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Showing 161 - 180 of 1819 items
By Michael Pugia. 2015
This book discusses recent advances in new anti- and pro-inflammatory pathways in diabetic disease and identifies new diagnostic immunological…
methods that offer potential companion diagnostics for diabetic diseases New methods in proteomics mass spectroscopy immunological assay design measurement of cellular signal transduction and protease inhibition are used to clarify new biochemical pathways Biomarker validation in animal models and correlations in humans for diagnostic clinical trials shed new light on the impact of diabetic diseases The book reviews current understanding of inflammatory pathways in the pathophysiology of insulin resistance metabolic syndrome nephritis and other diabetic inflammatory conditions and is the first to describe the impact of novel adipokines protease inhibitors and complement markers By presenting new methodologies for biomarker discovery it provides a valuable resource for researchers studying clinical diagnosis drug development bio-analytical chemistry proteomics and biochemistry It is also useful for those conducting clinical and biological studies for targeted drug development The methodologies and approaches can be applied to other markers and the information will be helpful in the preparation of research grant applicationsBy David Simmons, Helmut Wenzel, Janice C. Zgibor. 2017
Integrating care across disciplines and organisations around the needs of the person with diabetes has been proposed as an approach…
that could improve care while reducing cost- but has it and can it? Integrated Diabetes Care- A Multidisciplinary Approach collates evidence of worldwide approaches to both horizontal integration (across disciplines) and vertical integration (across organizations) in diabetes care and describe what was done, what worked and what appeared to be the barriers to achieving the goals of the programmes. Evidence is sought from groups who have developed different approaches to integrating diabetes care in different health systems (eg insurance vs tax payer funded, single vs multiple organization, published vs unpublished). A final chapter brings the evidence together for a final discussion about what seems to work and what does not.By Helena M. Tabery. 2010
This book on Herpes Simplex Virus Epithelial Keratitis shows a kind of 'living histology', revealing both morphological and dynamic features…
of the disease, and explaining mechanisms behind them. It offers great insights helpful for the differential diagnostics and the recognition of less known variants as well as of complications. It is also highly useful for the follow-up of treatment results and the differentiation between an active infection and sequelae. Thus, this book will be an invaluable aid for ophthalmologists and researchers working with ocular surface diseases.By Peter Hien. 2012
Der Band behandelt Grundlagen, Diagnostik und Therapie von Lungenerkrankungen. Was ist medizinisch und ökonomisch sinnvoll? Wie lässt sich die Kooperation…
zwischen ambulanter und stationärer Betreuung im Sinne des Patienten optimieren? Welche Werte müssen wie oft kontrolliert werden? Diese und andere Fragen beantwortet das Praxishandbuch knapp, klar und auf dem neuesten Stand von Diagnostik und Therapie. Vorgestellt wird eine individuell abgestimmte Stufentherapie, die Begleiterkrankungen, Alter und Geschlecht des Patienten berücksichtigt.By Berthold Rzany, Mauricio De Maio. 2009
The demand for cosmetic procedures by male patients has increased in recent years. With this trend has come the realization…
that male aesthetic needs are different from female aesthetic needs. This book is the first hands-on guide dedicated exclusively to the aesthetic treatment of the male patient, and provides cosmetic surgeons with important information on how to obtain a natural male look for such patients. It explains facial aesthetics and the aging process in men, as well as the current aesthetic medicine techniques available. It also offers valuable strategies for avoiding and treating undesired results. Written by internationally known experts in the field, this unique guide enables cosmetic surgeons to achieve the best possible treatment outcomes, as well as increased satisfaction in male patients.By Aled Rees, Andrew Lansdown, Miles Levy. 2017
Recognising a need to promote and enhance teaching of clinical endocrinology and diabetes in UK medical schools, the Society for…
Endocrinology, in collaboration with Diabetes UK and the Association of British Clinical Diabetologists, created a national curriculum that sets out the minimum recommended standards for undergraduate medical education. Clinical Endocrinology and Diabetes at a Glance corresponds to the curriculum and covers all important areas of diabetes and endocrinology in a clinically relevant and concise manner, with complementary figures to ensure principles are explained clearly. It highlights key practical skills for undergraduates in line with the GMC recommendations that medical graduates should be well prepared for their Foundation posts. There is also emphasis on the importance of multidisciplinary teams in the management of endocrine diseases and diabetes. These include sections on structured education programmes, psychosocial aspects, and patient self-management and monitoring. Clinical Endocrinology and Diabetes at a Glance will serve as a valuable resource for medical students and junior doctors treating patients with these conditions.By Zvi Laron, J. Kopchick. 2011
