drawn from four post-Soviet states—Russia, Ukraine, Belarus, and Moldova. The collected papers illustrate…
how the events that started in 1985 and brought down the USSR six years later led to the rise of fifteen successor states, with their own historicized collective memories. The volume’s analyses juxtapose history textbooks for secondary schools and universities and explore how they aim to create understandings as well as identities that are politically usable within their different contexts. From this emerges a picture of multiple perestroika(s) and diverging development paths. Only in Ukraine—a country that recently experienced two popular uprisings, the Orange Revolution and the Revolution of Dignity—the people themselves are ascribed agency and the power to change their country. In the other three states, elites are, instead, presented as prime movers of society, as is historical determinism. The volume’s contributors are Diana Bencheci, Andrei Dudchik, Liliya Erushkina, Marharyta Fabrykant, Alexandr Gorylev, Andrey Kashin, Alla Marchenko, Valerii Mosneaga, Alexey Rusakov, Natalia Tregubova, and Yuliya Yurchuk.By Lex Fullarton. 2016
Solar power has taken a journey from what was once considered the lunatic fringe to mainstream society and industry. Looking…
specifically at the Solex project in Carnarvon, Western Australia, which pioneered the harvest of solar energy, this book offers an introduction to the development of renewable energy and the rise of dispersed, embedded solar energy systems in Australia in the early 2000s. Fullarton shows how a practical demonstration of innovative existing technology can have an incredible impact on a national scale. The ideas behind the Solex project were adopted by the broader community and were eventually taken up enthusiastically by the general population of Australia. Analyzing government and utility policies throughout the 2000s, the book traces how ambivalence was followed by wholehearted incentives to the roll-out of alternative energy and then by active opposition to alternative energy in favor of traditional fossil fuel as government philosophies changed.By Daniel Karthe, Sergey Chalov, Nikolay Kasimov, Martin Kappas. 2015
The water resources of the Selenga River/Lake Baikal system are essential to the ecosystems and economic development of the surrounding…
region. In this large river and lake basin, there are strong contrasts between relatively pristine areas and massive anthropogenic impacts on the environment. The effects of climate change are more pronounced than in most other parts of the earth, and the transition from socialism into a market-oriented economy has led to a boom in mining but also to a partial collapse of environmental monitoring and urban wastewater management systems. Moreover, the expansion of agriculture and mining has triggered considerable land use change, rising water consumption, and the release of contaminants that had previously been unknown to the region. The consequences for the water resources and the aquatic and terrestrial ecosystems depending on them have become increasingly visible in recent years. This book, which is based on contributions to the 2014 Bringing Together Selenga-Baikal Research Conference, provides multidisciplinary insight into current water-related challenges and strategies for their solution from the viewpoint of the international scientific community.By Mohammad A. Tayebi, Uwe Glässer, David B. Skillicorn. 2020
This book shows how open source intelligence can be a powerful tool for combating crime by linking local and global…
patterns to help understand how criminal activities are connected. Readers will encounter the latest advances in cutting-edge data mining, machine learning and predictive analytics combined with natural language processing and social network analysis to detect, disrupt, and neutralize cyber and physical threats. Chapters contain state-of-the-art social media analytics and open source intelligence research trends. This multidisciplinary volume will appeal to students, researchers, and professionals working in the fields of open source intelligence, cyber crime and social network analytics. Chapter Automated Text Analysis for Intelligence Purposes: A Psychological Operations Case Study is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.By Jonathan P. Bowen, Zhiming Liu, Zili Zhang. 2020
This book constitutes the refereed proceedings of the 5th International School on Engineering Trustworthy Software Systems, SETSS 2019, held in…
Chongqing, China, in April 2019.The five chapters in this volume provide lectures on leading-edge research in methods and tools for use in computer system engineering. The topics covered in these chapter include Seamless Model-based System Development: Foundations; From Bounded Reachability Analysis of Linear Hybrid Automata to Verification of Industrial CPS and IoT; Weakest Preexpectation Semantics for Bayesian Inference: Conditioning, Continuous Distributions and Divergence; K – A Semantic Framework for Programming Languages and Formal Analysis Tools; and Software Abstractions and Human-Cyber-Physical Systems Architecture Modelling.By Mychailo Wynnyckyj. 2019
