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Pediatric Endocrinology
By Sally Radovick, Margaret H. Macgillivray. 2013
A state-of-the-art and concise guide to the clinical management of pediatric endocrine disorders, the second edition of the highly regarded…
Pediatric Endocrinology: A Practical Clinical Guide covers the most common and challenging conditions seen by practicing endocrinologists and primary care physicians, including growth, hypothalamic, pituitary, adrenal, thyroid, calcium and bone, and reproductive disorders, as well as metabolic syndromes. This expanded second edition includes new topics being seen more commonly in pediatric endocrinology practices related to obesity and type 2 diabetes mellitus and lipid disorders. Each chapter contains an introductory discussion of the problem, a review of the clinical features that characterize it, the criteria needed to establish a diagnosis, and a comprehensive therapy section delineating the risks and benefits of the best therapeutic options available. Invaluable tables summarize the critical factors in etiology, clinical presentation, diagnosis, and therapeutic dosages. Pediatric Endocrinology: A Practical Clinical Guide, Second Edition, is a comprehensive resource for all clinicians concerned with the myriad endocrinologic disorders seen in children and adolescents.Stem Cell Therapy for Diabetes
By Shimon Efrat. 2010
Stem Cell Therapy for Diabetes, one of the latest installments of the Stem Cell Biology and Regenerative Medicine series, reviews…
the three main approaches for generation of sufficient numbers of insulin-producing cells for restoration of an adequate beta-cell mass: beta-cell expansion, stem-cell differentiation, and nuclear reprogramming. Adeptly collecting the research of the leading scientists in the field, Stem Cell Therapy for Diabetes compares the merits of employing autologous versus banked allogeneic cell sources for generation of surrogate beta cells, and addresses tissue engineering and ways for cell protection from recurring autoimmunity and graft rejection. Stem Cell Therapy for Diabetes provides essential reading for those especially interested in tracking the progress in applying of one of the most exciting new developments in bio-medicine towards a cure for diabetes.Hypertension and Stroke
By Philip B. Gorelick, Venkatesh Aiyagari. 2011
This timely volume addresses the intimate pathophysiologic relationship between hypertension and cardiovascular disease. Hypertension is one of the most important…
global public health challenges, and its relationship to stroke and other catastrophic cerebrovascular diseases is an area of growing understanding. In this outstanding book, the editors and authors clearly and concisely synthesize our developing knowledge and place epidemiologic and physiologic information into a practical clinical context. Comprehensive chapters present the evidence supporting strategies for stroke prevention and care, including blood pressure lowering therapies, anti-coagulation, and management of other cerebrovascular risk factors. In addition to prescriptive measures for first stroke prevention, the book illuminates current regimens for care immediately after acute stroke and for the prevention of recurrent stroke. A unique section is dedicated to the exploration of the interaction between elevated blood pressure and brain function and cognition. The concluding chapter provides a resource towards optimizing the organization of stroke care. Hypertension and Stroke is of great utility for specialists in neurology and cardiovascular medicine and a valuable practical resource for all physicians caring for older adults and hypertensive patients.Thyroid Disorders with Cutaneous Manifestations
By Warren R. Heymann. 2008
The spectrum of the cutaneous manifestations of thyroid disease includes cutaneous metastases from thyroid malignancies and thryoglossal duct cysts, nonspecific…
alterations of the skin, hair, and nails reflecting both the hyperthyroid and hypothyroid states, and the multiple associations of thyroid disease with other cutaneous and systemic diseases. Internists, family practitioners, pediatricians, geriatricians, and dermatologists address these issues on a daily basis: When is it appropriate to evaluate a patient for thyroid disease? How should the patients be evaluated? How often should testing be performed? Should other family members be screened for thyroid disease? The purpose of The Thyroid in Dermatology is to raise awareness of the vast spectrum of thyroid-skin interactions, and to provide a framework for the appropriate diagnosis and management of these diseases.Health, Ethnicity and Diabetes
By Harshad Keval. 2016
This book explores the often contentious relationship between health, concepts of race and ethnicity, and the impact on South Asian…