Laron syndrome (LS), or primary growth hormone (GH) insensitivity, was first described in 1966. Since then, many patients worldwide have…
been diagnosed with LS, which involves defects in the GH receptor that cause combined congenital deficiency of GH and IGF-I activities. In this comprehensive book the authors draw upon 50 years of multidisciplinary clinical and investigative follow-up of the large Israeli cohort of LS patients. The genetic basis of the syndrome is fully considered, and all aspects of the pathophysiology of IGF-I deficiency are described. Data derived from the recently generated mouse model of LS are reviewed and compared with the human LS experience. Valuable advice is provided on treatment, and treatment effects, such as metabolic effects, adipose tissue alterations, and impact on aging, are fully explored. Together, this book condenses, consolidates, compares, and contrasts data derived from the human and mouse LS experiences and provides a unique resource for clinical and basic scientists to evaluate and compare IGF-I and GH actions.By Richard E. Brown, Michael Wilkinson, Wilkinson, Michael and Brown, Richard E.. 2015
How does the brain regulate sexual behavior, or control our body weight? How do we cope with stress? Addressing these…
questions and many more besides, this thoroughly revised new edition reflects the significant advances that have been made in the study of neuroendocrinology over the last twenty years. The text examines the importance of the hypothalamus in regulating hormone secretion from the endocrine glands, describing novel sites of hormone release including bone, heart, skeletal muscle and liver. The role of steroid hormone, neurotransmitter and peptide receptors, and the molecular responses of target tissues, is integrated into the discussion of the neuroendocrine brain, especially through changes in gene expression. Particular attention is attached to neuropeptides, including their profound influence on behavior. Complete with new full-color figures throughout, along with review and essay questions for each chapter, this is an ideal resource for undergraduate and graduate students of neuroscience, psychology, biology and physiology.By J. Sebag. 2014
The vitreous body long has been the most mysterious of all ocular structures, owing perhaps to its seeming simplicity. There…
have been few concerted, sustained efforts to unravel the mysteries of how vitreous is composed and what role it plays in normal physiology as well as pathology. Over the years, however, many studies have produced important findings concerning vitreous biochemistry, structure, physiology, and pathobiology. Published on the 25th anniversary of Sebag's first book on Vitreous, this second installment is nearly five times longer than its predecessor, reflecting how much has been learned in the past quarter century. This well-constructed compendium not only addresses the most current scientific knowledge, but also reviews clinical perspectives in a manner that lends richness to the scope of the book. Written by 90 authors, this book has 56 chapters organized into 7 sections: Biochemistry; Anatomy, Development, and Aging; Pathology/Pathobiology; Physiology and Phamacotherapy; Posterior Vitreo-Retinal Surgery; Peripheral Vitreo-Retinal Surgery; and Pharmacologic Vitreolysis. With a foreword by Coleman & Lincoff and an introduction by Wallace Foulds, Sebag's latest tome on vitreous is destined to be the authoritative text for years to come.By Adolf F. Holstein, Ralf Middendorff, Michail S. Davidoff, D. Müller. 2009
The discovery of the neuroendocrine features of Leydig cells gave rise to the hypothesis of a potential neuroectodermal and/or neural…
crest origin of testicular Leydig cells. In an experimental animal model the authors revealed that adult Leydig cells originate by transdifferentiation from stem/progenitor cells (pericytes and smooth muscle cells), underlying the close relationship of Leydig cells with testis microvasculature. This and the supporting data from the literature provided the basis for revealing the pericytes as a common adult stem cell type of mammalian species. Distributed by the microvasculature through the entire body, the pericyte, acting as a resting early pluripotent adult stem cell, provides an ingenious system to assure the maintenance, physiological repair and regeneration of organs, each under the influence of specific local environmental factors.By George N. Papaliodis. 2017
Uveitis is a practical guide for the diagnosis and treatment of uveitis and ocular inflammatory diseases. This text provides uveitis…