In early 2014, sparked by an assault by their government on peaceful students, Ukrainians rose up against a deeply corrupt,…
Moscow-backed regime. Initially demonstrating under the banner of EU integration, the Maidan protesters proclaimed their right to a dignified existence; they learned to organize, to act collectively, to become a civil society. Most prominently, they established a new Ukrainian identity: territorial, inclusive, and present-focused with powerful mobilizing symbols.Driven by an urban “bourgeoisie” that rejected the hierarchies of industrial society in favor of a postmodern heterarchy, a previously passive post-Soviet country experienced a profound social revolution that generated new senses: “Dignity” and “fairness” became rallying cries for millions. Europe as the symbolic target of political aspiration gradually faded, but the impact (including on Europe) of Ukraine’s revolution remained. When Russia invaded—illegally annexing Crimea and then feeding continuous military conflict in the Donbas—Ukrainians responded with a massive volunteer effort and touching patriotism. In the process, they transformed their country, the region, and indeed the world. This book provides a chronicle of Ukraine’s Maidan and Russia’s ongoing war, and puts forth an analysis of the Revolution of Dignity from the perspective of a participant observer.Zitovás literary analysis starts at the interface of Czech and German literature in the first half of the twentieth century.…
Thomas Mann's novel Joseph and His Brothers is set in comparative relation to Ivan Olbracht's prose texts Nikola Šuhaj loupeník and Golet v údolí. Olbracht translated three volumes of Mann's Joseph's tetralogy parallel to the composition of his own prose works. Zitová examines the influence of Olbracht's translation work on his own work. Zitovás literaturwissenschaftliche Analyse setzt an einer Schnittstelle der tschechischen und deutschen Literatur in der ersten Hälfte des zwanzigsten Jahrhunderts an. Thomas Manns Roman Joseph und seine Brüder wird vergleichend in Beziehung gesetzt zu Ivan Olbrachts in den dreißiger Jahren entstandenen Prosatexten Nikola Šuhaj loupeník und Golet v údolí. Olbracht übersetzte parallel zur Abfassung seiner Prosawerke insgesamt drei Bände aus Manns umfangreicher Josephs-Tetralogie. Diese Übersetzertätigkeit blieb, wie Zitová aufzeigt, nicht ohne Einfluss auf sein eigenes Schaffen. Das Buch knüpft an eine von Jirí Opelík geschriebene Studie Olbrachts reife Schaffensperiode sub specie seiner Übersetzungen aus Thomas Mann und Lion Feuchtwanger (1967) an, in der dieser tschechische Literaturwissenschaftler das Thema eröffnete. Mit Zitovás Tiefenanalyse schließt sich diese germanobohemistische Forschungslücke.The dynamic between the biographer and the subject is one of the most fascinating aspects of biography as a genre.…
How does the biographer stage the illusion that is the narrative life, the illusion that the subject assumes a living form through words? In contrast to purely fictional forms, biography writing does not allow total freedom to the biographer in this creative act. Ideally, a biography's backbone is structured by accurate historical facts. But its spirit lies elsewhere. Rana Tekcan explores how some of the most accomplished biographers manage to recreate "life" across time and space. She looks at their illusionary art through the narrative strategies in Samuel Johnson's Life of Savage, James Boswell's Life of Johnson, Lytton Strachey's Eminent Victorians, Michael Holroyd's Lytton Strachey, Park Honan's Jane Austen, and Andrew Motion's Keats. She notes three types of distance in biographical narrative: First, where the biographer and the subject personally know one another; second, where the biographer is a near contemporary of the subject; and third, where biographer and subject are distinctly separated, in some cases, by hundreds of years.By Michael Kuhn, Shujiro Yazawa. 2015
This innovative book provides new perspectives on the globalization of knowledge and the notion of hegemonic sciences. Tying together contributions…
of authors from all across the world, it challenges existing theories of hegemonic sciences and sheds new light on how they have been and are being constructed. Examining more closely the notions of 'human rights' and 'individualization', this much-needed volume offers new and alternative ideas on how to transform the universalization of the Western model of science and can serve as an eye-opener for all those interested in non-hegemonic scientific discourse.