groups. Using medical sociological and anthropological perspectives, it excavates racialised constructions of diabetes 'risk' within discourses, and highlights the contrasting counter narratives in people's accounts of their everyday lives. By identifying a number of components to the discursive, racialised construction of 'risky' South Asian bodies, this book problematises taken for granted understandings of culture, lifestyle and genetic risk. The mobilisation of these mechanisms in health science and interventions result in a racialising gaze, directed at groups already experiencing historically embedded race-related issues. The book situates these constructions of risk against the emergent, fluid and dynamic counter narratives to risk constructions. The new found momentum in genetic science is also critiqued in its formulation of racial-genetic risk, especially in the case of diabetes in South Asian groups, and is identified as perpetuating a series of racializing processes.Endocrine Hypertension
By Christian A Koch, George P Chrousos. 2013
The prevalence of hypertension is almost three times as high as that of diabetes mellitus type 2, with both conditions…
being major risk factors for stroke, ischemic heart disease, cardiac arrhythmias, and heart failure. The exact prevalence of hypertension related to hormonal derangements (endocrine hypertension) is not known but estimated to affect less than 15% of hypertensive patients. Recent scientific discoveries have increased the understanding of the pathophysiologic mechanisms of hypertension. In Endocrine Hypertension, a renowned panel of experts provides a comprehensive, state-of-the-art overview of this disorder, discussing when to assign an endocrine cause in one of many conditions that may present with hypertension. The first part of Endocrine Hypertension is dedicated to adrenal causes. The second part of the volume concerns potential nonadrenal causes of hypertension, such as growth hormone excess or deficiency, primary hyperparathyroidism, vitamin D deficiency, testosterone deficiency, insulin resistance, obesity-associated hypertension, and the role of central mineralocorticoid receptors and cardiovascular disease. An important contribution to the literature, Endocrine Hypertension is an indispensable reference not only for endocrinologists, diabetologists, and adrenal investigators, but also for translational scientists and clinicians from cardiology, internal medicine, pediatrics, family medicine, geriatrics, urology, and reproductive medicine / gynecology.Surgical Pathology of Endocrine and Neuroendocrine Tumors
By Ashraf Khan. 2009
Surgical pathology is the cornerstone in the management of neoplastic disorders. Written for the practicing surgical pathologist in mind, Surgical…
Pathology of Endocrine and Neuroendocrine Tumors provides an up-to-date text on surgical pathology of endocrine and neuroendocrine tumors. The text begins with radiological imaging of tumors, followed by a section on fine needle aspiration biopsy. The main section focuses on surgical pathology of endocrine and neuroendocrine tumors. The volume closes with applications of molecular techniques and their potential for the future. Surgical Pathology of Endocrine and Neuroendocrine Tumors is written by a panel of internationally recognized pathologists who are not only experts in their fields, but who also contribute their own valuable insights making this new book an essential resource for practicing general and specialist surgical pathologists and pathologists in training.Heart Failure in Clinical Practice
By Michael Y. Henein. 2010
Heart Failure in Clinical Practice provides a toolkit for clinicians to guide them in the diagnosis and treatment of patients…
with suspected heart failure. Algorithms and flow diagrams are included to give the reader an illustrated snapshot of the decisions involved in the management of these patients.Thyroid Fine Needle Aspiration
By Grace C. H. Yang. 2013
This practical text and color atlas tells the story of 350 patients, covering a wide range of thyroid lesions with…
high quality composite images that correlate cytology with histology, and radiology with pathology. Each case includes clinical presentation and final pathology. Concise, easy-to-read text enables readers to quickly find the information they need for accurate diagnosis. 'Lookalike' lesions are grouped together so the subtle cytological differences can be appreciated. The author's practical approach explains mistakes made and lessons learned, so diagnostic pitfalls can be avoided. Logarithmic triage diagrams are provided, as well as over 2000 printed photomicrographs and a CD-ROM offering images in downloadable format. Written by a leading cytopathologist who has performed onsite assessment for over 10,000 ultrasound-guided thyroid fine needle aspirations, this is an important resource for all healthcare professionals dealing with thyroid patients, including cytopathologists, surgical pathologists, cytotechnologists, sonographers, radiologists, endocrinologists and surgeons.Modern Dietary Fat Intakes in Disease Promotion
By Ronald Ross Watson, Sherma Zibadi, Fabien De Meester. 2001
The industrial and agricultural revolutions have dramatically changed our lifestyles including where we get foods and what we eat. Modern…