specialists, practicing ophthalmologists, and ophthalmology residents with the appropriate diagnostic testing and evidenced-based therapeutic options for managing patients afflicted with these conditions. The realm of ocular inflammatory diseases is constantly changing with improved diagnostic modalities and treatment options, however, despite these innovations, the ocular inflammatory diseases, including uveitis, are the third leading cause of blindness worldwide. Written and edited by leaders in the fields of ophthalmology, rheumatology, internal medicine, infectious disease, and oncology, Uveitis addresses the latest advances in the field, from the advent of PCR technology, intraocular depot steroid implants, neoplastic and infectious diseases masquerading as uveitis, and the use of systemic immunomoduatory therapies (including biologic agents/humanized monoclonal antibodies in the armamentarium).By Jr., Brendan C. Stack, Donald L. Bodenner. 2016
Medical and Surgical Treatment of Parathyroid Diseases is an accessible and user-friendly guide, addressing the key points of parathyroid diseases…
using case studies, as well as hundreds of high quality images and illustrations. Written and edited by respected leaders in the field of parathyroid surgery, this book aids in the comprehension of innovative concepts and focuses on the latest in clinical research. Written for otolaryngologists and oncologists at various stages of experience, Medical and Surgical Treatment of Parathyroid Diseases includes chapters dedicated to parathyroid anatomy, physiology, and embryology, medical therapy for parathyroid disease (indications and pharmacotherapy), diagnostic imaging, surgical treatments, and special topics such as health services and healthcare economics related to parathyroid surgery. By Celia Roberts. 2015
Puberty has long been recognised as a difficult and upsetting process for individuals and families, but it is now also…
being widely described as in crisis. Reportedly occurring earlier and earlier as each decade of the twenty-first century passes, sexual development now heralds new forms of temporal trouble in which sexuality, sex/gender and reproduction are all at stake. Many believe that children are growing up too fast and becoming sexual too early. Clinicians, parents and teachers all demand something must be done. Does this out-of-time development indicate that children's futures are at risk or that we are entering a new era of environmental and social perturbation? Engaging with a diverse range of contemporary feminist and social theories on the body, biology and sex, Celia Roberts urges us to refuse a discourse of crisis and to rethink puberty as a combination of biological, psychological and social forces.By Leo Plouffe. 2015
A practical approach to the field of androgen excess or deprivation in women's health. The content includes multiple viewpoints on…
the most common disorders in this class, such as polycystic ovary disease, hirsutism and menopausal issues. Each chapter provides a combination of long-lasting clinical principles in the diagnosis and management of these patients along with a state-of-the-art review. This text takes an innovative approach to uncommon conditions (such as congenital adrenal hyperplasia, transgender conditions). In addition to presenting clinical insights, and a review of the basic science underpinning these conditions, it focuses on key concepts that can be derived from these rare conditions to the entire field. This book is an essential addition to the library for any busy clinician who is looking for a practical reference guide but also for the sub-specialist who is looking for new and thought-provoking insights in this complex scientific area.By Leonard Wartofsky, Douglas Van Nostrand. 2016
Thoroughly revised and extensively expanded, this encyclopedic, highly acclaimed title addresses all aspects of the etiology, pathogenesis, diagnosis, initial treatment…
and long-term management of all varieties of thyroid cancer. Expertly edited by Drs. Leonard Wartofsky and Douglas Van Nostrand, this gold standard reference is divided into 11 Parts: General Considerations on Thyroid Cancer; General Considerations on Nuclear Medici≠ the Thyroid Nodu≤ Well-Differentiated Thyroid Cancer; Variants of Thyroid Cancer, Undifferentiated Tumors: Medullary Thyroid Carcinoma; Undifferentiated Tumors: Thyroid Lymphoma; Undifferentiated Tumors: Anaplastic Thyroid Cancer; New Frontiers and Future Directions; and Additional Resources. With exceptional breadth and depth, the book includes chapters dedicated to isotopes, isotope uptake and scanning procedures such as SPECT/CT, radioiodine ablation (with or without recombinant human TSH), stunning, dosimetry (with or without recombinant human TSH), Octreotide and FDG-PET scanning and other alternative imaging modalities. There is a valuable reference atlas of scan images and illustrations, and a scholarly summary of the side effects of radioiodine and how to avoid or minimize adverse effects of treatment. In addition to an updated section on ultrasonography of the thyroid gland, new sections have been added, including ones on ultrasonography of cervical lymph nodes and imaging for thyroid cancer employing computerized tomography (CT), positron emission tomography (PET) and magnetic resonance imaging (MRI). An indispensable reference source with chapters written by the field's leading authoritative experts, Thyroid Cancer: A Comprehensive Guide to Clinical Management, Third Edition, will be of great interest to not only pathologists, endocrine surgeons, endocrinologists, nuclear medicine physicians, and oncologists but all clinicians with an interest in thyroid cancer.By Carolyn Heller. 2015