diets have moved away from a close association with historically beneficial foods and diets towards foods and diets with increased fats and contaminants and with much lower intakes of fruits and vegetables. Modern Dietary Fat Intakes in Disease Promotion focuses on the scientific evidence that define such risks in modern diets with the consequences of increased illness, cancer and disease. There is also an emphasis on methods to reverse negative components of modern diets for health improvement. The volume is divided into six sections. The first section focuses on the behavioral aspects of eating and is followed by sections on fats, obesity and cardiovascular disease and fats and cholesterol. The fourth section contains novel chapters on the potential for contaminants in fats and oils to increase risk of illnesses. The fifth section examines fat induced disease and ill-health. The sixth section looks at dietary and pharmaceutical approaches to modify fat-induced disease and ill-health. Each section contains chapters that address treatment options as well as prevention strategies. Modern Dietary Fat Intakes in Disease Promotion provides practical, data-driven resources based upon the totality of the evidence to help the reader understand both the basics as well as treatments and preventive strategies that are involved in balancing the fats in one's diet as well as within one's body.Visual Dysfunction in Diabetes
By Colin J. Barnstable, Joyce Tombran-Tink, Thomas W. Gardner. 2012
An exciting contribution to the field, Visual Dysfunction in Diabetes: The Science of Patient Impairment and Improvement is designed with…
two overriding objectives: to help readers understand the impact of vision impairment in people living daily with diabetes rather than considering diabetic retinopathy solely as a medical problem, and to explore what we know and don't know about the ways diabetes affect the eye. With the plethora of new information being generated, there are still a series of fundamental questions that must be addressed if effective treatments for diabetic retinopathy are to be found and applied. Developed by a renowned group of authorities, Visual Dysfunction in Diabetes: The Science of Patient Impairment and Improvement offers responses and context for a range of questions, such as: do metabolic factors beyond glucose contribute to vision-threatening diabetic retinopathy? If so, how do these lead to vision impairment? Is diabetic retinopathy a response to systemic metabolic abnormalities or are there unique ocular problems related to insulin resistance? What is the relationship between the neural, vascular, and inflammatory abnormalities in diabetic retinopathy? Do they represent a pathological cascade induced sequentially or simultaneous responses to one or more metabolic perturbations? The authors note that if we do not address these types of questions, it is possible that the long process of developing new therapeutics will target only one arm of the pathology and leave the retina open to damaging consequences of the others. State-of-the-art, comprehensive, and an invaluable addition the research and clinical literature, Visual Dysfunction in Diabetes: The Science of Patient Impairment and Improvement offers guidance and a significant step toward new scientific approaches that can lessen the devastating vision impairment associated with diabetes.Molecular Dermatology
By Cristina Has, Cassian Sitaru. 2013
The sustained skin research efforts over the past decades has led to the accumulation of a significant collection of information…
on skin structure and physiology as well as on the pathogenesis of cutaneous diseases. In Molecular Dermatology: Methods and Protocols, leading experts in the field provide a collection of state-of-the-art reliable protocols covering a wide spectrum of techniques and experimental models, specific molecular assays and disease models, as well as overviews of diagnostic and research areas relevant to molecular dermatology. As a volume in the highly successful Methods in Molecular BiologyTM series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and authoritative, Molecular Dermatology: Methods and Protocols emphasizes the vital importance of skin research and collects the methodologies necessary to aid scientists in moving forward in this valuable field.The Diabetic Foot
By Aristidis Veves, Frank W. Logerfo, John M. Giurini. 2012
In The Diabetic Foot: Medical and Surgical Management, 3rd Edition, a distinguished panel of clinicians provides a thorough update of…
the significant improvements in knowledge surrounding the pathogenesis of diabetic foot problems, as well as the optimal healthcare treatment for this debilitating condition. The authors, many practicing at the famous Joslin-Beth Israel Deaconess Foot Center, again illuminate the successful new multidisciplinary approach now clearly required for the successful treatment of diabetic foot. Drawing on the experiences of diabetologists, podiatrists, vascular surgeons, infectious disease specialists, orthotists, plastic and orthopedic surgeons, this invaluable third edition, so timely given the continued rise of diabetes and its complications, clearly describes established techniques known to be effective. This updated edition blends new knowledge with the time-tested principles of diabetic foot management and will be of significant value to all physicians and researchers with an interest in a state-of-the-art understanding of diabetic foot.Ghrelin in Health and Disease