Moon Spotlight Georgian Bay & Cottage Country is a 112-page compact guide covering the best of south-central Ontario. Professional travel…
writer Carolyn B. Heller offers her firsthand advice on must-see attractions, as well as maps with sightseeing highlights, so you can make the most of your time. This lightweight guide is packed with recommendations on entertainment, shopping, recreation, accommodations, food, and transportation, making navigating this strikingly beautiful region of Ontario uncomplicated and enjoyable.This Spotlight guide is excerpted from Moon Ontario.This volume provides a detailed step-by-step description of protocols for the establishment of in vitro cultures of important medicinal plants,…
their mass multiplication in controlled environment, and step-wise secondary metabolite analysis. Many of these protocols also provide a basis for in vitro germplasm conservation or cryopreservation of medicinal plant species. Written for the Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Protocols for In Vitro Cultures and Secondary Metabolite Analysis of Aromatic and Medicinal Plants, Second Edition aims to ensure successful results in the further study of this vital field.By Ulrich Spandau, Zoran Tomic. 2015
This book describes step by step how to operate on the patient with diabetic retinopathy. After thorough explanation of surgical…
planning, including the potential need to perform individual procedures at different time points, each stage of the vitrectomy is clearly documented with the aid of color photographs and drawings as well as online surgical videos. Variations in approach are described that are potentially of value, depending on whether one is dealing with a straightforward diabetic retinopathy or a difficult case of tractional retinal detachment. In the second part of the book, a series of case reports are presented that illustrate the surgical procedures applicable in different circumstances. In addition, pearls and pitfalls are highlighted. Small-Gauge Vitrectomy for Diabetic Retinopathy will be an ideal source of information and guidance for all who are embarking upon such surgery or wish to further hone their skills.By Michael Freemark. 2010
Childhood obesity and its co-morbidities -- including type 2 diabetes, hypertension, dyslipidemia, sleep apnea, and fatty liver disease -- have…
seen striking increases in recent years. Despite a wealth of investigation, there is considerable controversy regarding the etiology of childhood obesity and the optimal approaches for prevention and treatment. Pediatric Obesity: Etiology, Pathogenesis, and Treatment addresses the controversy with a range of features that make it a unique resource for those who care for obese children and their families. Written from a perspective that is international in scope, the distinguished authors re-assess the roles of genetic and environmental factors in the pathogenesis of childhood obesity and critically review new studies of the effects of lifestyle, pharmacologic, and surgical interventions. The evidence-based approach of Pediatric Obesity: Etiology, Pathogenesis, and Treatment provides a comprehensive and invaluable guide for all healthcare providers concerned with the evaluation and care of children with nutritional and metabolic disease and with the societal implications of the obesity epidemic.By Antonio Ferreras. 2016
This atlas offers a truly comprehensive update on the use of imaging technologies for the diagnosis and follow-up of glaucoma.…
In addition to standard automated perimetry, gonioscopy, fundus photography, and stereophotography, other advanced, high-resolution methods for imaging the eye in glaucoma are explained in detail, including ultrasound biomicroscopy, confocal scanning laser ophthalmoscopy, scanning laser polarimetry, and spectral domain optical coherence tomography. The role of the various tests and the keys to optimizing their use in clinical practice are detailed with the aid of high-quality figures in order to enable the reader to achieve the best possible performance when applying these tools. The risk of developing visual disability and blindness as a consequence of glaucoma varies widely among affected individuals. Personalized testing strategies and tailored therapeutic interventions are required to effectively reduce visual impairment due to glaucoma. Glaucoma Imaging will assist residents, researchers, and clinicians in improving their ability to understand and integrate the information obtained using traditional techniques with the reports provided by computer-assisted image instruments.