By Michael O. Thorner, Roy G. Smith. 2012
Ghrelin, the endogenous ligand for the growth hormone secretagogue (GHS) receptor, is critical in the control of food intake and…
energy balance. The ghrelin receptors are now known to have important physiological properties as modulators of growth hormone release, appetite, glucose homeostasis, metabolism, immune function, neurotransmitter activity, cognitive function and neurodegeneration. Bringing all of this information together in the first comprehensive text on the topic, Ghrelin in Health and Disease provides a state-of-the-art synthesis of the latest work in this area for physicians and physician-scientists. This volume addresses the unique property of ghrelin as a modulator of function. Such a property provides potential utility for safe intervention in a wide variety of disease states. Indeed as we learn more about the basic physiology of ghrelin, the potential for treating new disease targets emerge requiring validation in the clinic. Each chapter in this volume is authored by a leading investigator in the field. The introductory chapter sets the background for the book and provides a superb overview of the relevance of ghrelin to physiology, describing how the discovery of ghrelin has prompted us to completely rethink traditional physiology. The authors conclude their chapters by critically addressing the future translational aspects of ghrelin biology and outlining what key basic research and clinical questions remain to be addressed. An invaluable resource, Ghrelin in Health and Disease distinguishes itself as the first comprehensive title covering all of the molecular and clinical issues relating to ghrelin and advancing our clinical understanding of obesity, growth, and reproductive pathogenesis.Obesity and Lung Disease
By Emmanuelle M. Clerisme-Beaty, Anne E. Dixon. 2013
As a result of the rapidly growing rate of obesity worldwide, clinicians are struggling to provide the best strategies for…
treating obese patients with concomitant pulmonary conditions. Obesity does not simply change the epidemiology of pulmonary disease; obesity has a profound impact on the pathophysiology of common pulmonary diseases. Obesity affects the severity of asthma, response to treatment, and is likely a major modifier of the phenotype of asthma. Obesity also appears to affect response to pathogens, and as such has a major influence on response to pneumonia, and has a significant impact on outcomes pertaining to acute lung injury in the intensive care unit. Obesity and Lung Disease: A Guide to Management is the first text in the field to cover the full range of issues related to managing obese patients with pulmonary problems. All the relevant conditions, in the context of obesity, are covered, including airway inflammation, sleep apnea, asthma, pulmonary hypertension, obesity hypoventilation, as well as others. Written by an international group of experts, this important new volume is an invaluable resource for all clinicians and scientists concerned with the challenging problems surrounding obesity and lung diseases.Management of Pediatric Obesity and Diabetes
By Robert J. Ferry. 2010
The twin epidemics of obesity and type 2 diabetes mellitus (T2DM) continue to affect an ever increasing number of children,…
adolescents, and young adults. Management of Pediatric Obesity and Diabetes provides healthcare trainees and professionals with practical, comprehensive, and contemporary approaches to the pediatric patient at risk for obesity, T2DM, and related conditions. A unique guide on the subject, this volume provides clinical paradigms for diagnosis and management of pediatric T2DM and related conditions, while succinctly describing state-of-the-art basic and clinical sciences underlying these problems. The chapters in this volume are independent and concise. Each chapter focuses on a key clinical issue or mechanism of disease. Providing practical, data-driven resources based upon the totality of the evidence, this important text helps the reader understand the basics of pediatric obesity and T2DM and implement strategies to prevent and treat obesity and diabetes in children and adolescents. Management of Pediatric Obesity and Diabetes provides health professionals across many areas of research and practice with up-to-date, well-referenced, and comprehensive evidence on identification, treatment, and prevention of these chronic, serious, metabolic diseases in children. This volume will serve the reader as the most authoritative resource in the field to date.Growth Hormone Related Diseases and Therapy
By Ken Ho. 2011
The molecular era ushered in the cloning of the growth hormone (GH) gene and the production of unlimited amounts of…
GH through recombinant technology. The continuing momentum of research from basic science to clinical evaluation has brought unprecedented advances to the understanding of GH biology for the clinical endocrinologist. Growth Hormone Related Diseases and Therapy: A Molecular and Physiological Perspective for the Clinician distills all the new information of relevance to the endocrinologist over the last 20 years by offering five sections: physiology, molecular genetics, GH deficiency, acromegaly and pharmacotherapy. The first section on physiology focuses on GH action. A review on the structure and function of the GH receptor is followed by a perspective on the regulatory role of ghrelin on GH secretion. The second section on genetics covers pituitary function and adenomas, including new and fascinating information on familial pituitary adenomas, their genotype and phenotype. The adult GH deficiency section spans the epidemiology and diagnosis of GH deficiency with a strong reminder for the clinician that the transition period represents a critical time of somatic maturation, which continues for years after cessation of liner growth. The section on acromegaly focuses on management, giving practical guides to the value of GH and IGF-1 measurements, the place of somatostatin analogues and of radiotherapy while reminding the reader as to why evaluating quality of life is an important part of management. Finally, the section on GH pharmacology takes the reader through innovative developments of long-acting GH formulations with some products on the threshold of clinical use. This section provides a balanced evidence based review of the effects of GH supplementation in aging and in sports where recent data indicates an enhancing effect on a selective aspect of performance. Growth Hormone Related Diseases and Therapy: A Molecular and Physiological Perspective for the Clinician integrates a wealth of information and will prove an invaluable reference for pediatric endocrinologists, adult endocrinologists, endocrine scientists and internists interested in the human biology of GH.Neuroendocrine Tumors
By Paulo M. Hoff, James C. Yao, Ana O. Hoff. 2012
New research has shown that neuroendocrine tumors are more common than previously thought. Progress in our understanding of the molecular…
pathogenesis of these not-so-rare cancers has resulted in renewed interest in developing innovative therapeutic options. In particular, novel molecular targeted agents have been shown to have significant anti-tumor activity, and integration of these therapies has led to critical advances in management. In this volume, an outstanding group of the world's leaders in the field have assembled to convey their knowledge of the epidemiology, biology, and management of all the major types of neuroendocrine tumors. The book takes a multi-modality approach to understanding disease processes and therapeutics, including chapters on medical and surgical treatment as well as a chapter devoted to imaging. Throughout, the authors emphasize recent advances in our understanding of molecular biology and the subsequent emerging therapeutic options.IGFs:Local Repair and Survival Factors Throughout Life Span
By David Clemmons, Iain C.A.F. Robinson. 2010
Insulin-like growth factors (IGFs), their binding proteins and their receptors play important roles in regulating growth, metabolism, proliferation and survival…
for many cells and tissues throughout lifespan in humans and other species. Circulating IGF1 is known to be an endocrine regulator, with metabolic effects related to, and partly convergent with, insulin signalling. IGF1 also mediates many of the growth promoting effects of GH, and there is an ongoing debate as to the relative contributions of endocrine-, vs locally-derived IGF1 for systemic growth. More recently however, it has become clear that IGFs may be key local growth and cellular survival factors for many different tissues, active from early in embryonic development, essential for normal maturation and growth during foetal life. IGFs continue to play important roles throughout adult life in many diverse processes such as tissue repair, cellular proliferation, tissue remodelling and metabolic regulation. IGF systems are tightly regulated; orderly control of cellular repair and metabolism is central to healthy ageing, whilst uncontrolled proliferation can lead to cancer.Molecular Endocrinology
By Thomas E. Curry, Ok-Kyong Park-Sarge. 2009
Over the course of the last hundred years, the field of endocrinology has received ever-increasing attention. Research and developing technologies…
have resulted in a significant leap in our understanding of the causes and treatment of endocrine dysfunction. In Molecular Endocrinology: Methods and Protocols, leaders in the field share a diversity of cutting-edge techniques that are becoming routinely employed in the quest to further understand hormone action. In order to reach the widest number of labs, this volume includes protocols that allow investigators at all stages of their scientific career to successfully perform these techniques. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include brief introductions to their respective subjects, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and expert notes on troubleshooting and avoiding known pitfalls. Comprehensive and easy to use, Molecular Endocrinology: Methods and Protocols is an ideal guide for researchers in labs across the world who seek a deeper understanding of the complex processes and biology of hormones.